Roman Gos

Medical University of Łódź | UMED · II Katedra Chorób Oczu

Purpose: In this study, we evaluated the efficacy of topical hypotensive treatment and/or systemic corticosteroids therapy in patients with elevated intraocular pressure and Graves' orbitopathy (GO). Methods: We included 172 eyes in 86 individuals with duration of GO ≥ 3 months, intraocular pressure in either eye ≥ 25.0 mmHg, and GO ranked ≥ 3 at l...

Systemic sclerosis (SSc) is a connective tissue disorder characterized by tissue hypoxia, excessive fibrosis of skin and internal organs, and angiogenesis imbalance. The aim of the study was to evaluate in SSc patients the association between the retinal microcirculation disturbances and the presence of peripheral trophic changes and to determine t...

Background Age-related macular degeneration (AMD) is a major cause of blindness worldwide. Circulating microRNAs (miRNAs) in serum have emerged as novel candidate biomarkers for many diseases. The aim of the present study was to identify a serum microRNA (miRNA) expression profile specific for dry and wet forms of AMD. Material/Methods Serum miRNA...

First lesions to occur in the course of systemic sclerosis (SSc) involve microcirculation. The study involved assessment of the suitability of laser Doppler flowmetry (LDF) in examination of the performance of skin microcirculation in the distal portion of the upper extremity in SSc patients. Overall the study involved 27 patients with systemic scl...

Systemic sclerosis (scleroderma, SSc) is a severe chronic connective tissue disease caused by immune system disorders and changes in the structure and functions of blood vessels, which consequently leads to enhanced tissue fibrosis. The aim of the study was to evaluate changes in the organ of vision in systemic sclerosis patients. Overall the study...

Purpose: To determine the prevalence of ocular disorders among Polish soldiers returning from Iraq and Afghanistan military campaigns. Material and methods: A retrospective review of medical records of the Military Medical Commission of Lodz, Poland was performed. Records of 296 randomly selected soldiers, including 98 who returned from Iraq in...

The aim of this study was to compare the efficacy of verteporfin photodynamic therapy (PDT), intravitreal injections of bevacizumab (IVB) and transpupillary thermotherapy (TTT) in patients with neovascular age-related macular degeneration (AMD). The study design was a prospective, interventional, comparative case series. Between December 2006 and M...

The aim of the study was to determine the correlation between pulsatile ocular blood flow (POBF) and sleep apnoea syndrome (SAS). Patients were recruited from those who underwent polysomnography in the "Sleep Unit" of the physiology department (Medical University, Lodz, Poland). A total of 52 Caucasian patients, 34 with SAS and 18 age- and gender-m...

The objective was to investigate whether microvascular disturbances in patients with type 2 diabetes (DM) as defined by retinal examination predict the existence of macrovascular disturbances found on radioisotopic perfusion examinations of the heart muscle. A total of 100 patients with type 2 DM and an additional cardiovascular risk factor were en...

The objective of this study was to investigate the relationship between microvascular and macrovascular disturbances in patients with type 2 diabetes, as shown by results of ophthalmological examination and by vascular and perfusion examinations of the lower limbs. A total of 85 patients with type 2 diabetes and an additional cardiovascular risk fa...

At present, the vascular theory of glaucomatous neuropathy is still the subject of intensive scientific studies aiming at settling the relationship between the development of glaucomatous neuropathy and vascular factors. Therefore the purpose of this study was to assess the blood flow parameters in the posterior ciliary artery and middle cerebral a...

We aimed to investigate activities of metalloproteinases 2 (MMP-2) and MMP-9 in aqueous humour of patients with diabetes mellitus with various stages of diabetic retinopathy. We included 36 samples of aqueous humour of patients suffering from diabetes mellitus, undergoing routine cataract surgery. Seven of them suffered from proliferative diabetic...

To compare the intraocular pressure- (IOP-) lowering efficacy of fixed combinations travoprost 0.004%/timolol 0.5% and dorzolamide 2%/timolol 0.5% in patients with ocular hypertension or open-angle glaucoma. In this prospective, multicenter, double-masked, randomized clinical trial, 319 qualifying patients received either travoprost/timolol once da...

To determine the prevalence of ocular diseases among young men and to assess the main ocular causes reflecting discharge from military service in Poland. A retrospective review of the medical records of 105 017 men undergoing a preliminary examination for military service during the period 1993-2004. Sample size for the study was calculated with 99...

To evaluate the prevalence of correctable and non-correctable visual impairment in a representative sample of young males commissioned for Military Service in Poland. Data concerning vision status was retrospectively reviewed in 969 subjects of European Caucasian origin, most of whom live and have lived in Poland. They were selected from the origin...

