Sare Safi

Shahid Beheshti University of Medical Sciences · Research Institute for Ophthalmology and Vision Science

Purpose To analyze the glaucoma research in the Web of Science (WoS) and Scopus to determine the top features, trends, and subject clusters. Methods In this scientometric study, all glaucoma publications in Scopus and WoS were analyzed based on various characteristics such as authors, journals, and co-word analysis. Data analysis was conducted usi...

Background Eyelid skin cancers are the most prevalent ophthalmic malignancies. This study aimed to evaluate the association of the Human Development Index (HDI) and lifestyle risk factors with eyelid skin cancers in Iran. Methods This ecological study analyzed the data collected from the Iranian National Population-based Cancer Registry (2005–2016...

Purpose: To evaluate the rate of complications in resident‐performed phacoemulsification and influencing factors. Methods: In this retrospective cohort study, the outcomes of cataract surgeries performed by 18 ophthalmology residents were analyzed. The outcome of first 80 phacoemulsification cataract surgeries (1440 cataract surgeries) performed by...

RATIONAL: The rationale of this study was to evaluate the visual and anatomical outcomes of pars plana lensectomy and iris-claw Artisan intraocular lens (IOL) implantation in patients with subluxated crystalline lenses secondary to Marfan syndrome. MATERIALS AND METHODS: In this retrospective case series, we evaluate the records of 21 eyes of 15 pa...

Investigating secular trends of ocular cancer registration in Iran. After acquiring Iranian national population-based cancer registry data, trends of age-standardised incidence rates (ASIR) of ocular cancers and annual percent changes (APC) between 2004 and 2016 were analysed in age groups, gender, topography and morphology types with joinpoint reg...

Purpose: To estimate the level of job satisfaction among ophthalmologists in Iran and determine the associated factors that may impact their overall job satisfaction. Methods: In this cross-sectional study, 181 ophthalmologists (79.0% male) were interviewed by the Warr-Cook-Wall questionnaire with 7-point-Likert scale, which transformed response...

Purpose: To evaluate the therapeutic response of retinal vein occlusion (RVO) to intravitreal bevacizumab (IVB) with and without concomitant vitamin D supplementation. Methods: Seventy eyes of 68 patients with macular edema associated with branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO) received three monthly IVB i...

Purpose To evaluate the outcomes and complications of simultaneous silicon oil removal (SOR) and phacoemulsification and intra ocular lens implantation. Methods In this retrospective non-comparative case series, the visual, refractive and anatomical outcomes of patients who underwent combined phacoemulsification/silicone oil removal (5700 centisto...

Purpose To report the incidence, management, and clinical outcomes of cases who developed acute endophthalmitis following the administering of the intravitreal bevacizumab (IVB) injection. Methods In this retrospective, non-comparative, single-center, cross-sectional study, the records of patients diagnosed with acute endophthalmitis following IVB...

This review is proposed to summarize the updates on COVID-19 and ophthalmology along with the bibliometric features of articles that have been published since the beginning of the COVID-19 outbreak. The databases, including PubMed, Scopus, and Web of Science, were searched using “Coronavirus,” “COVID-19,” “SARS-CoV-2,” “pandemic,” “ophthalmology,”...

Purpose: To investigate the role of serum uric acid and leukocyte counts and ratios as predictors of clinical outcomes of intravitreal bevacizumab in diabetic macular edema. Method: In this prospective study, the patients were treated with three monthly intravitreal bevacizumab. The correlation of serum uric acid and immune cell indices with the...

Purpose: To study the genetic basis and clinical manifestations of Wolfram syndrome in a multi-affected family. Methods: Complete clinical examinations including urological, ophthalmic, neurological, and endocrinologic assessment were performed for three affected family members. Genomic DNA was extracted from peripheral blood leukocytes with sal...

Purpose. To evaluate the retinal vascular response to hyperoxia in patients with diabetes at the preclinical stage of diabetic retinopathy (DR) and to quantify the changes in comparison with normal subjects using optical coherence tomography angiography (OCTA). Methods. In this prospective study, 40 eyes of 20 participants comprising 10 diabetic pa...

