Catherine Thomas-Antérion

Université Lumiere Lyon 2 | UL2 · Labo EMC

Background APP duplication is a rare genetic cause of Alzheimer disease and cerebral amyloid angiopathy (CAA). We aimed to evaluate the phenotypes of APP duplications carriers. Methods Clinical, radiological, and neuropathological features of 43 APP duplication carriers from 24 French families were retrospectively analyzed, and MRI features and ce...

The functional organization and related anatomy of executive functions are still largely unknown and were examined in the present study using a verbal fluency task. The objective of this study was to determine the cognitive architecture of a fluency task and related voxelwise anatomy in the GRECogVASC cohort and fMRI based meta-analytical data. Fir...

Apathy occurs in approximately one third of people after stroke. Despite its frequency and functional consequences, the determinants of apathy have only been partially defined. The major difficulty lies in disentangling the reduction in activity due to apathy itself from those secondary to comorbidities, such as depression, sensorimotor deficits, a...

GRN mutations are among the main genetic causes of frontotemporal dementia (FTD). Considering the progranulin involvement in lysosomal homeostasis, we aimed to evaluate if plasma lysosphingolipids (lysoSPL) are increased in GRN mutation carriers, and whether they might represent relevant fluid-based biomarkers in GRN-related diseases.We analyzed fo...

C9orf72 repeat expansions are rarely associated with primary progressive aphasias (PPA). In-depth characterization of the linguistic deficits, and the underlying patterns of grey-matter atrophy in PPA associated with the C9orf72 expansions (PPA-C9orf72) are currently lacking. In this study, we comprehensively analyzed a unique series of 16 patients...

Lors du recueil d’une plainte de mémoire, certains éléments de l’anamnèse, du bilan neurologique et le récit des difficultés peuvent dès lors orienter vers un diagnostic neurologique ou psychiatrique impliquant le lobe frontal. L’altération de la consolidation en mémoire et du stockage–le lot des maladies impliquant l’hippocampe- n’est pas la seule...

A (GGGGCC)n repeat expansion in C9orf72 gene is the major cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The relations between the repeats size and the age at disease onset (AO) or the clinical phenotype (FTD vs. ALS) were investigated in 125 FTD, ALS, and presymptomatic carriers. Positive correlations were found be...

Le terme fonctionnel est ambigu car il peut prendre bien des sens. Il existe néanmoins dans les classifications internationales notamment la CIM-10 et il est volontiers explicité au malade pour évoquer un mauvais « fonctionnement » de son organisme en absence de lésion objectivable. Concernant la mémoire, on a souvent utilisé le terme psychogène po...

Objectives: The aim of this study was to determine whether cognitive reserve in the elderly affects the evolution of cognitive performance and what its relationship is with active lifestyles in later life. Methods: Cognitive performance was evaluated at baseline and 8 years later in 543 participants of the PROOF cohort, initially aged 67 years....

Background: Subjective cognitive complaints (SCCs) may be an early marker of prodromal Alzheimer's disease. Objectives: Using a 10-item yes/no SCCs questionnaire (Le Questionnaire de Plainte Cognitive [QPC]), we evaluated the prevalence and distribution of SCCs in cognitively healthy Czech older adults and examined total score and specific QPC i...

L’encéphalopathie chronique traumatique (ECT) est un terme qui a été forgé pour remplacer celui de démence pugilistique. Elle survient après des traumatismes crâniens (TC) légers répétés ou un TC unique mais sévère. Les sujets les plus touchés sont les anciens militaires victimes de blast (effet de souffle) et les anciens sportifs ayant pratiqué ce...

Objectives: We describe the largest series of patients with TARDBP mutations presenting with frontotemporal dementia (FTD) and review the cases in the literature to precisely characterize FTD diseases associated with this genotype. Methods: The phenotypic characteristics of 29 TARDBP patients, including 10 new French and Dutch cases and 19 revie...

Introduction MB, âgée de 36 ans, présenta au décours d’un AVC insulaire postérieur gauche une appétence nouvelle pour la peinture, avec un certain talent et un réel engouement [1]. On nota le recours privilégié à « la palette chaude », celle-ci atténuant des douleurs centrales s’exacerbant notamment au froid ou au contact du métal, tandis que « la...

Supplementary data

Supplementary data

Supplementary data

Cet ouvrage a pour mission de mettre en commun des outils consensuels validés et de les faire connaître. Leur regroupement sous l’étendard de la neurologie, participent à la compréhension de la neuropsychologie : fonction, réseau de neurones, clinique, de façon holistique et consensuelle sans réinventer la roue. Enfin et comme dans le premier volum...

