Abu Ali Ibn Sina

Abu Ali Ibn Sina
Dana-Farber Cancer Institute | DFCI

PhD

About

52
Publications
8,101
Reads
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1,008
Citations
Introduction
My research focuses on developing transnational technologies for the early detection of cancer that can be operated from resource poor environments.
Additional affiliations
July 2013 - present
The University of Queensland
Position
  • PhD Student

Publications

Publications (52)
Article
The integration of nanoarchitectonics and hydrogel into conventional biosensing platforms offers the opportunities to design physically and chemically controlled and optimized soft structures with superior biocompatibility, better immobilization of biomolecules, and specific and sensitive biosensor design. The physical and chemical properties of 3D...
Article
Full-text available
Detecting circulating biomarkers sensitively and quantitatively is paramount for cancer screening, diagnosis, and treatment selection. Particularly, screening of a panel of circulating protein biomarkers followed by mapping of individual biomarkers could assist better diagnosis and understanding of the cancer progression mechanisms. Herein, we pres...
Article
Full-text available
The efficiency of conventional screening programs to identify early-stage malignancies can be limited by the low number of cancers recommended for screening as well as the high cumulative false-positive rate, and associated iatrogenic burden, resulting from repeated multimodal testing. The opportunity to use minimally invasive liquid biopsy testing...
Article
Liquid biopsy-based diagnosis in precision oncology exhibits significant advantages over the traditional tumour biopsies by offering dynamic assessment of tumour heterogeneity, minimally invasive procedures for frequent sampling, and cost-effective tests....
Article
Development of a facile, fast, sensitive and multiplex DNA detection for the quantitative verification of food adulterant is of high significance these days. RT-PCR, and nanoparticle based fluorescence and electrochemical detection techniques have been successfully used in clinical medicine. However, requirements of pre-conditioning steps and fluor...
Article
Full-text available
Polyimide-silica (PI-Silica) composites are of tremendous research interest as high-performance materials because of their excellent thermal and mechanical properties and chemical resistance to organic solvents. Particularly, the sol-gel method of fabricating such composites is popular for manipulating their properties. In this work, PI-silica comp...
Chapter
Liquid biopsy has emerged as the next generation target for diagnostics and therapeutic monitoring of many diseases including cancer. Liquid biopsy offers noninvasive analysis of aberrant biomolecular changes (e.g., aberrant protein expression, DNA mutation) which can provide crucial information on disease stages and therapy responses. As a diagnos...
Article
Full-text available
The introduction of immune checkpoint inhibitors has demonstrated significant improvements in survival for subsets of cancer patients. However, they carry significant and sometimes life-threatening toxicities. Prompt prediction and monitoring of immune toxicities have the potential to maximise the benefits of immune checkpoint therapy. Herein, we d...
Article
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Tomatoes are consumed worldwide as fresh vegetables because of their high contents of essential nutrients and antioxidant-rich phytochemicals. Tomatoes contain minerals, vitamins, proteins, essential amino acids (leucine, threonine, valine, histidine, lysine, arginine), monounsaturated fatty acids (linoleic and linolenic acids), carotenoids (lycope...
Article
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The field of precision oncology is rapidly progressing toward integrated “multiomics” analysis of multiple molecular species (such as DNA, RNA, or proteins) to provide a more complete profile of tumor heterogeneity. Micro/nanomaterial‐based systems, which leverage the unique properties of miniature materials, are currently well positioned to expand...
Article
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In article number 1909306, Simon Puttick, Kevin M. Koo, Matt Trau, and co‐workers discuss the use of micro/nanomaterial‐based systems to facilitate “multiomics” cancer signature profiling in clinical settings. This multiomics signature can provide a complete profile of tumor heterogeneity, as akin to assembling a whole jigsaw puzzle from separate p...
Article
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Protein phosphorylation is a post-translational modification of kinase proteins that changes a protein's conformation to regulate crucial biological functions. However, the phosphorylation of protein is significantly altered during cancer progression which triggers abnormal cellular pathways and this phosphorylation can serve as an emergent diagnos...
Article
