Mohammad S Mubarak

Mohammad S Mubarak
University of Jordan | UJ · Department of Chemistry

Ph. D.
Working on manuscripts and book chapters related to natural products, medicinal chemistry, and naonparticles in medicine

About

416
Publications
135,807
Reads
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6,591
Citations
Introduction
Professor Mubarak received his Ph.D. degree in organic chemistry from Indiana University, Bloomington, USA in 1982 under the supervision of Professor Dennis G. Peters. Research program is broadly based on synthetic organic chemistry, especially synthesis of compounds with expected biological activity, medicinal chemistry, natural products, and drug design and discovery.
Additional affiliations
January 2006 - December 2009
Indiana University Bloomington
January 1993 - December 2012
University of Jordan
Description
  • 1. Doing research in organic synthesis, especially, synthesis of compounds with potential biological activity. 2. Research on the synthesis and sorption properties of chelate-forming polymers. 3. Medicinal chemistry
January 1993 - June 2015
University of Jordan
Position
  • Professor of Chemistry, former Head of Department, and former Vice Dean of the Faculty of Science

Publications

Publications (416)
Article
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Despite the significant advances and mechanistic understanding of tumor processes, therapeutic agents against different types of cancer still have a high rate of recurrence associated with the development of resistance by tumor cells. This chemoresistance involves several mechanisms including the programation of glucose metabolism, mitochnodria dam...
Article
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The search for natural plant-based products as new pharmacological alternatives to treat various human pathologies has taken on great importance for researchers and research laboratories. In this context, research has intensified to extract and identify natural molecules endowed with biological effects. The objective of this study is to review the...
Article
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Autoimmune diseases are caused by the overactivity of the immune system towards self-constituents. Risk factors of autoimmune diseases are multiple and include genetic, epigenetic, environmental, and psychological. Autoimmune chronic inflammatory bowel diseases, including celiac and inflammatory diseases (Crohn's disease and ulcerative colitis), co...
Article
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In microbial electrochemical systems, microorganisms catalyze chemical reactions converting chemical energy present in organic and inorganic molecules into electrical energy. The concept of microbial electrochemistry has been gaining tremendous attention for the past two decades, mainly due to its numerous applications. This technology offers a wid...
Article
This pictorial essay focuses on ultrasound (US) and magnetic resonance imaging (MRI) features of fetal intracranial cysts. Intracranial cysts are common findings in prenatal imaging, and if great attention is paid to their size, location, and imaging features, they can be diagnosed accurately. They are usually detected by fetal ultrasound exams. Ho...
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Background: Bone disease-related fractures constitute a heavy burden on the healthcare systems and economy. Vitamin D is an important regulator of bone health and its deficiency is a global problem. This study aimed to evaluate the effect of the 1,500 IU nano-encapsulated vitamin D used for fortifying low-fat dairy products (milk and yogurt) on bo...
Article
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Eggplant is an important vegetable in South Asia. In Bangladesh, it is grown around the year in all parts of the country. However, it is highly sensitive to waterlogged conditions. In Bangladesh, during the monsoon, waterlogged conditions represent one of the hostile abiotic stresses that affect the growth and development of eggplant, leading to a...
Article
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Cancer is a complex pathology that causes a large number of deaths worldwide. Several risk factors are involved in tumor transformation, including epigenetic factors. These factors are a set of changes that do not affect the DNA sequence, while modifying the gene’s expression. Histone modification is an essential mark in maintaining cellular memory...
Article
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Apart from the nutritional value, Cucumis sativus L. has also been used in the traditional medicine of Iran, Pakistan, and India. Its seeds are used by herbalists to treat gastrointestinal, respiratory, and urinary problems. However, more investigations are required to explain its mechanisms for treating GI, respiratory, and urinary diseases. Accor...
Article
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Neuroinflammation, a protective response of the central nervous system (CNS), is associated with the pathogenesis of neurodegenerative diseases. The CNS is composed of neurons and glial cells consisting of microglia, oligodendrocytes, and astrocytes. Entry of any foreign pathogen activates the glial cells (astrocytes and microglia) and overactivati...
