Frédéric Roche

Université Jean Monnet · Faculté de Médecine

Funding Acknowledgements Type of funding sources: Other. Main funding source(s): Doctoral contract 2018-2022 Background Several studies have shown the importance of the relationship between the power-force-velocity profile (PFVP) and sport performance in elite athletes through optimised exercise training.[1] Optimising the training programme is co...

Funding Acknowledgements Type of funding sources: None. Background The importance of exercise electrocardiogram (ECG) is still controversial in the prevention of cardiovascular events among sportsmen. The aim of this study was to assess the relevance of exercise ECG as a significant prognostic marker for cardiovascular events when any CVD risk fac...

Background: Cardiac vagal dysfunction was documented in middle-aged patients with migraine. However, vagal activity depends on several psychophysical or physiological factors such as anxiety, depression, lifestyle or age. In this work, we studied cardiac parasympathetic activity in elderly volunteers with past or current migraine. Methods: Among PR...

Mathematical tools applied on physiological parameter have shown their ability to help in our understanding in physiological processes such as autonomic regulations. However, such methods are not adapted to quantify close-loop interactions between respiratory, blood pressure and heart rhythm. To overcome this limitation, classical Granger causality...

Baroreflex sensitivity (BRS) is known to be a predictor of morbidity and mortality in metabolic and cardiovascular diseases. However, although we know that BRS decreases with age, we do not know whether BRS is predictive of mortality in general elderly population. The objective of this work is to study the predictive value of BRS in the mortality o...

Background Although the benefits of physical activity (PA) on health are recognised, prostate cancer patients do not follow PA recommendations. The barriers to PA, whether physical, environmental or organisational, are known. Furthermore, even when such barriers are overcome, this achievement is not systematically accompanied by a change in lifesty...

Background Although heart rate variability (HRV) is widely used to assess cardiac autonomic function, few studies have specifically investigated nocturnal HRV. Objective We aimed to assess the association between nocturnal HRV and cardiovascular disease (CVD) incidence over 4 years in a population-based sample. Methods 1784 participants (48.2% ma...

The clinical efficacy of the inhibitors of the renin-angiotensin-aldosterone system (RAAS) as an upstream therapy for atrial fibrillation (AF) prevention is controversial. No study has itemized so far the role of RAAS inhibitors in AF prevention after atrial flutter (AFL) ablation. This trial aims to investigate the effect of ramipril compared with...

This editorial refers to ‘Association between insomnia symptoms and incident heart failure among middle-aged and older adults: a population-based cohort study’, by M. Mahmood et al., doi:10.1093/eurheartj/ehab500.

The present study aimed to evaluate the association between physical activity, knee extensors (KE) performance (i.e. isometric strength and fatigability) and biological parameters (i.e. muscle structural, microvascular and metabolic properties) in healthy very old men and women. Thirty very old adults (82±1 yr, 15 women) performed an isometric quad...

Obstructive sleep apnea (OSA) is characterized by repeated episodes of intermittent hypoxia (IH) and is recognized as an independent risk factor for vascular diseases that are mediated by a multitude of mechanistic pathophysiological cascades including procoagulant factors. The pro-coagulant state contributes to the development of blood clots and t...

Although recent trials have shown promising benefits of exercise on obstructive sleep apnea (OSA) severity, the long‐term effect of these interventions remains unknown. The aim of this study was to assess the effect of a 9‐month community physical activity program on OSA severity one year later in free‐living conditions. OSA patients, previously in...

Background: Falls affects one of three people after 65 years old, and it can lead to serious consequences. Scientific evidence point out that physical exercise is the most efficient way to prevent falls among older adults. Objective: The main objective of this study is to determine if a social marketing program can increase the attendance rate of p...

The aim of the study was to assess potential associations between obstructive sleep apnea (OSA) and the occurrence of diabetes mellitus and insulin resistance in the elderly. Nondiabetic volunteers (n = 549) with undiagnosed or untreated asymptomatic OSA (66.2+/−1 years at the inclusion) were evaluated as an ancillary study of the PROOF cohort stud...

Several studies suggest that physical activity improves cognitive functions and reduces cognitive decline, whereas others did not find any evidence of a neuroprotective effect. Furthermore, few cohort studies have analyzed the different physical activity types and particularly household activities. Our objective was to assess the association of two...

Introduction: Fibromyalgia (FM) is characterized by multiple symptoms including pain, fatigue, and sleep disorders, altering patient's quality of life. In the absence of effective pharmacological therapy, the last European guidelines recommend a multidisciplinary management based on exercise and education. Thus, our main objective was to measure th...

