This paper takes a macroperspective of entrepreneurship, and focuses on the issues and events involved in constructing an industrial infrastructure that facilitates and constrains entrepreneurship. This infrastructure includes: (1) institutional arrangements to legitimate, regulate, and standardize a new technology, (2) public resource endowments of basic scientific knowledge, financing mechanisms, and a pool of competent labor, as well as (3) proprietary R&D, manufacturing, marketing, and distribution functions by private entrepreneurial firms to commercialize the innovation for profit. Although extensive research substantiates the importance of these infrastructure components, they have been treated as externalities to entrepreneurship. By incorporating these components within a single framework, one can systematically examine how various actors and functions interact to facilitate and constrain entrepreneurship.