Article
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Objectives: To determine the association of Human leukocyte antigen B (HLA-B) alleles with ankylosing spondylitis and the allelic association of HLA-B27 with endoplasmic reticulum aminopeptidase 1 (ERAP1) single-nucleotide polymorphism (SNP) rs30187 in patients with ankylosing spondylitis (AS). Methods: We studied 48 consecutively enrolled well-def...
Chapter
Since ancient times, medicinal plants have been employed as reliable and important sources of bioactive compounds and to treat several diseases and ailments. Despite the significant advances in synthetic drugs, side effects remain, which necessitates the search for effective, inexpensive, and more accessible drugs. Medicinal plants may provide such...
Article
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Though the incidence of several cancers in Western societies is regulated wisely, some cancers such as breast, lung, and colorectal cancer are currently rising in many low- and middle-income countries due to increased risk factors triggered by societal and development problems. Surgery, chemotherapy, hormone, radiation, and targeted therapies are e...
Article
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Citation: Ahmad, N.; Qamar, M.; Yuan, Y.; Nazir, Y.; Wilairatana, P.; Mubarak, M.S. Dietary Polyphenols: Extraction, Identification, Bioavailability, and Role for Prevention and Treatment of Colorectal and Prostate Cancers. Abstract: Fruits, vegetables, and other edible plants in our diet have numerous health benefits, due to the bioactive compound...
Article
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Aging is a continuous process over time that is mainly related to natural alterations in mechanical–biological processes. This phenomenon is due to several factors, including the time and energy of biological processes. Aging can be attributed to biological factors such as oxidative stress, cell longevity, and stem cell senescence. Currently, aging...
Article
The aims of this study to assess the efficiency of AGL against acetaminophen (APAP)-induced hepatic toxicity that was generated by mitochondrial oxidative stress and glutathione depletion. Free radical scavenging potentiality was analyzed by using 2, 2-diphenyl-1-picrylhydrazyl (DPPH), hydrogen peroxide, nitric oxide, and hydroxyl radical scavengin...
Article
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Advancements in both material science and bionanotechnology are transforming the health care sector. To this end, nanoparticles are increasingly used to improve diagnosis, monitoring, and therapy. Huge research is being carried out to improve the design, efficiency, and performance of these nanoparticles. Nanoparticles are also considered as a majo...
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Alzheimer's disease (AD) is a common neurodegenerative brain disorder that causes cellular response alterations, such as impaired cholinergic mechanism, amyloid-beta (Aβ) AD aggregation, neuroinflammation, and several other pathways. AD is still the most prevalent form of dementia and affects many individuals across the globe. The exact cause of th...
Article
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Leishmaniasis is one of the six major tropical diseases that is spreading geographically in the world, with no definitive cure. The aim of the present study was to investigate the anti-leishmanial effects of Olea europaea and Ficus carica extracts against Leishmania major in both in vitro and in vivo experimental models. The in vitro efficiency con...
Article
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Bacterial strains have developed an ability to resist antibiotics via numerous mechanisms. Recently, researchers conducted several studies to identify natural bioactive compounds, particularly secondary metabolites of medicinal plants, such as terpenoids, flavonoids, and phenolic acids, as antibacterial agents. These molecules exert several mechani...
Article
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Diterpenes and their derivatives have many biological activities, including anti-inflammatory and immunomodulatory effects. To date, several diterpenes, diterpenoids, and their laboratory-derived products have been demonstrated for antiarthritic activities.This study summarizes the literature about diterpenes and their derivatives acting against rh...
Article
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Objectives To use data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) to estimate mortality and disability trends for the population aged ≥70 and evaluate patterns in causes of death, disability, and risk factors. Design Systematic analysis. Setting Participants were aged ≥70 from 204 countries and terri...
Article
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This work is focused on the isolation, in vitro and in silico studies of two natural bio-active flavonoids (1 & 2) isolated from Euphorbia pulcherrima bark. The phytochemical investigation resulted in the identification of two flavonoids: 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-4H-chromen-4-one (1) and 2-(3,4-dihydroxyphenyl)-3,5,7...
Chapter
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The trend of natural product consumption as therapeutics or pharmaceuticals is increasing day by day because of their safety profile in addition to other benefits such as organ specificity, extensive effectiveness, prolonged mode of action, and high solubility. Macromolecules such as carbohydrates, peptides, proteins, and lipids from natural origin...