Diagnostic investigation on pachychoroid spectrum disease (PSD) has been growing along with the rapid advancement of imaging technology. In optical coherence tomography (OCT)-based studies, choroidal thickness profile, luminal and stromal choroidal ratio, and abnormalities in the neurosensory retina have demonstrated various patterns in different c...

Purpose: To evaluate the visual and anatomical outcomes of pars plana lensectomy and iris-claw artisan intra-ocular lens (IOL) implantation in the patients with subluxated crystalline lens secondary to Marfan syndrome. Methods: In this retrospective case series, we evaluate the records of all patients with Marfan syndrome and moderate to severe cry...

Purpose: To evaluate the patient satisfaction of intravitreal bevacizumab (IVB) injection services for ocular complications of diabetes mellitus (DM) at a referral center. Methods: Patients with diabetic macular edema (DME) and diabetic retinopathy (DR) who had undergone IVB injections between March and September 2018 were interviewed by telepho...

Traumatic optic neuropathy (TON) is an uncommon vision-threatening disorder that can be caused by ocular or head trauma and is categorized into direct and indirect TON. The overall incidence of TON is 0.7–2.5%, and indirect TON has a higher prevalence than direct TON. Detection of an afferent pupillary defect in the presence of an intact globe in a...

Purpose: To assess the effects of oral vitamin D supplement therapy on clinical outcomes of intravitreal bevacizumab (IVB) injections in patients with diabetic macular edema (DME). Methods: Seventy-one patients with center-involving DME received IVB injections three times monthly. Cases with serum 25-hydroxyvitamin D (25(OH)D) levels < 30 ng/ml...

This is a Reply Letter and does not have an abstract. Please download the PDF or view the article in HTML.

Purpose: To present a case of central serous chorioretinopathy (CSC) in association with regressed familial retinoblastoma. Case report: A 23-year-old man with regressed unilateral familial retinoblastoma in his left eye presented with decreased vision of the left eye since two months ago. The patient had undergone chemotherapy and cryotherapy f...

This is a Letter to the Editor and does not have an abstract.

This is an Editorial and does not have an abstract.

Purpose: To report the 27-year statistical data from the Central Eye Bank of Iran (CEBI) and its activity. Methods: All CEBI records regarding procured eyes, tissue utilizations, corneal transplants per capita, and indications for keratoplasty from 1991 to 2017 were analyzed. Results: In total, 115,743 whole eyes were donated during the 27-year per...

Purpose: To evaluate the role of topical umbilical cord serum (TUCS) therapy in treating corneal epithelial defects (CEDs) after diabetic vitrectomy. Methods: In this double-masked, randomized clinical trial, we included 80 eyes of 80 patients who were candidates for vitrectomy due to proliferative diabetic retinopathy complications. In cases of co...

Retinal hemangioblastoma (also referred to as retinal capillary hemangioma) is a benign lesion originating from the endothelial and glial components of the neurosensory retina and optic nerve head. Historically known as a manifestation of the von Hippel- Lindau (VHL) disease, it can be seen as an isolated finding or in association with some rare oc...

Purpose: To determine inter-device agreement for central corneal thickness (CCT) measurement among ultrasound pachymetry, rotating Scheimpflug imaging (Pentacam, Oculus, Wetzlar, Germany), and scanning slit corneal topography (Orbscan II, Bausch & Lomb, Rochester, NY, USA) in highly myopic eyes before and after photorefractive keratectomy (PRK). Me...

In this prospective study, we implanted allograft Intrastromal corneal segment (ISACS) in four eyes of 3 patients with PMD as a new surgical procedure. A femtosecond laser-assisted stromal canal 4 mm in width was created in the 5.5 to 9.5 mm corneal zone.

Purpose: To investigate whether autologous platelet-rich plasma (PRP) eye drops accelerate re-epithelialization of post-keratoplasty persistent corneal epithelial defects (PEDs). Methods: A total of 34 eyes with PEDs after keratoplasty (24 penetrating keratoplasty and 10 deep anterior lamellar keratoplasty) that were refractory to conventional medi...

