About
11
Publications
681
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214
Citations
Introduction
1. Autophagy and tumor immune microenvironment
2. Autophagy-based drugs development and immunotherapy
3. Parasitic diseases and host immuno-regulation
4. Infectious diseases and cancer development
Additional affiliations
October 2020 - August 2021
February 2013 - present
Academia Sinica
Position
- PostDoc Position
Education
June 2008 - January 2013
National Defense Medical Center
Field of study
- Life science
June 2006 - June 2008
Taipei Medical University
Field of study
- Biomedical Technology
June 2003 - June 2006
Taipei Medical University
Field of study
- Biomedical Technology
Publications
Publications (11)
Cancer is usually a result of abnormal glucose uptake and imbalanced nutrient metabolization. The dysregulation of glucose metabolism, which controls the processes of glycolysis, gives rise to various physiological defects. Autophagy is one of the metabolic-related cellular functions and involves not only energy regeneration but also tumorigenesis....
The relationship between macroautophagy/autophagy and miRNA in regulating cancer cell motility is not clearly delineated. Here, we found that induction of BECN1-dependent or -independent autophagy decreased ubiquitin-binding proteins SQSTM1/p62 and CALCOCO2/NDP52. Downregulation of SQSTM1 (but not CALCOCO2) led to a decrease of the miRNA-processing...
Autophagy, a crucial process in cancer, is closely intertwined with both tumor progression and drug resistance development. However, existing methods used to assess autophagy activity often pose invasiveness and time-related constraints, limiting their applicability in preclinical drug investigations. In this study, we developed a non-invasive auto...
Recombinant capsid protein VP1 (rVP1) of foot-and-mouth disease virus is a protein exhibiting potent cytotoxicity to a variety of cancer cells. We have recently found that rVP1 is capable of decreasing cancer cell motility but increasing macrophages motility. The underlying molecular mechanism for such paradoxical effects of rVP1 on cancer and immu...
Macrophage proliferation and migration are important for many facets of immune response. Here we showed that stimulation of macrophages with type B CpG oligodeoxynucleotides (CpG-B ODNs) such as CpG-ODN 1668 increased the production of anti-inflammatory cytokine interleukin 1 receptor antagonist (IL-1Ra) in a TLR9- and MyD88-dependent manner. The C...
The monocyte/macrophage is critical for regulating immune and antitumor responses. Recombinant capsid protein VP1 (rVP1) of foot-and-mouth disease virus induces apoptosis and inhibits migration/metastasis of cancer cells. Here, we explored the effects of rVP1 on macrophages. Our results showed that rVP1 increased LC3-related autophagosome formation...
Previously, we found that peptidoglycan (PGN), a cell wall component of the gram-positive bacterium Staphylococcus aureus, may activate the Ras/Raf-1/extracellular signal-regulated kinase (ERK) pathway, which in turn initiates IκB kinases α/β (IKKα/β) and nuclear factor-κB (NF-κB) activation, and ultimately induces cyclooxygenase-2 (COX-2) expressi...
In this study, we investigated the signaling pathway involved in IL-6 production caused by peptidoglycan (PGN), a cell wall component of the Gram-positive bacterium, Staphylococcus aureus, in RAW 264.7 macrophages. PGN caused concentration- and time-dependent increases in IL-6, PGE(2), and cAMP production. PGN-mediated IL-6 production was inhibited...
