Olivier Godefroy

University Hospital/Jules Verne University of Picardy · neurology

Background Gait disorders and cognitive impairments are prime causes of disability and institutionalization after stroke. We hypothesized that relative to single-task gait rehabilitation (ST GR), cognitive-motor dual-task (DT) GR initiated at the subacute stage would be associated with greater improvements in ST and DT gait, balance, and cognitive...

Apathy occurs in approximately one third of people after stroke. Despite its frequency and functional consequences, the determinants of apathy have only been partially defined. The major difficulty lies in disentangling the reduction in activity due to apathy itself from those secondary to comorbidities, such as depression, sensorimotor deficits, a...

Introduction: Approximately 40% of dementia cases could be delayed or prevented acting on modifiable risk factors including hypertension. However, the mechanisms underlying the hypertension-dementia association are still poorly understood. Methods: We conducted a cross-sectional analysis in 2048 patients from the MEMENTO cohort, a French multice...

Background Blood biomarkers for Alzheimer's disease (AD) have consistently proven to be associated with CSF or PET biomarkers and effectively discriminate AD from other neurodegenerative diseases. Our aim was to test their utility in clinical practice, from a multicentric unselected prospective cohort where patients presented with a large spectrum...

Background and objectives Although action slowing is the main cognitive impairment in stroke survivors, its mechanisms and determinants are still poorly understood. The objectives of the present study were to determine the mechanisms of post-stroke action slowing (using validated, highly specific simple reaction time (SRT) and tapping tests) and id...

Objective Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare manifestation related to CAA, thought to be more severe. We aimed to compare the clinical and radiological outcomes of CAA-ri and non-inflammatory CAA. Materials and methods We retrospectively included all patients with CAA-ri from 13 French centers. We constituted a sex...

Gait disorders are one of the leading patient complaints at the sub-acute stroke stage (SSS) and a main determinant of disability. Walking speed (WS) is a major vital and functional index, and the Ten-Meter Walk Test is considered the gold standard after stroke. Based on a systematic review of the literature, studies published between January 2000...

Some patients with subjective cognitive decline (SCD) progress to neurocognitive disorders (NCD), whereas others remain stable; however, the neuropsychological determinants of this progression have not been identified. Our objective was to examine baseline neuropsychological indicators that could discriminate between stable SCD Versus progression t...

Background: Unilateral neglect is a common cognitive disorder following stroke. Neglect has a significant impact on functional outcomes, so it is important to detect. However, there is no consensus on which are the best screening tests to administer to detect neglect in time-limited clinical environments. Methods: Members of the European Academy...

Background: Neurocognitive disorders (NCDs) are a part of the post-acute coronavirus disease (COVID-19) syndrome. No study has specifically evaluated NCDs in post-acute COVID-19 patients with cognitive complaints or their MRI determinants. Objective: To characterize NCDs in post-acute COVID-19 patients with cognitive complaints. The secondary ob...

Introduction Bien que le ralentissement de l’action soit le trouble cognitif le plus fréquent après un accident vasculaire cérébral (AVC), ses mécanismes et déterminants lésionnels sont encore peu connus. Objectifs Cette étude vise à déterminer les mécanismes du ralentissement à l’aide de tests élémentaires, ainsi que ses déterminants lésionnels à...

Introduction Les troubles neurocognitifs (TNC) entraînent des changements dans la structure et les fonctions du cerveau. Les troubles exécutifs ont une fréquence élevée et peuvent apparaître précocement, les composantes clefs étant l’altération de l’initiation et de la vitesse d’action. Objectifs L’objectif de cette étude était d’explorer l’associ...

Introduction L’angiopathie de Moya-Moya est caractérisée par la progressive sténose des terminaisons carotidiennes et leurs branches proximales avec développement d’une circulation collatérale anarchique. On parle de syndrome de Moya-Moya (SMM) lorsqu’elle est de cause secondaire. Observation Un homme de 35 ans a été hospitalisé suite à la survenu...