Purpose: To provide the clinical recommendations for the administration of intravitreal anti-vascular endothelial growth factor (VEGF) drugs especially bavacizumab for ocular vascular diseases including diabetic macular edema, neovascular age-related macular degeneration, myopic choroidal neovascularization, retinal vein occlusion and central serou...

Diabetic retinopathy (DR) is a primary cause of visual impairment worldwide. Diabetes mellitus may be associated with ophthalmoscopically nonvisible neurovascular damage that progresses before the first clinical signs of DR appear. Reduction of the inner neuroretinal layer thickness on macular optical coherence tomography (OCT), reduced contrast se...

Purpose: The purpose of this study was to evaluate the safety and efficacy of intravitreal propranolol for the management of retinal capillary hemangioma in a patient with Von Hippel-Lindau. Methods: Two intravitreal injections of 50 μg/0.05 mL propranolol were administered 6 weeks apart in the left eye of a 26-year-old patient with bilateral mu...

Purpose: To evaluate the effects of intravitreal silicone oil (SO) on subfoveal choroidal thickness (SFCT). Methods: A total of 60 patients with unilateral pseudophakic macula-off rhegmatogenous retinal detachment were treated with a three-port pars plana vitrectomy and a 5,700-cSt SO endo-tamponade and subsequent SO removal. SFCT was measured b...

Glaucoma is the leading cause of irreversible blindness and vision loss in the world. Although intraocular pressure (IOP) is no longer considered the only risk factor for glaucoma, it is still the most important one. In most cases, high IOP is secondary to trabecular meshwork dysfunction. High IOP leads to compaction of the lamina cribrosa and subs...

Purpose To report a case of bilateral acute angle closure glaucoma after one dose of oseltamivir 75 mg. Case Report A 37-year-old man with a history of influenza developed high intraocular pressure and uniformly shallow anterior chamber in both eyes, 5 hours after the first dose of oseltamivir 75 mg. The condition was managed successfully with top...

The Rho-kinase/ROCK (Rho-associated coiled-coil-containing protein kinase) pathway is involved in the pathogenesis of multiple ocular and systemic disorders. Recently, ROCK inhibitors have been suggested as novel treatments for various ocular diseases. Several in vitro, in vivo and clinical studies have demonstrated the safety and efficacy of ROCK...

Int J Public Health. 2017 Aug 3. doi: 10.1007/s00038-017-1012-3. Burden of cardiovascular diseases in the Eastern Mediterranean Region, 1990-2015: findings from the Global Burden of Disease 2015 study. OBJECTIVES: To report the burden of cardiovascular diseases (CVD) in the Eastern Mediterranean Region (EMR) during 1990-2015. METHODS: We used the...

Objective To evaluate the ability of contrast sensitivity (CS) to discriminate loss of visual function in diabetic subjects with no clinical signs of retinopathy relative to that of normal subjects. Research design and methods In this prospective cross-sectional study, we measured CS in 46 diabetic subjects with a mean age of 48±6 years, a best-co...

New technological progress in robotics has brought many beneficial clinical applications. Currently, computer integrated robotic surgery has gained clinical acceptance for several surgical procedures. Robotically assisted eye surgery is envisaged as a promising solution to overcome the shortcomings inherent to conventional surgical procedures as in...

Purpose: To examine the safety of a single intravitreal injection of autologous bone Marrow Mesenchymal stem cells (MSCs) in patients with advanced retinitis pigmentosa (RP). Methods: A prospective, phase I, nonrandomized, open-label study was conducted on 3 eyes of 3 volunteers with advanced RP. Visual acuity, slit-lamp examination, fundus examina...

Purpose: To develop clinical practice guidelines (CPGs) for prevention, diagnosis, treatment and follow-up of ocular injuries caused by exposure to mustard gas. Methods: The clinical questions were designed by the guideline team. Websites and databases including National Guidelines Clearinghouse, National Institute for Clinical Excellence, Cochrane...

