Science topic

Physiology - Science topic

Physiology is the science of the function of living systems. This includes how organisms, organ systems, organs, cells, and bio-molecules carry out the chemical or physical functions that exist in a living system.
Questions related to Physiology
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Do you and your team have interesting results to share Linking Avian Physiology to Welfare? Would you like to submit them to a Research Topic in Frontiers in Physiology, Section Avian Physiology? If both answers are "YES", follow the link: https://www.frontiersin.org/research-topics/41580/linking-avian-physiology-to-welfare#overview Short description: Avian physiology and avian welfare are unequivocally linked. One of the seminal definitions of animal welfare indicates it is the "state of an animal as regards its attempts to cope with its environment". Developed as a hybrid scientific discipline, animal welfare has inspired part of its bases in physiology. In this sense, birds' abilities to cope with their environment have underlying physiological limits, as well as dynamical transition states which must be revealed and understood. Various environmental factors are known to challenge avian homeostasis (or rather, homeodynamics). Consequently, a series of physiological components and/or systems are activated to process the stimuli and coordinate the proper response, which may often involve behavioral aspects as well. This would lead to increased energy expenditure and the potential occurrence of various trade-offs aimed at coping. The mentioned environmental factors, i.e. stressors, challenge the avian' much-needed internal balance and may cause their attempts to cope with their environment to fail, directly impairing avian welfare.
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Yes Avian Physiology is provides interface for conducting research on wild species of birds, safeguard the birds at the verge of extinction, provide opportunity to study proteonomics,genomics genomics genomics
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For instance what roles does emergence play in inorganic chemistry, in the earth sciences, in organic chemistry, the molecular biology of the cell, physiology, psychology, sociology, in ecology, economics, or in astrophysics?
I am studying the development of emergence up through the levels of the hierarchic organization of material reality, from elementary particles to the emergence of galactic clusters.
Another goal is to reveal the isomorphic aspects of the stages of emergence as they occur throughout that development.
I am interested in the following:
1. What are the initial components of the process of emergence in cases of emergence in your field of research?
2. What are the major stages of the process of emergence in those cases?
3. How does the list of components change with the changing stages of your processes of emergence?
4. What then are the components that constitute the final emergent product, whether it be a quality, an object, or a pattern-of-organization of material structure or process?
An Emergence Primer
Ø In its simplest form, emergence is the coming into existence of newly occurring patterns-of-organization of material structure and process due to the motion of units of matter.
Ø Emergence is a creative process, and is the source of the organized complexity of the material universe.
Ø There are two basic stages of emergence—first there is the process of emergence, and second there is the event of emergence that occurs as the consequence of the prior process.
Ø Emergence develops. It occurs in simple forms in simple situations in which few other factors are playing roles, and in progressively more complex forms in progressively more complex situations where increasing numbers of other factors are playing roles.
Ø Emergence is isomorphic because the simplest form of emergence also occurs within the core of all developed forms, giving them their intrinsic-identity as cases of emergence. An isomorphy is a pattern-of-material-organization that occurs in two to many different situations or systems. What is known about an isomorphy and the role it plays in one situation can be used to enhance the understanding of a different situation in which that isomorphy also occurs and plays a role. Thus what is known about emergence and its role in one situation can be used to enhance the understanding of a different situation where emergence also occurs and plays a role.
The Intrinsic Nature of Emergence—With Illustrations.
Vesterby, Vincent. 2011. The Intrinsic Nature of Emergence—With Illustrations. Proceedings of the 55th Annual Meeting of the ISSS, Hull, U.K.
Emergence Is an Isomorphy
Vesterby, Vincent. 2017. Emergence Is an Isomorphy.
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Emergence has become the front and center of my research in the couple of last years. To be capable to understand its working in depth, I had developed several open-source Python programs (ranging from the simplest one to the most advanced one) that enables everyone first to understand the cellular automata programming, and later apply them to studies of emergence that is occurring in so-called 'Game of Life'.
Quite a few videos depicting animated emergent structures are accessible in my profile at sections about data and software: e.g., logic-gates AND, OR, NOT, and quite a few emergent structures emerging in generalized neighborhoods of the original GoL. The latest paper is describing another interesting area, the design of error-resilient emergents, which can withstand the of 1% of errors into their evaluation process.
With respect to the questions provided in this answer. I highly recommend watching said videos and even run the open-source GoL-N24 Python software and try to play with emergence on your own. The personal experience with those simulations is always the best way to start to understand that we do not understand the theory of emergence!
Everyone is welcomed to play with emergence. One thing is sure, there are hiding huge treasures both experimental and theoretical in such 'playing' with the concept of emergence. Hopefully, this year will be published a paper that is going to address, at least, some root questions about emergence and its very principles (stay tuned).
References:
There are all three logic-gates avaiable
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There are many biomarkers such as TNf-Alpha, CRP, and IL-1, but I'm looking for some novel biomarkers to measure.
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Dear respected Hamidreza Khalounejad,
Perhaps you could consider the high-density lipoprotein cholesterol ratio (MHR) as a NAFLD novel inflammatory biomarker.
Best wishes from Germany,
Martin
Zhao Y, Xia J, He H, Liang S, Zhang H, Gan W. Diagnostic performance of novel inflammatory biomarkers based on ratios of laboratory indicators for nonalcoholic fatty liver disease. Front Endocrinol (Lausanne). 2022;13:981196. https://doi.org/10.3389/fendo.2022.981196
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How can crop rotations be used to improve soil health and fertility, reduce pest and disease pressure, and increase yields?
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There are different types of crop rotations, and the specific sequence of crops will depend on factors such as soil type, climate, and farming goals. However, a common rotation might involve planting a nitrogen-fixing legume crop, followed by a cereal crop, and then a vegetable crop. The legume crop helps to replenish nitrogen in the soil, the cereal crop can benefit from the nitrogen and also help break up soil compaction, and the vegetable crop can benefit from the improved soil structure and reduced pest and disease pressure.
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Why and how is this kind of long-term potentiation (LTP) possible?
Is LTP even needed for all sorts of synaptic plasticity and long-term memory formation?
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Longer version:
Long-term potentiation (LTP which is necessary for synaptic plasticity and long-term memory formation) needs repeats and reinforcement of the engrams to be triggered.
However, apparently everybody automatically "absorbs" a lot of information immediately and also permanently, even without needing any extra effort (at least any conscious effort), which seems to be needed for LTP to happen. Everyone seems to have this ability, although it is even stronger in those with better memories.
