Behzad Houshmand

• Professor
• Shahid Beheshti University of Medical Sciences

Background In soft tissue regeneration, the clinical efficacy of fibrin membranes has been a pressing concern. The key to this efficacy lies in the stability of membrane and its controlled absorption. Human serum albumin, with its influence on the formation and stability of fibrin networks, could hold the key to developing a more stable alternative...

Dental implants are now the best treatment method to replace missing teeth. However, complications may necessitate further therapeutic interventions because of anatomic limitations and mistakes during surgical procedures. In this case report, a nasopalatine duct cyst (NPDC) due to implant placement was studied. After clinical and radiographic evalu...

Background The success rate of dental implants diminishes over time; the lack of osseointegration and infection are the major causes of most implant failures. One of the effective methods to improve the surface properties is to irradiate ultraviolet (UV) light. This study investigated the effect of UV photofunctionalization on the ultrasuperficial...

Background Autogenous soft-tissue graft is the gold-standard approach to augment oral soft tissues. However, tissue engineering is increasingly surveyed to overcome its substantial drawbacks, including the secondary site of operation, patient’s pain and discomfort, limited tissue of donor site, and so on. Chitosan and gelatin have been utilized in...

Background: No systematic review/meta-analysis has been conducted on the microbiological profile associated with the occurrence of periodontitis in patients with HIV. The aim of this study was to evaluate the prevalence of identified bacteria in HIV-infected patients with periodontal disease. Methods: Three English electronic databases (MEDLINE...

Background: Xenograft and allograft bone substitutes are widely used to replace the missing bone in defects. Since removing the packaging of these grafts can nullify their sterilization, this study aimed to evaluate the sterility and bioactivity changes of an allograft and a xenograft following uncapping/recap. Methods: Two types of commercial a...

Objective: The present study was conducted to compare the effects of 810 nm, 980 nm, and dual (810: 50%-980: 50%) diode lasers on the surface modifications of implants contaminated by a standard strain of Escherichia coli. Methods: Based on the operation on their surface, the implants were divided into six groups: "Group 1" was the positive control...

Background The novel two‐stage technique presented in this study is based on guided bone regeneration for three‐dimensional bone augmentation. Methods and Results The proposed technique was performed to augment an atrophic alveolar ridge in the maxilla and mandible. This method is based on using an autogenous bone plate, a mixture of allogeneic bo...

Background The rapidly developed vaccines against the severe acute respiratory syndrome coronavirus 2 carry a risk of provoking side effects. This study aimed to evaluate current vaccination non-serious/serious side effects. Methods A multicenter electronic questionnaire via an online platform was conducted over a 1-week period among vaccinated de...

Implant design and biomaterial composition are contributing factors in stress distribution throughout the implant body and the surrounding bone. The aim of this study was to evaluate the pattern of stress distribution using four different implant systems based on finite element analysis. This study was conducted using a cone beam computed tomograph...

Background: Oral health is an integral part of general health and one of the necessities of a good life. Having a healthy mouth and teeth requires individual care, the development and implementation of community-based intervention programs, and professional care. The purpose of this study was to design a model for the management of dental services...

In the indoor environment of dental clinics, dental personnel and patients are exposed to a risk of infection because of the transmission of SARS-CoV-2 via particles or droplets. This study investigated the presence of SARS-CoV-2 RNA in indoor air of dental clinics in Tehran, Iran. Air sampling was done (n = 36) collecting particulate samples on PT...

Background: No systematic review/meta-analysis has been conducted on the microbiological profile associated with the occurrence of periodontitis in patients with HIV. The aim of this study was to evaluate the prevalence of identified bacteria in HIV-infected patients with periodontal disease. Methods: Three English electronic databases (MEDLINE (vi...

Introduction SARS-CoV-2 is a novel coronavirus that causes an infectious disease named COVID-19. Respiratory distress syndrome and multiple organ failure are the common outcomes of COVID-19 that may finally lead to death. During COVID-19, cytokine storm takes place that is known by the release of notable amounts of pro-inflammatory cytokines includ...

