Gábor Holló

Tutkimusz Ltd

Objective: Analysis and comparison of country-level data from the VISIONARY study, examining treatment outcomes with the topical fixed-dose combination of preservative-free tafluprost (0.0015%) and timolol (0.5%) (PF tafluprost/timolol FC) in adults with open-angle glaucoma (OAG) and ocular hypertension (OHT) who were insufficiently treated with o...

Introduction: The VISIONARY study demonstrated statistically significant intraocular pressure (IOP) reductions with the preservative-free fixed-dose combination of tafluprost 0.0015% and timolol 0.5% (PF tafluprost/timolol FC) in open-angle glaucoma (OAG) or ocular hypertension (OHT) patients, sub-optimally controlled with topical prostaglandin an...

Purpose The VISIONARY study assessed the efficacy of the preservative-free tafluprost/timolol fixed-dose combination (PF tafluprost/timolol FC) in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT) who were inadequately controlled with prostaglandin analogue (PGA) or beta-blocker (BB) monotherapy. This analysis examined IOP reduct...

Purpose The VISIONARY study assessed, in a real-world clinical practice setting, the efficacy of preservative-free tafluprost/timolol fixed-dose combination (PF tafluprost/timolol FC) in adults with open-angle glaucoma (OAG) or ocular hypertension (OHT) who did not achieve an adequate response to initial prostaglandin (PGA) or beta-blocker (BB) mon...

Introduction: In the last 25 years, topical prostaglandin analogues (PGAs) have emerged to become first line and first choice therapeutic options in the management of glaucoma and ocular hypertension (OHT). Although the short-term efficacy and safety of PGAs has been extensively investigated, less is known about their long term safety and tolerabi...

Background: In ophthalmology, thickness and vessel density (VD) measurements for the 6 x 6 mm inner macular retinal area have received increasing attention in glaucomatous progression research. For this area, the Angiovue optical coherence tomography system introduced a 304 x 304 A/B scans function (classic Angio Retina scan) in 2014, and a 400 x 4...

We report 2 peripapillary pit cases, in which the isolated visual field defects spatially correspond to the pit-related retinal nerve fiber layer and optical coherence tomography (OCT) angiography (OCTA) perfusion damage areas. A high myopic eye of a 39-year-old Japanese male patient, and a moderate myopic eye of a 47-years old Caucasian female pat...

In the last years optical coherence tomography imaging of the optic nerve head and the peripapillary retina became a part of the routine clinical practice worldwide. Unfortunately, performing optic nerve head imaging routinely does not mean that all acquired images are technically correct and clinically informative. Imaging artifacts are common, an...

Background For clinical practice it is important to evaluate and compare anxiety, depression and quality of life of glaucoma patients with painless one-eye blindness and a normal fellow eye to unaffected age-matched individuals from a similar environment. Methods Twenty-eight stable glaucoma patients (age, mean ± SD: 69.0 ± 13.3 years) with one no...

Introduction: Preservative-free (PF) medications represent a valuable treatment strategy in the lifelong management of glaucoma. By removing preservative toxicity, PF formulations provide tangible clinical benefits to glaucoma patients worldwide. They improve tolerability and adherence, leading to a positive impact in long-term intraocular pressure...

The key clinical attributes of preserved dorzolamide/timolol fixed combination (DTFC) and the emerging potential of preservative-free (PF) DTFC are reviewed with published evidence and clinical experience. The indications and role of DTFC in current glaucoma management are critically discussed. Preserved DTFC became the first intraocular pressure (...

Introduction Fixed dose combinations (FCs) represent a potentially valuable treatment strategy in glaucoma management. Fixed combinations not only improve adherence by reducing the medication burden, but also decrease the total amount of potentially deleterious preservatives an eye is exposed to. Areas covered We provide a critical review of selec...

