Md. Ibrahim Khalil

Jahangirnagar University · Department of Biochemistry and Molecular Biology

Thalassemia is a hereditary hemoglobinopathies that results from the absence of a globulin chain and it is a very common problem in Southeast Asia. Like many other countries’ community based premarital carrier screening (PMCS) of thalassemia is extremely rare in Bangladesh. This study aimed to investigate knowledge, attitude, practice, and awarenes...

Environmental exposure to multiple metals and metalloids is widespread, leading to a global concern relating to the adverse health effects of mixed-metals exposure, especially in young children living around industrial areas. This study aimed to quantify the concentrations of essential and potentially toxic elements in blood and to examine the pote...

Background: Chronic obstructive pulmonary disease (COPD) is the most prevalent long-term respiratory condition. Patients with COPD experience detrimental effects of COVID-19 infection. Objective: To figure out whether COPD is a risk factor influencing the progression of COVID-19 and to explore the clinical value of laboratory biomarkers to assess t...

Simple Summary Autoimmune diseases cause cancer deaths through thromboembolic events caused by antiphospholipid antibodies. A total of 40 adult cancer patients and 40 age- and sex-matched healthy subjects participated. Blood samples were tested by ELISA methods for anticardiolipin antibodies. Cancer patients had 60.0% (n = 24) aCL antibodies versus...

The prevalence of anemia is high among children and adolescents in low- and middle-income countries because of undernutrition resulting from their poor socioeconomic status and lack of knowledge on proper nutrition. We conducted a systematic review and meta-analysis to determine the prevalence of anemia among children and adolescents aged between 6...

Blumea lacera (Burm. f.) DC. is attracting scientific interest due to the diverse biological activities of its various parts and its use in folk medicine. The present study was undertaken to investigate the tissue‐specific differential expression pattern of its total bioactive compounds. The study was further extended to whole plant phenolics profi...

Alternanthera philoxeroides, a tropical herb and edible vegetable, has been popular as a medicinal plant. Applying in vitro approach, we initially attempted to assess the phytochemicals, bioactive chemicals, as well as antioxidant and anticoagulant activities of this plant. Following that, the in vivo toxicological effects of methanolic extracts of...

Chemical pollution arising from heavy metals and metalloids is a growing global concern and a major cause of pollution-related diseases in the world today, especially in low- and middle-income countries. The present study investigated the urinary concentrations of metals and metalloids in primary school-aged children (N = 142), living in three diff...

Microbiological quality of four different cultivars (viz., Deglet Noor, Dabbas, Barni and Lulu) of date palm fruits imported into Bangladesh was evaluated. The microbiological quality analysis revealed that the date palm fruit samples are contaminated with bacteria and fungi. Among the studied samples, total aerobic plate count varied from 6.85 ×10...

Many of the aquatic pathogenic microflora belong to the non-lactose fermenting (NLF) Enterobacteriaceae and emergence as well as the spread of antibiotic resistance in them is now a serious threat to public health worldwide. Growth of textile industries has heavily flourished acting as hub for the ready-made garments factories in Bangladesh. Textil...

Tomatoes are consumed worldwide as fresh vegetables because of their high contents of essential nutrients and antioxidant-rich phytochemicals. Tomatoes contain minerals, vitamins, proteins, essential amino acids (leucine, threonine, valine, histidine, lysine, arginine), monounsaturated fatty acids (linoleic and linolenic acids), carotenoids (lycope...

In this study, we estimate the proximate compositions, phytochemicals (po-lyphenol, flavonoids, flavonol, tannin, protein, carbohydrate, reducing sugar, and β carotene), antioxidant activities, vitamins, minerals, and heavy metals of the four pulses (mung, anchor, chickpea, lentils) and compare among them to find out more nutritious pulse samples....

Diabetes is a chronic metabolic disorder triggered by disturbances in carbohydrate, protein, and lipid metabolisms, where either reduced secretion or sensitivity of insulin is observed coupled with poor glucose control. Date palm fruits are one of the fruits reported to have good potential in diabetes treatment due to its presence of polyphenols ex...

Background: According to a number of previous studies, citrus fruits are rich in phytochemicals, minerals and bioactive compounds. Objective: The aim of this study was to investigate the antioxidant, antimicrobial and anticoagulant activities, phytonutrients, bioactive compounds, mineral and heavy metals in peel and pulp of Elachi lemon (Citrus li...

Potatoes (Solanum tuberosum L.) are one of the common vegetables in Bangladesh. The present study was aimed to assess the effect of boiling on the nutritional value, phytochemical contents, and antioxidant activity of two commonly consumed potato varieties in Bangladesh; Lal Sheel and Diamant. Our results show that boiling increased moisture and cr...