Purpose: To customize clinical practice guidelines (CPGs) for management of diabetic retinopathy (DR) in the Iranian population. Methods: Three DR CPGs (The Royal College of Ophthalmologists 2013, American Academy of Ophthalmology [Preferred Practice Pattern 2012], and Australian Diabetes Society 2008) were selected from the literature using the AG...

This review article aimed to evaluate ocular biometric changes after trabeculectomy. The PubMed database was searched using the keywords “axial length” (AL), “anterior chamber depth” (ACD), “corneal astigmatism,” “corneal topography” and “trabeculectomy.” The extracted studies were categorized based on the evaluated parameters and the biometry meth...

Purpose: To determine inter-device agreement for central corneal thickness (CCT) measurement among ultrasound pachymetry, rotating Scheimpflug imaging (Pentacam, Oculus, Wetzlar, Germany), and scanning slit corneal topography (Orbscan II, Bausch & Lomb, Rochester, NY, USA) in highly myopic eyes before and after photorefractive keratectomy (PRK). Me...

Purpose: To compare corneal stromal and endothelial cells after photorefractive keratectomy with intraoperative mitomycin C in alcohol-assisted versus mechanical epithelial debridement using confocal microscopy. Methods: This prospective randomized comparative study was performed on 88 eyes (44 patients) with myopia up to -6.00 diopters. The right...

Purpose: To compare corneal stromal and endothelial cells after photorefractive keratectomy with intraoperative mitomycin C in tetracaine assisted versus mechanical epithelial debridement using confocal microscopy. Methods: This prospective randomized comparative study was performed on 88 eyes (44 patients) with myopia up to -6.00 diopters. The rig...

Purpose: To report changing trends in indications and techniques of corneal transplantation in Iran. Methods: We reviewed eye bank records of 47,129 patients who had undergone corneal transplantation between 2006 and 2013 at different eye centers throughout Iran. Results: The most common indication for corneal transplantation was keratoconus (...

Purpose: Determine the safe dose of intravitreal propranolol (IVP), and evaluate its inhibitory effect on laser-induced choroidal neovascularization (CNV). Methods: To determine the IVP safe dose, 32 rabbits were divided into 4 groups. Three of these groups received IVP (15 μL) corresponding to 15 μg (group B), 30 μg (group C), and 60 μg (group...

Purpose: To customize clinical practice guidelines (CPGs) for cataract management for Iranian population. Methods: First, four CPGs (American Academy 2006 and 2011, Royal College of Ophthalmologists 2010 and Canadian Ophthalmological Society evidence-based clinical practice guidelines 2008) were selected from a number of available CPGs for cataract...

Purpose: To compare corneal stromal and endothelial cells after photorefractive keratectomy with intraoperative mitomycin C in tetracaine assisted versus mechanical epithelial debridement using confocal microscopy. Setting: Imam Hossein Medical Center, Shahid Beheshti University Medical Sciences, Tehran, Iran. Methods: This prospective randomized c...

Purpose: To study Endothelial cell count after Artiflex Lens Implantation in patients with moderate to high myopia. Methods: In this prospective study 53 eyes from 53 patients undergoing Artiflex intraocular lens implantation for correction of myopia from -4.5 diopter to -14 diopter in Vanak Eye Clinic, Tehran, Iran from 2007 to 2014 were evaluated...

Purpose: A two-phase preclinical study was designed to determine the safe dose of intravitreal topotecan and its inhibitory effect on experimental choroidal neovascularization (CNV) in a rat model. Methods: In phase I, 42 rats were categorized into 6 groups, 5 of which received intravitreal topotecan injections of 0.125 μg, 0.25 μg, 0.5 μg, 0.75...

PURPOSE: To compare corneal stromal and endothelial cells after photorefractive keratectomy with intraoperative mitomycin C in alcohol-assisted versus mechanical epithelial debridement using confocal microscopy. METHODS: This prospective randomized comparative study was performed on 88 eyes (44 patients) with myopia up to -6.00 diopters. The right...

