Md Nazmul Islam

Md Nazmul Islam
Teesside University · School of Health & Life Sciences

PhD, M.Sc
Cancer Early Detection, Biosensor Development, Exosome Enrichment, Circulating Biomarker Sensing

About

38
Publications
34,575
Reads
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1,683
Citations
Introduction
My research focuses on the molecular diagnostics of cancer. My particular aim is to develop nanobiosensors for the detection of clinically relevant exosomes and circulating biomarkers. Find more here https://research.tees.ac.uk/en/persons/md-nazmul-islam
Additional affiliations
August 2018 - January 2020
Imperial College London
Position
  • PostDoc Position
Description
  • Development of an automated modular screening device for the detection of clinically relevant miRNAs.
January 2016 - June 2018
Griffith University
Position
  • PhD Student
Description
  • Thesis title : Engineering translational approaches for molecular diagnostics of cancer: Multifunctional nanomaterials and electrochemical sensors for clinically relevant RNA biomarker detection
April 2014 - January 2016
The University of Queensland
Position
  • Research Assistant
Description
  • Transferred PhD to Griffith University
Education
January 2016 - April 2018
Griffith University
Field of study
  • Analytical Chemistry, Lab-on-a-Chip, Biosensor Developement
April 2014 - December 2015
The University of Queensland
Field of study
  • Biotechnology
August 2004 - August 2010
Jahangirnagar University
Field of study
  • Biochemistry & Molecualr Biology