People simply "learn" many things once; and many of those learned items remain there for a pretty long duration, and in many cases even for the rest of their lives. This seems to happen without any repeats, at least without any apparent or conscious efforts to remember or re-remember those memories. This is the case for a lot of semantic information (especially the information of interest or importance to the person) as well as a large portion of the contents of episodic memory.
Why and how is this kind of LTP possible?
Perhaps attention plays a major role here, e.g., being interesting and important automatically triggers LTP without a further need for repeats.
But such effortless long-term memorization happens also in the case of a lot of semantic information or autobiographical events that are not inherently interesting or significant to the person.
Is LTP even needed for all sorts of synaptic plasticity and long-term memory formation?
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Jerry Waese thanks a lot for your nice software and the image. I will try to play with it and understand what is what.
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What is this curious non-updatable mega memory? Does it have any scientific terms?
What are its causes and mechanisms?
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Explanation:
I have had the honor of witnessing very rare people who have some strange forms of mega memory: They effortlessly, automatically, and immediately memorize many difficult things such as phone numbers or their difficult and comprehensive books, etc. And they retain those easily captured memories for a very very long time (a couple of decades at least), without any smallest effort or reinforcement. Not to mention that they record or remember almost everything else (semantic or episodic) quite easily, and also with a lot of details. Furthermore, they are very very accurate in recalling those items. For example, they can serve as pretty reliable living phone books; or for example, they are extremely awesome at medicine, etc.
But when I am talking about "strange", I don't mean their super-human ability to easily capture such vast amounts of information for such long durations and recall them accurately.
Their super-human ability is of course strange. But the even stranger part of their memory is that once it is captured, it cannot be updated or revised easily. For example, if they misunderstand something the first time, it will take perhaps 10 or 20 attempts over days or weeks for their colleagues to remind them of the mistake and ask them to correct their misunderstanding.
It is like that once their memory is formed the very first time, it is set in stone. It is absorbed very efficiently and strongly, and at the same time, not much prone to future updates.
What is this curious non-updatable mega memory? Does it have any scientific terms?
What are its causes and mechanisms?
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Jerry Waese to Larry Carlson:
Larry Carlson memory content can be stronger in so many ways but the memory engram is never any stronger than any other memory engram except in terms of accessibility of it.
i.e. how many different things lead to the reflex activation of the engram.
Greater access is afforded by the extent of interconnection with other engram patterns, while greater clarity is afforded by the extent of difference or uniqueness to other engrams.
I may have 500 "master engrams" that are instrumental in my most salient reflexes as I sit before the laptop screen in my bath. AND I may have 500 similarly instrumental salient reflex perturbing engrams that govern driving while seated in my car.
In the first case, what I am typing may have or may not have any effect on where I go, or what others think. In the second case my own life and others lives depend on what those reflexes do while driving.
The many conditions that lead to me hitting the brakes make that set of braking engrams (maybe 20/500 "master braking engrams" (i.e. administrative controlling engrams that cascade into multiple body articulation and movement engrams)) more accessible than the left turn engrams (maybe 100/500 deal with left turn considerations)
Fortunately I spend more time typing (not always in the bath) than driving.
The relation to intelligence and thermodynamics is a different story, but if we make it the same story it probably will not matter if I get clean (in the bath), communicate well (at RG) or drive into a wall.
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Please spread the word: Folding at Home (https://foldingathome.org/) is an extremely powerful supercomputer composed of thousands of home computers around the world. It tries to simulate protein folding to Fight diseases. We can increase its power even further by simply running its small program on our computers and donating the spare (already unused and wasted) capacity of our computers to their supercomputation.
After all, a great part of our work (which is surfing the web, writing texts and stuff, communicating, etc.) never needs more than a tiny percent of the huge capacity of our modern CPUs and GPUs. So it would be very helpful if we could donate the rest of their capacity [that is currently going to waste] to such "distributed supercomputer" projects and help find cures for diseases.
The program runs at a very low priority in the background and uses some of the capacity of our computers. By default, it is set to use the least amount of EXCESS (already wasted) computational power. It is very easy to use. But if someone is interested in tweaking it, it can be configured too via both simple and advanced modes. For example, the program can be set to run only when the computer is idle (as the default mode) or even while working. It can be configured to work intensively or very mildly (as the default mode). The CPU or GPU can each be disabled or set to work only when the operating system is idle, independent of the other.
Please spread the word; for example, start by sharing this very post with your contacts.
Also give them feedback and suggestions to improve their software. Or directly contribute to their project.
Folding at Home's Forum: https://foldingforum.org/index.php
Folding at Home's GitHub: https://github.com/FoldingAtHome
Additionally, see other distributed supercomputers used for fighting disease:
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Vahid Rakhshan I will definitely spread the word about this amazing initiative. It's great to know that we can contribute to such a noble cause by simply utilizing our excess computer power. Thank you for bringing this opportunity to my attention. Let's join hands in making a difference in the fight against diseases.
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In most contexts, the terms alternative medicine, complementary medicine, integrative medicine, holistic medicine, natural medicine, and unconventional medicine are almost synonymous.
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Yes. Naturopathy and phytopharmacology, for example, make great sense, especially as balancing treatments and therapies.
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I have some complex physiological data that varies quite a bit across participants. Best way to capture this variability? For more background...participants were exposed to different kinds of prejudice and some participants varied as to what type they responded more to. Any thoughts would be helpful.
Thanks!
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' Partial' correlation istead of correlation controls the confounding effect due to the variabe exposure of prejudices.
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i am a medical student, however i would like to learn molecular biology to the extent that makes me comfortable with putting a hypothesis, a theory or possible treatment and testing this with the help of a specialized research team and as such, i want to reach to the point where i fully understand modern molecular biology and specially the LAB TECHNIQUES. What is the process that i should follow in order to achieve this.
keeping in mind that i have near full access to springerlink, RSC and online wiley libraries
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I suggest you to start with the books "Molecular Biology of the Cell" by Bruce Alberts and "Molecular cloning: A laboratory manual" by Tom Maniatis. The first is an easy read which will help you to gain overall understanding of molecular biological processes and the second will provide a detailed knowledge regarding lab techniques used in this field.
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I've been talking to the girl from my group about intimate relationships and social interactions and she said that she has troubles with it. What surprised me the most is her reasoning - she said that after getting close with someone she might feel sick, get a headache, start crying or shaking, and that it makes her keep the distance. All my life I only considered rejection of others and repulsion to other people as a social phenomenon and her story opened my eyes. So I want to ask if there are any studies on such physiological reaction to intimacy and interactions with others. Can anyone recommend me some?