Synthetic scaffolds, as an alternative to allograft and xenograft scaffolds, are suitable for bone regeneration. This study aimed to synthesize a composite biomaterial of zeolite and beta-tricalcium phosphate (βTCP) to obtain a biocompatible material with physical and mechanical properties in bone regeneration. One scaffold without zeolite (βZG 0)...

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes serious acute respiratory diseases including pneumonia and bronchitis with approximately 2.3% fatality occurrence. Main body: This study argues the main concepts that need to be considered for the gradual reopening of dental offices include treatment planning approac...

COVID-19 is a viral disease caused by SARS-CoV-2 that quickly became a global pandemic during 2020. Considering the recent outbreak, the lack of adequate data regarding SARS-CoV-2, and consequently the risk of dental practice and potential cross-infection, this article attempted to address the information collected so far in accordance with the int...

Background Ineffective integration has been recognized as one of the major causes of early orthopedic failure of titanium-based implants. One strategy to address this problem is to develop modified titanium surfaces that promote osteoblast differentiation. This study explored titanium surfaces modified with TiO2 nanotubes (TiO2 NTs) capable of loca...

The second author’s name was incorrect in the initial online publication.

Periodontitis is the most common periodontal disease. Because of its infectious-inflammatory nature, as well as the difficulty of complete elimination of pathogens from oral cavity, antibiotics have been proposed as adjunctive modalities to control the disease and prevent its recurrence. Systemic antibiotics could lead to a further reduction in pro...

Introduction: The enhancement of osteogenesis by tissue engineering is a challenge in periodontal therapy. Several graft materials in conjunction with carriers, such as blood or saline, are used for this purpose. This study aimed to assess the effect of phosphate buffered saline (PBS), Hank's balanced salt solution (HBSS) and saline on the activity...

The purpose of this study is to evaluate the general function and properties of a new class of reinforced glass-ionomer cements (GICs). In this regard, GIC powders based on a molar composition of 4.5SiO2.3Al2O3.1.5P2O5.3CaO.2CaF2 were synthesised via a melt-quenching method. The cement reinforced with silanized fibers (CSFs) were made by adding sil...

Background: Zeolite is a microporous aluminosilicate compound which has been successfully used in tissue engineering. The effects of Zeolite on the morphology and functions of pre-osteoblastic MG-63 cells as new bone enhancer material is still unclear. Methods: In this vitro experimental study, MTT and Alizarin red staining test were performed on s...

In this study, blends of chitosan (CS)/silk fibroin (SF) and reduced graphene oxide (rGO) as guided bone regeneration membranes were fabricated by solvent casting method and their architectural features, hydrophilicity, porosity, swelling, degradation, and mechanical properties were investigated. The influence of CS, SF and rGO on osteoblasts sprea...

In the present study, a systematic review was conducted to evaluate the biomaterials and their effectiveness for bone augmentation in implant dentistry. The databases of Cochrane Library, Google Scholar, PubMed (National Center for Biotechnology Information), and Scopus were searched for published studies between 2006 and March 30, 2018. We only in...

Early and effective integration of titanium-based materials into bone tissue is of vital importance for long-term stability of implants. Surface modification is commonly used to enhance cell-substrate interactions for improving cell adhesion, proliferation, and activity. Here, the surface of titanium substrates and commercial implants were coated w...

Periodontitis and tooth decay are common dental diseases. There are some bacterial risk factors such as Streptococcus mutans, Aggregatibacter actinomycetemcomitans and Candida albicans fungi. Considering the increasing resistance of bacteria and fungi to antibiotics and their complications, tubers of Cyperus rotundus was used to determine the antim...

Many approaches have been developed to regenerate biological substitutes for repairing damaged tissues. Guided bone/tissue regeneration (GBR/GTR) that employs a barrier membrane has received much attention in recent years. Regardless of substantial efforts for treatment of damaged tissue in recent years, an effective therapeutic strategy is still a...