Glaucoma, a well-defined group of progressive optic neuropathies is one of the leading causes of irreversible blindness worldwide. In order to stop or slow down the progression of glaucomatous vision deterioration, intraocular pressure reduction by medical, laser or surgical treatment is needed. To ensure that treatment is efficient and tailored to...

In the original article, the The VISIONARY Study Group Principal Investigator Jose Javier Garcia-Medina.

PRéCIS:: Four parameters of the noninvasive, portable RETeval electroretinogram (ERG) system were found to correlate with visual field mean deviation and optical coherence tomography (OCT) thickness parameters, and may therefore be suitable for glaucoma detection. Purpose: To investigate the RETeval full-field ERG parameters for accuracy of separ...

IntroductionA non-interventional, multicenter, European, prospective evaluation of the effectiveness, tolerability, and safety of a topical preservative-free tafluprost (0.0015%) and timolol (0.5%) fixed-dose combination (PF tafluprost/timolol FC) in adults with open-angle glaucoma (OAG) and ocular hypertension (OHT) demonstrating insufficient resp...

Purpose To investigate the intraocular pressure (IOP)-lowering efficacy and tolerance of brinzolamide/brimonidine fixed combination (BBFC) under real-life conditions in a tertiary glaucoma centre. Methods Medical records of all ocular hypertensive and open-angle glaucoma patients (n = 52) treated with BBFC were retrospectively analysed. Results T...

Cystoid macular edema (CME) is a form of macular retina thickening that is characterized by the appearance of cystic fluid-filled intraretinal spaces. It has classically been diagnosed upon investigation after a decrease in visual acuity; however, improvements in imaging technology make it possible to non-invasively detect CME even prior to a clini...

PRéCIS:: In primary open-angle glaucoma unlogged mean macular hemifield visual field sensitivity correlates significantly better with superficial capillary vessel density than with ganglion cell complex thickness of the opposite macular hemifield. Purpose: To compare the relationship of the spatially corresponding superficial retinal capillary ve...

Az összefoglaló írás a magyarországi glaucomaellátás utóbbi harminc évének eredményeit és kudarcait tekinti át. Teszi ezt annak alkalmából, hogy a Lege Artis Me­di­cinae folyóirat három évtizede indult út­jára, és a glaucomatémájú közlemények megjelentetésével már a kezdetektől segítette az ellátás fejlődéséről szóló eredmények bemutatását. Harminc...

Glaucoma is one of the main clinical areas where OCT angiography is used. In contrast to medical retinal application, where qualitative image analysis and semiquantitative measurements are frequently satisfactory for clinical decision-making, in glaucoma the exact quantitative measurements provide the useful information. Therefore both general opht...

Purpose: To determine the optical coherence tomography angiography (OCTA) characteristics of a case of optic disc melanocytoma (ODM) associated with glaucomatous visual field and retinal nerve fiber layer (RNFL) defects in normal tension glaucoma. Methods: The left eye of a 37-year-old female patient followed for a stable ODM for 10 years was in...

Background We report a case of advanced juvenile open-angle glaucoma (JOAG) in which peripapillary capillary vessel density (PcVD) in the inferior retina showed significant progression while the spatially corresponding retinal nerve fiber layer thickness (RNFLT) and visual field cluster defect values had reached their minimal detectable values, and...

Purpose: To evaluate and compare the diagnostic performance of circumpapillary microperimetry (MP) sensitivity and circumpapillary retinal nerve fiber layer thickness (cpRNFLT) measured with optical coherence tomography (OCT) for detection of early to moderate open-angle glaucoma. Methods: Eleven eyes (11 patients) with early or moderate open-an...

Purpose To compare the relationships between circumpapillary microperimetry (MP)-sensitivity measurements and various circumpapillary retinal thickness parameters in healthy and primary open-angle glaucoma (POAG) eyes. Methods In 14 eyes of 14 healthy subjects and 22 early–moderate POAG eyes of 22 patients, circumpapillary optical coherence tomogr...