To determine the prevalence of ocular diseases among candidates and members of Military Service. A retrospective review of medical examinations for entry to the military service from The Area of Military Medical Ophthalmic Commission in Lodz. We used statistic analysis to review the results. Statistic analysis revealed that the commonest ocular dis...

Purpose To determine the correlations of pulsatile ocular blood flow (POBF) and intra ocular pressure (IOP) with sleep apnea syndrome (SAS). Methods The study design was cross-sectional. A total number of 26 patients, recruited into the study between January 2006 and February 2008, who underwent polysomnography were selected for the study. All of...

Purpose To investigate the incidence and associations of various types of double vision and limitations of gaze among patients presenting with ocular complaints related to thyroid associated ophthalmopathy. Methods We included 325 patients (268 female and 57 male) aged 42 to 78 (mean 51.1 +/‐5.2) referred with ocular symptoms and the diagnosis of T...

Purpose To determine the prevalence of ocular diseases among young males and to assess the main ocular causes reflecting discharge from military service in Poland. Methods A retrospective review of the medical records, of the 105017 men preliminary examined to military service during the period 1993-2004. All of them were of European Caucasian ori...

To determine the prevalence of refractive errors in population. A retrospective review of medical examinations for entry to the military service from The Area Military Medical Commission in Lodz. Ophthalmic examinations were performed. We used statistic analysis to review the results. Statistic analysis revealed that refractive errors occurred in 2...

To assess ocular causes for rejection from the military service. A retrospective review of medical examinations for entry to the military service from The Area Military Medical Commission in Lodz. Ophthalmic examinations were performed according to meet eligibility criteria. We used statistic analysis to review the results. Statistic analysis revea...

Purpose: To evaluate the prevalence of non‐correctable refractive error in a representative sample of Polish young men. Methods: A retrospective study of medical records of Military‐Medical Commission of Lodz, Poland. Distance visual acuity (VA) was assessed in 105017 men examined during period 1993‐2004. Visual acuity was checked on Snellen's char...

Purpose: To determine the prevalence of glaucoma and ocular hypertension (OHT) in a representative sample of Polish young men. Methods: A retrospective study of medical records of Military‐Medical Commission of Lodz, Poland. Intraocular pressure (IOP) was measured in 105017 men examined during period 1993‐2004. We chose for the study a representati...

Tissue ischaemia is an important factor in the development of several eye diseases. The commonly accepted idea regarding management of ischaemic effects is that a normal blood flow should be increased. Trimetazidine, an anti-ischaemic agent, can have a positive effect on retinal disorders with an ischaemic component. Trimetazidine seems to have an...

Introduction: The purpose of the study was to evaluate selected visual parameters in the group of patients undergoing long-term treatment with trimetazidine as an adjuvant therapy for primary open angle glaucoma and degenerative myopia.Material and methods: Thirty patients, including 20 patients with advanced primary open angle glaucoma (40 eyes) a...

To evaluate bacterial flora of conjunctival sac, the skin of the eyelids and inflammatory lesions in patients with acne vulgaris, rosacea and of healthy people. Bacterial colonization of conjunctival sac, the skin of the eyelids and skin lesions is more frequent in patients with acne vulgaris and rosacea. Because antibiotic resistant strains of bac...

TNFalpha (tumor necrosis factor alpha) plays a central role in the development of thyroid associated ophthalmopathy (TAO). We describe and document by ophthalmic (CAS and NO SPECS scales) and radiological (MRI) evaluation a positive effect of anti-TNFalpha antibody (infliximab) administration on active TAO in a 58 years old woman with Graves' disea...

To present some relevant stages of phacosclerothalamotomy procedure. Surgery comprised: superior clear corneal phacoemulsification with in the bag IOL implantation combined with 4 ab interno sclerostomy with high frequency diathermic probe. The position of the probe was checked under gonioscopic view and microscopic or endoillumination light. Six p...

To measure the temperature parameters on the corneal surface during the delivery of standardized ultrasound energy assisted with ophthalmic viscosurgical devices (OVDs) or different temperatures of irrigating solutions in an experimental animal model. Department of Ophthalmology and Visual Rehabilitation, Medical University of Lodz, and Central Ins...

Purpose: To quantify the maximal level of temperature and the time the maximal temperature is achieved and correlate the temperature parameters to the mean rate of endothelial cell loss after standardized ultrasound delivery assisted with four viscoelastic substances or different temperature of balanced salt solution (BSS). Methods: Thirty rabbi...

