Yoshihiro Hagiwara's research while affiliated with Tohoku Medical and Pharmaceutical University and other places
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Publications (199)
Sporadic inclusion body myositis (sIBM) is a muscle disease in older people and is characterized by inflammatory cell invasion into intact muscle fibers and rimmed vacuoles. The pathomechanism of sIBM is not fully elucidated yet, and controversy exists as to whether sIBM is a primary autoimmune disease or a degenerative muscle disease with secondar...
Purpose
The objective of the present study was to examine the relationship between anxiety and sleep disorder during the COVID-19 pandemic and to evaluate whether sleep disorder is mediated by the decreased frequency of going out.
Methods
The data of a total of 1976 residents aged 18 years and over who had responded to a self-reported questionnair...
Low back pain (LBP) and neck pain (NP) are common health problems worldwide. LBP often coexists with NP; however, the association between these pains remains unclear. The purpose of this study was to clarify the association between LBP and NP, focusing on dose-dependent effects. This study used a 3-year longitudinal cohort data of people living in...
Background:
Atraumatic rotator cuff tears (ARCTs) are frequently concomitant with adduction restriction of the glenohumeral joint (GHJ). Adduction manipulation (AM) removes the restriction and relieves pain. The present study aimed to investigate the clinical efficacy of AM versus physiotherapy (PT) in ARCTs.
Methods:
Eighty-eight patients with...
Background
Knee is the most commonly injured part of the body in young athletes. Knee pain in several studies have been seen to be more prevalent in active adolescents compared to inactive, although common in both groups. Nevertheless, few studies with large sample size have been published reporting the difference of the prevalence of knee pain for...
Background:
Low back pain and sleep disturbance are common health problems worldwide which are also commonly observed among people after natural disasters. These symptoms are well known to coexist, and recent reports have indicated that sleep disturbance is a risk factor for low back pain. However, the influence of low back pain on sleep disturban...
Background
Functional disability is a major health issue in an aging population. Low back pain (LBP) is a common health concern that can lead to functional disability in the elderly; nonetheless, their association has not yet been clarified. This study aimed to examine the association between LBP and functional disability in the elderly, with a foc...
Purpose
The objective of the present study was to examine the relationship between anxiety and sleep disorder during the COVID-19 pandemic and to evaluate whether sleep disorder is mediated by the decreased frequency of going out.
Methods
The data of a total of 1,976 residents aged 18 years and over who had responded to a self-reported questionnai...
Joint immobilization, which ensures rest and accelerates tissue recovery in musculoskeletal disorders, often causes joint contracture, for which there is still no effective prevention. To address this, we investigated the effects of extracorporeal shockwave therapy (ESWT) in preventing joint contracture, in a unilaterally immobilized knee rat model...
The physiological significance of skeletal muscle as a secretory organ is now well known but we can only speculate as to the existence of as-yet-unidentified myokines, especially those upregulated in response to muscle contractile activity. We first attempted to establish an “insert-chamber based in vitro exercise model” allowing the miniature but...
Background:
Thickening of the ligamentum flavum is considered to be the main factor for lumbar spinal canal stenosis (LSCS). Although some mechanisms have been speculated in the thickening of the ligamentum flavum, there are only a few comprehensive approaches to investigate its pathology. The objective of this study was to investigate the patholo...
Objectives
Cognitive social capital (SC), such as attitude, trust, or norms, may help improve resilience among survivors, thus improving their health. However, the association between cognitive SC and the risk of all-cause mortality among survivors after the natural disaster has never been investigated. The purpose of the present study is to invest...
Background
Knee pain is a common symptom among young sports players. Nevertheless, few studies with large sample size have been published reporting the difference of the prevalence of knee pain for each sport among young sports players.
Methods
This study was to investigate the point prevalence of knee pain according to age, sex and sports discipli...
Background
Neck pain is a common health problem in the general population as well as in people after natural disasters. Sleep disturbances are gaining attention as risk factors for musculoskeletal pain; however, the association between sleep disturbance and neck pain has not been clarified. The present study aimed to clarify the association between...
Shoulder pain is more common among survivors of natural disasters than the general population. This study aimed to examine the occurrence of shoulder pain, especially the association between prior and later shoulder pain episodes, in survivors living in coastal areas severely damaged by the Great East Japan Earthquake (GEJE) (n = 1,821) over a peri...
Background: Neck pain is a common health problem in the general population as well as in people after natural disasters. Sleep disturbances are gaining attention as risk factors for musculoskeletal pain; however, the association between sleep disturbance and neck pain has not been clarified. The present study aimed to clarify the association betwee...