Purpose: To investigate the acute effect of smoking on peripapillary and superficial parafoveal vessel density (VD) in healthy smokers. Materials and methods: One eye each of 7 healthy smokers (age 40 y and above) was imaged using the Angiovue/RTvue-XR optical coherence tomography after a period of at least 2 hours without smoking (baseline) and...

Purpose To investigate the suitability of multi-scale spatial information in 30o visual fields (VF), computed from a Convolutional Neural Network (CNN) classifier, for early-glaucoma vs. control discrimination. Method Two data sets of VFs acquired with the OCTOPUS 101 G1 program and the Humphrey Field Analyzer 24–2 pattern were subdivided into con...

The is the file including data sets used in this work. Training, validation and test splits are given separately. (ZIP)

Purpose: To investigate the influence of posterior subcapsular cataract (PSC) on structural optical coherence tomography (OCT) and OCT angiography vessel density (VD) measurements. Materials and methods: One eye each of 10 consecutive participants with PSC were imaged using the Angiovue/RTvue-XR OCT via undilated pupil, and 30 minutes later via...

The present review casts a critical eye on intraocular pressure (IOP) monitoring and its value in current and future glaucoma care. Crucially, IOP is not fixed, but varies considerably during the 24-h cycle and between one visit and another. Consequently, a single IOP measurement during so-called office hours is insufficient to characterize the rea...

Optical coherence tomography angiography (OCTA) comprises different OCT-based technologies developed for non-invasive assessment and measurement of optic nerve head and retinal perfusion. Currently the most clinically established approach is based on the split spectrum amplitude decorrelation algorithm, which detects moving red blood cells and elim...

Purpose: To analyze the appropriateness of referrals for incisional glaucoma-surgery in Europe. Methods: Referrals for the first open-angle glaucoma surgery between January and October 2017 were analyzed in 18 countries: 8 "old" European Union, 7 "new" European Union and 3 non-European Union European countries. Results: Most eyes had primary o...

PURPOSE: To analyze the appropriateness of referrals for incisional glaucoma-surgery in Europe. METHODS: Referrals for the first open-angle glaucoma surgery between January and October 2017 were analyzed in 18 countries: 8 "old" European Union, 7 "new" European Union and 3 non-European Union European countries. RESULTS: Most eyes had primary ope...

Purpose: To investigate the potential influence of breath holding on the results of peripapillary vessel density (VD) measurement with optical coherence tomography angiography (OCTA). Methods: Three peripapillary VD measurements were made at 2-minute intervals on the right eye of 12 healthy young volunteers using the Angiovue/RTvue-XR OCT (softw...

Purpose: To investigate the usefulness of removing the large vessel-related information from peripapillary optical coherence tomography (OCT) angiography progression analysis. Peripapillary vessel density (VD) image series which had shown no progression with an earlier software version that did not separate capillary and large vessel-related effec...

Both exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) are associated with systemic vascular diseases and abnormalities. Though no uniform relationship between XFS/XFG and clinical systemic vascular diseases has been established across various populations, vascular dysfunction with or without clinically significant consequences has been rep...

Purpose: To investigate the applicability of peripapillary optical coherence tomography angiography angioflow vessel-density measurements in the retinal nerve fiber layer for the detection of glaucomatous progression; and to compare its performance with that of retinal nerve fiber layer thickness (RNFLT) measurements. Methods: Prospective RNFLT...

Glaucoma therapy-related ocular surface disease (OSD) is a serious pathology with a broad spectrum of insidious clinical presentations and complex pathogenesis that undermines long-term glaucoma care. Preservatives, especially benzalkonium chloride (BAK), contained in topical intraocular pressure-lowering medications frequently cause or aggravate O...

Purpose To compare the detection rate of central visual field defect (CVFD) between the 30-degree Octopus G1 program (Dynamic strategy) and the HFA 10–2 SITA-Standard test in early glaucoma eyes not showing any CVFD on the HFA 24–2 SITA-Standard test. Methods One eye of 41 early glaucoma patients without CVFD in the central 10° on HFA 24–2 test wa...

