Zheng-Feng Gong's research while affiliated with Nanjing University of Traditional Chinese Medicine and other places
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Publication (1)
Flavones have the potential of being used as a dietary supplement for bone health promotion beyond calcium and vitamin D. Recent studies have showed that flavones enhanced bone formation and inhibited bone resorption by affecting osteoblast and osteoclast differentiation through various cell signaling pathways. In this study, we investigated the ef...
Citations
... Adenosine 30,50-cyclic monophosphate (cAMP) and guanosine 30,50-cyclic monophosphate (cGMP) signaling pathways have an opposite effect on cell proliferation and differentiation. Zhang et al. (50) found that the elevation of intracellular cAMP could enhance bone morphogenetic protein (BMP) action and increase the ALP activity of osteoblastic cells in experimental animals. Therefore, the long-term proliferation-promoting effect of MGF may attribute to the concentration of intracellular cAMP being lower than cGMP. ...