Introduction Des marqueurs pronostiques cliniques et radiologiques de l’infarctus cérébral sont décrits. Peu d’études se sont intéressées aux D-Dimères dans l’évaluation pronostique de l’infarctus cérébral après procédure de revascularisation. Objectifs L’objectif principal était la recherche d’une relation entre le score de Rankin à 3–6 mois et l...

Introduction Les troubles neurocognitifs (TNC) font partie du syndrome post-« coronavirus disease » (COVID-19). Aucune étude n’a évalué spécifiquement les TNC chez les patients ayant une plainte cognitive post-COVID-19 ainsi que leurs déterminants IRM. Objectifs Notre objectif principal était de caractériser les TNC chez les patients ayant une pla...

Introduction L’apathie concerne 1/3 des patients après un AVC. Malgré sa fréquence et ses conséquences, ses déterminants ne sont que partiellement définis. La difficulté consiste à différentier l’hypoactivité liée à l’apathie de celle secondaire à des comorbidités. Objectifs Nous avons cherché à examiner la prévalence de l’apathie, à identifier le...

Background: Post-stroke cognitive impairment (PSCI) is a common consequence of stroke. Accurate prediction of PSCI risk is challenging. The recently developed network impact score, which integrates information on infarct location and size with brain network topology, may improve PSCI risk prediction. Aims: To determine if the network impact scor...

Background: The present study aimed at determining the contributions of background disorders responsible for participation restriction as indexed by a structured interview for the modified Rankin scale (mRS-SI). Methods: A subset of 256 patients was assessed at 6 months after stroke using the National Institutes of Health Stroke Scale (NIHSS), g...

Background and purpose: Unilateral neglect is a common cognitive disorder following stroke. Neglect has a significant impact on functional outcomes, so it is important to detect. However, there is no consensus on which are the best screening tests to administer to detect neglect in time-limited clinical environments. Methods: Members of the Europea...

Introduction: Blood-based biomarkers are the next challenge for Alzheimer's disease (AD) diagnosis and prognosis. Methods: Mild cognitive impairment (MCI) participants (N = 485) of the BALTAZAR study, a large-scale longitudinal multicenter cohort, were followed-up for 3 years. A total of 165 of them converted to dementia (95% AD). Associations o...

This multicenter study was conducted in French memory clinics during the first COVID-2019 lockdown (March–May 2020). The objective was to evaluate the effect of a telemedicine consultation on treatment modification in dementia care. Among 874 patients who had a telemedicine consultation, 103 (10.7%) had treatment modifications, in particular those...

Background: In early 2020, COVID-19 outbreak struck France leading to a national lockdown between March 17th and May 11th . While standard in-person medical consultation was complicated, telemedicine dramatically expanded. In order to evaluate the impact of this unpreceded situation on clinical practice and use of psychoactive drug in dementia car...

Kidney function has two important elements: glomerular filtration and tubular function (secretion and reabsorption). A persistent decrease in glomerular filtration rate (GFR), with or without proteinuria, is diagnostic of chronic kidney disease (CKD). While glomerular injury or disease is a major cause of CKD and usually associated with proteinuria...

Background and Purpose Poststroke cognitive impairment is common, but the trajectory and magnitude of cognitive decline after stroke is unclear. We examined the course and determinants of cognitive change after stroke using individual participant data from the Stroke and Cognition Consortium. Methods Nine longitudinal hospital-based cohorts from 7...

Kidney dysfunction can profoundly influence many organ systems, and recent evidence suggests a potential role for increased albuminuria in the development of mild cognitive impairment (MCI) or dementia. Epidemiological studies conducted in different populations have demonstrated that the presence of increased albuminuria is associated with a higher...

Neuropeptide Y (NPY) is a 36-amino-acid peptide member of a family also including peptide YY and pancreatic polypeptide which are all ligands to Gi/Go coupled receptors. NPY regulates several fundamental biologic functions including appetite/satiety, sex and reproduction, learning and memory, cardiovascular and renal function and the immune functio...

Neurocognitive disorders are frequent among chronic kidney disease (CKD) patients. Identifying and characterizing cognitive impairment (CI) can help to assess the ability of adherence to CKD risk reduction strategy, identify potentially reversible causes of cognitive decline, modify pharmacotherapy, educate the patient and caregiver and provide app...