Background To investigate the outcomes of glaucoma referrals across different European countries. Methods 250 patients newly referred to tertiary referral glaucoma specialist practices in the UK, Hungary, Slovenia, Italy and Greece were prospectively enrolled (50 consecutive patients per centre). Referral accuracy and predictive value of referral...

Purpose: To present a case of early primary open-angle glaucoma in which retinal nerve fiber layer thickness (RNFLT), ganglion cell complex (GCC), and visual field progression were accompanied with significant progression of peripapillary angioflow vessel density (PAFD) measured with optical coherence tomographic angiography. Methods: A 68-year-...

The term optical coherence tomography angiography (OCTA) comprises different OCT-based technologies which all allow noninvasive assessment of retinal perfusion, based on moving red blood cells. The main areas where OCTA is currently used are investigation of perfusion and vascular structure of the macular retina (e.g., in macular degenerations and...

Subconjunctival absorption of aqueous humor is an essential part of glaucoma filtration surgery. Mitomycin C (MMC) and 5-fluorouracil have been used to reduce postoperative episcleral fibrosis and scar formation in the filtering bleb area for more than 2 decades. Both antimetabolites have also been frequently injected before needling revision of fa...

Purpose of the study: The purpose of the study was to investigate the relationship between optical coherence tomography angiography angioflow vessel-density (PAFD) measured in the retinal nerve fiber layer in the temporal peripapillary sector and the average of the spatially corresponding superior and inferior paracentral cluster mean defect value...

Purpose To compare the relationship of Octopus perimeter cluster mean-defect (cluster MD) values with the spatially corresponding optical coherence tomography (OCT) sector peripapillary angioflow vessel-density (PAFD) and sector retinal nerve fiber layer thickness (RNFLT) values. Methods High quality PAFD and RNFLT images acquired on the same day...

Anonymous raw measurement data used for calculation of the relationship between sector peripapillary angioflow density and Octopus visual field cluster mean defect. (XLSX)

Purpose The purpose of this study is to evaluate the applicability of a new optical coherence tomography parameter, the circumpapillary ganglion cell complex (cpGCC) thickness for glaucoma diagnostics. Subjects and Methods The RS-3000 Advance SD-OCT (NIDEK, Aichi, Japan) was used to measure global and sector macular GCC (mGCC) thickness, circumpap...

Background Intrachoroidal cavitation (ICC) in the temporal peripapillary area is a relatively frequent finding in high myopia. However, ICC associated with a full thickness retinal defect rarely observed. We report an unusual case of ICC combined with a full thickness retinal defect in the papillo-macular bundle, in which the spatially correspondin...

Purpose To evaluate intrasession and between-visit reproducibility of sector peripapillary angioflow vessel-density (PAFD, %) values in the optic nerve head (ONH) and radial peripapillary capillaries (RPC) layers, respectively, and to analyze the influence of the corresponding sector retinal nerve fiber layer thickness (RNFLT) on the results. Meth...

Background/purpose: Optical coherence tomography (OCT) angiography is a new noninvasive method to measure peripapillary microcirculation in various retinal layers, separately. In this case series, we investigate whether large medical intraocular pressure (IOP) reduction (>50% of the untreated baseline value) to IOP≤18 mm Hg influences peripapillar...

Exfoliation syndrome (XFS) is a genetically determined systemic condition characterized by the production and accumulation of an abnormal protein, the exfoliative material. Though XFS is a systemic elastosis, the most significant clinical consequences occur in the eye (nuclear cataract formation, Zinn’s zonule fragility, increased risk for cataract...

Background/purpose: Using adaptive bracketing "normal" (N) strategy it has been shown that cluster trend analysis is useful for early detection of glaucomatous progression with Octopus perimetry. However, in clinical practice "tendency-oriented perimetry" (TOP) is mostly used. In TOP, responses given at neighboring points modify the threshold valu...

