
Siti Amrah SulaimanUniversity of Science Malaysia | USM · Department of Pharmacology
Siti Amrah Sulaiman
MD; M.Med Sci. (Pharm); PhD
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173
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Publications
Publications (173)
Tualang honey (TH) stored for more than 12 months is characterised as aged TH (ATH). Surprisingly, majority of the general public is unaware of the recommended consumption period for honey, since most honeys marketed locally have no determined expiry dates. The present work determined 5-hydroxymethylfurfural (HMF) content in four-year stored ATH, a...
This is the first study to report on the effects of honey in asymptomatic HIV positive subjects in ameliorating CD4 count, viral load (VL) and quality of life (QOL). It is a randomized, controlled, open labelled study, comparing the effects of Tualang honey (TH) administration for six months at three different doses: 20 g (THL), 40 g (THI) or 60 g...
The protective effect of tualang honey (TH) on neuroinflammation and caspase-3 activity in rat cerebral cortex, cerebellum, and brainstem after kainic acid- (KA-) induced status epilepticus was investigated. Male Sprague-Dawley rats were pretreated orally with TH (1.0 g/kg body weight) five times at 12 h intervals. KA (15 mg/kg body weight) was inj...
Honey as a traditional medicine has been used to cure several ailments since ancient times. This study was conducted to investigate the potential effects of acute administration of Malaysian jungle Tualang honey (TH) and Austrian/New Zealand Manuka honey (MH) in albino rats model. Thirty nulliparous female rats were divided into three groups: Group...
Honey clasps several medicinal and health effects as a natural food supplement. It has been established as a potential therapeutic antioxidant agent for various biodiverse ailments. Data report that it exhibits strong wound healing, antibacterial, anti-inflammatory, antifungal, antiviral, and antidiabetic effects. It also retains immunomodulatory,...
Objective: The present study examined the protective effect of tualang honey (TH) against kainic acid (KA)-induced oxidative stress in the cerebellum and brainstem of rats.Methods: Male Sprague-Dawley rats were randomly divided into four groups: Control, KA-treated, TH+KA-treated, and topiramate (TPM, an antiepileptic agent)+KA-treated groups. Rats...
Numerous nutraceutical products containing the powdered or extracted parts of Labisia pumila (Myrsinaceae) have been widely available for years in Malaysia, aimed at women of reproductive age. However, there is scarce of information concerning the effects of this plant on the reproductive function of nulliparous females prior to the present study....
Breast cancer has been recognized as the leading cause of death in women worldwide. Research has shown the importance of complementary and alternative therapies in cancer. In this study, we investigated the antitumoural therapeutic effects of Malaysian Tualang honey (TH) and Australian/New Zealand Manuka honey (MH) against breast cancer in rats. Th...
Propolis contains high concentrations of polyphenols, flavonoids, tannins, ascorbic acid, and reducing sugars and proteins. Malaysian Propolis (MP) has been reported to exhibit high 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity and ferric reducing antioxidant power (FRAP) values. Herein, we report the antioxidant properties and c...
p> Objective: The objective of this research was to investigate the possible protective effect of Tualang honey (TH) in acute paraquat (PQ) toxicity in rats.
Methods: A total of 48 male Sprague-Dawley rats aged eight weeks old were used. Oral PQ and TH were administered at 225 mg/kg and 0.2 g/kg, respectively. The effects of single and multiple TH...
Increased consumption of sugars and sweetened beverages contributes to increased prevalence of obesity. The aims of this study were to investigate the effects of honey supplementation on body weight (BW), weight gain, body mass index (BMI) and adiposity in Wistar rats fed a high-fat diet (HFD). The study also investigated if administration of high...
Paraquat (PQ) is a dopaminergic neurotoxin and a well-known pneumotoxicant that exerts its toxic effect via oxidative stress-mediated cellular injuries. This study investigated the protective effects of Tualang honey against PQ-induced toxicity in the midbrain and lungs of rats. The rats were orally treated with distilled water (2 mL/kg/day), Tuala...
In the present study, the phenolic acid and flavonoid composition of eight different honeys (acacia, pineapple, gelam, longan, borneo, rubber tree, sourwood and tualang honeys) originating from different regions of Malaysia are reported. Solid phase extraction followed by high performance liquid chromatography (HPLC) was used for their identificati...