(1) Background: Aging is associated with a progressive decline in muscle mass and function. Aging is also a primary risk factor for metabolic syndrome, which further alters muscle metabolism. However, the molecular mechanisms involved remain to be clarified. Herein we performed omic profiling to decipher in muscle which dominating processes are ass...

Objectif L’apnée du sommeil augmente avec l’âge. Cependant l’évolution de l’apnée du sommeil chez la personne âgée est inconnue. L’objectif de cette étude est donc de suivre le devenir de cette pathologie et notamment de ses index polygraphiques. Méthodes Parmi les 1011 sujets sains de l’étude PROOF inclus à l’âge de 65 ans en 2001, 213 sujets ont...

Objectif Le diagnostique du syndrome d’apnées du sommeil (SAS) nécessite la pose et l’analyse d’une polygraphie ou une polysomnographie (PSG). Ces examens demeurent coûteux et les délais d’attente peuvent atteindre plusieurs mois. De plus, cette pathologie étant généralement asymptomatique avec une prévalence importante après 50 ans, un diagnostic...

Objectif Dans le cadre d’un programme de prévention des AVC, pharmaciens, médecins de centres de prévention, infirmiers libéraux proposent à leur patientèle de plus de 65 ans un dépistage des apnées du sommeil via un boîtier connecté. Le repérage est associé à une orientation vers le médecin traitant et des séances collectives de prévention. Commen...

Objectif Évaluer si la variabilité nocturne de la fréquence cardiaque (VFC) peut prédire l’incidence d’événements cardiovasculaires (CV) 5 ans plus tard. Méthodes Le profil CV a été évalué au départ et après 5 ans dans la cohorte HypnoLaus (Lausanne, Suisse). L’incidence d’événements CV (AVC, infarctus, angioplastie, pontage coronarien, maladie ar...

Background Although insufficient sleep among firefighters reduces work efficiency and increases the risk of injury, little is known about the sleep quality of French firefighters in the Loire department. The aim of the FIRESLEEP study was to evaluate sleep quality and sleep disturbances among professional and voluntary French firefighters. Methods...

Background: Periodontal diseases (PD) seem to appear today as predictors of some cardiovascular diseases (CVD). There is a lack of data on the oral health among Cameroonian military population, and its relationship with CVD. Purpose: Investigate on the link between oral health of Cameroonian military from the Ngaoundéré garrison and their cardio...

Background The prevalence of small-fiber neuropathy (SFN) is high in patients with hereditary transthyretin amyloidosis (ATTRv) but remains unknown in transthyretin wild-type cardiac amyloidosis (ATTRwt-CA). Objective To determine the prevalence of SFN in patients with ATTRwt-CA using Sudoscan®, a non-invasive method used to provide evidence of SF...

Aims The prevalence of autonomic neuropathy (AN) is high in patients with hereditary transthyretin amyloidosis but remains unknown in transthyretin wild‐type cardiac amyloidosis (ATTRwt‐CA). This study aimed to determine the prevalence of AN in patients with ATTRwt‐CA using Sudoscan®, a non‐invasive method used to provide evidence of AN in clinical...

Background/aims: Obstructive sleep apnea (OSA) is characterized by repeated episodes of complete or partial obstruction of the upper airways, leading to chronic intermittent hypoxia (IH). OSA patients are considered at high cerebrovascular risk and may also present cognitive impairment. One hypothesis explored is that disturbances may be linked to...

Aim To describe the progression of vigilance and sleepiness over the shift and the coping strategies of nurses working 12‐hour day or night shifts. Background The spread of 12h shift‐work in nursing raises the question of whether sufficient vigilance can be maintained to ensure quality of care Method 18 nurses working 12‐hour shifts filled out a...

Background: Previous cohorts studied the association of various types of physical activities with the incidence of cognitive disorders. The objective of this work was to analyze the association of leisure, domestic and professional physical activities with mild and moderate cognitive disorders in older people living in the community. Methods: We us...

An amendment to this paper has been published and can be accessed via the original article.

Introduction Recurrent vasovagal syncope (VVS) is associated with decreased quality-of-life and frequent use of emergency services. The evidence base for causality, diagnostic procedures and potential VVS treatments is poor. Scattered observations in the literature suggest a link between respiratory disturbances during sleep and VVS. Empirical obse...

Introduction Excellent biomarqueur du DFG, la cystatine C sérique (cysC) est également un meilleur prédicteur de morbi-mortalité que la créatinine sérique (CrS). Les raisons restent inconnues. Contrairement à la CrS, la cysC est corrélée positivement avec la CRP et pourrait ainsi refléter un dysfonctionnement du système nerveux autonome (SNA) qui e...