Introduction: Medical therapy of glaucoma aims to maintain the patient's visual function and quality of life. This generally commences with monotherapy, but it is often difficult to reach the predetermined target pressure with this approach. Fixed combinations (FCs) are therefore selected as the next step of the medical therapy algorithm. By emplo...

Background/aims: Previously, we found a strong structure-function relationship between Octopus visual field cluster sensitivity and corresponding sector retinal nerve fibre layer thickness (RNFLT) values, using normal strategy and 16 custom-made cluster-sector pairs. However, Octopus commercially offers 10 clusters, correction for diffuse defect (...

Purpose: To determine retinal nerve fiber layer thickness (RNFLT) and ganglion cell complex (GCC) progression rates for healthy eyes and undertreatment ocular hypertensive (OHT) and glaucoma eyes with the Avanti RTVue-XR optical coherence tomography. Materials and methods: Seventeen healthy subjects (34 eyes), 17 medically treated OHT patients (...

Myelinated retinal nerve fibers (MRNF) represent an asymptomatic developmental anomaly in which myelin sheaths extend to a group of retinal nerve fibers along their intraocular portion. The additional volume of the myelin sheaths causes displacement of the axons toward the vitreous body. We investigated the effect of localized MRNF on peripapillary...

The 6th edition of the Visual Field Digest is a comprehensive and practical guide to perimetry and the Octopus perimeter. This edition not only presents all key features of the Octopus perimeter, but also explains fundamentals of perimetric testing with more than 200 illustrations in an easy to grasp and practical manner and concludes with a clinic...

The 6th edition of the Visual Field Digest is a comprehensive and practical guide to perimetry and the Octopus perimeter. This edition not only presents all key features of the Octopus perimeter, but also explains fundamentals of perimetric testing with more than 200 illustrations in an easy to grasp and practical manner and concludes with a clinic...

Carbonic anhydrase inhibitors are IOP-lowering sulfonamide derivatives which inhibit the activity of CA in the ciliary processes of the eye, thus reducing aqueous humor formation and consequently decreasing IOP. Systemic CAIs provide an approximately 40% IOP reduction, and their effect develops rapidly. Therefore, systemic CAIs (most frequently ace...

Purpose: Disturbed peripapillary microcirculation may have a role in the development of glaucoma. Recently, using noninvasive optical coherence tomography (OCT) angiography with the AngioVue OCT (Optovue Inc., -Fremont, CA, USA), reduced peripapillary vessel density was found in glaucoma. In this case series, we investigate the relationship betwee...

Purpose: To evaluate the intrasession reproducibility of various thickness parameters used to diagnose and follow-up glaucoma, in particular circumpapillary total retinal thickness (cpTR) provided by the RS-3000 optical coherence tomograph (OCT). Methods: Fifty-three healthy eyes of 28 subjects underwent three consecutive imaging with the RS-300...

Purpose: To evaluate the current status of glaucoma diagnostics and care in Europe. Methods: A questionnaire addressing glaucoma patient organizations, resident education, access to an ophthalmologist, use and reimbursement of techniques/instruments for glaucoma diagnostics and follow-up, prescription rules, and glaucoma drug reimbursement was s...

Purpose: In addition to retinal nerve fiber layer thickness measurements, the recently introduced AngioVue optical coherence tomography (OCT) offers corresponding layer-by-layer Doppler OCT and en face OCT functions, for simultaneous evaluation of perfusion and structure of the optic nerve head. We investigated the clinical usefulness of combined...

To compare the current (6.3) and a novel software version (6.12) of the RTVue-100 optical coherence tomograph (RTVue-OCT) for ganglion cell complex (GCC) and retinal nerve fiber layer thickness (RNFLT) image segmentation and detection of glaucoma in high myopia. RNFLT and GCC scans were acquired with software version 6.3 of the RTVue-OCT on 51 high...