Goose bone is traditionally used in the treatment of many ailments including in bone fracture. e aim of the present study was to evaluate the subacute toxicity of goose bone in a rat model by investigating some hematological and biochemical parameters in rats. Subsequently, a histopathological study was performed to confirm the presence of patholog...

The aim of the present study was to evaluate the protective effect of Syzygium cymosum leaf methanol extract (SCL) against carbofuran (CF)-induced hepatotoxicity in Sprague-Dawley rats, along with the identification and quantification of polyphenolic composition by high-performance liquid chromatography (HPLC). Results revealed the presence of alka...

The aim of this study was to investigate the antioxidant potentials, subacute toxicity, and beneficiary effects of methanolic extract of pomelo (Citrus grandis L. Osbeck) in rats. Long Evans rats were divided into four groups of eight animals each. The rats were orally treated with three doses of pomelo (250, 500, and 1000 mg/kg) once daily for 21...

In this study, the antioxidant potentials and protective effect of ethanolic extract of monkey fruits (Artocarpus lakoocha) (AL) was investigated against paracetamol-induced toxicity in rats. AL which contains high concentration of polyphenols, flavonoids, tannins and protein, exhibited high radical scavenging activity and ferric reducing antioxida...

Background To date, there is no x-ray crystallography or structures from nuclear magnetic resonance (NMR) on royal jelly proteins available in the online data banks. In addition, characterization of proteins in royal jelly is not fully accomplished to date. Although new investigations unravel novel proteins in royal jelly, the majority of a protein...

Propolis which is a natural resinous product from the honeybees, is becoming increasingly popular for its diverse therapeutic and industrial applications. In this study, we report for the first time the antioxidant, cytotoxic, and antinociceptive activities of propolis from Bangladesh (BDP). The antioxidant activities were measured by biochemical a...

The current study aimed to investigate the ameliorative effects of two types of mushrooms, Ganoderma lucidum (GL) and Auricularia polytricha (AP), against carbofuran-(CF) induced toxicity in rats. Male Wistar rats (í µí±› = 42) were divided into six equal groups. The rats in the negative control group received oral administration of CF at 1 mg/kg w...

An organic compound known as 5-hydroxymethylfurfural (HMF) is formed from reducing sugars in honey and various processed foods in acidic environments when they are heated through the Maillard reaction. In addition to processing, storage conditions affect the formation HMF, and HMF has become a suitable indicator of honey quality. HMF is easily abso...

Helicobacter pylori (H. pylori), which is found in the stomach of approximately 50% of humans, remains there for almost the entire lifetime of the infected individual, leading to various gastrointestinal tract-associated disorders following full-blown infection. Due to the emergence of antibiotic resistance, recurrence and high cost of therapy, mos...

The antihyperglycemic, antidiabetic, and antioxidant potentials of the methanolic extract of Garcinia pedunculata (GP) fruit in rats were investigated. The acute antihyperglycemic effect of different doses of GP was studied in normal male Wistar rats. Diabetes was induced by streptozotocin (STZ) injection in another cohort of male Wistar rats and t...

Increases in the incidence of cardiovascular disease (CVD) have aroused strong interest in identifying antioxidants from natural sources for use in preventive medicine. Citrus macroptera (C. macroptera), commonly known as “Satkara”, is an important herbal and medicinal plant reputed for its antioxidant, nutritious and therapeutic uses. The aim of t...

The aromatic volatile organic compounds present in honey is important since they contribute toward organoleptic characteristics, identity, and quality of honey. A good number of scientific data and information from some literatures corroborate bioactivity with toxicity of volatile organic compounds present in honey. Nevertheless, systematic scienti...

Since diabetes mellitus (DM) is one of the most common and serious endocrine metabolic disorders, it is important to elucidate novel antidiabetic therapeutic agents from various sources, including natural products. Bee venom (BV) is a complex mixture of proteins, peptides, and low molecular components, and melittin is the main constituent. Melittin...

Context: Turmeric (Curcuma longa L. [Zingiberaceae]) is used in the treatment of a variety of conditions including pesticide-induced toxicity. Objective: The study reports the antioxidant properties and the protective effects of turmeric against carbofuran (CF)-induced toxicity in rats. Materials and methods: The antioxidant potential was determi...

Honey contains many active constituents and antioxidants such as polyphenols. Polyphenols are phytochemicals, a generic term for the several thousand plant-based molecules with antioxidant properties. Many in vitro studies in human cell cultures as well as many animal studies confirm the protective effect of polyphenols on a number of diseases such...