Background Few previous cohorts have studied the different type of physical activities and the degree of cognitive decline. The objective of this work was to analyze the leisure, domestic and professional activities with mild and moderate cognitive disorders in older people living in community. Methods The study used data from the longitudinal and...

Background: Falls are a significant source of morbidity in people aged 65 and over, affecting one in three people in this age group. The scientific evidence indicates that physical activity is the most effective method for preventing falls among seniors. Although public health professionals often use social marketing to design and plan successful...

Obstructive sleep apnea syndrome (OSAS) is characterized by repeated episodes of hypoxia during the night. The severity of the disorder can be evaluated using an apnea–hypopnea index (AHI). The physiological consequences are mainly cardiovascular and neuronal dysfunctions. One hypothesis to explain such associated neurological disorders is disrupti...

Pain sensation is characterized by abrupt changes in central nervous system activity producing autonomic reactivity. While clinical hypnosis has demonstrated its benefits for children in pain management, it is not clear whether hypnosis modulated autonomic pain response in children in clinical conditions. Here, we studied autonomic responses under...

Objective To test the association between exposure to perinatal inflammation – i.e. clinical chorioamnionitis or early-onset neonatal infection – in preterm children without severe neonatal brain injury and neurodevelopmental outcome at 30 months of corrected age (CA). Design Cross-sectional study from a French regional cohort of clinical follow-u...

Background: Cardiovascular diseases remain as the leading cause of morbidity and mortality in industrialized countries. Ageing and gender strongly modulate the risk to develop cardiovascular diseases but very few studies have investigated the impact of gender on cardiovascular diseases in the elderly, which represents a growing population. The pur...

Firefighters’ activities increase the risk of sudden cardiac events. The main objective of this study was to describe the Loire firefighters’ cardiovascular risk factors according to their cardiovascular risk and to their professional status. A retrospective study of the entire population of firefighters of the Loire department was conducted. Risk...

Background: Vascular calcification is an established feature of atherosclerosis process. The sodium/phosphate transporter PiT-1 acts as a biosensor in vascular calcification of VSMCs. [99mTc]-Pentavalent dimercaptosuccinic acid (99mTc-(V)-DMSA) was mediated by PiT-1 transporter in tumoral cells and we propose its evaluation in a vascular calcifica...

Background and Aims While being a GFR biomarker with comparable performance than serum creatinine (SCr), Serum cystatin C (ScysC) is a better predictor of morbi-mortalilty in the general as well as the CKD population. The mechanisms underlying the prognostic dimension of ScysC are unclear. Unlike SCr, ScysC is known to strongly and positively corre...

Background: Antibiotic therapy during preterm labor with intact membranes has been associated with an increased risk of neonatal death. Objectives: Using an established rat model of group B Streptococcus (GBS)-induced chorioamnionitis, we hypothesized that ampicillin treatment increases placental inflammation, as shown in other bacterial infecti...

New findings: What is the central question of this study ? Can Granger causality analysis of RR intervals, systolic blood pressure, and respiration evidence different physiological mechanisms induced during thermoneutral water immersion, 6° head-down tilt, and supine position tests, that are not accessible using traditional heart rate variability...

Background: Physical activity may decrease the risk of dementia; however, previous cohort studies seldom investigated the different types of physical activity and household activities. Our objective was to analyze the links between two physical activity types and dementia in older people. Methods: The study used data from the prospective observa...

BACKGROUND NCDs are the leading cause of death worldwide. They are responsible for 38 million out of the 56 million deaths recorded worldwide. In Cameroon, epidemiological studies have been devoted to NCDs and their risk factors. However, none of them provides specific information on the extent of NCDs and/or the distribution of their risk factors...

Background Noncommunicable diseases (NCDs) are the leading causes of death worldwide. They were responsible for 40 million of the 57 million deaths recorded worldwide in 2016. In Cameroon, epidemiological studies have been devoted to NCDs and their risk factors. However, none provides specific information on their extent or the distribution of thei...

Background Physical activity may decrease the risk of dementia; however, previous cohort studies seldom investigated the different types of physical activity and household activities. Our objective was to analyze the links between two physical activity types and dementia in older people. Methods The study used data from the prospective observationa...

Background Physical activity may decrease the risk of dementia; however, previous cohort studies seldom investigated the different types of physical activity and household activities. Our objective was to analyze the links between two physical activity types and dementia in older people. Methods The study used data from the prospective observationa...

Objectif La mise en place d’un traitement du SAS chez le sujet âgé est toujours débattue. En effet, dans cette population, le lien entre la pathologie et l’augmentation du risque de mortalité n’a pas été clairement établi et les indices de sévérité du SAS utilisés en clinique (AHI et ODI) restent controversés. Méthodes Nous avons suivi la mortalit...

