Saeed Reza Motamedian

Shahid Beheshti University of Medical Sciences · Department of Orthodontics

Aim: To improve osteogenic differentiation and attachment of cells. Methods: An electronic search was conducted in PubMed from January 2004 to December 2013. Studies which performed smart modifications on conventional bone scaffold materials were included. Scaffolds with controlled release or encapsulation of bioactive molecules were not include...

We sought to assess implant success/survival/failure rate following cortical autogenous tenting technique (CATT) versus inferior alveolar nerve transposition (IANT) in the posterior mandible. Patients who underwent these two procedures between 2007 and 2011 were analyzed. CATT was performed using lateral ramus block graft and implants were inserted...

Purpose: The aim of this study was to measure the thickness of bone labial and palatal to maxillary anterior teeth on cone beam computed tomographic (CBCT) images and to compare these measurements with direct clinical measurements to determine the reliability and accuracy of CBCT. Materials and methods: Eighteen healthy subjects were randomly se...

Introduction: Cell delivery in treatment of bone defects has been introduced to promote tissue healing in the recent years. However, no general consensus has been reached regarding the outcome of regenerative medicine for this purpose. The aim of this study was to review our 10 years of experience in application of mesenchymal stem cells (MSCs) in...

Despite a possible risk of donor site morbidity, autogenous bone grafting is considered the gold standard treatment for human alveolar cleft defect. Tissue engineering methods have recently been investigated with the aim of minimizing donor site morbidities. Here we systematically review the various tissue engineering methods applied to human alveo...

Objectives: Impacted canines can cause canine-induced root resorption (CIRR), potentially leading to root resorption and even incisor loss. The aim of this study was to usedeep learning to automatically evaluate the diagnosis of CIRR in maxillary incisors more accurately using CBCT images. Methods: A total of 50 CBCT images and 176 incisors were se...

This study aimed to review and synthesize studies using artificial intelligence (AI) for classifying, detecting, or segmenting oral mucosal lesions on photographs. Inclusion criteria were (1) studies employing AI to (2) classify, detect, or segment oral mucosa lesions, (3) on oral photographs of human subjects. Included studies were assessed for ri...

Mechanical loading can play a critical role in bone modeling/remodeling through osteoblasts, with several factors being involved in this process.The present study aims to systematically review the effect of mechanical stimulation on human osteoblast cell lineage combined with other variables.The PubMed and Scopus databases were electronically searc...

This study aims to review deep learning applications for detecting head and neck cancer (HNC) using magnetic resonance imaging (MRI) and radiographic data. Through January 2023, a PubMed, Scopus, Embase, Google Scholar, IEEE, and arXiv search were carried out. The inclusion criteria were implementing head and neck medical images (computed tomograph...

The accuracy of cephalometric landmark identification for malocclusion classification is essential for diagnosis and treatment planning. Identifying these landmarks is often complex and time-consuming for orthodontists. An AI model for classification was recently developed. This model was investigated based on current regulatory considerations as a...

Digital images allow for the objective evaluation of facial appearance and abnormalities as well as treatment outcomes and stability. With the advancement of technology, manual clinical measurements can be replaced with fully automatic photographic assessments. However, obtaining millimetric measurements on photographs does not provide clinicians w...

Introduction: This study aimed to compare the characteristics of pleasant and unpleasant smiles from the perception of laypeople. Methods: Two-hundred posed smile photographs were obtained from adult participants with no anomaly, restoration, or severe crowding and spacing in anterior teeth. Photographs were shown to 26 judges to give each photo...

Intelligent systems’ capabilities have noticeably improved in image analyzing and learning the visual patterns. Integration of such progressions with recent advancements in diagnostic imaging techniques (i.e., panoramic radiography, computed tomography (CT), cone beam computed tomography (CBCT), surface scanners, and digital photographs) has signif...

Artificial intelligence (AI) has made it possible for machines to perform human tasks. Healthcare is one of the main fields where AI and machine learning have been successfully employed. There have been many articles presenting the various applications of AI and its favorable outcomes in dentistry and maxillofacial surgery. It may be difficult for...