Exfoliative glaucoma is the most common type of secondary open-angle glaucoma worldwide. It is characterized by high intraocular pressure (IOP) and worse 24-hour IOP characteristics. In order to minimize progression, treatment of exfoliative glaucoma has to provide a low long-term mean IOP and good 24-hour IOP control. To achieve these goals, fixed...

The purpose was to compare the current (6.3) and a novel software version (6.12) of the RTVue-100 optical coherence tomograph (RTVue OCT) for ganglion cell complex (GCC) and retinal nerve fibre layer thickness (RNFLT) changes after phacoemulsification in healthy cataract eyes, and to investigate whether version 6.12, in which image segmentation is...

To compare the current (6.3) and a novel software version (6.12) of the RTVue-100 optical coherence tomograph (RTVue-OCT) for detection of glaucomatous inner macular retinal thickness (ganglion cell complex [GCC]) and retinal nerve fiber layer thickness (RNFLT) progression. In this prospective, observational study, 109 participants (17 healthy cont...

To present a case of topical prostaglandin analogue-induced skin pigmentation in a location previously never reported, with a differential diagnostic significance. An 83-year-old man successfully treated for primary open-angle glaucoma of both eyes with the bimatoprost/timolol fixed combination for 6 years reported increased pigmentation of the ski...

Introduction: The preservative-free (PF) fixed combination (FC) of tafluprost 0.0015%/timolol 0.5% is the newest member of the prostaglandin analogue/timolol FC class. Areas covered: In this review, we summarize data on safety and tolerability of this FC. Expert opinion: The intraocular pressure-lowering effect of the tafluprost/timolol FC is...

These proceedings are based on a symposium that were presented at the European Society of Ophthalmology 2015 Congress in Vienna, Austria on 8 June 2015. The symposium was arranged to bring together leaders in ophthalmology to explore advances in the medical treatment of glaucoma. Many patients with glaucoma require combination therapy. Fixed-dose c...

Abstract We investigated the intraocular pressure (IOP) lowering efficacy of preservative-free fixed and non-fixed combination of tafluprost 0.0015% and timolol 0.5% in pseudoexfoliative glaucoma (XFG). A per protocol worse eye analysis was made on all XFG patients who participated in a recent 6-month, prospective, randomised, double-masked, parall...

Exfoliation syndrome (XFS) is a systemic condition. Intraocular alterations represent only a part of the exfoliation-related clinical signs. Exfoliation material has been identified in the visceral organs, skin, and vessel walls. This triggered several studies that investigated association between XFS and cardiovascular diseases. In many population...

Mitochondrial (mt) disorders are metabolic conditions with multiorgan involvement, which often cause neuroophtalmological symptoms. The aim of the study was to investigate the relation between progressive external ophthalmoplegia (PEO), visual pathway and mitochondrial DNA (mtDNA) mutations in patients younger than 55 years of age. Five female pati...

A new preservative-free fixed-dose combination of 0.0015% tafluprost, a prostaglandin F2α analog, and 0.5% timolol (TAF/TIM; Santen Oy, Tampere, Finland), a beta-adrenergic antagonist has recently been developed. The intraocular pressure (IOP) reduction with TAF/TIM in open-angle glaucoma and ocular hypertension is similar to that of other prostagl...

Purpose: Previously, we have shown that age-related macular degeneration (AMD) influences glaucoma classification with the ganglion cell complex (GCC) parameters of the RTVue-100 optical coherence tomograph (RTVue-OCT) in nonglaucomatous eyes. Now, we reevaluated the influence of AMD on GCC image segmentation and classification for glaucoma on the...

Introduction: Several large, randomized, prospective clinical trials have demonstrated that medical therapy to reduce intraocular pressure (IOP) delays the onset and decreases progression of glaucoma. Many patients with glaucoma require more than one ocular hypotensive medication to achieve and maintain their target IOP; however, use of multiple t...