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The detection of circulating biomarkers in liquid biopsies has the potential to provide a non-invasive route for earlier cancer diagnosis and treatment management. Melanoma chondroitin sulfate proteoglycan (MCSP) is a membrane protein characteristic for melanoma cell migration and tissue invasion with its soluble form (sMCSP) serving as a potential...
Article
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Advances in nanoarchitectonics enable a wide variety of nanostructured electrodes with tunable shapes and surface for constructing sensitive biosensors. Herein we demonstrate the fabrication of a mesoporous gold (Au) biosensor for the specific and sensitive detection of miRNA in a relatively simple and portable manner. The electrocatalytic activity...
Article
Full-text available
Protein phosphorylation is a posttranslational modification of kinase proteins that changes protein’s conformation to regulate crucial biological functions. However, phosphorylation of protein is significantly altered during cancer progression which triggers abnormal cellular pathways and can serve as an emergent diagnostic and prognostic biomarker...
Article
Extracellular vesicles (EV) play a major role in intercellular communication by transmitting cellular materials (e.g. Protein, RNA) among distant cells. Recent evidence suggests that they could also contribute to carrying DNA which could inform on the mutational status of the parent tumour DNA. Thus, the fundamental analysis of evDNA could open a b...
Article
Full-text available
Monitoring targeted therapy in real time for cancer patients could provide vital information about the development of drug resistance and improve therapeutic outcomes. Extracellular vesicles (EVs) have recently emerged as a promising cancer biomarker, and EV phenotyping shows high potential for monitoring treatment responses. Here, we demonstrate t...
Article
Surface enhanced Raman scattering (SERS) DNA biosensing is an ultrasensitive, selective, and rapid detection technique due to its ability to produce molecule specific distinct fingerprint spectra. It supersedes the long...
Article
Monitoring soluble immune checkpoints in circulating fluids has potential for minimally-invasive diagnostics and personalised therapy in precision medicine. Yet, the sensitive detection of multiple immune checkpoints from small volume liquid biopsy samples is challenging. In this study, we develop a multiplexed immune checkpoint biosensor (MICB) fo...
Article
Eukaryotic cell DNA conserves a distinct genomic methylation pattern, which acts as a molecular switch to control the transcriptional machinery of the cell. However, pathological processes can alter this methylation pattern, leading to the onset of diseases such as cancer. Recent advances in methylation analysis provide a more precise understanding...
Article
The development of a sensitive and specific detection platform for exosomes is highly desirable as they are believed to transmit vital tumour-specific information (mRNAs, microRNAs, and proteins) to remote cells for secondary metastasis. Herein, we report a simple method for the real-time and label-free detection of clinically relevant exosomes usi...
Article
The analysis of circulating cancer biomarkers in the form of liquid biopsies confers several potential benefits as compared to traditional surgical tissue sampling. As a common key anomaly strongly implicated across several cancer types, the BRAFV600E mutation is one the most valuable oncogenic biomarkers available in liquid biopsies. Crucially, BR...
Article
Full-text available
Epigenetic reprogramming in cancer genomes creates a distinct methylation landscape encompassing clustered methylation at regulatory regions separated by large intergenic tracks of hypomethylated regions. This methylation landscape that we referred to as Methylscape is displayed by most cancer types, thus may serve as a universal cancer biomarker....
Article
T-cells play a major role in host defense mechanisms against many diseases. With the current growth of immunotherapy approaches, there is a strong need for advanced technologies to detect and characterize these immune cells. Herein, we present a simple approach for the isolation of antigen specific T-cells from the complex biological sample based o...
Article
Circulating biomarkers have emerged as promising non-invasive, real-time surrogates for cancer diagnosis, prognosis and monitoring of therapeutic response. Current bio-sensing techniques mostly involve detection of either circulating cells or proteins which are inadequate in unfolding complex pathologic transformations. Herein, we report parallel d...
Article
Interfacial biosensing performs the detection of biomolecules at the bare- metal interface for disease diagnosis by comparing how biological species derived from patient and healthy individuals interact with bare metal surfaces. This technique retrieves clinicopathological information without complex surface functionalisation which is a major li...
Article