To quantify the maximal level of temperature and the time the maximal temperature is achieved and correlate the temperature parameters to the mean rate of endothelial cell loss after standardized ultrasound delivery assisted with four viscoelastic substances or different temperature of balanced salt solution (BSS). Thirty rabbits (60 eyes) were div...

retrospective, comparative analysis of the effectiveness of the results among patients who underwent removal of complicated cataract due to uveitis and senile cataract. Patients with cataract enrolled in this study were divided into two groups. Group 1 comprised 30 eyes with complicated cataract due to uveitis. The main causes of uveitis were: rheu...

There are currently some techniques of combined cataract and glaucoma treatment. They have been under debate for many years. We present efficacy of different techniques of combined cataract and glaucoma surgery 50 patients (60 eyes, 21 male and 29 female), mean age 64.9+/-5.6 years enrolled in the study were divided into 3 groups in which the combi...

Purpose: There are currently some techniques of combined cataract and glaucoma treatment. They have been under debate for many years. We present efficacy of different techniques of combined cataract and glaucoma surgery Material and methods: 50 patients (60 eyes, 21 male and 29 female), mean age 64.9± 5.6 years enrolled in the study were divided in...

The aim of that study was to identify the mutations in rhodopsin and peripherin genes in Polish families with autosomal dominant form of retinitis pigmentosa and determine the population polymorphism in both genes in adRP families. We performed ERG, visual acuity, Goldman visual fields, intraocular pressure measurements and fundoscopy in all the pa...

To assess temperature on the eye surface after local anesthesia due to phacoemulsyfication. 15 patients treated with local anesthesia: peribulbar - 5, retrobulbar - 5 and sub Tenon anesthesia. Mean temperature on both eye surface was assessed with termovision camera (Inframetrics 760) before surgery, 20 minutes and 1 hour after anesthesia. In all e...

The iridocorneal endothelial syndrome (ICE) consists of some disorders, like: progressive essential iris atrophy, Chandler disease and the iris nevus syndrome that are characterized by corneal endothelium proliferation and migration, iris atrophy, corneal oedema and/or pigmentary iris nevi. Secondary, refractory glaucoma affects about 50% of patien...

To measure the nitric oxide (NO) level in the aqueous humor of rabbit eyes after common cataract surgery techniques. Department of Ophthalmology, Military Medical University, and Department of Immunology and Immunotoxicology of Respiratory System, Clinic of Pneumonology and Allergology, Medical University of Łódź, Łódź, Poland. Thirty rabbits were...

Neurochorioretinitis due to the course of ocular sarcoidosis is relatively rare case. It usually responds well to conventional treatment with corticosteroids. We want to present the patient effectively treated with long acting analogue of somatostatin (Octreotide), who failed to respond to previous corticosteroids treatment.

To estimate the amount of the tear-film and its stability among women treated due to endocrinological or gynecological indications with hormone replacement therapy. 60 women treated with hormonal replacement therapy (HRT) were divided into 3 groups of examination: group 1 (20 women), treated with HRT after up to 1 year of menopausal symptoms, group...

To estimate the status of the conjunctival morphology among women treated due to endocrinological or gynecological indications with hormone replacement therapy. 60 women treated with hormonal replacement therapy (HRT) were divided into three groups of examination: group 1 (20 women), treated with HRT after up to 1 year of menopausal symptoms, group...

To evaluate clinical, physiochemical and biochemical changes in rabbit vitreous body caused by local injection of sulphur hexafluoride gas. The volume of fluid vitreous fraction was measured with Na+, K+, Mg2+, Ca2+ levels and full proteins concentration in both vitreous fractions in 24 New Zealand rabbits at 2, 7 and 14 day after SF6 injection. Th...

Anterior segment ischaemia manifesting in aqueous malformation may follow tenotomy of the extraocular muscles. Tenotomy of 2 or 4 rectus eye muscles was performed on the right eyes of 23 adult rabbits. The aqueous humor was withdrawn from the anterior chamber of both eyes in 7 rabbits on the 11th, on the 22nd in 8 and on the 32nd postoperative day...

To evaluate the presence of nitric oxide and measure its level in the aqueous humor of the rabbit's eye, in physiological conditions and after extracapsular lens extraction and PMMA artificial lens implantation. We also investigated nitric oxide maintenance during early postoperative period (between 1-5 day after surgery). We used 30 rabbits (weigh...

To evaluate the presence of nitric oxide (NO) and its level in the aqueous humor of rabbit's eye physiological conditions and after phacoemulsification and acrylic foldable artificial lens implantation. We also investigated nitric oxide maintenance during early postoperative period (between 1-5 days after surgery). We examined 30 rabbits (weighing...