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This reaction may be due to an previous such relationship with no bad experiment..make her afraid from repeated scenario..so as a defense mechanism generated in brain and expressed as behavior..from moral to real proceed. Like the shivering and sickness..brain can make the body as what he want in real.
Moreover, the stress initiated by fairness lead to dangerous declining in immunological marker that make the body susceptible to diseases.
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Kindly, explain your answer. Thanks in advance.
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I agree with my colleaques answer espically focus dysfunction of parathyroid gland and level of excreated calcium
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Activation of naive T cells generally requires antigen to be presented by dendritic cells in lymph nodes. Activation of naive B cells generally requires opsonized antigen to be displayed by follicular dendritic cells in lymph nodes.
Thus, it seems that dendritic cells and complement (innate immune system) need to recognize a pathogen before an adaptive immune response can be initiated. Is this always the case?
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B1 b cells can respond to pathogens present in body cavity fluids indepenantt of t cells or innate immune cells. They make low affinity igm and have no memory. So yes.
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I would like to acquire a wereable metabolic system to use with a MoCap system in sports studies (jumping, running in a treadmill) and in human movment analysis studies (gait in a walkway, stairs...)
What is your experience and the best option with the next equipments? What is the advantage/disadvantage of each one?
-Cosmed K4b2
-Cosmed K5
-Cortex Metamax 3B
-Other system?
Thanks,
Best,
Jose Heredia-Jimenez
University of Granada. Spain
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Hola , dónde me podrían orientar sobre la página para comprar , para comprar un Cosmed k4 o k5
Saludos
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During exercise shear stress is increased. The mode and duration of exercise also has an effect over shear stress. Pathological high shear stress (>10,000 s-1) and low shear rate (<1,000 s-1) are two sides that I wish to measure.
I will be using volunteers, who will be exercising, and I am interested how can I measure shear stress during the exercise as well as before and after.
All help is welcomed, thank you
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Thank you either way!
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Please help to circulate this questionnaire, which is part of a big international study (you can find below the questionnaire in different languages):
The project has the collaboration of researchers (including sport scientists) from 6 continents.
Globally, the coronavirus (COVID-19) pandemic has transformed people’s day-to-day life. The world’s sporting calendar, recreational and professional, is almost unrecognisable. Athletes have seen access to training facilities and/or the ability to even leave their homes (i.e., to run, cycle) severely restricted, if not removed entirely. This questionnaire will investigate how the lockdown is affecting (or has affected) athletes’ lifestyle (including nutritional, psychological and sleep aspects) and how athletes are responding (have responded) to the pandemic.
Why participate in this project? Project outcomes will be used for research purposes and to inform current/future guidelines for athletes, coaches, sports scientists and (potentially) policymakers. It will reveal what has happened globally, across every inhabited continent, during the pandemic relative to athletes and their training practices. Your participation will contribute to improving the current and future lifestyle of athletes.
Target population: Elite or sub-elite athletes (amateur or professional from both genders, including Para athletes) from any country that is experiencing, or has experienced, a lockdown during the COVID-19 pandemic.
Privacy, confidentiality, and Data security : All responses will be de-identified and processed anonymously (you will not be asked to provide us with your name, ensuring total anonymity). No other identifying information, including IP address will be recorded. At the end of the study, the data will be destroyed in compliance with international regulations. Precautions will be taken to control access to all data. Only authorized individuals (principal investigators) will have access to the dataset. We’re minimizing the risk of breach of confidentiality by collecting and storing the data anonymously, and by saving data with password protection. This international survey has been approved by the Ethics Committee of Imam Khomeini International University.
Results : The results of this project will be used for scientific publications where it will not possible to identify any of the participants. To inquire about the results of the survey, please email the principal investigator. For any inquiries, please feel free to contact the principal investigator: Morteza Taheri E-mail: m.taheri@soc.ikiu.ac.ir
English
Arabic
Persian:
Turkish:
Portuguees
Germany
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Hello dear colleague.
A very interesting study. I can join.
I have experience in questioning student-athletes.
As well as the correction of their nutrition in order to increase immunity and endurance.
I would be happy to work together.
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I have just recently started a new "weekend project" in addition to my master's studies and I am looking for a data-set. I would like to use some Operations Research to design an optimal gym schedule that conforms to a specific set of constraints.
The idea is to create a daily gym schedule that conforms to a set of constraints (e.g. time, target muscles etc) as well as a set of physiological constraints. The physiological constraints are things such as do not exercise muscle-x and muscle-y together or do not do abdominal exercises for two consecutive days etc.
However the problem I face is data, specifically a data-set (or data-sets).
Are there any open-source datasets which list an exercise, as well as all the muscles targeted? Preferably one that lists as much of the physiological data as possible. E.g. which stabilizers are activated, which secondary muscle is also activated, is it an extension or flexion. I am also looking for datasets which could help me with some of the physiological constraints, such as muscle recovery times, which muscles not to exercise together etc?
My goal is to algorithmically capture an OR model which I can provide with input data such as muscle group target and time and the model must output a schedule of exercises which targets all the muscles in that muscle group, is not physiologically harmful and is within the time constraint.
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I don't have a specific data set or study in mind, but the US Army should have some data sets from recent studies. They recently transitioned to a new physical fitness plan developed with the physiological aspects of job performance in different areas, instead of a generalized physical fitness plan for all soldiers. Also, it should be fairly varied with categories ranging from 18 to 40 years old, various Heights, body fat content, sex, ethnicity, and race. Not to mention most soldiers are in good physical condition, healthy with proper nutrition and hydration.
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Hi, I am wondering if anyone could provide or recommend a protocol about the isolation of stellate ganglion from adult mice? Thank you!
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Hi Tianyi,
Below is a illustrated procedure for the dissection.
best wishes,
Refik
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Does creatine supplementation increase insulin sensitivity?
What is your opinion?
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Evidence:
"Acute Cr supplementation (20 g.d(-1) for 5 d) followed by short-term Cr supplementation (3 g.d(-1) for 28 d) did not alter insulin action in healthy, active untrained men"
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Hi, I would like to find a good anterograde tracer. Which is better, BDA or Fluoro-Ruby? Thanks a lot in advance!
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يمكن مراجعة المختصين
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Asthma is a chronic, obstructive disease;
In asthma we have hypersecretion of mucos ;the main component of mucos is mucin ; the main airway mucins are muc 5ac and muc 5b that are released from goblet cell and submucosal glands ,respectively.