Accumulation of uric acid (UA) during muscular trauma is a factor involved in the development of muscle hyperalgesia. Neutrophil extracellular traps (NETs), DNA-based reticular structures to capture UA, play a central role in the pain onset of gout attacks; however, the involvement of NETs via the elevation of local UA level in muscle hyperalgesia...
Makalah ini menjelaskan implementasi perangkat lunak dengan antar muka pengguna grafis (GUI) untuk menganalisis citra bergerak ultrasonik dari ligament bahu. Perangkat lunak yang dirancang dapat bermanfaat di bidang medis khususnya sebagai alat bantu identifikasi penyakit yang berhubungan dengan kelainan gerak dan nyeri pada bahu. Pada prinsipnya,...
Study design:
Experimental study of LF thickness among patients with LSCS.
Objectives:
To elucidate the factors associated with thickening of the LF on magnetic resonance imaging (MRI).
Summary of background data:
Thickening of the LF is a major contributor to LSCS. This thickening is attributed to tissue hypertrophy or buckling of the ligamen...
Contractile activity is a fundamental property of skeletal muscles. We describe the establishment of a “feeder-supported in vitro exercise model” using human-origin primary satellite cells, allowing highly-developed contractile myotubes to readily be generated by applying electrical pulse stimulation (EPS). The use of murine fibroblasts as the feed...
Some studies suggested a correlation between tissue elasticity and diseases, such as Adhesive Capsulitis (AC) of the shoulder. One category of method to measure elasticity is by utilizing Doppler imaging. This paper discusses color Doppler shear wave elastography methods and demonstrated an experiment with biological tissue mimicking phantom. A sim...
Background: Knee pain is a common symptom among natural disaster survivors as well as general population. However, its long-term course is unclear. The purpose of this study was to clarify the course of knee pain, especially focusing on the association between prior and subsequent knee pain, among people living in disaster-stricken areas.
Methods:...
Introduction
The proximal femur (PF) is one of the most common locations of benign cystic lesions. A fracture after bone biopsy is a rare but severe complication. However, the risk of fracture after biopsy of this lesion has not been well-studied. Computed tomography (CT)-based finite element (FE) modeling estimates the elastic modulus and compress...
Study design:
A longitudinal study.
Objective:
The aim of this study was to clarify the association between sleep disturbance and low back pain (LBP) using 3-year longitudinal data after the Great East Japan Earthquake, with a focus on the duration or frequency of sleep disturbance and the effect of sleep disturbance on LBP.
Summary of backgrou...
Objectives
The COVID-19 pandemic has forced many people to stay at home and to maintain social distancing. This study aimed to assess the association of reduced physical activity during the COVID-19 pandemic with new onset of neck pain (katakori) among a rural Japanese population living in areas damaged by the Great East Japan Earthquake (GEJE).
D...
Objective
Neck pain is a common health problem among both the general population and natural disaster survivors. However, the long-term course of neck pain has rarely been reported. The aim of this study was to elucidate the 5-year course of neck pain among survivors of the Great East Japan Earthquake (GEJE) by assessing the association of neck pai...
IntroductionThe “Comma sign” is a well-known indicator of the subscapularis torn edge of the shoulder. We undertook a histoanatomical study of the fiber bundle forming Comma sign (FBCS) to determine why FBCS is maintained even in cuff tear cases.Materials and methodsPart 1: five tissue blocks including the supraspinatus tendon (SSP), rotator interv...
PurposeIntra-articular pathologies, such as labral and chondral lesions, are common in patients with frozen shoulder. This study evaluated the correlations between the range of motion and labral and chondral lesions in patients with frozen shoulder and investigated their pathophysiologies.Methods
In total, 125 individuals (53 men and 72 women) who...
Accumulation of uric acid (UA) during muscular trauma is a causative factor involved in the development of muscle hyperalgesia. Neutrophil extracellular traps (NETs), DNA-based reticular structures to capture UA, play a central role in the pain onset of gout attacks; however, the involvement of NETs via the elevation of local UA level in muscle hyp...
Background: Accumulation of uric acid during muscular trauma is potentially a causative factor of damage-associated molecular patterns (DAMPs) involved in the development of muscle hyperalgesia. Neutrophil extracellular traps (NETs), DNA-based reticular structures to capture DAMPs, play a central role in the onset of pain in gout attacks associated...
Skeletal muscle health is important for the prevention of various age-related diseases. The loss of skeletal muscle mass, which is known as sarcopenia, underlies physical disability, poor quality of life and chronic diseases in elderly people. The transcription factor NRF2 plays important roles in the regulation of the cellular defense against oxid...