Causative variants in APP, PSEN1 or PSEN2 account for a majority of cases of autosomal dominant early-onset Alzheimer disease (ADEOAD, onset before 65 years). Variant detection rates in other EOAD patients, that is, with family history of late-onset AD (LOAD) (and no incidence of EOAD) and sporadic cases might be much lower. We analyzed the genomes...

Résumé Pathologies cérébrovasculaires Le bénéfice de la thrombectomie à la phase aiguë de l’infarctus cérébral est maintenant établi lorsqu’il existe une occlusion proximale d’une artère intracrânienne, indépendamment de son mécanisme étiologique. L’indication des anticoagulants dans les dissections des troncs supra-aortiques demeure incertaine al...

Introduction Déclenchée par un stress psychologique, l’amnésie dissociative n’est associée à aucune lésion neurologique identifiable. Ses caractéristiques cliniques et ses bases fonctionnelles font toujours l’objet de controverses. Méthodes Nous rapportons trois cas d’amnésie rétrograde portant sur les événements autobiographiques, ayant débuté br...

La prise en charge de la maladie d’Alzheimer repose sur une approche multidisciplinaire. Elle nécessite une prise en charge globale intégrant les traitements médicamenteux et non médicamenteux. Les interventions psycho-sociales concourent au maintien ou à la réhabilitation des capacités fonctionnelles, des fonctions cognitives et sensorielles, au m...

A case of episodic amnesia with impairment of time perception is described; it illustrates the link between time perception and autobiographical memory. This woman suffered from a Sheehan syndrome with anoxia at the age of 36 and since that date has had a strong and isolated difficulty to estimate the date and duration of events in a range of weeks...

The MoCA was built as a screening test for detecting patients in the general population with light cognitive dysfunctions and at a higher risk for dementia. It is available in 20 languages (http://www.mocatest.org/), but it does not have normative data in French. This test assesses different cognitive functions in 10 tasks: executive functions, att...

Objective: To test the influence of functional cerebral reorganization in amyotrophic lateral sclerosis (ALS) on disease progression. Methods: Nineteen predominantly right-handed ALS patients and 21 controls underwent clinical evaluation, functional Magnetic Resonance Imaging (fMRI), and diffusion tensor imaging. Patients were clinically re-eval...

Vascular cognitive impairment (VCI) includes vascular dementia (VaD), vascular mild cognitive impairment (VaMCI) and mixed dementia. In clinical practice, VCI concerns patients referred for clinical stroke or cognitive complaint. To improve the characterization of VCI and to refine its diagnostic criteria, an international group has elaborated a ne...

Objectives: The aim of this overview is to present the developments of music therapy in France, its techniques, mechanisms and principal indications, mainly in the context of Alzheimer's disease. Methods: An international review of the literature on music therapy applied to Alzheimer's disease was conducted using the principal scientific search...

L'Art est une forme de mystère. Il habite l'humain depuis la nuit des temps sous toutes les latitudes et dans toutes les cultures. Cet ouvrage collectif réunissant chercheurs et cliniciens est le fruit d'un Forum de la Société de Neuropsychologie de Langue Française consacré à ce thème pour deux raisons. Tout d'abord, la nécessité de faire le point...

A decline in the ability to identify fearful expression has been frequently reported in patients with Alzheimer's disease (AD). In patients with severe destruction of the bilateral amygdala, similar difficulties have been reduced by using an explicit visual exploration strategy focusing on gaze. The current study assessed the possibility of applyin...

Background: In mild Alzheimer's disease (AD), a deficit in episodic memory, particularly autobiographical memory, is clearly established. Several recent studies have also shown impaired semantic memory from the onset of the disease. Musical memory capacities may be especially preserved and listening to music might encourage autobiographical recall...

Nous rapportons 50 situations de novo rencontrées consécutivement dans une seule consultation de mémoire dans un service de neurologie d’un CHU, à l’issue de laquelle le diagnostic de psychopathologie avec plaintes cognitives a été posé. Elles ont représenté 40,3 % de l’activité de cette consultation. Dans 76 % des cas, le bilan neuropsychologique...

Few vascular dementias are diagnosed in memory clinic consultations. One type, a rare etiology, Sneddon syndrome, can lead patients to consult for an isolated memory complaint. We report the cases of two patients, aged 63 and 66 years, who presented frontocortical cognitive profile and behavior disorders. Seronegative Sneddon syndrome, complicated...

Ethics and its relation to testing are historically an important question and still are. In this article, we briefly report on how neuropsychology emerged as a specific field, how tests are developed and we particularly focus on the ethical conditions under which a test can be administered. The point of view of the neuropsychologist who develops a...

We report 124 cases of somatoform disorders, considering psychogenic disorders at the same level as neurological disorders. We noted any psychic, somatic or social condition (history taking) and facilitating circumstances. The patients were aged 16 to 84 years old; 71.7% were women. We observed pain (35.4%), psychogenic headache (25%), sensorimotor...