We investigated the aqueous and ethanolic extracts of different forms (local names: mura and chora ) of turmeric (Curcuma longa) from the Khulna and Chittagong divisions of Bangladesh for their antioxidant properties and polyphenol, flavonoid, tannin, and ascorbic acid contents. The antioxidant activity was determined using the 1,1-diphenyl-2-picry...

The study reports on major and trace elements as well as antioxidant properties of honey samples from Bangladesh. Four major cationic elements, seven trace elements, and three heavy metals were determined in the 12 honey samples using atomic absorption spectrophotometer. Nutritional values in these honey samples were further investigated according...

Polymorphisms of the ADIPOR2 gene are frequently linked to a higher risk of developing diseases including obesity, type 2 diabetes and cardiovascular diseases. Though mutations of the ADIPOR2 gene are detrimental, there is a lack of comprehensive in silico analyses of the functional and structural impacts at the protein level. Considering the invol...

Propolis contains high concentrations of polyphenols, flavonoids, tannins, ascorbic acid, and reducing sugars and proteins. Malaysian Propolis (MP) has been reported to exhibit high 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity and ferric reducing antioxidant power (FRAP) values. Herein, we report the antioxidant properties and c...

This study was undertaken to investigate the toxicological profile of a methanolic extract of Garcinia pedunculata fruit in rats by conducting hematological, biochemical, and histopathological examinations. Long Evans rats were divided into four groups, each with 6 animals, and were treated with three oral doses (250, 500, and 1000 mg/kg) once dail...

Alzheimer’s disease (AD), which largely affects the elderly, has become a global burden. Patients with AD have both short- and long-term memory impairments. The neuronal loss in AD occurs due to abnormally folded amyloid beta proteins and aggregation of hyperphosphorylated tau proteins in the brain. Eventually, amyloid plaques and neurofibrillary t...

Bee venom (BV) is used to treat many diseases and exhibits anti-inflammatory, anti-bacterial, antimutagenic, radioprotective, anti-nociceptive immunity promoting, hepatocyte protective and anti-cancer activity. According to the literature, BV contains several enzymes, including phospholipase A2 (PLA2), phospholipase B, hyaluronidase, acid phosphata...

Parkinson’s disease (PD) is characterized by neurodegeneration and a progressive functional impairment of the midbrain nigral dopaminergic neurons. The cause remains unknown; however, several pathological processes and central factors, such as protein aggregation, mitochondrial dysfunction, iron accumulation, neuroinflammation and oxidative stress,...

The present study was designed to investigate the cardioprotective effects of Sundarban honey (SH) in rats with isoproterenol-(ISO-) induced myocardial infarction. Adult male Wistar Albino rats were pretreated with Sundarban honey (5 g/kg) daily for a period of 6 weeks. After the treatment period, ISO (85 mg/kg) was subcutaneously injected into the...

Cardioprotective potential of bee propolis against isoproterenol induced myocardial infarction in rat model Rizwana Afroz1,2, Romana Ahmed1, E. M. Tanvir1,3, Nurul Karim1, Md. Ibrahim Khalil1 1Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh. 2Department of Biochemistry, Primeasia University...

Type 2 diabetes mellitus (T2DM), the most common form of diabetes, is characterized by insulin resistance in the hepatic and peripheral tissues. Glucose transporter 4 (GLUT4) plays a major role in the pathophysiology of T2DM. Its defective expression or translocation to the peripheral cell plasma membrane in T2DM patients hinders the entrance of gl...

Globally, thrombosis-associated disorders are one of the main contributors to fatalities. Besides genetic influences, there are some acquired and environmental risk factors dominating thrombotic diseases. Although standard regimens have been used for a long time, many side effects still occur which can be life threatening. Therefore, natural produc...

Diabetes mellitus (DM) is one of the most common endocrine metabolic disorders. In addition to exercise and diet, oral anti-diabetic drugs have been used as a part of the management strategy worldwide. Unfortunately, none of the conventional anti-diabetic drugs are without side effects, and these drugs pose an economic burden. Therefore, the invest...

Honey is a popular natural food product with a very complex composition mainly consisting of both organic and inorganic constituents. The composition of honey is strongly influenced by both natural and anthropogenic factors, which vary based on its botanical and geographical origins. Although minerals and heavy metals are minor constituents of hone...

Although Citrus macroptera (Rutaceae), an indigenous fruit in Bangladesh, has long been used in folk medicine, however, there is a lack of information concerning its protective effects against oxidative damage. The protective effects of an ethanol extract of Citrus macroptera (EECM) against acetaminophen-induced hepatotoxicity and nephrotoxicity we...