Article
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Syzygium cumini, locally known as Jamun in Asia, is a fruit-bearing crop belonging to the Myrtaceae family. This study aims to summarize the most recent literature related to botany, traditional applications, phytochemical ingredients, pharmacological activities, nutrition, and potential food applications of S. cumini. Traditionally, S. cumini has...
Chapter
Reactive oxygen species (ROS) are reactive chemical and/or biochemical intermediates or fragments containing oxygen as peroxides, superoxide (O2●−), hydrogen peroxide (H2O2), hydroxyl radical (●OH), hydroxyl ion (−OH), singlet oxygen, and nitric oxide (NO). At optimal concentration ROS have been implicated to serve varieties of important physiologi...
Article
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Studies of the ethyl acetate extract bark extract of Olea ferruginea led to the isolation of one new compound Ferruginan A (1) in addition to two known compounds, Ferruginan (2) and cycloolivil (3). Structures of the isolated compounds were confirmed by mass spectrometry (MS) and NMR spectral data. The ethyl acetate fraction and compounds (1–3) wer...
Article
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Food components have long been recognized to play a fundamental role in the growth and development of the human body, conferring protective functionalities against foreign matter that can be severe public health problems. Micronutrients such as vitamins and minerals are essential to the human body, and individuals must meet their daily requirements...
Article
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Carvone is a monoterpene ketone contained in the essential oils of several aromatic and medicinal plants of the Lamiaceae and Asteraceae families. From aromatic plants, this monoterpene is secreted at different concentrations depending on the species, the parts used, and the extraction methods. Currently, pharmacological investigations showed that...
Article
Chalcones are attractive chemical motifs with various biological activities. Aryl substituted chalcones have been extensively studied and reviewed through the years. However, α‐substituted chalcones have rarely been investigated. Hence, this review highlights the α‐substituted chalcones: their synthetic routes, reported biological activities, and t...
Article
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COVID-19 is a pandemic disease caused by novel corona virus, SARS-CoV-2, initially originated from China. In response to this serious life-threatening disease, designing and developing more accurate and sensitive tests are crucial. The aim of this study is designing a multi-epitope of spike and nucleocapsid antigens of COVID-19 virus by bioinformat...
Article
Coronavirus disease 2019 (COVID-19) which is a highly contagious viral illness caused by the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2 has had a catastrophic effect on the world's demographics, resulting in more than 3.8 million deaths worldwide, establishing itself as the most serious global health crisis since the 1918 influenza...
Article
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Tobacco is grown in large quantities worldwide as a widely distributed commercial crop. From the harvest of the field to the process into the final product, a series of procedures generate enormous amount of waste materials that are rarely recycled. In recent years, numerous potential bioactive compounds have been isolated from tobacco, and the mol...
Preprint
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Five new 2,4,6-triarylpyridine analogues with potential biological importance have been synthesized using the multicomponent reaction (MCR) solid support catalyst synthetic approach. This green synthesis furnished method simplicity, reduce reaction time, and excellent yield, along with an additional feature of catalyst reusability. A number of spec...
Article
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Peganum harmala (P. harmala) belongs to the family Zygophyllaceae, and is utilized in the traditional medicinal systems of Pakistan, China, Morocco, Algeria, and Spain to treat several chronic health disorders. The aim of the present study was to identify the chemical constituents and to evaluate the antioxidant, anti-inflammatory, and toxicity eff...
Article
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Plant-derived chemicals are a source of novel chemotherapeutic agents. Throughout the human civilization, these novel chemicals have led to the discovery of new pharmacological active agents. Research on herbal medi- cine is of great importance, as most of the active agents used for treating numerous diseases are from natural sources, while other a...
Article
Article Info Scientific reports suggest that Xylocarpus moluccensis has numerous important biological activities, including antioxidant, anti-inflammatory, anti-microbial, anti-cancer, anti-diarrheal, insecticidal, antifeedent, neuropharmacological (e.g., CNS depressant), anti-atherosclerotic, and lipid-lowering activity. Anxiety disorders are comm...