Objective: Distraction osteogenesis is one of the treatment options in patients with severe maxillomandibular abnormalities to treat morphological and respiratory problems (obstructive sleep apnea syndrome). The study aimed to evaluate the effect of Le Fort I, II and III distraction osteogenesis (DO) on upper airway dimensions and respiratory func...

Objective: To review the application of machine learning (ML) in the facial cosmetic surgeries and procedures METHODS AND MATERIALS: Electronic search was conducted in PubMed, Scopus, Embase, Web of Science, ArXiv and Cochrane databases for the studies published until August 2022. Studies that reported the application of ML in various fields of fa...

Background: The objective of this study was to assess the soft and hard tissue cephalometric indexes of facial profiles perceived as attractive. Methods: A total of 360 individuals (180 females and 180 males) with well-balanced faces and no history of orthodontic or cosmetic procedures were selected. Twenty-six raters (13 females and 13 males) r...

Background: This study aimed to investigate age- and gender-specific soft and hard tissue cephalometric features in an Iranian population with normal class I occlusion. Methods: A total of 111 Iranians (56 females and 55 males) in two age groups including individuals aged between 12-16 years and individuals aged over 16 years, with well-balanced fa...

Introduction: The aim of this systematic review and meta-analysis was to investigate the overall accuracy of deep learning models in detecting periapical radiolucent lesions in dental radiographs, when compared to expert clinicians. Methods: Electronic databases of Medline (via PubMed), Embase (via Ovid), Scopus, Google Scholar, and arXiv were s...

Purpose: The accuracy of cephalometric landmark identification for malocclusion classification is essential for the diagnosis and treatment planning. The identification of these landmarks is often complex and time consuming for the orthodontists. An AI model for the classification was recently developed. Due to the strict regulation on software sys...

Objective: The current study aimed to systematically review the randomized clinical trials assessing the preventive effect of professional fluoride interventions on enamel demineralization in patients undergoing fixed orthodontic treatment. Methods: The electronic search was performed in PubMed and Cochrane library in September 2021. No restrict...

Purpose This study aimed to analyze the effect of injecting chemical factors compared to conventional distraction osteogenesis (DO) treatment on the bone formation of the distracted area of the maxillofacial region in human and animal studies. Method Electronic search was done in PubMed, Scopus, Embase, and Cochrane database for studies published...

Deep learning (DL) has been employed for a wide range of tasks in dentistry. We aimed to systematically review studies employing DL for periodontal and implantological purposes. A systematic electronic search was conducted on four databases (Medline via PubMed, Google Scholar, Scopus, and Embase) and a repository (ArXiv) for publications after 2010...

Objective The application of stem cells in regenerative medicine depends on their biological properties. This scoping review aimed to compare the features of periodontal ligament stem cells (PDLSSCs) with stem cells derived from other sources. Design an electronic search of PubMed/Medline, Embase, Scopus, Google Scholar and Science Direct was cond...

Objectives Detecting caries lesions is challenging for dentists, and deep learning models may help practitioners to increase accuracy and reliability. We aimed to systematically review deep learning studies on caries detection. Data We selected diagnostic accuracy studies that used deep learning models on dental imagery (including radiographs, pho...

Objective Objective: To analyze the efficacy and complications of regenerative medicine compared to autogenous bone graft for alveolar cleft reconstruction. Method Method: Electronic search was done in PubMed, Scopus, Embase and Cochrane database for studies published until May 2021. No limitations were considered for the type of the included stud...

Introduction Maxillary constriction is a relatively common condition. Various treatment modalities have been proposed for this condition such as rapid maxillary expansion (RME). Although RME can significantly expand the suture in a relatively short period of time, it has a number of drawbacks, mainly a lengthy retention period. The primary objectiv...

Introduction: We aimed to systematically review the animal studies that have investigated the efficacy of periodontal ligament stem cells (PDLSCs) in bone regeneration. Methods: Web of science, Scopus, PubMed, Embase, Cochrane Library, and ProQuest were searched to September 2022 for animal studies investigating bone regeneration using PDLSCs. Resu...

Objectives Cephalometric radiographs are widely used in diagnosis and treatment planning. In the past, these radiographs used to be analyzed manually, but nowadays due to the possibility of errors and time-consuming nature of manual tracing, digital methods are replacing the manual methods. The reliability of computer-assisted analysis is of great...