A specific strain of naturally occurring oral lactobacilli was isolated and identified based on morphological, biochemical, and 16S rRNA gene sequencing. The phylogenetic affiliation of the isolate confirmed that the NK02 strain had close association with the Lactobacillus salivarius. An effective mouthwash was developed for treatment of periodonti...

Objective: To evaluate to the effect of metformin on attachment of human dental pulp stem cells (hDPSCs) and their proliferation and osteogenic differentiation on biphasic hydroxyapatite/beta-tricalcium phosphate granules of macro-porous biphasic calcium phosphate (MBCP). Materials and methods: This in vitro study included four groups: A:hDPSCs + M...

Background The aim of the current study was to detect hepatitis C virus (HCV) RNA in blood and saliva of a population of patients with thalassemia who have HCV antibody in their serum. Materials and Methods In this cross-sectional study, blood and saliva samples were collected and were analyzed with quantitative reverse transcription polymerase ch...

Purpose: Titanium-based biomaterials present good biocompatibility, while their osseointegration and antibacterial properties need to be improved. This study aimed to enhance the bone-bonding ability of titanium-based granules, which are intended to be used as bone graft. Materials and methods: The titanium granules were anodized in ethylene gly...

The aim of this research was to develop chitosan/gelatin/keratin composite containing hydrocortisone sodium succinate as a buccal mucoadhesive patch to treat desquamative gingivitis, which was fabricated through an environmental friendly process. Mucoadhesive films increase the advantage of higher efficiency and drug localization in the affected re...

Tissue expansion is used by plastic/reconstructive surgeons to grow additional skin/tissue for replacing or repairing lost or damaged soft tissues. Recently, hydrogels have been widely used for tissue expansion applications. Herein, a self-inflating tissue expander blend composition from three different molecular weights (2, 6, and 10 kDa) of poly...

Introduction: Diode laser irradiation has recently shown promising results for treatment of gingival pigmentation. This study sought to compare the efficacy of 2 diode laser irradiation protocols for treatment of gingival pigmentations, namely the conventional method and the sieve method. Methods: In this split-mouth clinical trial, 15 patients wit...

Aims The purpose of this multi-phase explorative in vivo animal/surgical and in vitro multi-test experimental study was to (1) create a 3 wt%-nanostrontium hydroxyapatite-enhanced calcium phosphate cement (Sr-HA/CPC) for increasing bone formation and (2) creating a simvastatin-loaded poly(lactic-co-glycolic acid) (SIM-loaded PLGA) microspheres plu...

Purpose: The highly porous titanium granules are currently being used as bone substitute material and for bone tissue augmentation. However, they suffer from weak bone bonding ability. The aim of this study was to create a nanostructured surface oxide layer on irregularly shaped titanium granules to improve their bioactivity. This could be achieve...

Delayed wound healing is one of the complications of diabetes mellitus. Low-level laser therapy (LLLT) has been used to accelerate wound healing however the effect of LLLT on the hard palate wound healing in streptozotocin-induced diabetic (STZ-D) mice has not yet been characterized. This study aims to determine the effect of LLLT (He–Ne and Ga–Al–...

Periodontium is a complex organ composed of mineralized epithelial and connective tissue. Dexamethasone could stimulate proliferation of osteoblast and fibroblasts. This study aimed to assess the osteogenic effect of dexamethasone on periodental ligament (PDL) stem cells. PDL stem cells were collected from periodontal ligament tissue of root of ext...

The periodontium is a supportive structure which surrounds the teeth and supports them. This structure consists of different tissues including gingiva, cementum, periodontal ligament and alveolar bone. The aim of this study is to analyze the osteogenic stimulatory effect of the combination of dexamethasone and L.L.L.I. on the periodontal stem cell...

Titanium granules can be used as bone graft substitute in the field of orthopedic and periodontal surgery, but their bone bonding ability needs to be promoted. Nanostructured materials have shown to enhance bioactivity and the overall bioperformance of biomaterials. In the present study, the effects of time and voltage of anodic oxidation process a...