Asthma characterized by some changes, like: thickening of the lamina reticularis, epithelial shedding, subepithelial fibrosis, inflammatory cell infiltration, goblet cell hyperplasia, myofibroblast proliferation, smooth muscle hyperplasia and hypertrophy, and neovascularization of the airway wall
According to the findings ; increased amount of the muc5ac and decreased amount of muc5b is observed.
Goblet cell hyperplasia can cause more expression of muc5 ac but there is no evidence for the reason of decreased amounts of muc5b .I'm looking toward this decreasing reasons.
I will be thankful if you share your ideas with me .
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يمكنك مراجعة اهل الاختصاص
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Expanded Disability Status Scale (EDSS) is a method of quantifying disability in multiple sclerosis that is the most widely used measurement tool to describe disease progression in patients with MS.
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Resistant exercises can tire MS disease quickly. This is an undesirable situation in patients with MS.
I recommend more ROM exercises and short-term isometric exercises.
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What types of exercise and training variables (volume, intensity, repetitions, frequency, exercise selection, exercise order, and rest) are recommended for patients with Multiple sclerosis (MS)?
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The best MS exercises are aerobic exercises, stretching, and progressive strength training. Aerobic exercise is any activity that increases your heart rate, like walking, jogging, or swimming. You just don't want to overdo it—it should be done at a moderate level. https://www.pennmedicine.org/updates/blogs/neuroscience-blog/2017/may/multiple-sclerosis-and-exercise
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For a depot injection designed for absorption by macrophage action, which injection route would be optimal to have most drug introduced into the lung by the lymph vessel?
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Dear Dr Min Gui Jang . See the following useful RG link:
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In my personal experience I have find the higher rate of sprouting when fresh cow dung is applied on the top side of cutting what might be its reason.
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I need to preserve termite samples for future quantification of juvenile hormone in their bodies. Or extract the Juvenile Hormone and keep that samples stored for future quantification.
I may need to keep the samples stored for up to two months and they also need to "survive" an international trip.
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Follow the procedure given by Brent & Dolezal, 2009
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It is difficult to use standard imprints method.
Can anybody help? Thank you.
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Heart Rate Variability is a well known and useful concept in Biomedical Engineering and Medical Sciences. Breath Rate is a lesser researched field and a newer measure Breath-Rate Variability is introduced recently to quantify meditation effect.
It is gaining attention of researchers as BRV has a number of novel applications. What could they be.
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Breath rate variability (BRV) as an alternate measure of meditation even over a short duration is proposed. The main objective of this study is to test the hypothesis that BRV is a simple measure that differentiates between meditators and nonmeditators.
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HI All,
I'm doing a survey as part of an Audacious program (https://www.startupdunedin.nz/audacious), which essentially is a StartUp initiative at Otago University. I'm curious to understand what level of programming do biologists these days need during their day to day research.
For all the biologists out there here are some questions to start the discussion on this topic:
1) Have you done any programming till date? If so which language did you use and for what purpose?
2) How have to overcome programming limitations? For example, did you get the work done through bioinformaticians, or sought help from your programming friend, etc?
3) Have you used online biological databases for your research? If so, which one?
4) How much of artificial intelligence have you used in your research? Do you see AI potential in your current work?
If you have anything else to add, please feel free.
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Please have look on our(Eminent Biosciences (EMBS)) collaborations.. and let me know if interested to associate with us
Our recent publications In collaborations with industries and academia in India and world wide.
Our Lab EMBS's Publication In collaboration with Universidad Tecnológica Metropolitana, Santiago, Chile. Publication Link: https://pubmed.ncbi.nlm.nih.gov/33397265/
Our Lab EMBS's Publication In collaboration with Moscow State University , Russia. Publication Link: https://pubmed.ncbi.nlm.nih.gov/32967475/
Our Lab EMBS's Publication In collaboration with Icahn Institute of Genomics and Multiscale Biology,, Mount Sinai Health System, Manhattan, NY, USA. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/29199918
Our Lab EMBS's Publication In collaboration with University of Missouri, St. Louis, MO, USA. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30457050
Our Lab EMBS's Publication In collaboration with Virginia Commonwealth University, Richmond, Virginia, USA. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27852211
Our Lab EMBS's Publication In collaboration with ICMR- NIN(National Institute of Nutrition), Hyderabad Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/23030611
Our Lab EMBS's Publication In collaboration with University of Minnesota Duluth, Duluth MN 55811 USA. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27852211
Our Lab EMBS's Publication In collaboration with University of Yaounde I, PO Box 812, Yaoundé, Cameroon. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30950335
Our Lab EMBS's Publication In collaboration with Federal University of Paraíba, João Pessoa, PB, Brazil. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30693065
Our Lab EMBS's Publication In collaboration with collaboration with University of Yaoundé I, Yaoundé, Cameroon. Publication Link: https://pubmed.ncbi.nlm.nih.gov/31210847/
Our Lab EMBS's Publication In collaboration with University of the Basque Country UPV/EHU, 48080, Leioa, Spain. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27852204
Our Lab EMBS's Publication In collaboration with King Saud University, Riyadh, Saudi Arabia. Publication Link: http://www.eurekaselect.com/135585
Our Lab EMBS's Publication In collaboration with NIPER , Hyderabad, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/29053759
Our Lab EMBS's Publication In collaboration with Alagappa University, Tamil Nadu, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30950335
Our Lab EMBS's Publication In collaboration with Jawaharlal Nehru Technological University, Hyderabad , India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/28472910
Our Lab EMBS's Publication In collaboration with C.S.I.R – CRISAT, Karaikudi, Tamil Nadu, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30237676
Our Lab EMBS's Publication In collaboration with Karpagam academy of higher education, Eachinary, Coimbatore , Tamil Nadu, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30237672
Our Lab EMBS's Publication In collaboration with Ballets Olaeta Kalea, 4, 48014 Bilbao, Bizkaia, Spain. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/29199918
Our Lab EMBS's Publication In collaboration with Hospital for Genetic Diseases, Osmania University, Hyderabad - 500 016, Telangana, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/28472910
Our Lab EMBS's Publication In collaboration with School of Ocean Science and Technology, Kerala University of Fisheries and Ocean Studies, Panangad-682 506, Cochin, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27964704
Our Lab EMBS's Publication In collaboration with CODEWEL Nireekshana-ACET, Hyderabad, Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/26770024
Our Lab EMBS's Publication In collaboration with Bharathiyar University, Coimbatore-641046, Tamilnadu, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27919211
Our Lab EMBS's Publication In collaboration with LPU University, Phagwara, Punjab, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/31030499
Our Lab EMBS's Publication In collaboration with Department of Bioinformatics, Kerala University, Kerala. Publication Link: http://www.eurekaselect.com/135585
Our Lab EMBS's Publication In collaboration with Gandhi Medical College and Osmania Medical College, Hyderabad 500 038, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27450915
Our Lab EMBS's Publication In collaboration with National College (Affiliated to Bharathidasan University), Tiruchirapalli, 620 001 Tamil Nadu, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27266485
Our Lab EMBS's Publication In collaboration with University of Calicut - 673635, Kerala, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/23030611
Our Lab EMBS's Publication In collaboration with NIPER, Hyderabad, India. ) Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/29053759
Our Lab EMBS's Publication In collaboration with King George's Medical University, (Erstwhile C.S.M. Medical University), Lucknow-226 003, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/25579575
Our Lab EMBS's Publication In collaboration with School of Chemical & Biotechnology, SASTRA University, Thanjavur, India Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/25579569
Our Lab EMBS's Publication In collaboration with Safi center for scientific research, Malappuram, Kerala, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30237672
Our Lab EMBS's Publication In collaboration with Dept of Genetics, Osmania University, Hyderabad Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/25248957
Our Lab EMBS's Publication In collaboration with Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Hyderabad Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/26229292
Sincerely,
Dr. Anuraj Nayarisseri
Principal Scientist & Director,
Eminent Biosciences.