Chronic kidney disease (CKD) perturbs the crosstalk with others organs, with the interaction between the kidneys and the heart having been studied most intensively. However, a growing body of data indicates that there is an association between kidney dysfunction and disorders of the central nervous system. In epidemiological studies, CKD is associa...

Metabolic acidosis, defined as a plasma or serum bicarbonate concentration <22 mmol/L, is a frequent consequence of chronic kidney disease (CKD) and occurs in ~10–30% of patients with advanced stages of CKD. Likewise, in patients with a kidney transplant, prevalence rates of metabolic acidosis range from 20% to 50%. CKD has recently been associated...

Background Brain tumor extraction from magnetic resonance (MR) images is challenging due to variations in the location, shape, size and intensity of tumors. Manual delineation of brain tumors from MR images is time-consuming and prone to human errors. Method In this paper, we present a method for automatic tumor extraction from multimodal MR image...

Previous studies have reported (i) freezing-like posturographic correlates in response to painful as compared to non-painful scenes vision (Lelard et al., Front Hum Neurosci 7:4, 2013) and (ii) an increase of this response during the mental simulation as compared to the passive viewing of the painful scenes (Lelard et al., Front Psychol 8:2012, 201...

Background: Post-stroke cognitive impairment (PSCI) occurs in approximately half of people in the first year after stroke. Infarct location is a potential determinant of PSCI, but a comprehensive map of strategic infarct locations predictive of PSCI is unavailable. We aimed to identify infarct locations most strongly predictive of PSCI after acute...

BACKGROUND: Post-stroke cognitive impairment (PSCI) occurs in approximately half of people in the first year after stroke. Infarct location is a potential determinant of PSCI, but a comprehensive map of strategic infarct locations predictive of PSCI is unavailable. We aimed to identify infarct locations most strongly predictive of PSCI after acute...

Introduction Nous rapportons le cas d’un jeune homme de 25 ans présentant une algie vasculaire de la face résistante aux traitements révélant un syndrome d’Eagle. Observation Il s’agit d’un jeune homme de 25 ans présentant des céphalées hémicrâniennes gauches répondant aux critères IHS d’algie vasculaire de la face à bascule. Ces céphalées sont ap...

Purpose Many daily-life clinical decisions in patients with cerebrovascular disease and cognitive impairment are complex. Evidence-based information sustaining these decisions is frequently lacking. The aim of this paper is to propose a practical clinical approach to cognitive impairments in patients with known cerebrovascular disease. Methods The...

Purpose Practical suggestions on clinical decisions about vascular disease management in patients with cognitive impairment are proposed. Methods The document was produced by the Dementia Committee of the European Stroke Organisation (ESO) based on the evidence from the literature where available and on the clinical experience of the Committee mem...

Background Fat embolism syndrome (FES) is a rare syndrome induced by embolization of lipid droplets in the bloodstream, commonly seen after long-bone fractures or orthopedic surgery. Case presentation We report an unusual case of cognitive impairment following a motor scooter accident for which repeated brain MRI, performed on the tenth day after...

INTRODUCTION: Studies on the association of cancer and risk of dementia are inconclusive due to result heterogeneity and concerns of survivor bias and unmeasured confounding. METHODS: This study uses data from the Memento cohort, a French multi-center cohort following persons with either mild or isolated cognitive complaints for a median of five y...

Introduction: The clinical relevance of brain atrophy subtypes categorization in non-demented persons without a priori knowledge regarding their amyloid status or clinical presentation is unknown. Methods: A total of 2083 outpatients with either subjective cognitive complaint or mild cognitive impairment at study entry were followed during 4 yea...

Introduction Depuis quelques années, les prescriptions d’anticoagulants oraux directs (AOD) ciblant directement le facteur II (ex : dabigatran) ou le facteur X (ex apixaban, rivaroxaban, edoxaban, betrixaban) tendent à remplacer progressivement les antivitamines K (AVK) dans certaines indications telles que la fibrillation auriculaire ou la maladie...