Communication between parents and their children’s coaches is important for children’s sports activities, but the relationship between parents and coaches is not well understood. It is possible that parents feel a lack of communication with coaches, which could be due to parents’ experience with sports activities or the social environment of the te...
Objective
Shoulder pain is a common health problem coexisting with other musculoskeletal pain. However, the effects of pre-existing musculoskeletal pain on the development of shoulder pain are not clear. The present study aimed to elucidate the association between coexisting musculoskeletal pain at other body sites and new-onset shoulder pain among...
Study design:
A cross-sectional study.
Objective:
The purpose of this large cohort study was to assess the prevalence of low back pain (LBP) among young players participating in several types of sports.
Summary of background data:
LBP is a significant problem among young sports players. Sport discipline among young players is thought to be ass...
Background
Greater Tuberosity (GT) malunion can lead to impingement against the acromion, resulting in pain, stiffness, and weakness of the rotator cuff. For patients with lesser degrees of displacement, partial removal of the GT with rotator cuff repair (tuberoplasty) under fluoroscopic guidance is considered.
Case report
A sixty-five year old fe...
Study design:
A longitudinal panel study.
Objective:
The aim of this study was to examine the occurrence of low back pain (LBP), especially the association of previous LBP with further episodes of LBP, in survivors of the Great East Japan Earthquake (GEJE) during the course of 5 years.
Summary of background data:
LBP is common among survivors...
Sporadic inclusion body myositis (sIBM) is the most common idiopathic inflammatory myopathy, and several reports have suggested that mitochondrial abnormalities are involved in its etiology. We recruited 9 sIBM patients and found significant histological changes and an elevation of growth differential factor 15 (GDF15), a marker of mitochondrial di...
Background
The Simple Shoulder Test (SST) is a widely used patient-reported outcome assessment. The purpose of this study was to develop and validate a Japanese version of the SST (SST-Jp).
Methods
A two-stage observational study was conducted to validate the cross-cultural adaptation of the SST. A total of 100 patients with shoulder disorders com...
Background
We aimed to retrospectively determine the effects of arthroscopic pan-capsular release with or without entire coracohumeral ligament (CHL) release and diabetes mellitus (DM) in patients with frozen shoulder (FS).
Methods
The study included 34 patients (20 male and 14 female patients) who underwent arthroscopic pan-capsular release witho...
Background
Joint hemorrhage is caused by trauma, ligament reconstruction surgery, and bleeding disorders such as hemophilia. Recurrence of hemorrhage in the joint space induces hemosiderotic synovitis and oxidative stress, resulting in both articular cartilage degeneration and arthropathy. Joint immobilization is a common treatment option for artic...
Introduction
Bifocal disruption of the knee extensor system is rare. Coincident bifocal proximal and distal disruptions of the patellar tendon are extremely rare in adults.
Case Report
A 38-year-old man presented to our clinic with severe right knee pain after falling down the stairs and abruptly bending the right knee. Plain radiographs of this k...
Myofascia, deep fascia enveloping skeletal muscles, consists of abundant collagen and elastin fibres that play a key role in the transmission of muscular forces. However, understanding of biomechanical dynamics in myofascia remains very limited due to less quantitative and relevant approaches for in vivo examination. The purpose of this study was t...
Background: Joint hemorrhage is caused by trauma, ligament reconstruction surgery, and bleeding disorders such as hemophilia. Recurrence of hemorrhage in the joint space induces hemosiderotic synovitis and oxidative stress, resulting in both articular cartilage degeneration and arthropathy. Joint immobilization is a common treatment option for arti...
Martial arts, such as judo, kendo, and karate, are popular worldwide, not only among adults but also among children and adolescents. Although low back pain (LBP) is considered to be a common problem in these sports, it has been scarcely studied, especially in young athletes. The purpose of this study was to elucidate the point prevalence of and fac...
Background
The Shoulder Pain and Disability Index (SPADI) is a simple disease specific questionnaire that is used to evaluate the impact of shoulder disorders. The purpose of this study was to translate the SPADI into Japanese (SPADI-Jp) and evaluate its reliability and validity in Japanese patients with shoulder disorders.
Methods
Cross-cultural...
Background:
Low back pain (LBP) is a common problem among young basketball players in addition to lower extremity injuries. However, studies that focus on LBP with lower extremity pain are limited. From the perspective of the kinematic chain, disrupted lower extremity function can lead to LBP. The association between these two symptoms in basketba...
Background
The physical and psychological health impacts on victims of the Great East Japan Earthquake (GEJE) have lasted for a long time. Some cross-sectional studies have reported a relationship between social networks and/or social support and mental health among victims. Previous studies were cross-sectional observations at one time point after...