Despite the reported association of adiponectin receptor 1 ( ADIPOR1) gene mutations with vulnerability to several human metabolic diseases, there is lack of computational analysis on the functional and structural impacts of single nucleotide polymorphisms (SNPs) of the human ADIPOR1 at protein level. Therefore, sequence- and structure-based comput...

The present study was designed to investigate the cardioprotective effects of Sundarban honey (SH) in rats with isoproterenol- (ISO-) induced myocardial infarction. Adult male Wistar Albino rats were pretreated with Sundarban honey (5 g/kg) daily for a period of 6 weeks. After the treatment period, ISO (85 mg/kg) was subcutaneously injected into th...

Cumulatively, degenerative disease is one of the most fatal groups of diseases, and it contributes to the mortality and poor quality of life in the world while increasing the economic burden of the sufferers. Oxidative stress and inflammation are the major pathogenic causes of degenerative diseases such as rheumatoid arthritis (RA), diabetes mellit...

Table S1 to S5 depict results of nonsynonymous SNPs of the human ADIPOR1 gene analyzed by SIFT, SNAP2, nsSNPAnalyzer, PolyPhen-2, PhD-SNP, PANTHER, SNPs&GO, and Fathmm.

A comparative study of the extraction efficiency of nine known polyphenols [phenolic acids (benzoic acid, dihydroxybenzoic acid, gallic acid, trans-cinnamic acid and vanillic acid) and flavonoids (naringenin, naringin, quercetin and rutin)] was conducted by deliberately adding the polyphenols to an artificial honey solution and performing solid pha...

Sundarban honey is one of the most renowned and popular types of honey from Bangladesh. This study was undertaken to investigate the antioxidant and DNA damage inhibition potentials of Sundarban honey. The estimated polyphenol, flavonoid, ascorbic acid, reducing sugar and protein contents in the investigated honey were found to be 593.96 ± 13.71 mg...

We investigated the protective role of Withania somnifera leaf extract (WSLEt) on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats. Subcutaneous injection of ISO (85mg/kg body weight (b.w.)) administered to rats for two consecutive days caused a significant increase in cardiac troponin I (cTnI) levels and serum lipid profiles, as we...

In this study, the antioxidant potential of Citrus macroptera fruit was compared between its pulp (CMPU) and peel (CMPE). The biochemical effects of an ethanol extract of CMPU were investigated on major organs, including the liver, kidney and pancreas. Male wistar rats (n = 24) were randomly divided into four groups, including Group I (control), Gr...

Background and Aim: Luteolins, naturally occurring flavonoids found in many types of fruits and vegetables, exhibit numerous pharmacological properties. However, very little is known about their biochemical targets. Currently, there is some preliminary evidence showing the anticancer effects of luteolins. The aim of this study was to disclose the t...

Residual levels of seven frequently used pesticides were investigated in 140 samples of two common vegetables, eggplants and tomatoes, from agricultural fields in the Narayanganj district of Bangladesh. The analysis of pesticide residues was performed by high-performance liquid chromatography with photodiode array detection. A large percentage of t...

Background and Purpose: Pomelo (Citrus grandis L.), which belongs to the family Rutaceae, is one of the most widely cultivated crops in Southeast Asia. Pomel fruit is used as appetizer, antitoxic, cardiac stimulant and stomach tonic. Moreover, the fruit juice has reported to contain several flavoniods and hence show high antioxidant activity. Howev...

Background and Aim Carbofuran (CF) is one of the widely used carbamate based pesticides applied for insects but has adverse effects on different life forms through production of free radicals by peroxidation of cell membrane. In order to mitigate this oxidative stress, mushrooms, especially Ganoderma lucidum and Auricularia auricular, with rich ant...

This study was conducted to investigate the effects of different honey processing parameters (temperature, light, gamma irradiation, evaporation and sachet packaging) on the physical, biochemical and antioxidant characteristics of Tualang honey samples that have been stored for 1 year. The protein and proline contents doubled following radiation an...

Background: Honey is renowned for its antioxidant, antimicrobial and medicinal properties. It is typically heated and filtered during processing to avoid crystallization. However, few studies have reported its heating effect and the antioxidant and antimicrobial activities of honey. Materials and Methods: In this study, honey samples were collected...

Background: Honey is renowned for its antioxidant, antimicrobial and medicinal properties. It is typically heated and filtered during processing to avoid crystallization. However, few studies have reported its heating effect and the antioxidant and antimicrobial activities of honey. Materials and Methods: In this study, honey samples were collected...

The present study was designed to investigate the cardioprotective effects of Malaysian Tualang honey against isoproterenol-(ISO-) induced myocardial infarction (MI) in rats by investigating changes in the levels of cardiac marker enzymes, cardiac troponin I (cTnI), triglycerides (TG), total cholesterol (TC), lipid peroxidation (LPO) products, and...