Article
Diabetes affects a substantial part of the world’s population and, possibly, is the world’s fastest-growing metabolic disease. Garlic, Allium sativum L., Liliaceae, a popular cooking spice with a long history as traditional medicine, has been demonstrated to exhibit antidiabetic properties. Garlic is a rich natural source of bioactive sulfur-contai...
Article
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Background: Uterine cervical malignancy is one of the commonly detected malignancies related to the human papillomavirus (HPV) and is increasing incidentally in developing countries. Therefore, the use of an efficient diagnostic method is required as an effectual step for cervical cancer prevention and treatment. The purpose of the study was to di...
Article
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Pistacia integerrima grows in some areas of Pakistan and some other south Asian countries such as Afghanistan, India, Nepal, and Myanmar. It is an important medicinal plant which has been traditionally used for the treatment of asthma, cough, and dysentery. In the present study, we intend to re-isolate bioactive compounds (I–III) from P. integerrim...
Article
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This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Abstract Myricetin is a critical nutritive component of diet providing immunological protection and beneficial for maintaining good health. It is...
Article
After cannabis, opiates are the world's second most widely abused illegal drug. Opium is the latex of unripe pods of Papaver somniferum (Opium poppy). Opium has been used traditionally for lowering blood lipids, and postpone cardiac diseases, as well as used for the treatment of diabetes and cancer. In eastern countries, the high prevalence of opiu...
Article
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Genistein is an isoflavone first isolated from the brooming plant Dyer’s Genista tinctoria L. and is widely distributed in the Fabaceae family. As an isoflavone, mammalian genistein exerts estrogen-like functions. Several biological effects of genistein have been reported in preclinical studies, such as the antioxidant, anti-inflammatory, antibacte...
Article
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Globally, Alzheimer’s disease (AD) is one of the most prevalent age-related neurodegenerative disorders associated with cognitive decline and memory deficits due to beta-amyloid deposition (Aβ) and tau protein hyperphosphorylation. To date, approximately 47 million people worldwide have AD. This figure will rise to an estimated 75.6 million by 2030...
Article
Background Cancer is a global threat to humans and a leading cause of death worldwide. Cancer treatment includes, among other things, the use of chemotherapeutic agents, compounds that are vital for treating and preventing cancer. However, chemotherapeutic agents produce oxidative stress along with other side effects that would affect the human bod...
Article
The dietary phytochemical thymoquinone (TQ), belonging to the family of quinones, mainly obtained from the black and angular seeds of Nigella sativa, is one of the promising monoterpenoid hydrocarbons, which has been receiving massive attention for its therapeutic potential and pharmacological properties. It plays an important role as a chemopreven...
Article
Although treatment with natural products and the substances derived from them has gained much attention, it is important to know the genomic safety of these substances prior to their use in humans. The present review aims to present the current knowledge on the genoprotective effects and possible mechanism of actions of natural compounds. Therefore...
Article
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The Sophora mollis is one of the best anti-inflammatory, antioxidant and anticancer plant therefore the isolated chemical constitutes i.e Scopoletin (1), pinitol (2), 2-propenoic acid, 3-(3,4-dihydroxyphenyl)-, octacosyl ester (3), betulin (4), and β-sitosterol glucoside (5) were tested for these folklores. Structures of isolated compounds were con...
Article
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In this study, activated carbon was derived from inexpensive and abundant biomass feedstock Mahogany fruit shell and activated with KOH to act as a heterogeneous base catalyst for transesterification of waste cooking oil to biodiesel. The catalyst was characterized by means of FT-IR, XRD, FESEM-EDS and particle size analysis techniques. Box-Behnken...
Article
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Limited permeability through the stratum corneum (SC) is a major obstacle for numerous skin care products. One promising approach is to use lipid nanoparticles as they not only facilitate penetration across skin but also avoid the drawbacks of conventional skin formulations. This review focuses on solid lipid nanoparticles (SLNs), nanostructured li...
Article
Many short-lived and highly reactive oxygen species, such as superoxide anion (O2 - ) and hydrogen peroxide (H2O2), are toxic or can create oxidative stress in cells, a response involved in the pathogenesis of numerous diseases depending on their concentration, location, and cellular conditions. Superoxide dismutase (SOD) activities as an endogenou...