Menopause plays an important role in lipid distribution that leads to the apparent acceleration in cardiovascular diseases in women. The aim of this study is to investigate the effectiveness of combination of regular exercise and estrogen therapy in reducing cardiovascular risk factors in postmenopausal animal model. Forty-eight Sprague Dawley fema...
This study was conducted to investigate the effects of different honey processing parameters (temperature, light, gamma irradiation, evaporation and sachet packaging) on the physical, biochemical and antioxidant characteristics of Tualang honey samples that have been stored for 1 year. The protein and proline contents doubled following radiation an...
Free radicals induced by cigarette smoking have been linked to an increase in oxidative stress resulting in smoking-related cardiovascular diseases. However, the possible effect of honey that has antioxidant property in improving oxidative stress status among smokers has not yet been reported. Hence, this study was to determine the effects of 12-we...
This study investigated effects of cessation of exercise and honey supplementation on bone properties in young female rats. Eightyfour
12-week-old Sprague-Dawley female rats were divided into 7 groups: 16S, 16J, 16H, 16JH, 8J8S, 8H8S, and 8JH8S (8 = 8 weeks,
16 = 16 weeks, S = sedentary without honey supplementation, H = honey supplementation, and...
Introduction: National Cancer Statistics reported that lung cancer listed as third highest
among most prevalent cancer in Malaysia. Objectives: In this study, the possibility of using
virgin coconut oil (VCO) as new potential anti-apoptosis agent to combat this cancer was
evaluated. Experimental design: Two lung cancer cell lines were exposed to...
Breast cancers are diagnosed based on WHO classification worldwide. Meanwhile in Japan, the Japanese General Rules has been used for long time. This classification uniquely adds subtypes into the group of invasive ductal carcinomas (IDC) and known to correlate to patient clinical course. The latest St. Gallen consensus meeting introduced 5 intrinsi...
The present study was designed to investigate the cardioprotective effects of Malaysian Tualang honey against isoproterenol-(ISO-) induced myocardial infarction (MI) in rats by investigating changes in the levels of cardiac marker enzymes, cardiac troponin I (cTnI), triglycerides (TG), total cholesterol (TC), lipid peroxidation (LPO) products, and...
Background: Petrol is known to be hazardous to human health and is associated with various health effects, such as haematotoxicity and oxidative stress. Although Malaysia has adopted the European fuel quality standards in recent years in order to reduce petroleum pollutants and to improve air quality, gasoline with research octane number 95 (RON95)...
Abstract
Introduction: Honey and other bee hive products have been reported to contain many highly
nutritious substances in various medical fields. A combination of bee hives products known
as Honey Cocktail 124 may provide additional values to Tualang Honey.
Objectives: The objective of this study was to investigate the effects of of Tualang Honey...
Objective. To investigate the potential effect of Hydrocotyle sibthorpioides Lam. (H. sibthorpioides) extracts against in vitro dengue viral replication. Methods. The cytotoxicity of H. sibthorpioides was evaluated using a cell viability assay. Cells were pre- and posttreated with water and methanol extracts of H. sibthorpioides, and the viral inhi...
Introduction: Honey and other bee hive products have been reported to contain many highly nutritious substances in various medical fields. A combination of bee hives products known as Honey Cocktail 124 may provide additional values to Tualang Honey.
Excitotoxicity is well recognized as a major pathological process of neuronal death in neurodegenerative diseases involving the central nervous system (CNS). In the animal models of neurodegeneration, excitotoxicity is commonly induced experimentally by chemical convulsants, particularly kainic acid (KA). KA-induced excitotoxicity in rodent models...
Corresponding author: Dasuki M. S Andrographis paniculata has been extensively used in Malay traditional medicine for promotion of well-being. However, the information of its potential toxic effects on male reproductive system are lacking. Therefore, the present study was aimed to investigate the possible effect of 50% ethanolic extract of A. panic...
Introduction. This study aims to evaluate the effectiveness of Tualang honey on sperm parameters, erectile function, and hormonal and safety profiles. Methodology. A randomized control trial was done using Tualang honey (20 grams) and Tribestan (750mg) over a period of 12 weeks. Sperm parameters including sperm concentration, motility, and morpholo...
The performance of gas chromatography (GC) combined with a hybrid quadrupole time-of-flight (QTOF) mass spectrometry (MS) system for the determination of volatile and semi-volatile compounds in honey samples is evaluated. After headspace (HS) solid-phase microextraction (SPME) of samples, the accurate mass capabilities of the above system were eval...