Using a direct method, with selective and nitric oxide sensitive electrode Iso-NO, we estimated the level of the Nitric Oxide (NO) in the aqueous humor of the rabbit's eye after phacoemulsification and acrylic foldable lens implantation. We also analysed the NO level during early postoperative days between the 1st and the 5th postoperative day. The...

To estimate the level of the nitric oxide (NO) within the aqueous humor of the rabbit eye after ECCE and PMMA artificial lens implantation using selective, nitric oxide sensitive electrode Iso-NO. We analysed the NO level during early postoperative period between the 1st and the 5th day. We examined 30 gray rabbits (weighing 3.0-3.5 kg). Just befor...

Kerathoprosthesis application is limited to strictly definite indications such as: after a severe corneal scald, after repeated graft rejections or temporarily just before the intricate eye operation to expose the posterior segment. Considerable progress in this province has been observed since PMMA were introduced. Recently a new successful method...

The aim of our paper was to observe the physical and chemical changes in the aqueous humor, lens, gelatous and fluid part of the vitreous body after the sulfurhexafluoride injection into the vitreous body. The New Zealand rabbits were randomized into the control and experimental group which were injected the gas into the vitreous body. The interest...

Lacrimal fluid plays a very significant role in maintaining proper functions of conjuctivas, cornea and eyelids. The fluid is secreted by the main lacrimal gland and additional glands. It produces the so called preocular lacrimal film. A number of clinical tests, such as Chirmer's tests I and II, break-up-time (BUT), lysozyme, and flow tests are us...

To evaluate the enzymatic activity of antioxidant system of rabbit's vitreous after sulfur hexafluoride (SF6) application. Activity of CuZn-SOD, catalase and concentration of MDA in fluid and gel fraction of vitreous were determined in 24 rabbits of New Zealand race on the 2nd, 7th and 14th day after SF6 application. Control group consisted of 6 an...

To determine the activity of superoxide dismutase, catalase and the concentration of malondialdehyde (MDA) in aqueous humor, lens and red blood cells after application of sulfur hexafluoride (SF6) into vitreous of rabbits. 0.5 ml of 100% SF6 was injected into the vitreous of 24 rabbits of New Zealand race. The animals were randomly divided into 3 g...

Unlabelled: The aim of the study was to evaluate blood flow rate by means of Doppler pulsating ultrasonography focused in internal carotid artery, opthalmic artery and posterior ciliary arteries in patients with different types of retinal veins occlusion. The material included 8 patients with congestive venous retinopathy, 27 with ischaemic centra...

Unlabelled: The aim of the study was to evaluate the coagulant and fibrinolytic system, lipid economy and neurological condition in patients with various types of retinal vein occlusion. The material was 70 patients: 8 with diagnosed congestive venous retinopathy, 27 with ischaemic central retinal vein occlusion and 35 with central retinal vein br...

Unlabelled: The aim of the study was to analyse the clinical course and frequency of complications depending on type of retinal vein occlusion. The material included 70 patients (27 men, 43 women) aged 60.3 +/- 10.5 years. Follow-up period was 3 to 36 months from the occurrence of first clinical symptoms. Case history included occurrence of common...

The authors emphasize the complex and multifactorial mechanism by which retinal vein occlusion occurs. A special attention is paid to arterial insufficiency which impacts formation of clinical picture as well as the development of occlusion and the complications.

The Farnsworth-Munsell 100 Hue test was used to examine 75 males aged 25-60 years before and after a break in exposure to petroleum derivatives and 30 males non-occupationally involved in the petrochemical industry. Acquired colour vision disturbances were found in 29% of those under study before and in 16% after a break in exposure and rest while...

The authors described the technique, usefulness and complications of 2 types of local anesthesia applied in patients who underwent ocular surgery. In 25 cases, peribulbar and in 136 sub-Tenon anesthesia were performed. Both methods were evaluated as efficacious. It was found that the simple and safer sub-Tenon anesthesia could replace retrobulbar b...

The aim of the experimental studies, carried-out on 32 rabbits, was to explain the hypotensive effect of cytostatic drugs. It was found that a statistically significant lowering of the intraocular pressure without any changes in the coefficient of the outflow of intraocular fluid occurred on the 1st, 2nd, 3rd and 4th day after administration of cyt...

The studies comprised 45 patients qualified for chemotherapy on account of neoplastic disease. The measurement of the intraocular pressure on the 1st, 2nd, 3rd and 4th day after administration of cytostatic drugs revealed its statistically significant lowering. During the observation no statistically significant differences were observed in the coe...