Objective To conduct a systematic review and meta-analysis of studies that evaluated the association between gingival phenotype (GP) and the underlying alveolar bone thickness (ABT). Design An electronic search was performed in PubMed, Embase, Scopus, ProQuest, and Web of Science. The following inclusion criteria were applied: English original stu...

Context: The nose and lips area play an important role in facial appearance and nasolabial angle (NLA) can be considered as a determinant factor for attractiveness. The perception of beauty and attractiveness is vastly influenced by media and thus, can change with trends over time. The aim of this study was to conduct a systematic review of literat...

Background: Considering the complications associated with autogenous bone grafting, the use of freezedried bone allograft (FDBA) granules may be considered as an alternative treatment plan. Objectives: The aim of this study was to evaluate the effect of metformin on both the proliferation and osteogenic capability of dental pulp stem cells (DPSC...

Objective To systematically review and meta-analyse the Alveolar Bone Thickness (ABT) overlying healthy teeth. The secondary objective was to review the association of ABT with gender, age, and smoking. Materials and methods The PubMed, Embase, Scopus, ProQuest, Web of Science, and Cochrane Library databases were searched up to July 2020. English...

Objective To evaluate the effect of bone mesenchymal stem cells (BMSCs) with or without Platelet-rich plasma (PRP) carriers on sutural new bone formation after rapid palatal expansion (RPE). Settings and sample population Sixty male Wistar rats were used in this study. Material and Methods All samples were subjected to 50cN of palatal expansion f...

Context: The labial cortical bone may influence the outcomes of several treatments including fresh socket implant placement and orthodontic treatments. A thin labial plate may contribute to increased risks of periodontal consequences during dental procedures. Acknowledgment of the average values may guide clinicians to take particular consideration...

Introduction In recent years, artificial intelligence (AI) has been applied in various ways in medicine and dentistry. Advancements in AI technology show promising results in the practice of orthodontics. This scoping review aimed to investigate the effectiveness of AI-based models employed in orthodontic landmark detection, diagnosis, and treatmen...

More than 2 million people have died as a result of the COVID-19 outbreak. Angiotensin-converting enzyme 2 (ACE2) is a counter-regulatory enzyme that converts angiotensin-2 to Ang-(1-7) form in the renin-angiotensin system. Several studies have been analyzed the correlation between ACE2 and COVID-19. Indeed, ACE2/Ang (1-7) system protects the lung...

This article is a scoping review of the studies that assessed the effect of mechanical forces on the behavior of dental stem cells (DSCs). PubMed and Scopus searches were done for in-vitro studies evaluating the effect of tension, hydrostatic pressure (i.e., the pressure applied through an incompressible fluid), compression, simulated microgravity,...

Objective Different surgical and non-surgical approaches have been proposed to accelerate tooth movement and decrease the duration of orthodontic treatments. Recently, less invasive techniques such as micro-osteoperforation (MOP) are becoming more common. Several clinical trials have been performed to analyse the effect of MOP. This systematic revi...

Introduction: This study was performed to compare the effects of single and multiple irradiations of low-level laser therapy (LLLT) on bone regeneration in a mid-palatal suture following rapid palatal expansion (RPE). Methods: In this animal study, 40 male Wistar rats underwent RPE for 7 days and were divided into 4 groups including A: single LLLT...

Introduction: One of the most common orthodontic problems is maxillary constriction, which is mostly treated by rapid palatal expansion (RPE). However, its high rate of relapse and prolonged retention period have led to some challenges for orthodontists. To encounter these issues, accelerating bone regeneration can provide long-term stability of e...

Background: Growth hormone plays a significant role in determining craniofacial morphology. Mutations of its receptor gene might be associated with mandibular prognathism (MP). Purpose: The aim of the current study was to evaluate growth hormone receptor (GHR) gene polymorphisms in relation to facial dimensions. Material and Method: The study enrol...

Introduction: Pain related to orthodontic tooth movement is common and cause dissatisfaction and discomfort. Objective: The present study aimed to compare the efficacy of naproxen patches in pain control during orthodontic tooth separation, by means of visual analogue scale (VAS) and interleukin 1β (IL-1β) levels in gingival crevicular fluid (GCF)....