Publications

Publications (38)
Article
Full-text available
Exosomes are cell derived vesicles secreted by both normal and cancerous cells into the extracellular matrix and in blood circulation. Tumor-derived exosomes have attracted increasing attention in non- invasive cancer diagnosis and prognosis. However, their effective capture and specific detection pose significant technical challenges. Current dete...
Article
Full-text available
This paper reports the development of a nonenzymatic, amplification-free, and sensitive platform for the detection of microRNA based on a new class of electrocatalytically active superparamagnetic gold-loaded nanoporous iron oxide nanocubes (Au@NPFe2O3NC). The assay showed an excellent detection sensitivity down to 100 fM and specificity towards th...
Article
Full-text available
Enzyme-mimicking activity of iron oxide based nanostructures have provided a significant advantage in developing advanced molecular sensors for biomedical and environmental applications. Herein, we introduce the horseradish peroxidase (HRP)-like activity of gold loaded nanoporous ferric oxide nanocubes (Au-NPFe2O3NC) for the development of a molecu...
Article
Herein, we report the soft-templated preparation of mesoporous iron oxide using the asymmetric poly(styrene-b-acrylic acid-b-ethylene glycol) (PS-b-PAA-b-PEG) triblock copolymer. To the best of our best knowledge, this block copolymer has not yet been used for the preparation of mesoporous iron oxide. This polymer forms a micelle consisting of a PS...
Article
Short single-stranded nucleic acids as found in a variety of bodily fluids have recently emerged as minimally invasive biomarkers for a broad range of pathologies, most notably cancer. Because of their small size, low natural abundance and high sequence homology between family members they are challenging to detect using standard technologies suita...
Article
The integration of nanoarchitectonics and hydrogel into conventional biosensing platforms offers the opportunities to design physically and chemically controlled and optimized soft structures with superior biocompatibility, better immobilization of biomolecules, and specific and sensitive biosensor design. The physical and chemical properties of 3D...
Chapter
Electrochemical sensors are common analytical tools for the sensing of cancer biomarkers and biomarkers in general. They provide fast analysis times, high sensitivities, and the ability to perform complex measurements such as multiplexed analyses or screening tests. This chapter introduces the fundamental principles being electrochemical sensing an...
Conference Paper
Full-text available
Despite immense potential of nanomaterials as nanozyems (i.e., enzyme-mimicking activities) in biomedical and environmental applications 1 , peroxidase mimetics of nanostructured materials for direct analysis of circulating biomarkers such as autoantibodies in readily available body fluids is yet to be explored. 2 Herein, we demonstrated the horser...
Article
We report the electrocatalytic activity of a new class of superparamagnetic nanoparticles, graphene‐oxide‐loaded iron oxide (GO/IO hybrid material), towards the reduction of ruthenium hexaammine(III) chloride (Ru(NH3)6]3+, RuHex). Leveraging the electrocatalytic activity of the GO/IO hybrid material and the signal enhancement capacity of [Ru(NH3)6]...
Article
An inexpensive, simple and rapid sensor platform capable of detecting cancer-related long non-coding RNA (lncRNA) with high accuracy is of great interest in the field of molecular diagnostics. Herein, we report on the development of a new colorimetric and electrochemical assay platform for long non-coding HOX transcript antisense intergenic RNA (HO...
Article
Cell free DNA (cfDNA) refers to short fragments of acellular nucleic acids detectable in almost all body fluids, including blood, and are involved in various physiological and pathological phenomenon such as immunity, coagulation, aging, and cancer. In cancer patients, a fraction of hematogenous cfDNA originates from tumors, termed as circulating t...
Article
Recent evidence suggests that small non-coding RNAs or microRNA (miRNA)s encapsulated in exosomes represent an important mechanism of communication between the cells. Exosomal miRNAs play an important role in oncogenesis via stimulating cell to cell communication and facilitating metastasis in cancers. Despite progressive advances, current methods...
Article
Full-text available
Correction for ‘Gold-loaded nanoporous iron oxide nanocubes: a novel dispersible capture agent for tumor-associated autoantibody analysis in serum’ by Sharda Yadav et al. , Nanoscale , 2017, 9 , 8805–8814.
Article
A crucial issue in microRNA (miRNA) detection is the lack of sensitive method capable of detecting the low levels of miRNA in RNA samples. Herein, we present a sensitive and specific method for the electrocatalytic detection of miR-107 using gold-loaded nanoporous superparamagnetic iron oxide nanocubes (Au-NPFe2O3NC). The target miRNA was directly...
Article
Full-text available
DNA methylation is one of the key epigenetic modifications of DNA that results from the enzymatic addition of a methyl group at the fifth carbon of the cytosine base. It plays a crucial role in cellular development, genomic stability and gene expression. Aberrant DNA methylation is responsible for the pathogenesis of many diseases including cancers...
Article
Despite having reliable and excellent diagnostic performances, the currently available messenger RNA (mRNA) detection methods mostly use enzymatic amplification steps of the target mRNA which is generally affected by the sample manipulations, amplification bias and longer assay time. This paper reports an amplification-free electrochemical approach...
Article
Autoantibodies are produced against tumor associated antigens (TAAs) long before the appearance of any symptoms and thus can serve as promising, non-invasive biomarkers for early diagnosis of cancer. Current conventional methods for autoantibody detection are highly invasive and mostly provide diagnosis in the later stages of cancer. Herein we repo...
Article
Ribonucleic acids (RNAs) are considered as effective and minimally invasive biomarkers for disease diagnosis and prognosis due to their critical role in the regulation of different cellular processes. Over the past several years, the rapid progress in RNA biomarker research has resulted in the development of a large number of high-performance RNA-d...
Article
Full-text available
Ribonucleic acids (RNAs) are considered as effective and minimally invasive biomarkers for disease diagnosis and prognosis due to their critical role in the regulation of different cellular processes. Over the past several years, the rapid progress in RNA biomarker research has resulted in the development of a large number of high-performance RNA-d...
Article
Full-text available
Tumor-derived exosomes have emerged as promising cancer biomarkers due to their unique composition and functions. Herein, we report a stripping voltammetric immunoassay for the electrochemical detection of tumor-specific exosomes using quantum dots as signal amplifier. The assay involves three subsequent steps where bulk exosome populations were in...
Article
We report a simple colorimetric (naked-eye) and electrochemical method for rapid, sensitive and specific quantification of global methylation levels using only 25ng of input DNA. Our approach utilises a three-step strategy, (i) initial adsorption of the extracted, purified and denatured bisulfite-treated DNA on a screen-printed gold electrode (SPE-...
Article
Development of simple and inexpensive method for the analysis of gene-specific DNA methylation is important for the diagnosis and prognosis of patients in cancer. Herein, we report a relatively simple and inexpensive electrochemical method for the sensitive and selective detection of gene-specific DNA methylation in oesophageal cancer. The underlyi...
Conference Paper
Full-text available
DNA methylation is one of the clinically relevant epigenetic biomarkers that regulate gene expression via transcriptional alteration, genomic stability, X chromosome inactivation, genomic imprinting and mammalian cell development 1. Rapid profiling and quantification of gene specific DNA methylation is crucial with respect to understanding DNA meth...
Conference Paper
Full-text available
Point mutations play critical role in multiple alterations in gene sequences, protein structure, expression levels and function of key regulatory genes in human diseases including cancer. 1 Inexpensive, simple and rapid DNA sensors capable of accurate and sensitive detection of cancer specific point mutations in DNA biomarkers are crucial for the r...
Conference Paper
Full-text available
mRNA plays a crucial role in the pathogenesis of cancer via exhibiting altered mRNA expression pattern and regulating apoptosis, chromatin modification, cell adhesions and cell cycles.1Therefore detection of mRNA could be a focal point of molecular diagnostic of cancer and other chronic diseases. Despite this, the applications of mRNA in the manage...
Article
Full-text available
Despite the excellent diagnostic applications of the current conventional immunoassay methods such as ELISA, immunostaining and Western blot for FAM134B detection, they are laborious, expensive and required a long turnaround time. Here, we report an electrochemical approach for rapid, sensitive, and specific detection of FAM134B protein in biologic...
Article
DNA methylation is an epigenetic modification of DNA, where a methyl group is added at the fifth carbon of the cytosine base to form 5 methyl cytosine (5mC) without altering the DNA sequences. It plays important roles in regulating many cellular processes by modulating key genes expression. Alteration in DNA methylation patterns becomes particularl...
Article
We report a new method for the detection of regional DNA methylation using base-dependent affinity interaction (i.e., adsoption) of DNA with graphene. Due to the strongest adsorption affinity of guanine bases towards graphene, bisulfite-treated guanine-enriched methylated DNA leads to a larger amount of the adsorbed DNA on the graphene-modified ele...
Conference Paper
Full-text available
DNA methylation is a cell-type specific epigenetic marker, essential for controlling gene expression via transcriptional regulation, silencing of repetitive DNA and genomic imprinting. We report a new method for the detection of regional DNA methylation using base-dependent affinity interaction (i.e., adsoption) of DNA with graphene. Due to the str...
Article
There is a wealth of information about the nutritional and medicinal properties of honey. However, honey may contain compounds that may lead to toxicity. A compound not naturally present in honey, named 5-hydroxymethylfurfural (HMF), may be formed during the heating or preservation processes of honey. HMF has gained much interest, as it is commonly...
Article
Full-text available
Background: There is no available information on physicochemical and antioxidant properties on Bangladeshi honey. We investigated five different monofloral and three different multifloral honey samples collected from different parts of Bangladesh. Methods: The levels of phenolics, flavonoids, ascorbic acid, ascorbic acid equivalent antioxidant c...
Article
Full-text available
The aim of the present study was to characterize the physical, biochemical and antioxidant properties of Algerian honey samples (n = 4). Physical parameters, such as pH, moisture content, electrical conductivity (EC), total dissolved solids (TDS), color intensity, total sugar and sucrose content were measured. Several biochemical and antioxidant te...
Article
Full-text available
Stroke is the third leading cause of death in Bangladesh. The World Health Organization ranks Bangladesh's mortality rate due to stroke as number 84 in the world. The reported prevalence of stroke in Bangladesh is 0·3%, although no data on stroke incidence have been recorded. Hospital-based studies conducted in past decades have indicated that hype...