BAU Kul (Zizyphus mauritiana) is a new and improved variety of plum fruit from Bangladesh. This study was to investigate the antioxidant potency and antimicrobial activity of BAU Kul. BAU Kul is a very good source of phenolics, flavonoids, ascorbic acid and tannins. The reducing sugar and protein content of BAU Kul were 1.68 and 0.81% by weight, re...

The present study was designed to investigate the cardioprotective effects of Malaysian Tualang honey against isoproterenol-(ISO-) induced myocardial infarction (MI) in rats by investigating changes in the levels of cardiac marker enzymes, cardiac troponin I (cTnI), triglycerides (TG), total cholesterol (TC), lipid peroxidation (LPO) products, and...

Lablab bean [Lablab purpureus (L.) Sweet] is an important nutritious food supplement in Bangladesh. But it suffers from various kinds of diseases which reduce greatly its quality and quantity. The present investigation was conducted to control the fungal infection of the seed of eleven varieties of lablab bean with hot water treatment. In this inve...

Background and Purpose: Honey is known to be a rich source of antioxidants, minerals and trace elements. As there are several types of honey in Bangladesh, this study was executed to determine the basic composition and the essential and toxic elements of twelve Bangladeshi honey samples collected from different botanical origins. Methods: The level...

The purpose of the present study is to investigate the antioxidant and antimicrobial activities of a methanolic extract of Apple kul (Zizyphus mauritiana) as it has not been studied extensively. Apple kul was found to be a rich source of polyphenols (52.19 ± 2.38 mg gallic acid equivalents/100 g), flavonoids (13.19 ± 1.31 mg catechin equivalents/10...

Honey, a supersaturated natural product of honey bees, contains complex compounds with antioxidant properties and therefore has a wide a range of applications in both traditional and modern medicine. In the present study, the protective effects of Sundarban honey from Bangladesh against acetaminophen-(APAP-) induced hepatotoxicity and nephrotoxicit...

Diabetic wounds are unlike typical wounds in that they are slower to heal, making treatment with conventional topical medications an uphill process. Among several different alternative therapies, honey is an effective choice because it provides comparatively rapid wound healing. Although honey has been used as an alternative medicine for wound heal...

Rheumatoid Arthritis is the most common, chronic autoimmune disease with no known cure, and a priority for biological research in the twenty first century. The limitations in the efficacy and safety of current treatment strategies are driving the need for new, safe and effective medications. Recent experimental findings focus on the potential of ne...

There is a wealth of information about the nutritional and medicinal properties of honey. However, honey may contain compounds that may lead to toxicity. A compound not naturally present in honey, named 5-hydroxymethylfurfural (HMF), may be formed during the heating or preservation processes of honey. HMF has gained much interest, as it is commonly...

Honey is the only insect-derived natural product with therapeutic, traditional, spiritual, nutritional, cosmetic, and industrial value. In addition to having excellent nutritional value, honey is a good source of physiologically active natural compounds, such as polyphenols. Unfortunately, there are very few current research projects investigating...

Here, we report the phase distribution of chronic myeloid leukemia (CML), defined based on the World Health Organization criteria, among 63 patients in Bangladesh. All patients were diagnosed based on complete blood count, bone marrow examination including bone marrow aspiration and reverse-transcriptase polymerase chain reaction (RT-PCR). Out of 6...

Since orchid seeds lack endosperm, their germination in nature is very limited. Moreover, ruthless collections, destruction of habitats by reclamation and deforestation, unauthorized trade have led to reduction in natural population of many orchid species. In the meantime some of the orchid species have been extinct and a large number of species ha...

Lactic acid bacteria (LAB) have been studied for many years to be used as biopreservative due to production of various antimicrobial compounds. This study was carried out for the determination of natural antimicrobial activity of LAB isolated from curd samples. LAB were screened for antagonistic activity against Gram-negative Escherichia coli and G...

Adiponectin appears as a molecular tool for the prediction of the development of type 2 diabetes mellitus (T2DM). A reduced level of serum adiponectin has been shown negatively correlated with the risk of developing T2DM. The role of adiponectin in developing T2DM in Bangladeshi population is not clearly understood. The present study aims to invest...

The present study was carried out to investigate the effectiveness of chemical (0.2% and 0.3% citric acid and potassium sorbate) and radiation (0.5 and 1.0 kGy) at room and low temperature (4°C) in extending the post-harvest life in relation to delay ripening of mango (Mangifera indica L.) during storage to reduce the post-harvest losses which will...