Background and Aim: Evaluation of the treatment outcome is an important stage in every healthcare system, including orthodontics. This study aimed to assess the attitude and practice regarding treatment outcome assessment (TOA) among Iranian orthodontists. Materials and Methods: In this cross-sectional survey, a questionnaire was developed, which c...

Background and Aim: Evaluation of the treatment outcome is an important stage in every healthcare system, including orthodontics. This study aimed to assess the attitude and practice regarding treatment outcome assessment (TOA) among Iranian orthodontists. Materials and Methods: In this cross-sectional survey, a questionnaire was developed, which c...

Objectives:: To compare archwire selection on dental casts with archwire selection using a three-dimensional (3D) software program (OrthoAid) and assess agreement between clinicians. Materials and methods:: The best-fitting archwires were selected for dental casts of 100 patients with malocclusion using two approaches by three orthodontists. The...

The aim of this study was to compare human dental pulp stem cells’ (DPSCs) attachment, proliferation and osteogenic differentiation on allogenic and synthetic biphasic bone granules. In this in vitro study, two types of bone granules were used: allograft [freeze-dried bone allograft (FDBA)] and biphasic granules [hydroxyapatite/beta-tricalcium phos...

Objective The aim of this study is to compare the adaptation of a straight wire between brackets positioned at the mid-lingual surface and those placed gingivally by using a three-dimensional simulation software. Methods This cross-sectional study was performed using OrthoAid, an in-house software. The subjects were 36 adolescents with normal Clas...

Objective: To evaluate to the effect of metformin on attachment of human dental pulp stem cells (hDPSCs) and their proliferation and osteogenic differentiation on biphasic hydroxyapatite/beta-tricalcium phosphate granules of macro-porous biphasic calcium phosphate (MBCP). Materials and methods: This in vitro study included four groups: A:hDPSCs + M...

A simple overview of daily orthodontic practice involves use of brackets, wires and elastomeric modules. However, investigating the underlying effect of orthodontic forces shows various molecular and cellular changes. Also, orthodontics is in close relation with dentofacial orthopedics which involves bone regeneration. In this review current and fu...

Aim: To assess the failure rates of various pediatric dental treatments performed under general anesthesia (GA) after six months to five years of follow-up. Design: This multicenter retrospective cohort study was performed on patients treated by five pedodontists in two private hospitals located in northern Iran during 2010–2013 and comprised 155 p...

Previous in vitro studies have suggested that simvastatin can be used as a direct pulp capping material due to its ability to induce odontoblastic differentiation and angiogenesis. The aim of this animal study was to evaluate the pulpal response to mineral trioxide aggregate (MTA) and four concentrations of simvastatin/MTA in combination. The study...

Background The aim of the current study was to detect hepatitis C virus (HCV) RNA in blood and saliva of a population of patients with thalassemia who have HCV antibody in their serum. Materials and Methods In this cross-sectional study, blood and saliva samples were collected and were analyzed with quantitative reverse transcription polymerase ch...

Background Guided bone regeneration (GBR) is the most common technique for localized bone augmentation. Purpose The purpose of this review was to categorize and assess various GBR approaches for the reconstruction of human alveolar bone defects. Materials and Methods Electronic search of four databases including PubMed/Medline, EMBASE, Web of Sci...

Purpose: The current systematic review investigated the results of application of some of the most commonly used scaffolds in conjugation with stem cells and growth factors in animal and clinical studies. Methods: A comprehensive electronic search was conducted according to the PRISMA guidelines in NCBI PMC and PubMed from January 1970 to Decemb...

Introduction: To systematically review high-quality randomized controlled trials (RCTs) and meta-analysis on the effectiveness of use of ibuprofen and low-level laser therapy (LLLT) for pain control during fixed orthodontic appliance therapy. Materials and methods: A web-based systematic search of PubMed and Medline database using relevant keywo...

Different degrees of clinical success have been reported for synthetic, allograft, and xenograft bone substitutes in human trials. Although these substitutes have been clinically investigated, their in vitro effects on cell differentiation remain unclear. Proliferation, differentiation, and attachment of dental pulp stem cells (DPSCs) to β-tricalci...