PURPOSE: To determine inter-device agreement for central corneal thickness (CCT) measurement among ultrasound pachymetry, rotating Scheimpflug imaging (Pentacam, Oculus, Wetzlar, Germany), and scanning slit corneal topography (Orbscan II, Bausch & Lomb, Rochester, NY, USA) in highly myopic eyes before and after photorefractive keratectomy (PRK). ME...

Purpose: To compare corneal stromal and endothelial cells after photorefractive keratectomy with intraoperative mitomycin C in alcohol-assisted versus mechanical epithelial debridement using confocal microscopy. Methods: This prospective randomized comparative study was performed on 88 eyes (44 patients) with myopia up to -6.00 diopters. The rig...

Objective/Purpose To compare the effects of alcohol-assisted versus mechanical epithelial debridement on corneal endothelial cells after photorefractive keratectomy using confocal microscopy. Materials/Patients This prospective randomized, clinical trial was performed on 88 eyes from 44 patients with the spherical equivalent refraction of <-6.00 d...

Purpose To determine inter-device agreement for central corneal thickness (CCT) measurement among ultrasound pachymetry, rotating Scheimpflug imaging (Pentacam, Oculus, Wetzlar, Germany), and scanning slit corneal topography (Orbscan II, Bausch & Lomb, Rochester, NY, USA) in highly myopic eyes before and after photorefractive keratectomy (PRK). M...

Purpose: To compare the effects of alcohol-assisted versus mechanical epithelial debridement on corneal endothelial cells after photorefractive keratectomy using confocal microscopy. Setting: Imam Hossein Medical Center, Tehran, Iran. Methods: This prospective randomized, clinical trial was performed on 88 eyes from 44 patients with the s...

Purpose: To compare visual outcomes and contrast sensitivity after wavefront-optimized or conventional photorefractive keratectomy (PRK) in myopic patients with or without astigmatism. Setting: Vanak Eye Surgery Center, Tehran, Iran. Methods: Patients with low to moderate myopia with or without astigmatism were allocated into 2 groups. Th...

Purpose: To assess the safety, efficacy and predictability of photorefractive keratectomy (PRK) [Tissue-saving (TS) versus Plano-scan (PS) ablation algorithms] of Technolas 217z excimer laser for correction of myopic astigmatism Methods: In this retrospective study one hundred and seventy eyes of 85 patients (107 eyes (62.9%) with PS and 63 eyes (3...

Photorefractive Keratectomy Purpose: To compare the effects of alcohol-assisted to mechanical epithelial debridement on corneal endothelium after photorefractive keratectomy.Methods: Mechanical and alcohol-assisted epithelial debridement were compared in 88 eyes from 44 patients with spherical equivalent refraction < -6.00 D. Results: Three months...

Purpose : To investigate long-term visual outcome and complications after cataract extraction and intraocular lens (IOL) implantation in Fuchs’ heterochromic iridocyclitis (FHI) Methods : In this retrospective study in a private eye clinic in Tehran, 25 eyes of 24 patients with FHI who underwent cataract extraction and IOL implantation were evaluat...

To compare visual outcomes and contrast sensitivity after wavefront-optimized or conventional photorefractive keratectomy (PRK) in myopic patients with or without astigmatism. Vanak Eye Surgery Center, Tehran, Iran. Comparative case series. Patients with low to moderate myopia with or without astigmatism were allocated into 2 groups. The study grou...

This paper presents an objective methodology for maintenance data analysis. The purposes of these analyses are to identify strengths and weaknesses in the maintenance management system, opportunities for improvements, and benchmark maintenance key elements against maintenance best practice. A wide range of reports can be provided from analysing the...

Maintenance data (i.e. work orders) for one fiscal year 2002/2003 in a large Alumina refinery is investigated in an attempt to established short, medium and long-term maintenance improvement strategies. Data set included more than 61,000 individual work orders with a total amount of actual cost recorded as high as $63m with more than 330,000 hours...