AIM: High concentration of sugar is carcinogenic. Honey which is rich in sugars has been shown to have anti-cancer effect. There is no study reported on the effect of sugars mimicking the concentration of sugars of honey in inhibiting breast carcinoma in rats. The aim of the study is to investigate if the honey-sugar mimic has similar effect as nat...
Introduction: The incidence of breast cancer in women is alarmingly high worldwide. Honey has been proven to be an effective anticancer agent against different types of cancers. Only a few studies suggested that honey might be useful in modulating breast carcinoma.
AIM: To study the inhibitory effects of Malaysian Jungle Tualang honey (TH) on N-me...
Introduction
Recent studies have shown that honey has anticancer properties in tissue culture and in-vivo animal experiment against different types of cancers. Only a few studies suggested that honey might be useful in modulating experimental breast carcinoma in vivo.
Aim
To study the inhibitory effects of Malaysian Jungle Tualang honey (TH) on N-...
Background
Breast cancer is the most common cancer amongst Malaysian women. Both the disease and its treatment can disrupt the lives of the woman and adversely affect all aspects of life and thus can alter a woman’s quality of life. The aim of this study was to examine the effect of virgin coconut oil (VCO) on the quality of life (QOL) of patients...
Introduction
Exposure to stress during pregnancy has been shown to have adverse effects on pregnancy outcomes such as low birth weight, spontaneous abortion and premature delivery. Honey has been shown to improve testicular function in rats exposed to cigarette smoke. The aim of this study was to determine the effects of honey on corticosterone lev...
The aim of the present study was to characterize the phenolic acids, flavonoids, and antioxidant properties of monofloral honey collected from five different districts in Bangladesh. A new high performance liquid chromatography (HPLC) equipped with a UV detector method was developed for the identification of the phenolic acids and flavonoids. A tot...
Respiratory illness were a major problem and caused high hospital admission during hajj seasons. One of the contributing cause to this illness is infection. Various measures had been implemented to reduce respiratory infections. The aim on the study is to determine the effect of influenza vaccination against acute respiratory illness among Malaysia...
The present study was undertaken to determine the content of six minerals, five trace elements, and ten pesticide residues in honeys originating from different regions of Malaysia. Calcium (Ca), magnesium (Mg), iron (Fe), and zinc (Zn) were analyzed by flame atomic absorption spectrometry (FAAS), while sodium (Na) and potassium (K) were analyzed by...
Background
Honey is widely used in folk medicine to treat cough, fever, and inflammation. In this study, the effect of aerosolised honey on airway tissues in a rabbit model of ovalbumin (OVA)-induced asthma was investigated. The ability of honey to act either as a rescuing agent in alleviating asthma-related symptoms or as a preventive agent to pre...
Polio vaccination crusade by World Health Organization (WHO) to annihilate the polio from the kyte of world aspiringly has been fruitful; however, there seems some disagreement and hullabaloos by some Muslim communities especially in four countries viz., Pakistan, Nigeria, Afghanistan and India. This hostility has numerous factors involved but the...
Propolis (a bee product) which has a long history of medicinal use by humans has attracted a great deal of research interest in the recent time; this is due to its widely reported biological activities such as antiviral, antifungal, antibacterial, anti-inflammatory, antioxidant, and anticarcinogenic properties. Crude form of propolis and its phenol...
The gut microbiota plays a number of important roles including digestion, metabolism, extraction of nutrients, synthesis of vitamins, prevention against pathogen colonization, and modulation of the immune system. Alterations or changes in composition and biodiversity of the gut microbiota have been associated with many gastrointestinal tract (GIT)...
This study aimed to evaluate in vitro whole blood (WB) clot lysis method for the assessment of fibrinolytic activity. Standardized unresected (uncut) retracted WB clot was incubated in pool platelet poor plasma (PPP) for varying incubation times and in streptokinase (SK) at different concentrations. The fibrinolytic activity was assessed by D-dimer...
Honey is a natural product known for its varied biological or pharmacological activities-ranging from anti-inflammatory, antioxidant, antibacterial, antihypertensive to hypoglycemic effects. This review article focuses on the role of honey in modulating the development and progression of tumors or cancers. It reviews available evidence (some of whi...
Background
The aim of the present study was to evaluate the physical, biochemical and antioxidant properties of four Malaysian monofloral types of honey (gelam, longan, rubber tree and sourwood honeys) compared to manuka honey.
Several physical parameters of honey, such as pH, moisture content, electrical conductivity (EC), total dissolved solids...