Introduction: The aim of the study w as to evaluate the effects of estrogen histomorphologically and low level laser irradiation on wound healing process in the oral cavity of female Wistar rats,. The biological effects of estrogen and lowtherapy (LLLT) on wound healing is still level laser controversial. Methods: Sixty female wistar rats with gene...

Background: Periodontal ligament stem cells (PDLSCs) are considered as a type of mesenchymal stem cell that is beneficial target for numerous clinical applications in periodontal tissue regeneration therapy. Materials and Methods: This study examined the effects of dexamethasone (Dex) on human PDLSCs in vitro. PDLSCs obtained from the roots of pati...

Microorganisms are main etiologic causes of periodontal disease and dental caries. Antimicrobial agent with mechanical debridement (as main treatment) can help elimination of microbial factor. Recently extreme usage and non-reasonable application of antimicrobial agent develop bacterial tolerance and side effect associated to existing agent, so it...

Objectives: Despite great achievements and evidence developments in the field of dentistry, searching and retrieving evidence seems to be not very well applied and effective in academic settings. The aim of this study was to assess search for evidence behavior among dental faculty members in Iran. Methods: A cross-sectional study was conducted on...

Background: Allium sativum, commonly known as garlic, exhibits antibacterial effects against a wide range of bacteria. Aim: The objective of this in vitro study was to assess the antibacterial effect of different concentrations of garlic extract against human dental plaque microbiota. Materials and Methods: Antibacterial activities of four differen...

Root surface debridement (RSD) is necessary to create an environment suitable for reattachment of the periodontium. Root surface conditioning may aid the formation of a biocompatible surface suitable for cell reattachment. BioPure™ MTAD (mixture of Doxycycline, citric acid and a detergent) is an endodontic irrigant with antibacterial properties and...

Educating dental practitioners is a major component in obtaining evidence-based approach to oral health care, but there is no evidence about knowledge and attitude of dental faculty members towards evidence-based dentistry (EBD) in Iran. A cross-sectional study was conducted using self-administered questionnaires on dental school faculties in Iran...

Background and aims. Periodontitis is a multifactorial disease. Varieties of microbial and environmental, as well as genetic factors are reported to influence risk for periodontitis. The present study sought to test the putative involvement of Il-10 and Il-18 gene polymorphism in pre-disposition to periodontitis in patients had exposure to chemical...

Objective: Implant dentistry accounts for a significant part of general dental practice. A modern curriculum should therefore adequately prepare dental students with knowledge and competencies in implant dentistry at both undergraduate and postgraduate level of study. Dental implant education has no well-defined place in our country’s dentistry edu...

Various types of materials are used in bone regeneration procedures. The aim of this study was to investigate the use of the enamel matrix derivative (EMD), deproteinized bovine bone mineral (Bio-Oss), and a combination of Bio-Oss plus EMD in the treatment of bone defects created in the rabbits' calvaria. Twenty New Zealand white rabbits were inclu...

Many environmental and genetic factors are known as factors that increase the susceptibility to periodontitis. As IL-8 is a chemokine that mediate the inflammatory process in periodontal disease, we decided to evaluate the effect of its polymorphism on chronic and aggressive periodontitis. In this cross-sectional study DNA was isolated from the who...

Persistent host inflammatory immune response against the pathogens results in the destruction of periodontal tissues. Cytotoxic T lymphocyte antigen 4 (CTLA-4) is a particularly important molecule in down-regulating T-cell expansion and cytokine production. This study aimed to assess three functional SNPs within CTLA-4 gene, -1722 T/C, -318 C/T, an...

Low-level laser therapy (LLLT) has been used to accelerate wound healing, yet questions remain concerning its therapeutic applications. This study aimed to compare the healing efficacy of helium-neon (He-Ne) red light (laser) and gallium aluminum arsenide (Ga-Al-As) infrared lasers at two different doses on hard palate wounds. In a randomized contr...