We report 124 cases of somatoform disorders, considering psychogenic disorders at the same level as neurological disorders. We noted any psychic, somatic or social condition (history taking) and facilitating circumstances. The patients were aged 16 to 84years old; 71.7% were women. We observed pain (35.4%), psychogenic headache (25%), sensorimotor...

The term "chameleon" was first used in the seventeenth century by Sydenham to describe a patient with a protean semiology. We report a single case of "chameleon" syndrome that challenges the current international criteria for somatoform disorders, dissociative amnesia, and Ganser syndrome. The florid symptoms were as follows: anterograde and retrog...

Psychiatric diagnoses are frequent in memory units, but most neurologists do not feel comfortable about making the diagnosis of psychopathologic cognitive complaint or disorder. The full diagnosis usually requires careful history taking and a neuropsychological examination followed by a clear joint explanation to the patient. There are no good vali...

The need to detect early changes in instrumental activities of daily life led us to modify the Disability Assessment for Dementia Scale (DAD) by focusing on executive components of 6 instrumental items (DAD-6). To evaluate the relevance of the DAD-6 for detecting early impairment in a nondemented population. The DAD-6 was administered to informants...

Tau proteins and amyloid-β (Aβ) peptides are the current recognized cerebrospinal fluid (CSF) biomarkers used as an aid in the diagnosis of Alzheimer's disease (AD). However, there is no consensus on their clinical use due to non-qualified cut-off values, probably related to the observed high pre-analytical and analytical variability. Standardized...

Performing exome sequencing in 14 autosomal dominant early-onset Alzheimer disease (ADEOAD) index cases without mutation on known genes (amyloid precursor protein (APP), presenilin1 (PSEN1) and presenilin2 (PSEN2)), we found that in five patients, the SORL1 gene harbored unknown nonsense (n=1) or missense (n=4) mutations. These mutations were not r...

In dissociative amnesia (DSM-IV), also referred to as psychogenic amnesia (DSM-III), the main disturbance consists of inability to recall personal information. Identity amnesia is observed in most cases. Dissociative disorder can sometimes be explained as a coping defensive strategy in subjects confronting a stressful situation recalling a situatio...

The aim of the present study was to assess the possibility of compensating early facial expression recognition impairments in amnestic Mild Cognitive Impairment (a-MCI) patients. Twelve patients with a-MCI and 17 healthy participants matched according to age and education participated in the study. The originality of the present study was to cue th...

To the Editor: Total tau protein (hTau),1 its phosphorylated isoform (p-Tau181P), and Aβ1–42 peptides are the currently accepted cerebrospinal fluid (CSF) biomarkers used as aids in the diagnosis of Alzheimer disease (1). Although polypropylene (PP) was previously reported as the best material for CSF collection tubes (2), heterogeneity in CSF Aβ1...

We have examined and diagnosed confabulation in a 20-year-old woman who had suffered severe traumatic brain injury (TBI) when she was 12. Spontaneous confabulations were associated with dysexecutive behavior involving perseveration and impulsiveness. The patient was amnesic during neuropsychological tests but did not present intrusion, confabulatio...

Introduction: Asymmetrical apraxia is a possible mode of onset of corticobasal degeneration (CBD) in relation with parietal focal atrophy. Case report: We report two cases of apraxia, with or without extrapyramidal syndrome. In case 1, the DaT scan showed a reduced overall striatal uptake. In the other case, Alzheimer's disease biomarkers, Tau prot...

IntroductionPure progressive amnesia is a rare and unusual syndrome involving long preservation of autonomy and absence of progression in other cognitive domains.

La rééducation neuropsychologique permet en plus d’une amélioration cognitive ciblée attendue, des progrès émotionnels, thymiques, comportementaux et psychosociaux. Elle doit être proposée dans les atrophies lobaires progressives. Cette approche repose sur le choix d’un objectif et d’un but précis à atteindre. Les choix et les priorités sont évalué...

In 1836, Marc Dax presented a revolutionary conclusion based on both his clinical observations and reports from the literature: the localisation of language in the left hemisphere. Twenty-seven years later, his son, Gustave Dax, extended and enriched his work. Their involvement in 19th century neuropsychology is impressive and recognition should ha...

To describe CSF biomarker profiles in posterior cortical atrophy (PCA), which induces high-order visual deficits often associated with Alzheimer disease (AD) pathology, and relate these findings to clinical and neuropsychological assessment. This prospective observational study included 22 patients with PCA who underwent CSF biomarker analysis of t...

Pure progressive amnesia is a rare and unusual syndrome involving long preservation of autonomy and absence of progression in other cognitive domains. We report a case which remained quiescent for 16 years characterized by severe isolated episodic amnesia and preservation of spatial, semantic and implicit memory and autonomy. MRI revealed bilateral...