Questions

Questions (13)
Question
I have seen many researchers including Prof Alan Bond measure the effective areas by measurement of the peak current obtained as a function of scan rate under linear sweep voltammetric conditions for the one-electron oxidation of Fc [1.0 mM in CH3CN (0.1 M Bu4NPF6)] or reduction of [Fe(CN)6] 3- [1.0 mM in water (0.5 M KCl)] and use of the Randles-Sevcik equation.
The classic IUPAC paper (Trasatti and Petrii 1991, https://www.sciencedirect.com/science/article/pii/002207289280162W) provided us with some other important recommendations in different conditions (one example is via reduction of gold oxide)!
I would like to know whether there are any disadvantages of using the Randles-Sevcik equation for measuring the area? Do you prefer any other methods over this one while working with a reversible reaction on gold disk electrode?
Question
What is the average molecular weight of a microRNA? For instance, miR-21?
Question
What should I do for a good understanding?
Question
Is their any developmental anomalies where a patient lack one digit having four fingers? If so what might be the reason?
Question
I am giving some herbal extracts to my rat model of liver cancer. Lets assume I got a good result and I want to continue my research in genetic and immunological level, can you share some ideas, like going for gene expression levels of the gene responsible for the cancer, or something else. Because I have to take preparation before sacrificing rats.
Thanks in advance.
Question
I have been informed by companies and different papers of a number of columns but if anyone shares personal experience it would be helpful.
Question
Is there any specific open access journal or any source where I could find publications related to clinical trial of a number of drugs ?
Question
I have been planning to work on a plant, but I am not getting a lot of sample at a time since its been cultivated in a short place. Every 3 months I used to get sample and then after oven drying I grinded it to powder and keep it in 4 degree. Then I go for soxhlet extraction, I have been collecting plants from the same place, same land. What else should be considered during these procedure to make all my batches of sample standardized? I have to do RRLC, GC-MS, animal study with this plant.

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Projects

Project (1)
Project
The project goal is to discover genetic and epigenetic novel molecular biomarkers. The project further aims to demonstrate molecular bioassays to develop simple and inexpensive diagnostic technologies for POC detection of cancer, infectious and neurodegenerative diseases.