Objective Growth prediction plays a significant role in accurate diagnosis and treatment planning of orthodontics patients. It was hypothesized that the unique pattern of pneumatization of the frontal sinus as a component of craniofacial structure would influence the skeletal growth pattern and may be used as a growth predictor. Materials and Meth...

Objectives: Clinicians commonly consider atrophic site topography as an important determinant in deciding the augmentation technique to utilize, as well as forecasting the likelihood of success. The purpose of this retrospective study was to examine the influence of initial atrophic posterior mandible morphology on the outcome of implants placed f...

Introduction: In evaluating bond failure, considerable attention has been paid to the various factors that affect bond strength. The bracket–resin interface is the site of usual bond failure. Therefore, many efforts have been accomplished on this interface. The aim of this study was to compare the effects of sandblasting on shear bond strength of t...

Introduction: Classic bone tissue engineering involves use of osteogenic cells, growth factors, and bone scaffolds to generate a graft material to replace the gold standard which is autogenous bone graft. Several modifications have been applied to the classic approach but none of them can fully regenerate bone defects. The current study reviewes th...

The importance of recipient site on success rate of augmentation procedure of jaws has been less issued. We have focused on recipient site characteristics in ABC classification as follows: 1. Presence of vertical regenerative walls in both sides of the recipient site or one site which classified as A and B group, respectively. Absence of regenerati...

Keratocystic odontogenic tumor (KCOT) is an odontogenic tumor which has the highest rate of recurrence. This report describes a rare case of bilateral ciliated epithelium-lined odontogenic keratocyst in the maxilla of a 15-year-old male. Panoramic radiography showed two lytic lesions on both sides of the maxilla associated with impacted third molar...

The aim of this study is to review and compare survival/success rate of dental implants inserted in autogenous and allogenic bone blocks (ALBs). A PubMed search was performed from January 1990 to June 2014 limited to English language and human studies. Studies that reported treatment outcome of implants inserted in augmented alveolar ridges with au...

The tissue engineering scaffold acts as an extracellular matrix that interacts to the cells prior to forming new tissues. The chemical and structural characteristics of scaffolds are major concerns in fabricating of ideal three-dimensional structure for tissue engineering applications. The polymer scaffolds used for tissue engineering should posses...

Aim: This study aimed to measure the thickness of labial bone overlying maxillary and mandibular anterior teeth and the distance between cementoenamel junction and bone crest in a Persian population. Materials & methods: Two calibrated examiners evaluated tomographic data of 152 maxillary and 200 mandibular anterior teeth. Labial bone width was...

Dental anxiety is one the most important reasons preventing children to enjoy dental services. Several methods can be applied in order to reduce dental anxiety and manage children’s behavior. Both dentists and parents mostly prefer not to use medications. However to treat anxious children, those with systemic disease or movement disorders, sedation...

In modern implantolotology there are several indications for laser. Different laser systems can be applied in soft and hard tissues surgery. In this review, literature was searched for application of laser in second-stage surgery of implants, treatment of peri-implant bony defects, removal of peri-implant hyperplastic tissues, and the preparation o...

Tissue engineering is knowledge of designing tissues such as maxillofacial bone. Three key factors of tissue enginee-ring comprise of morphogenesis factors, responding stem cells and scaffolds. Growth factors have an important role in differentiation and cell morphogenesis. In this review, literature was searched for bone engineering in craniomaxil...

Objective: Data regarding the width of anterior facial bone in different populations and different ethnic groups is insufficient in order to establish a global norm. The purpose of this study was to measure the thickness of facial bone overlying both maxillary and mandibular anterior teeth and the distance between cementoenamel junction (CEJ) and b...

Objective: Data regarding the width of anterior facial bone in different populations and different ethnic groups is insufficient in order to establish a global norm. The purpose of this study was to measure the thickness of facial bone overlying both maxillary and mandibular anterior teeth and the distance between cementoenamel junction (CEJ) and b...

Objectives: One of the key indicators of functional state of the masticatory system is maximum bite force. Determination of individual bite force has been widely used in dentistry to understand the therapeutic effects of prosthetic devices and to provide reference values for the studies on the biomechanics of prosthetic devices. In addition, bite f...