Mob :+91 97522 95342
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In some cases you see structurally similar ligands work as agonists/antagonists for the same receptors, but it's not always the case. Do receptors allow molecules to bind because of their shape/structure or is it independent from ligand to ligand?
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I will try to explain. A receptor might or not allow the binding of a ligand, but maybe this binding depends on circumstances, like feedback regulation, inhibition or changes in structure. this change in structure permits the ligand to bind to the receptor. This working systems means when the ligand is present, the recpetor has changed shape, and is why the ligand sticks to it. Of course, it might depend on the regulation system, and not all receptors chose the same system. The energy demands is an important factor. Maybe it is not necesary. Sometimes it works constitutively.
For example, drugs. Drugs are substances which imitate molecular shapes to which the normal ligand will bind to. This means as it is similar it will confuse the receptor and take it as its normal ligand. The effects of the drug are as it is.
The enzyme or the receptor, might have several forms of regulation, the turning off of a receptor, might mean the turning on of another receptor or the turning on of the molecule. I will try to stick to receptors. Maybe you are describing allosteric regulation, but you are right when you say recpetors could be enzymes. The mechanism of action could be similar to MM, Michaelis Menten.
Maybe a receptor will change shape. But this does not mean the recpetor has to change shape for the same ligand. It might be by the regulation or the circumstance. The ligand is still the same.
For example, insulin, has to go through several activation stages, before it is activated. The hornone insulin is activated by enzymes. In this case, I am trying to say the ligand is inactivated.
The sodium potassium channel translocates, but only when the ions are present. Aquaporins need to be activated for it to allow the passage of water.
unless you mean why every movement is done by a receptor, this means, it may just diffuse through the membrane
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Any explanation is appreciated!
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Your welcome Keyvan Sobhani.
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Higher affinity for CO induce suffocation which may be fatal.
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In agreement with Pranita Kamble Waghmare, the Oxygen axis after oxygen binding with heme is at an angle while Carbon monoxide binds to free heme with the CO axis perpendicular to the plane of the porphyrin ring via carbon-Iron bonding. So, the two oxygen atoms in oxygen exhibit steric hindrances on each other. In which case, CO doesn't experience the same.
This perpendicular orientation is favorable for Hb binding.
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Dear researchers,
I hope you and everyone in your circle are doing well and healthy.
I’m going to work on some factors that affect on differentiation of cardiac progenitor cells to cardiomyocytes.
I’ve collected stem cells from mice and now I require the best and cheapest protocol for their differentiating to cardiomyocytes. As I am an amateur in this field of research, I hope you can suggest a useful protocol.
Thanks all.
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Dear Soudabeh,
In this article (attached), there are several protocols treating your topic. I hope it will help you.
Best wishes
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I know that an infant's brain can repair itself when damaged but why doesn't the same happen in adults after stroke or brain injuries?
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With Regenerative Medicine, using stem cells, the ongoing Programs are doing it, with good results and promising expectations.
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Hello, I am looking for a good (affordable with scientific evidence) device to measure heart rate variability (HRV) by Electrocardiograph (ECG) or Photoplethysmography (PPG), and I will use it to compare a new smartphone-based HRV measuring App. May I have some recommendations?
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Dear Qi,
I recently saw a review, which might be interesting for you. They have campared 32 devices, which are able to measure HRV.
Good luck,
Milad
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The yield of plants is found to be increased with the conservation of perennial to annual plants what are the processes, advantages, and disadvantages?
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Firstly, it is next to impossible to make perennial plants behave like annual plants.....secondly , if at all you try , it won't be a sustainable exercise. Bonsai you can try....like perennial ornamental plants into annual plants...But , i doubt for fruit crops...
Good question, out of box thinking....
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As my experience and many consumer experience they feel the different taste of the same item served cooked in a different source, is it real or not, what is the reason behind this.
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thank you a lot dear professor Dariusz Prokopowicz, Mirosław Grzesik for your wonderful answer and suggestion.
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kindly provide list of physiology/ yoga journals with no publication charges indexed in pubmed/scopus/WOS/DOAJ.
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leaf low quality is inherent to the tropical grasses ?
as physiology and physicochemical features could justify this?
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In deed, leaf of grasses have less energy concentration, both in tropical and temperate places if you compare with legumes.
Regards
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The apple fruits bought from the market after a few days in the refrigerator changed their skin color from red to almost brown, while the fruit was healthy and no signs of a pathogen were seen, and it turns out that these changes are physiological. Who knows what is the cause of this skin color change?
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I thank it because storage at low temperature, which led to chilling injury and increases in PPO activity
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Are functional maps in the cortex used by the brain to carry out computations or are they just a byproduct of wiring minimization?
A key element to answer this question is to know if, when neurons from a cortical map project their axons to the dendrite of a downstream neuron, they retain any spatial order proportional to their location in the map.
For example, in the cartoon below, the four neurons from a cortical map (in black) project their axons to a downstream neuron's dendrite (in green). The relative spatial position of the synapses (black circles) is proportional to the relative position of the neuron in the map.
I would be very grateful if you could point me to any relevant paper addressing this question, in particular in the cortex of the primate (e.g. axon tracing experiments).
Thanks!
