Jordan P. Lewis's research while affiliated with University of Minnesota Duluth and other places

... The human brain is a highly intricate organ in the human body: with a complex network of connected neurons, each with thousands of synapses, understanding the many different links and pathways that make the brain function in the ways it does is a demanding task . Two of the major challenges in research into neurodegenerative diseases and dementia manifestations is that distinct brain areas are affected differently, as corroborated by non-invasive multimodal imaging techniques (Aberathne et al., 2023; Cogswell and Fan, 2023;Shimizu et al., 2018), and that multifactorial interactions of genetic, environmental, social and behavioral risk factors modulate phenotypic expression in a nuanced manner (Barati et al., 2022;Dunn et al., 2019;Hamrah et al., 2023;Ribeiro et al., 2023;Wiese et al., 2023). Research driven by human pangenomic methods may open the possibility of looking at the genetic interactions between different brain areas in extreme detail, to better understand how diseases progress and how potential therapies could be developed. ...

... Challenges prompting outmigration from rural to urban Alaskan communities involve barriers to health care, the breakdown of social networks and subsistence lifestyles, the cost of living, and limited employment opportunities (Driscoll et al., 2010;Foutz et al., 2016;Lewis, 2013;Lewis et al., 2023). The extent of these barriers is exemplified in the price of a gallon of milk, $18, and a gallon of gas, up to $16, with the employment rate ranging between 7 -28% (Bureau of Labor Statistics, 2023). ...

... 14 Ensuring respect for and elevation of Indigenous Peoples' brilliance and strengthsbased approaches 14 in advancing culturally grounded solutions for all areas of health will therefore be crucial for addressing the Indigenous determinants of health across all practice areas, levels of healthcare service delivery, research, and health policy. [13][14][15] Additionally, Indigenous Peoples are recognised through varied national and international mechanisms as self-determined peoples, 16 and therefore specific and delineated actions to address the key priority areas shown in the panel should be mobilised on the ground from within Indigenous Peoples' communities and be specific to unique and diverse geopolitical and cultural contexts. ...