Objective. Our aim in this paper was to investigate the possible genetic association between three Ser563Asn, Leu125Val and Arg670Gly polymorphisms of the PECAM-1 gene and periodontitis. Methods. Genomic DNA was isolated from whole blood of 105 periodontal patient (52 with chronic periodontitis and 53 with aggressive periodontitis) and 101 healthy...

Among several bacteria examined, an antibacterial-producing Lactobacillus strain with probiotic characteristics was selected and identified based on 16S rRNA gene sequencing. Subsequent purification and mode of action of the antibacterial compounds on target cells including E. coli were investigated. Maximum production of the antibacterial compound...

Background & Objectives: Probiotics are live micro-organisms that when administered in adequate amounts confer health benefits upon the host. Aim of this study, investigating the probiotic potential of new strain of Lactobacillus isolated from Dairy products with certain properties relevant to probiotic action, e.g. resistance to acid, bile toleran...

Background & Objectives: Different food additives and divalent metal cations have different effects on antibacterial compound production. The aim of this research was to screen antimicrobial-producing lactic acid bacteria (LAB) strains from Iranian traditional dairy products and affect of food additives and divalent metal cations on their antibacte...

Objectives: Translation of dental research evidence into practice seems to be not fully applied by all dental practioners. The path towards an increase in evidence based practice seems to face many obstacles. In this study barriers on implementing evidence based practice in Iran (EBP) were explored. Methods: We conducted a qualitative study based...

Objectives: Host immune and defensive mechanisms play an important role in the multifactorial disease of periodontitis. Since PECAM-1 is involved in the transmigration of inflammatory cells therefore polymorphism of this molecule might affect the inflammatory process in periodontitis. Our aim in this study was to investigate the possible genetic...

Objectives: Periodontitis is considered a multifactorial inflammatory disease. Mannose-binding lectin (MBL) is an important part of the innate immune system and a protein of the complement system. Our aim in this study was to investigate the possible genetic association between three single-base substitutions positioned in exon-1 of the MBL-2 gen...

To increase the understanding of the applicability of biomaterials and growth factors in enhancing stem cell-based bone regeneration modalities, this study evaluated the effects of enamel matrix derivative (EMD) and recombinant human transforming growth factor-beta (rhTGF-β) on osteoblastic differentiation of human bone marrow mesenchymal stem cell...

To evaluate the determinants of Iranian dentists' behaviour regarding infection control (IC). Design:  A cross-sectional questionnaire survey. Iranian general dental practitioners (GDP) participating in a national dental congress. The GDPs filled in a self-administered questionnaire containing questions regarding their attitudes towards and their b...

Objectives: Furthering the applicability of biomaterials and growth factors for enhancing stem cell-based bone regeneration modalities; this study was aimed to evaluate the effects of enamel matrix derivative (EMD, Emdogain, Biora, Malm, Sweden) and transforming growth factor-β (TGF-β) on osteoblastic differentiation of human bone marrow mesenchyma...

Statins, the mevalonate pathway inhibitors, have effects on bone formation in vitro and in vivo. The aim of the present study was to investigate whether injection of statins could lead to ectopic bone formation in rats. Materials and methods. A single dose (0.5 mg) of simvastatin, atrovastatin, lovastatin and polyethylene glycol (control material)...

Periodontitis is a multifactorial disease in which environmental and genetic determinant factors contribute to individual subjects susceptibility. A DNA polymorphism in the regulating region of adhesion molecule genes is suggested to modulate the molecules physiological effects. The aim of this study was to investigate the genetic association betwe...

Periodontitis is a multifactorial disease and immunologic and genetic factors have an important role in its pathogenesis. Mutation in the promoter regions of the interleukin-4 and interferon-gamma genes has been reported to modify the protein expression. The objective of this study was to evaluate the possible role of interleukin-4 (C-590T) and int...

The effect on bone regeneration, of adding pamidronate disodium to bovine-derived hydroxyapatite, was histologically evaluated, using the sheep bone model. Twenty-four intrabony defects were prepared in the lower jaw of eight sheep using trephine 6 mm burs. One cavity was left unfilled and the other two were filled with bovine-derived hydroxyapatit...