Introduction La dégénérescence cérébelleuse progressive (DCP) est une présentation typique des syndromes paranéoplasiques associés aux anticorps (Ac) onco-neuronaux, notamment les Ac anti-Yo dans les cancers gynécologiques ou les Ac anti-Tr ou mGlur1 dans les lymphomes hodgkiniens. Observation Patient de 53 ans, aux antécédents d’HTA et angiomyoli...

Introduction Le syndrome de Dide & Botcazo décrit en 1902 est une entité rare se rencontrant principalement dans les AVC postérieurs bilatéraux. Il se caractérise par la triade clinique : cécité corticale, amnésie antérograde et agnosie topographique. Observation Nous rapportons le cas d’un homme de 71 ans (93 kg, 1,77 m) aux antécédents d’hyperte...

Introduction Il existe des indices neuropsychologiques pour identifier les plaintes cognitives subjectives (PCS) à risque d’évolution mais dont les valeurs discriminantes restent inconnues. Objectifs Notre objectif était d’analyser les indicateurs neuropsychologiques précoces qui permettraient de discriminer les patients avec PCS évoluant vers un...

Background Eagle’s syndrome, also called stylohyoid complex syndrome, is a rare syndrome pathology characterised by latero-cervical pain radiating to the face, linked to an abnormal enlargement of the styloid or calcification of the stylo-hyoid ligament. Case We report here the case of a young man of 25 suffering from cluster headache resistant to...

Objectives Antidepressant use is often reported as a risk factor for Orthostatic Hypotension (OH), however this relationship has never been explored in those with mild/moderate Alzheimer Disease (AD), who may represent a particularly vulnerable cohort. Methods We performed a cross‐sectional analysis of baseline data from the NILVAD study. Particip...

Introduction: Subjective cognitive complaints may be a signature of preclinical stage Alzheimer's disease. However, the link between subjective cognitive and non-cognitive complaints and brain alterations remains unclear. Methods: The relationship between cognitive and non-cognitive complaints and brain biomarkers, measured by structural magneti...

IntroductionCognitive impairment is frequent in patients with high-grade glioma and requires cognitive follow-up. Cognitive screening tools such as the Montreal Cognitive Assessment (MoCA) have been used to assess cognition in these patients. Here we assessed the sensitivity of the MoCA in screening for cognitive impairment in a cohort of 156 patie...

6th Congress of the European-Academy-of-Neurology (EAN), ELECTR NETWORK, MAY 23-26, 2020

Introduction La sclérothérapie à base de mousse (SM) a acquis une large reconnaissance pour le traitement des varices, principalement en raison de son efficacité immédiate et de son faible taux de complications. Quelques essais ont montré des effets secondaires mineurs liés à la procédure chez seulement quelques patients, principalement au site d’i...

Introduction Les endocardites paranéoplasiques ou marastiques (EM) sont des pathologies rares, elles compliqueraient l’évolution de 1 à 18 % des cancers selon les études [1], [2]. Leur physiopathologie est imparfaitement connue, elles seraient secondaires à un état d’hypercoagulabilité multifactoriel : facteurs pro-coagulants exprimés par les cellu...

The study of brain-function relationships is undergoing a conceptual and methodological transformation due to the emergence of network neuroscience and the development of multivariate methods for lesion-deficit inferences. Anticipating this process, in 1998 Godefroy and co-workers conceptualized the potential of four elementary typologies of brain-...

Objective: To address the variability in prevalence estimates and inconsistencies in potential risk factors for poststroke cognitive impairment (PSCI) using a standardized approach and individual participant data (IPD) from international cohorts in the Stroke and Cognition Consortium (STROKOG) consortium. Methods: We harmonized data from 13 stud...

Major depressive disorder (MDD) is one of the most frequent psychiatric illnesses, leading to reduced quality of life, ability to work and sociability, thus ranking among the major causes of disability and morbidity worldwide. To date, genetic and environmental determinants of MDD remain mostly unknown. Here, we investigated whether and how the Pla...

BACKGROUND Cognitive dysfunction is frequent in patients with primary brain tumor, impairing attention, memory and executive function. It compromises functional independence, decision making capacity and psycho-social well-being. Cognitive functioning is highly correlated to disease progression and quality of survival, thus cognitive follow-up is e...