Objectif Évaluer l’effet à long terme d’un programme d’activité physique supervisé de 9 mois en condition de vie réelle chez des patients souffrant d’un syndrome d’apnées obstructives du sommeil (SAOS). Méthodes À l’issue des 9 premiers mois de suivi, les patients randomisés dans le groupe exercice (EXE) ont été encouragés à maintenir une activité...

Objectif Les marqueurs de risque de survenue d’une dysfonction endothéliale NO-dépendante sont bien décrits chez l’adulte et la charge hypoxémique nocturne représente un des facteurs aggravants. Le rôle des troubles respiratoires liés au sommeil chez le sujet âgé est moins documenté. C’est l’objectif de la présente étude ancillaire de l’étude de co...

Objectif Les rythmes professionnels des sapeurs-pompiers (SP) perturbent leur sommeil. Des études chez les SP à l’étranger ont montré que le manque de sommeil pourrait diminuer l’efficacité au travail. L’objectif de l’étude FIRESLEEP était d’évaluer la qualité du sommeil et des troubles du sommeil chez les SP professionnels (SPP) et volontaires (SP...

We performed an individual patient data meta-analysis to investigate the association between obstructive sleep apnoea (OSA) severity and the reactive hyperaemia index (RHI) measured by peripheral arterial tonometry (PAT), a validated measurement of endothelial function, and a strong predictor of late cardiovascular (CV) events. Patients from 12 stu...

Background: Falls are a significant source of morbidity in people aged 65 and over, affecting one in three people in this age group. The scientific evidence indicates that physical activity is the most effective method for preventing falls among seniors. Although public health professionals often use social marketing is to design and plan successfu...

Purpose Thermoneutral head-out water immersion (WI) and 6° head-down tilt (HDT) have been considered as suitable models to increase central blood volume and simulate autonomic cardiovascular adaptations to microgravity, swimming or scuba diving. However, any differences in autonomic cardiovascular adaptations are still unclear. In this study, we hy...

Résumé L’objectif de cet article de mise au point est de discuter de la place de l’activité physique dans la stratégie thérapeutique du syndrome d’apnées obstructives du sommeil (SAOS). Une revue de littérature sur le niveau d’activité physique et l’incidence du SAOS a été effectuée et montre qu’un faible niveau d’activité physique est associée à l...

Background The force-velocity-power (FVP) profile is used to describe dynamic force production capacities, which is of great interest in training high performance athletes. However, FVP may serve a new additional tool for cardiac rehabilitation (CR) of coronary artery disease (CAD) patients. The aim of this study was to compare the FVP profile betw...

Study Objectives To explore the clinical significance of pulse wave amplitude (PWA)-drops during sleep as a biomarker for cardiometabolic disorders and describe their main characteristics in a general population sample. Methods Cross-sectional study of HypnoLaus cohort, in which 2162 individuals underwent clinical assessment and in-home full polys...

Background Physical activity may decrease the risk of dementia; however, previous cohort studies seldom investigated the different types of physical activity and household activities. Our objective was to analyze the links between two physical activity types and dementia in older people. Methods The study used data from the prospective observationa...

Background: The success of health research depends on the involvement of participants. Few studies have examined the participation of subjects in cohorts. Drawing on a sociological survey on a French cohort around aging, this study proposes to question the nature of interactions between researchers and subjects that would help to understand the mo...

The brain is a complex organ protected by the blood-brain barrier (BBB), which also has a complex organization. To play its protective role, the BBB acts by limiting the paracellular passage of potentially cytotoxic compounds through tight junctions as well as limiting transcellular passage by efflux pumps (ABC transporters). In many conditions suc...

Introduction La dysfonction endothéliale (DE) prédit la survenue d’événements cardiovasculaires (CV) tardifs et pourrait être le lien entre le syndrome d’apnées obstructives du sommeil (SAOS) et les maladies CV. Toutefois, les revues et méta-analyses antérieures évaluant l’association entre le SAOS et la DE présentaient certaines limites méthodolog...

Background: Falls are a significant source of morbidity in people aged 65 and over, affecting one in three people in this age group. Physical activity represents the most effective method for preventing falls among seniors. Social marketing has already shown its utility in the construction of prevention programs. Its use and evaluation in preventio...

Background: Falls are a significant source of morbidity in people aged 65 and over, affecting one in three people in this age group. The scientific evidence indicates that physical activity is the most effective method for preventing falls among seniors. Although public health professionals often use social marketing to design and plan successful i...

Background: Falls are a significant source of morbidity in people aged 65 and over, affecting one in three people in this age group. The scientific evidence indicates that physical activity is the most effective method for preventing falls among seniors. Although public health professionals often use social marketing to design and plan successful i...