Denise A. Dillard's research while affiliated with University of Washington Seattle and other places

... Authors have diverse backgrounds, ranging from clinical geneticists and genetic counsellors to health scientists, policy advisors, psychologists, sociologists, ethicists, legal experts and experts in education. Contributions come from all over the world and discuss applications relevant for many countries or groups, such as Ireland, Turkey, Jordan, USA (including tribal groups in Alaska and Latina women in Texas), and also countries in Africa and South America (Ward et al. 2023;Kadiroğlu et al. 2023;Abudahab et al. 2023;Beans et al. 2023;Madhiri et al. 2023;Opoku et al. 2023;Ruderman 2023). The application of genomics knowledge will, we hope, contribute to sustainable development worldwide, especially in health (SDG3), education (SDG4) and reducing inequalities (SDG10) as these are the areas that not only this journal but also others in the SpringerNature stable are best positioned to support. ...

... A recent observational study of AI/AN adults starting the Quit Tobacco Program (QTP) at Southcentral Foundation found that 28% of participants demonstrated slow nicotine metabolism (NMR < 0.31), 66% had normal nicotine metabolism (NMR ≥ 0.31), and 6% had an NMR that was unquanti able (either cotinine or 3-hydroxycontinine values were < 1.5 ng/mL at baseline). 9 Of the total sample, 24% were smoking-abstinent at six weeks. A combined group of people with slow metabolism who used NRT and people with normal metabolism who used varenicline had a quit rate of 36.5%, a 13% higher quit rate than in the total sample. ...

... Twenty-five studies focused on the association between pre-pregnancy BMI or weight (referred to hereafter as 'pre-pregnancy BMI') and a range of maternal and child health outcomes (Table 2) [10,41,42,46,47,[49][50][51]53,55,56,60,62,64,66,67,72,73,75,85,86,91,[93][94][95]. In general, these studies found associations between a higher pre-pregnancy BMI and adverse maternal and child health outcomes, including gestational diabetes [41,47,51,56,73,75], gestational hypertension [42,50,51], pre-eclampsia [93], caesarean section [51,93], high birthweight [51,55,67,72,85], and developing diabetes after pregnancy [53]. ...

... Specifically, involvement of family members in the study process, emphasizing community benefits, and study flexibility is highlighted as a facilitator to retention in Asian communities [13]. Similar benefits of study retention in longitudinal research were found by making 2 or more successful phone calls to Alaska Native and American Indian people, rather than contact by text or email [14]. While prior studies have identified that young adults respond favorably to incentives as a method of retention, the methods of contact and follow-up are dated in the era of the internet and social media [15]. ...

... Asian Americans have poor control of their HTN and have high HTN medication nonadherent rates [38][39][40]. In addition, the prevalence of selfreported HTN is also high among ANAI individuals than in the majority US population [41,42]. This gap in the literature is a limiting factor to achieve better HTN medication adherence among all racial/ethnic groups. ...

... However, researchers should be aware that RCTs may be viewed as unacceptable within some Indigenous communities (e.g., it may be perceived as unfair that only certain community members receive a desired intervention within a context of scarce resources; Dickerson et al., 2020). Shaw et al. (2021) have recently articulated best practices for conducting responsible clinical trials with Indigenous communities; these practices include principles of community-based research that we discuss in later paths (see Goodkind et al., 2015). In addition, researchers should prioritize the inclusion of Indigenous individuals in clinical trials; when ethically possible, researchers should report data from Indigenous participants, as this could enable for analyses across publications (Crouch et al., 2022). ...

... Table S1, column 6, shows the detailed information for this analysis. Difficulty to enable and enhance trusting relationships 17 8,18,33,35,61,65,87,93,95,114,137,139,154,[175][176][177]183,187,191,194,196,208,216,231,234 Communication challenges 16 18,39,93,95,109,110,131,135,141,149,152,154,161,170,173,177,185,189,194,223,231,239,243,248 Technical difficulties with the technology 16 33,34,39, 73,76,88,91,93,95,109,112,120,137,154,160,167,169,173,176,194,198,231,240 Reduced access to the equipment 16 8 Appropriate training 12 6,19,35,37,39,41,61,72,94,107,110,113,117,127,133,177,179,189,193,199 Good audiovisual quality 9 ...

... Notably, frequencies of CYP variants are highly variable and population-specific. Novel genetic variants at relatively high frequency have been identified in several CYP genes in AIAN populations that may result in altered enzyme activity [16][17][18]21 . There is a tendency to treat AIAN peoples as a homogenous group, but data from CYP pharmacogenes highlight the extensive heterogeneity within AIAN peoples. ...

... AIANs include 574 federally recognized sovereign tribes-and more unrecognized tribes, Native Hawaiians, and Pacific Islanders-with each having distinct cultural, social, and political structures, though many values are shared. Concerns shared among Indigenous peoples about genomics research include maintaining research oversight, upholding tribal sovereignty, biospecimen and data storage/use, and culturally appropriate research 4,5 . While Indigenous values are diverse, respecting holistic relationships in health and the environment, cultural integrity, and the inclusion of Indigenous knowledge resonate with many Indigenous communities, and reflect a commitment to the collective while maintaining a respectful relationship with the land and other beings [6][7][8][9] . ...

... This concept is often implemented as training of community members to participate as members of the research team (e.g.,41 ). In the discussions at this meeting, however, community capacity encompassed the potential to formulate research questions, inform research methodology, and lead research projects, in keeping with more recent commentaries.[42][43][44] In addition, researchers' willingness to become knowledgeable about the communities in which they propose to work emerged as an important factor. ...