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Neocortex pyramidal cells are the same with this polarized distribution. You can find Min Wang’s HCN paper in Monkey. Hippocampus circuit could be very clear nowadays. Non-pyramidal cell usually do not have this polarized HCN, but they could have polarized distribution of synaptic AMPA/NMDA/GABA receptor, like I mention in one paper previously. You can check neuron morphology, active properties of the membrane and synaptic mechanisms in your case to evaluate the total computation function.
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Are there distinct or unique physiological responses to humorous stimuli? Of special interest is political humor such as in editorial/political cartoons. Such political humor also has been posited as generating anger responses so a second question would be if there are differences in humor and anger responses that can clearly identify the source of the humor/anger response.
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Lee: Check out this PowerPoint about Laughter and Smiling:
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Many people believe that some stretching sports with vertical jump such as basketball and volleyball can increase the body height. On the other hand, others do not agree with this argument.
The problem is that there are many scientific websites that have explained and discussed this issue but as I see, both of them don't refer to any scientific article with specific statistical experiments.
I just found this article that has not a regular scientific content.
I am pleased to answer this question with a scientific article.
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I do not think that
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What do you think about the balance between exploring widely different designs vs. local optimization at different levels of biology (genomics, transcriptomics, proteomics, anatomy, etc.)? Which levels are more or less modular or plastic?
In the endocrine system, for example, one feels that having tropic hormones (i.e., those controlling the release of other signaling hormones at other glands) may offer a finer and perhaps more robust regulation, compared to a being where all hormones were non-tropic. However, the anatomic location of elements in these networks is not trivial. For example, in the renin-angiotensin-aldosterone system, renin is produced in the kidney, and aldosterone eventually exerts its effects in the kidney as well. However, the intermediate step by angiotensin-converting enzyme (ACE) mainly occurs in the lungs, which could introduce a delay in the regulation.
Do we have good explanations for the sites of production and action of different hormones in the body? Are there common principles to be learned as optimized by evolution in this respect? Or are happenstances/contingent evolution stronger determinants?
Thank you for sharing your thoughts!
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What is the in vivo dose and duration of administration of diazoxide for neurodegenerative disease models in rats? Are there studies in which hyperglycemia, pancreatic toxicity, diabetic neuropathy have been observed in animals after the application?
thanks.
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I fallowing
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What would land a neuroscience paper in Nature Neuroscience? What is the minimum a paper should have to pass the editorial scrutiny in Nature Neuroscience or the journals around the same cadre? May be a list of things and at the same time explanation of each point would work.
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Hi there,
Basically you need an important topic (most of the articles in Nat.Neurosci. are disease-related) and various, extremely good methods (often collaboration with specialized labs for EM, imaging, electrophysiology, ...).
Moreover, you should be working in a renowned lab, since the reputation of your PI will greatly influence if your paper has a chance to be accepted.
Also, you should think, how the journal would benefit from your paper:
For example, the neurocience community can greatly benefit from a ressource such as a proteomic or transcriptomic database, and such a paper would get a large number of citations, which is also beneficial of the journal.
Eventually, you will still need a good amount of luck to get accepted. ;-)
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Do you think the plant can communicate with each other, what is the level of feeling in plants?
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The study reveals that plants communicate to each other through their roots.
Thanks!
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Hello there
As we know researches are being rapidly evolved in most majors. I would like to know where animal reproduction physiology researches will go to in future. where do animal reproduction physiologist see themselves in 5 to 10 years later?
In my opinion, it is vital for researchers in this field to find out which aspects of their major define future studies and accordingly researchers should empower their knowledge in growing areas.
It is my pleasure to know your idea about the future of animal reproduction physiology researches and related areas.
I would appreciate if any related papers, sites and other stuffs be suggested.
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Increased research pertaning to infertility, it physiological and pathological causes as prevelence of infertility in animals is presenting increased trend with time. Similarly, retention of placenta and increase in dystocia, it is all related to chane in physiology.
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Why some basidiomycete cultures died quickly when stored at 5C on plate or slopes?
and is there any method to return them back to life ? specially if the culture produce anamorphic stage ?
and what is the best preservation methods, also some died when stored at -80C in 10% glycerol after few months!!
Thanks in advance.
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You can use 50% glycerol in medium and cool gradually maybe 1 degree per minute this may help in long-term preservation or else you can transfer the growth in sterile water and store at 15-20 degree centigrade it will survive for more than a year.
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We are looking to stain zebrafish cells with BrdU. What are the Pros and Cons of the Intraperitoneal method vs adding the stain to the environment? 
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A study by Peeters et al. (2017) suggests that sugar traps cancer in a 'vicious cycle' which make it more aggressive and harder to treat (1). On the question-and-answer site Quora, Ray Schilling, MD, concludes: "there is a connection between the consumption of sugar and starchy foods and various cancers in man. Animal experiments are useful in suggesting these connections, but many clinical trials including the Women’s Health Initiative have shown that these findings are also true in humans. It is insulin resistance due to sugar and starch overconsumption that is causing cancer" (2).
References
1. Peeters K, Van Leemputte F, Fischer B, Bonini BM, Quezada H, Tsytlonok M, Haesen D, Vanthienen W, Bernardes N, Gonzalez-Blas CB, Janssens V, Tompa P, Versées W, Thevelein JM. Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras. Nat Commun 2017; 8: 922. doi: 10.1038/s41467-017-01019-z. https://www.nature.com/articles/s41467-017-01019-z.pdf
2. Schilling R. Why isn't sugar portrayed as bad like cigarettes? https://www.quora.com/Why-isnt-sugar-portrayed-as-bad-like-cigarettes
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The fact that cancer cells use more sugar than non-cancer cells, known as the Warburg effect, appears to form the basis of the current question. Nevertheless, it is not yet known if this effect is merely a symptom of cancer or whether it is the cause of cells becoming cancerous. Evidence indicating the way cancer cells metabolize sugar is not conclusive, either. Considering refined or added sugar, the bulk of the available evidence indicates that sugar is not a carcinogen. There is no evidence that eating sugar causes cancer or speeds up its growth. There is also no evidence that eliminating dietary sugar causes cancer to shrink or disappear. However, it is known that eating excess sugar, especially added sugars, can contribute to many chronic diseases such as obesity and diabetes, which are potential risk factors for several types of cancer.
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What is Cadmium toxicity?
How it binds Cadmium in human body?
What is the nature of Cadmium?
Which are the functional group of metallothionein?
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. Does the pain for the survival of the human have any meaning?
. The cellular and tissue thermal or chemical lesion causes a sensation and avoidance reflex, to avoid further damage to the affected site
. The perception of cellular or tissue damage, by making the noxious stimulus conscious, induces, in a targeted manner, protective behaviors and limiting the damage.