The aim of investigations was to evaluate the changes in the eyeball, after extraocular rectus muscles myotomy. In 16 rabbits two muscles and in 17 four muscles were cut in one eye; the opposite eye was control. In early postoperative period intraocular pressure was statistically significantly lower, as compared with the control eyes and it depende...

Clinical observations of 7 patients with metastatic intraocular tumors are presented. The primary sites of neoplasms were breast cancer in 4 women, pulmonary cancer in 2 men and in 1 cancer of prostate. In 4 patients metastases were observed also in the anterior segment of uveal tract. Secondary retinal detachment was found in 6 cases, central reti...

The vessels proliferating into cornea cause epithelium biotransformation and lipid keratopathy, decreasing corneal transparency. In 9 patients (10 eyes) argon laser obliteration of these vessels was performed. In 8 eyes improvement of corneal transparency and visual acuity was achieved, in other two the neovascularization was restrained. The best r...

The authors presented the data concerning pathogenesis, diagnostic principles and methods of treatment of pupillary block in the eyes with intraocular lenses. 3 cases with pupillary block in the eyes with anterior chamber lenses have been presented. Neodymium YAG laser iridotomy was successful in the treatment of these cases.

The internal carotid artery occlusion causing an insufficiency of the cerebral circulation manifests itself--besides the neurological symptoms--by disorders of the visual organ. One can distinguish among them early, functional symptoms in the form of transient unilateral hemianopia on the side opposite to the occluded carotid artery and the attacks...

Stickler's syndrome or congenital, progressive arthro-ophthalmopathy refers to disturbances of the connective tissue of the organism but mainly the osteoarticular and visual systems. In the visual system one discovers a congenital high myopia, pathological changes in the vitreous in the form of membranes and proliferative bands as well as retinal d...

Photocoagulation of the iris surface in the course of rubeosis iridis was performed in 11 patients (12 eyes) with secondary absolute glaucoma. The intraocular pressure was lowered down to 30-35 mm Hg in 8 eyes, in the remaining 4 eyes it oscillated between 45 and 50 mm Hg. The pain receded in all the cases. One considers the possibility that in the...

In 24 patients with simple glaucoma in whom the IOP did not normalize under the conservative treatment the authors checked--between others--the Po, the outflow coefficient (C) and calculated Po/C. Laser trabeculoplasty was performed subsequently. The enumerated indexes were examined the day after surgery, then after the 1-st and 2-nd week, after a...

Prospective study of workers exposed to simultaneous action of petroleum derivatives and psychic stress proved statistically remarkable differences between the first study and control study (after two years) as related to macular degeneration and opacification of the lens. So far, the results do not seem to point to these phenomena as related to th...

The ophthalmological examinations of petrochemical plant workers that have been carried out so far did not enable working out a simple method of rapid ophthalmological evaluation of subclinical aromatic hydrocarbons poisonings. Neither the results of our own studies nor the experience of other authors explained fully the pathogenesis of the describ...

The results of functional examinations of the sight organ (vision acuity, colour differentiation, ability to differentiate shapes in darkness at lowest luminances, glare test, stereometry), both in welders and controls, were not significantly changed after eight-hours' work. On the other hand, a statistically significant difference was found betwee...

Basing on the results of examinations of 752 workers of the Refinery-Petro-chemistry Plant, correlations have been searched for between changes in the macula region of retina and disturbances found due to other specialist tests (internal, laryngological, dermatological), as well as laboratory--and toxicological investigations. A statistically signi...

Sight organ impairments have been compared in a group of M-5 Division welders, Brown Coal Mine in Bełchatów, and control group of randomly selected administration workers. In the group of welders statistically more frequent were degenerative changes in the eye macula, melanomatosis and conjunctivitis. Those with changes in the area of the macua lut...

35 young, healthy men were divided at random into two groups. Each of them made physical effort of different intensity and different quantity of the work performed. It was found that intraocular pressure was decreased in both groups but its drop was bigger in the group whose work was more strenouos. From the difference of performance of intraocular...

The most frequent ocular symptoms in 125 cases of cerebral aneurysms were pupillary disturbances and pareses of the 3rd and 4th nerves. In addition, 78.4% of patients presented with changes in the eye fundus, mainly in the form of hyperemia and edema of the optic disc. Analysis of the ocular changes shows that the ophthalmologic examination may be...

Hyaluronidase was introduced into the vitreous of 65 rabbits. In a 84 days period of observation, the animals showed a considerable fall of the intraocular tension, persisting for 7 to 14 days, decrease of the vitreous transparency, a slight inflammatory reaction, and extensive changes in the posterior segment in the form of breaks and tears of the...