Résumé Les céphalées sont un motif de consultation fréquent. Elles peuvent avoir des présentations et des étiologies multiples rendant leur diagnostic et leur prise en charge difficiles. L’analyse sémiologique fine des caractéristiques d’une céphalée tient par conséquent une part importante dans la démarche diagnostique. Nous rapportons ici le cas...

Background: Although simple reaction time (SRT) slowing is associated with dementia in Alzheimer's disease (AD), its presence in individuals with mild cognitive impairment (MCI) is subject to debate. Objective: The aim of this study was to perform a systematic review and meta-analysis of the literature data on SRT slowing in MCI. Methods: Publ...

Background: Pathogenic variants in the autosomal dominant genes PSEN1, PSEN2, or APP, APOE4 alleles, and rare variants within TREM2, SORL1, and ABCA7 contribute to early-onset Alzheimer's disease (EOAD). However, sporadic EOAD patients have been insufficiently studied to define the probability of being a carrier of one of these variants. Objectiv...

BACKGROUND: Hypertension is common among patients with Alzheimer disease. Because this group has been excluded from hypertension trials, evidence regarding safety of treatment is lacking. This secondary analysis of a randomized controlled trial assessed whether antihypertensive treatment increases the prevalence of orthostatic hypotension (OH) in p...

Introduction Les traitements par antivitamines K (AVK) sont utilisés comme anticoagulants depuis les années 1950. Ils disposent d’une marge thérapeutique étroite rendant parfois difficile l’équilibration posologique du fait d’une grande variabilité inter- et intra-individuelle. Cette variabilité est à l’origine de nombreux évènements iatrogènes par...

Following the initial case report on Phineas Gage, research in the first half of the XXth century showed that damage to the frontal cortex can result in a variety of behavioral changes. In the 1960s, the introduction of experimental neuropsychological tasks marked the start of attempts to define the cognitive impairments behind these behavioral cha...

Background/Aims: Post-stroke neurocognitive disorders (post-stroke NCD) have been reported with a very variable prevalence. Methods: Based on a systematic literature search, hospital-based studies published between January 1990 and September 2015 were selected when they reported the prevalence of total, mild, and major post-stroke NCD diagnosed by...

Objective: To validate the ability of a specifically developed cognitive risk score to identify patients at risk of poststroke neurocognitive disorders (NCDs) who are eligible for a comprehensive cognitive assessment. Methods: After assessing 404 patients (infarct 91.3%) in the Groupe de Réflexion pour l'Evaluation Cognitive VASCulaire (GRECogVA...

Background and Purpose— We aimed to define the neuroimaging determinants of poststroke cognitive performance and their relative contributions among a spectrum of magnetic resonance imaging markers, including lesion burden and strategic locations. Methods— We prospectively included patients with stroke from the GRECogVASC study (Groupe de Réflexion...

Although executive function disorders are among the most prevalent cognitive impairments a consensus on diagnostic criteria has yet to be reached. With a view to harmonizing these criteria, the present position paper (i) focuses on the main dysexecutive disorders, (ii) examines recent approaches in both the behavioral and cognitive domains, (iii) d...

Objectives: The ability of voxel-based lesion-symptom mapping (VLSM) to define the functional anatomy of the human brain has not been fully assessed. With a view to assessing VLSM's validity, the present study analyzed the technique's ability to determine the known clinical-anatomic correlates of hemiparesis in stroke patients. Design: Lesions (dam...

Neuroimaging studies have described the brain alterations in primary progressive aphasia (PPA) variants (semantic, logopenic, nonfluent/agrammatic). However, few studies combined T1, FDG-PET, and diffusion MRI techniques to study atrophy, hypometabolism, and tract alterations across the three PPA main variants. We therefore explored a large early-s...

The purpose of this study was to characterize cognitive impairments and behavioral disorders in a sample of patients with chronic kidney disease (CKD). A total of 52 patients with CKD were prospectively recruited over a 344-day period. Cognitive functions (memory, action speed, executive function, and language) and behavioral characteristics were a...