. The Central Nervous System (CNS) and Peripheral System, puts us in contact through our senses, with the internal biochemical and neurophysiological environment, in addition to experiencing the external or natural environment, through sensations and reflex acts, such as perceptions and behaviors to preserve the integrity of the organism.
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Regarding evolutionary biology and paleobiology, solid evidence has been found that supports the conjecture that the Nendaertales had a lower pain threshold, a situation that will have to be evaluated in terms of whether this finding explains their extension and predominance of Sapiens. The following evidences are some of them:
  • Since several high-quality Neanderthal genomes are now available, researchers can identify the genetic changes that were present in many or all Neanderthals; allowing to investigate its physiological effects and analyze its consequences when they occur in people today.
  • Researchers Hugo Zeberg, Svante Pääbo, and their colleagues found that some people, especially from Central and South America, but also from Europe, have inherited a Neanderthal variant of a gene that encodes an ion channel that initiates pain sensation.
  • At the molecular level, the Neanderthal ion channel is more easily activated, which may explain why people who inherited it have a lower pain threshold. "It is difficult to say whether Neanderthals experienced more pain because pain is also modulated in both the spinal cord and brain," says Pääbo. "But this work shows that their threshold for initiating pain impulses was lower than in most humans today."
regards
José Luis
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I am trying the determine how effective HRV is at quantifying transient psychophysiological stress in comparison to blood pressure, the experiment comprises of 4 (45 second long) stressors with 3 minutes baseline in between. Which HRV frequency range ( LF, HF or LF/HF ratio) should I use and why ?
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Hi Samreen,
If you haven't accessed it yet, the 1996 Standards of Measurements by Malik are still applicable to current HRV research. Germane to your question would be the sub-sections spectral components - Short-term recordings and Summary and Recommendations for Interpretation of HRV Components.
Also, this article by Shaffer and Ginsberg offers a good summary of both frequency and time-domain HRV measures.
In direct response to your question, LF-HRV can be influenced by both the PNS and SNS, and at rest, it doesn't offer a good representation of sympathetic innervation of the heart, but rather baroreflex activity.
Good luck with your project.
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FDA has issued guidance to provide recommendations to health care providers and investigators on the administration and study of investigational convalescent plasma collected from individuals who have recovered from COVID-19 (COVID-19 convalescent plasma) during the public health emergency.
The guidance provides recommendations on the following:
  • pathways for use of investigational COVID-19 convalescent plasma
  • patient eligibility
  • collection of COVID-19 convalescent plasma, including donor eligibility and donor qualifications
  • labeling, and
  • record keeping
Because COVID-19 convalescent plasma has not yet been approved for use by FDA, it is regulated as an investigational product.  A health care provider must participate in one of the pathways described below.  FDA does not collect COVID-19 convalescent plasma or provide COVID-19 convalescent plasma.  Health care providers or acute care facilities should instead obtain COVID-19 convalescent plasma from an FDA-registered blood establishment.
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I requirement to know the most trusty extractant for chlorophylls a and b.
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Thank you Kathryn De Abreu
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COVID- 19
Respiratory infections can be transmitted through droplets of different sizes: when the droplet particles are >5-10 μm in diameter they are referred to as respiratory droplets, and when then are <5μm in diameter, they are referred to as droplet nuclei. According to current evidence, COVID-19 virus is primarily transmitted between people through respiratory droplets and contact routes.2-7 In an analysis of 75,465 COVID-19 cases in China, airborne transmission was not reported.
Droplet transmission occurs when a person is in in close contact (within 1 m) with someone who has respiratory symptoms (e.g., coughing or sneezing) and is therefore at risk of having his/her mucosae (mouth and nose) or conjunctiva (eyes) exposed to potentially infective respiratory droplets. Transmission may also occur through fomites in the immediate environment around the infected person. Therefore, transmission of the COVID-19 virus can occur by direct contact with infected people and indirect contact with surfaces in the immediate environment or with objects used on the infected person (e.g., stethoscope or thermometer). 
Airborne transmission is different from droplet transmission as it refers to the presence of microbes within droplet nuclei, which are generally considered to be particles <5μm in diameter, can remain in the air for long periods of time and be transmitted to others over distances greater than 1 m. 
In the context of COVID-19, airborne transmission may be possible in specific circumstances and settings in which procedures or support treatments that generate aerosols are performed; i.e., endotracheal intubation, bronchoscopy, open suctioning, administration of nebulized treatment, manual ventilation before intubation, turning the patient to the prone position, disconnecting the patient from the ventilator, non-invasive positive-pressure ventilation, tracheostomy, and cardiopulmonary resuscitation. 
There is some evidence that COVID-19 infection may lead to intestinal infection and be present in faeces. However, to date only one study has cultured the COVID-19 virus from a single stool specimen.  There have been no reports of faecal−oral transmission of the COVID-19 virus to date.
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Probiotics are live microorganisms that are intended to have health benefits when consumed or applied to the body. They can be found in yogurt and other fermented foods, dietary supplements, and beauty products.
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The virus is primarily spread between people during close contact, often via small droplets produced by coughing, sneezing, or talking. While these droplets are produced when breathing out, they usually fall to the ground or onto surfaces rather than remain in the air over long distances.People may also become infected by touching a contaminated surface and then touching their eyes, nose, or mouth. The virus can survive on surfaces for up to 72 hours. It is most contagious during the first three days after the onset of symptoms, although spread may be possible before symptoms appear and in later stages of the disease.
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Khem Raj Meena I agree with you. But everyone is scared again of the vaccination because of the numerous rumours around it
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A hospital-acquired infection (HAI), also known as a nosocomial infection, is an infection that is acquired in a hospital or other health care facility. To emphasize both hospital and nonhospital settings, it is sometimes instead called a health care–associated infection (HAI or HCAI).
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Please see the following RG link.
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I work with female mice and I have this doubt. If they are all put together on the same cage, are all of them on the same estrous cycle stage?
If so, is there any literature that supports this?
I do not measure and/or calibrate estrous cycle because I do a protocol where I don't want the animals to be stressed by it.
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After a period(days) the synchronization will occur
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Hello y'all
Could anybody recommend some papers on the ecological/physiological role of RiPPs on their producers, especially on cyanobacterial producers.
I've been trying to track any paper on this topic, but I've had no luck so far.