Honey is a good source of several important chemical compounds and antioxidants and is harvested throughout the year. However, no study has determined how their contents change over the years. The aim of the present research was to investigate the changes in the phenolics, flavonoids and antioxidant properties, as well as other physicochemical prop...
Gasoline (petrol) is primarily used as fuel for internal combustion engines. Different health risks including haematotoxicity and oxidative stress have been reported for gasoline [1, 2]. Although Malaysia has in the recent years adopted the European fuel quality standards in order to help improve the air quality in the environment, gasoline with Re...
Infusions of Orthosiphon stamineus Benth., Lamiaceae, leaves are widely used in Southeastern Asia to treat different illnesses. Nonetheless, no data is available on the safety of O. stamineus for pregnant women and their babies. This study was undertaken to evaluate the developmental toxicity of O. stamineus standardized aqueous extract in female S...
The study was conducted to determine the effect of Malaysian jungle Tualang Honey (TH) on development of breast cancer induced by the carcinogen 7,12-dimethylbenz(α)anthracene (DMBA) in rats. Forty nulliparous female Sprague-Dawley rats were given 80 mg/kg DMBA then randomly divided into four groups: Group 1 served as a Control while Groups 2, 3 an...
Petrol is used as fuel for internal combustion engines. Different health risks including weight loss, haematotoxicity, and oxidative stress have been reported for gasoline. Supplementation with antioxidants such as vitamins A, C, and E has been shown to ameliorate the toxicity effects of gasoline vapours exposure. Honey is a natural product which c...
Cigarette smoking is associated with sexual dysfunction and impaired fertility in males. The aim of this study was to determine the potential protective effect of honey against the toxic effect of cigarette smoke (CS) on sexual behavior and fertility of male rats. Thirty-two adult Sprague-Dawley rats were randomly divided into four groups (8 rats/g...
Background
The aim of the present study was to evaluate the physicochemical and antioxidant properties of Malaysian monofloral honey samples---acacia, pineapple and borneo honey---and compare them with tualang honey. Acacia and pineapple honey are produced by Apis mellifera bees while borneo and tualang honey are produced by Apis cerana and Apis do...
Objectives: The objective of the study was to investigate the effect of Tualang honey on the safety profiles among postmenopausal women. Designs: A preliminary trial to investigate the effect of Tualang honey involving postmenopausal women aged 45-60 years old. Materials and Methodology: Forty healthy postmenopausal Malay women were given 20 g/day...
Cancer cells generate reactive oxygen species (ROS) resulting from mitochondrial dysfunction, stimulation of oncogenes, abnormal metabolism, and aggravated inflammatory activities. Available evidence also suggests that cancer cells depend on intrinsic ROS level for proliferation and survival. Both physiological and pathophysiological roles have bee...
Syzygium polyanthum (Wight) Walp. var. polyanthum leaves are consumed as a traditional Malay treatment of hypertension. This study investigates hypotensive potential of aqueous (AESP) and residual methanolic (met-AESP) extracts of S. polyanthum leaves and possible involvement of autonomic receptors. AESP and met-AESP (20 to 100 mg/kg) were intraven...
This study was conducted to evaluate the effects of evaporation, gamma irradiation and temperature on the total polyphenols, flavonoids and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activities of Tualang honey samples (n = 14) following storage over three, six or twelve months. The mean polyphenol concentrations of the six gamma irrad...
Honey is a natural substance with many medicinal properties, including antibacterial, hepatoprotective, hypoglycemic, antioxidant and antihypertensive effects. It reduces hyperglycemia in diabetic rats and humans. However, the mechanism(s) of its hypoglycemic effect remain(s) unknown. Honey comprises many constituents, making it difficult to ascert...
The global prevalence of chronic diseases such as diabetes mellitus, hypertension, atherosclerosis, cancer and Alzheimer's disease is on the rise. These diseases, which constitute the major causes of death globally, are associated with oxidative stress. Oxidative stress is defined as an "imbalance between oxidants and antioxidants in favor of the o...
Objectives:
To investigate the effect of Tualang honey on cytochrome P450 2C8 (CYP2C8) activity in vitro using an amodiaquine N-desethylase assay.
Methods:
CYP2C8 and NADPH cytochrome P450 reductase was cotransformed, expressed and harvested. The incubation assay contained expressed proteins, MgCl(2), NADP, glucose 6-phosphate, glucose-6-phospha...