Barbara Colurcio's research while affiliated with University of Naples "L'Orientale" and other places
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Publications (7)
Objectives: Leptin is involved not only in energy homeostasis but also in the regulation of reward mechanisms. Therefore, in order to evaluate the role of this peptide in opioid addiction we assessed its secretion in chronic heroin addicts before and after a pharmachological detoxifcation treatment. Methods: Twenty healthy controls and 30 male hero...
Malnutrition and absence of exogenous luminal nutrients in the gastrointestinal tract affect intestinal permeability (IP) leading to an increased penetration of substances that passively cross intestinal epithelium via intercellular pathways. We hypothesised that an increase in IP could occur in patients with anorexia nervosa because of their prolo...
Increased plasma levels of allopregnenolone (3alpha,5alpha-tetrahydroprogesterone [3alpha,5alpha-THP]), dehydroepiandrosterone (DHEA), and DHEA sulphate (DHEA-S) have been reported in patients with anorexia nervosa or bulimia nervosa. To assess whether those changes are related to malnutrition, we investigated plasma levels of neuroactive steroids...
A reduction in circulating leptin has been reported in some patients with BN, but not in others. The reasons for such diversity have not been explained. Therefore, we measured plasma levels of leptin and other hormones in a large sample of patients with eating disorders and in healthy controls and explored differences between bulimics with low plas...
Animal data suggest that neuroactive steroids, such as 3alpha,5alpha-tetrahydroprogesterone (3a,5a-THP), dehydroepiandrosterone (DHEA), and its sulfated metabolite (DHEA-S), are involved in the modulation of eating behavior, aggressiveness, mood, and anxiety. Anorexia nervosa (AN) and bulimia nervosa (BN) are eating disorders characterized by abnor...
Citations
... As previously reported [23], anorexia nervosa and atypical anorexia nervosa were not diagnosed in women with PCOS. Lower levels of testosterone have been observed with anorexia nervosa [41]. As androgens have been proposed to act as appetite-stimulants, induce binge-eating behaviours and impair impulse control [42], the elevated levels of testosterone commonly observed in PCOS may explain the more common observance of binge-eating behaviours in comparison to anorexia nervosa [11,40]. ...
... [26] Some studies have suggested a positive correlation between concentration of leptin and estradiol during the follicular phase, but there is not enough evidence to confirm the findings. [27] Fluctuations in leptin levels can cause weight changes and reproductive cycle disturbances. Both, deficiency of, and resistance to leptin can lead to infertility. ...
... However, there are some controversial and heterogeneous findings in the studies analyzing this relationship (154,155,167). Moreover, there are disorders associated with HPA axis dysregulation that are more highly prevalent among obese subjects compared to the general population such as night-eating syndrome, binge eating disorder, sleep, and hormonal disorders as well as psychological symptoms (168)(169)(170)(171). It is worth of mentioning that treatment for weight loss in obese subjects with these disorders is less successful than in obese individuals without these types of disorders (168,172). ...
... However, the results from studies focused on intestinal barrier function in AN are not definitive. Monteleone et al. found reduced intestinal permeability in patients with AN using the lactulose/ mannitol test (Monteleone et al., 2004). Contrary, intestinal permeability was increased in severely malnourished patients (Grigioni et al., 2022). ...