Thanks for the help
Jose
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The ribosomally synthesized and posttranslationally modified peptides (RiPPs), also called ribosomal peptide natural products (RPNPs), form a growing superfamily of natural products that are produced by many different organisms and particularly by bacteria. They are derived from precursor polypeptides whose modification by various dedicated enzymes helps to establish a vast array of chemical motifs. RiPPs have attracted much interest as a source of potential therapeutic agents, and in particular as alternatives to conventional antibiotics to address the bacterial resistance crisis. However, their ecological roles in nature are poorly understood and explored. The present review describes major RiPP actors in competition within microbial communities, the main ecological and physiological functions currently evidenced for RiPPs, and the microbial ecosystems that are the sites for these functions. We envision that the study of RiPPs may lead to discoveries of new biological functions and highlight that a better knowledge of how bacterial RiPPs mediate inter-/intraspecies and interkingdom interactions will hold promise for devising alternative strategies in antibiotic development
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I am looking for solid reference to infer mean (human) plasma cortisol concentration of a time unit (e.g. 12hrs) from measured urinary cortisol concentrations (mean cortisol concentration of a 12hr unit, normalised to creatinine concentration). I need it to use a mathematical cortisol model, of which most published ones only use plasma concentrations, but I only have urinary measures.
Currently I am brute-forcing papers from 50-60 years ago, which doesn't quite help me. Is there anything more recent, or a physiology book that gives me more information about the topic?
Sofar I found that "Urinary free cortisol excretion increases directly in proportion to the plasma unbound cortisol level (Beisel et al, 1964) and provides an integrated measure of plasma free cortisol over time (Burke & Roulet, 1970). (from Carroll76)
Thank you very much.
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I'm not sure that you can, with any meaningful accuracy. There are several difficulties, the most problematic being that cortisol has a diurnal pattern of expression, and this pattern may be different in different biofluids overall, and more or less discordant as concentrations increase or decrease.
In saying that, here are some references which might be useful to you - serum and plasma levels are likely to be very similar so you might have better luck with that literature.
DOI:10.1016/s1440-2440(02)80031-7
DOI: 10.1080/036107399244075
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Oncology is a branch of medicine that deals with the prevention, diagnosis, and treatment of cancer. A medical professional who practices oncology is an oncologist. The name's etymological origin is the Greek word ὄγκος (óngkos), meaning 1. "burden, volume, mass" and 2. "barb", and the Greek word λόγος (logos), meaning "study".
Cancer survival has improved due to three main components: improved prevention efforts to reduce exposure to risk factors (e.g., tobacco smoking and alcohol consumption), improved screening of several cancers (allowing for earlier diagnosis), and improvements in treatment.
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Lauren Pecorino
Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics
3rd Edición
ISBN-13: 978-0199577170, ISBN-10: 019957717X
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In my study I have exposed the volunteers to 4 separate 45 second stressors that are a mixture of modalities (audio/visual) and task types (emotion-evoking/cognitive) with 3 minute baselines in between. A continuous ECG is trace is taken throughout the experiment, from the gross heart rate I hope to work out heart rate variability. My aim is to test the validity of heart rate variability as an objective stress assessment method for psychophysiological stress. My question is at what point on the ECG trace for each volunteer would I analyse the gross heart rate to work out Heart Rate variability for each of the four stressors i.e. pre-stressor, post-stressor and why ?
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The body's should develop compensatory response to stress with 20seconds in which the effect could be felt by the brain although it depends most times on the intensity of the stressor
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The most accepted definition for RRP is " a small subset of the many vesicles in presynaptic bouton that is more readily released than other vesicles which are in the recycling and reserve pool", and RRP consists of "docked" vesicles. Well, can we increase the number of docked vesicles in the presynaptic terminal? If we do it, what is the physiological mechanism underlying this increment? Does this increment depend on the increase of intracellular Ca2+? Does the increment of the size of active bouton lead to the increment of the size of RRP?
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Actually I believe that the RRP size is just a result of the instant probability of vesicle exocytosis. If so, current Ca2+ concentration strongly impact RRP size by mean docking molecular machinery (SNAP-25, syntaxin, synaptotagmin and so on). Increasing the concentration of Ca2+ leads to more probable activation of Ca-sensors and more reliable exocytosis.
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I want to know the Hematopoietic stem cells' surface charge? is there any authentic article about that? and How we can measure this charge? what is the method or protocol as we know that assessment stem cells in in-vitro are difficult?
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I would search the literature first, but if nothing useful turns up, you could measure the net charge on the stem cells (assuming that you have a reliable way of collecting them) by setting up an aqueous version of the Michelson-Morley experiment for measuring the charge on the electron, but scaled up to the larger size and charge on the cell. Essentially, by placing electrodes above and below a cell culture suspension with a medium density less than that of the cells, so that they will tend to sink in the absence of a current, one can maintain those cells with charge sufficient to offset their gravitational sedimentation. Adjusting the charge across the electrodes to find one that maintains the cells in suspension (offsets their gravitational force and density against the electrical force to suspend them) should let you calculate the net charge on the cells.
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I grew Podocarpus seedlings at elevated temperatures for 16 weeks after which I ran temperature response curves using a Licor 6400 IRGA.
The optimum temperature for photosynthesis remained roughly the same for heat acclimated and none-heat acclimated plants, however, max photosynthesis decreased in the heat acclimated plants. The graph is attached!
Does anyone have an explanation for this?
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Besides other parameters mentioned by Kathryn, did you look at stomatal density?
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Below is the project title:
This project will investigate how psychological stress and mental workload impact physiology. Using Heart Rate Variability in comparison to an array of ‘gold standard’ physiological measures to investigate how task interaction impacts on psychophysiological stress.
Physiometric analysis methods -
•Stethography
•Galvanometry
•Blood pressure
•Core Body Temperature
Which of one of the physiological measures stated above would be best to use to measure acute stress during a driving simulation and why ?
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cortisol, heart rate, blood pressure
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I want to know whether tumor cells share their information by time passing. I were wondering if anybody could answer my question and introduce some good resources in this regard?
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The answer is "Yes". Please see the following PDF attachments.
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I'm trying to set up KiloSort2 (https://github.com/MouseLand/Kilosort2) in MATLAB 2019a on Windows 10. Per the github instructions, I've successfully installed Visual Studio Community 2013 and am trying to set it as my compiler in MATLAB. However, when I enter the 'mex -setup' command, MATLAB tells me that there are no supported compilers on my machine.
While VS2013 isn't listed in the MATLAB documentation as a supported compiler, I know that a lot of people use KiloSort and KiloSort2 for spike sorting, so I'm wondering if anyone knows the proper work around or if there exists a different compiler that will get the job done.
Thanks!
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