We report a new multiplexed strategy for the electrochemical detection of regional DNA methylation across multiple regions. Using the sequence dependent affinity of bisulfite treated DNA towards gold surfaces, the method integrates the high sensitivity of micro-fabricated multiplex device comprising microarray of gold electrodes, with the powerful...
Article
Protein phosphorylation is one of the most prominent post-translational mechanisms for protein regulation, which is frequently impaired in cancer. Through the covalent addition of phosphate groups to certain aminoacids, the interactions of former residues with nearby aminoacids are drastically altered, resulting in major changes of protein conforma...
Article
Full-text available
Tumor-derived exosomes possess significant clinical relevance due to their unique composition of genetic and protein material that is representative of the parent tumor. Specific isolation as well as identification of proportions of these clinically relevant exosomes (CREs) from biological samples could help to better understand their clinical sign...
Article
We report a new method for the electrochemical detection of glycosylation on proteins, which relies on lectin-protein interaction on a bare gold electrode. The target protein isolated by immunoaffinity is directly adsorbed onto a gold surface and its glycosylation status is retrieved by subsequent addition of specific lectins. The adsorption and su...
Conference Paper
Full-text available
We report a new method for the electrochemical detection of glycosylation on proteins, which rely on lectin-protein interaction on a bare gold electrode. The target protein isolated by immunoaffinity is directly adsorbed onto a gold surface and its glycosylation status is retrieved by subsequent addition of specific lectins. The adsorption and subs...
Article
Full-text available
The adsorption of DNA onto gold due to affinity interactions is highly desirable for developing low-cost, convenient and sensitive biosensors. To date, DNA-gold adsorption phenomenon has been demonstrated as one of the most promising physical mechanisms for achieving precise control over unmodified gold nanoparticles (AuNPs) aggregation, and DNA mo...
Article
Full-text available
A ferrocenyl imine complex, Fc-C(CH 3)=N-NH-C 6 H 3-2,4-(NO 2) 2 (Fc = ferrocenyl) has been synthesized by the condensation reaction between acetylferrocene and 2,4-dinitrophenyl hydrazine. The compound was synthesised previously, and characterized by IR, 1 H and elemental analysis. It was further characterized by 13 C { 1 H} NMR spectroscopy and m...
Article
Full-text available
Simple, sensitive and inexpensive regional DNA methylation detection methodologies are imperative for routine patient diagnostics. Herein, we describe eMethylsorb, an electrochemical assay for quantitative detection of regional DNA methylation on a single-use and cost-effective screen-printed gold electrode (SPE-Au) platform. The eMethylsorb approa...
Article
ABSTRACT The analysis of DNA methylation is becoming increasingly important both in the clinic and also as a research tool to unravel key epigenetic molecular mechanisms in biology. Current methodologies for the quantification of regional DNA methylation (i.e., the average methylation over a region of DNA in the genome) are largely affected by comp...
Article
A new family of luminescent platinum(II) acetylide complexes and polymers were formed by the copper(I) catalyzed reaction of cis-[PtCl2(PR3)2](R = C6H5–p-CH3) with appropriate acetylide ligands. The reaction of metal precursors with 2.5 equivalents of monoterminal acetylide ligands provided metal complexes trans-[Pt(p-tolyl3P)2(C≡C-R)2] (R = C6H4-p...
Article
We report a simple electrochemical method referred to as "eMethylsorb" for the detection of DNA methylation. The method relies on the base dependent affinity interaction of DNA with gold. The methylation status of DNA is quantified by monitoring the electrochemical current as a function of the relative adsorption level of bisulphite treated DNA sam...
Article
Full-text available
DNA methylation has the potential to be a clinically important biomarker in cancer. This communication reports a real-time and label-free biosensing strategy for DNA methylation detection in the cancer cell line. This has been achieved by using surface plasmon resonance biosensing combined with the highly specific molecular inversion probe based am...
Article
Full-text available
A study was carried out to examine the removal of dye and pathogenic bacteria from textile dye effluent by different adsorbents such as water hyacinth, tuberose pulp, sugarcane pulp and coconut pulp. The study shows that most of the adsorbents were active in removal of dye from the dye effluent. Especially, the efficiency of water hyacinth for dye...

Projects

Projects (2)
Project
Cancer is one of the leading causes of death globally. The aim of this project is to develop clinically applicable technologies for the early detection of cancer that can be operated from resource-poor environments.