There is no unified consensus on the pathophysiology of adhesive capsulitis which is also called as frozen shoulder. Some studies have suggested that coracohumeral ligament (CHL) played an important role in adhesive capsulitis. These studies showed relation between disease prevalence and CHL thickness by means of ultrasound or MRI. Other possible e...
Background
Frozen shoulder (FS) is clinically diagnosed on the basis of patients’ medical history and physical examination. Its confirmation is based on joint capsule and coracohumeral ligament thickening, subcoracoid fat obliteration, and joint capsule contrast enhancement on magnetic resonance imaging (MRI). We performed bilateral contrast-enhanc...
Background
Proximal humeral fractures are one of the most common fractures in adults. Some patients treated operatively have restriction in range of motion (ROM) after surgery. This study aimed to evaluate arthroscopic pancapsular release in patients with severe stiffness after treatment with intramedullary nailing for proximal humeral fractures....
Background
A thickened joint capsule is believed to be one of the most specific manifestations of and the primary restraint against range of motion (ROM) in frozen shoulders. The purpose of this study was to evaluate the relationship among ROMs under general anesthesia before surgery and the effects of each joint capsular release on ROM.
Methods
R...
Musculoskeletal pain is a major problem among survivors of natural disasters. Functional disabilities in older adults increase after disasters and can lead to musculoskeletal pain. However, the effects of poor physical function on musculoskeletal pain after natural disasters remain unclear. This study aimed to elucidate the association of poor phys...
Background: Joint hemorrhage is caused by trauma, ligament reconstruction surgery, and bleeding disorder such as hemophilia. Recurrence of hemorrhage in the joint space induces hemosiderotic synovitis as well as oxidative stress, resulting in both articular cartilage degeneration and arthropathy. Joint immobilization is a common treatment option fo...
Background: Joint hemorrhage is caused by trauma, ligament reconstruction surgery, and bleeding disorders such as hemophilia. Recurrence of hemorrhage in the joint space induces hemosiderotic synovitis and oxidative stress, resulting in both articular cartilage degeneration and arthropathy. Joint immobilization is a common treatment option for arti...
Background:
Low back pain (LBP) is a common health problem experienced after natural disasters. LBP is often concurrent with other musculoskeletal pain; however, the effects of preexisting musculoskeletal pain on the development of LBP are not clear. The purpose of this study was to elucidate the association of musculoskeletal pain in other body s...
Background
The etiology of frozen shoulder (FS) remains uncertain. Advanced glycation end-products (AGEs) cause the cross-linking and stabilization of collagen and are increased in FS. The purpose of this study was to elucidate the pathogenesis of FS by evaluating the receptor of AGE (RAGE)-dependent pathways.
Methods
Tissue samples of the coracoh...
Background
The pathophysiology of atraumatic rotator cuff tears (ATTs) has not been fully understood. Adduction restriction of the glenohumeral joint can cause pain and disability in patients with ATTs. We aimed to use our adduction test (pushing the humerus toward the side in the coronal plane with scapular fixation) to fluoroscopically measure th...
Sporadic inclusion body myositis (sIBM) is the most common idiopathic inflammatory myopathy, and several reports have suggested that mitochondrial abnormalities are involved in its etiology.
We recruited 9 sIBM patients and found significant histological changes and an elevation of growth differential factor 15 (GDF15), a marker of mitochondrial di...
Basketball is a major sport worldwide among different age groups that leads to a high frequency of injuries at multiple body sites. Upper and lower extremities and lower back are common pain sites in basketball players; however, there is little information about the relationship between upper or lower extremity pain and lower back pain. This study...
Background:
Lower back pain (LBP), as well as lower extremity injuries, are major problems among young volleyball players. Nevertheless, only few studies have focused on the relationship between lower extremity injuries and LBP.
Objective:
This study investigated the association between LBP and lower extremity pain, including knee and ankle pain...
Background
Low back pain (LBP) is a common health problem experienced after natural disasters. LBP is often concurrent with other musculoskeletal pain; however, the effects of preexisting musculoskeletal pain on LBP are not clear. The purpose of this study was to elucidate the influence of other musculoskeletal pain on new-onset LBP among survivors...
Background: Low back pain (LBP) is a common health problem experienced after natural disasters. LBP is often concurrent with other musculoskeletal pain; however, the effects of preexisting musculoskeletal pain on the development of LBP are not clear. The purpose of this study was to elucidate the association of musculoskeletal pain in other body si...
Introduction
The need for implant use during orthopedic surgeries has been increasing. Accordingly, increased implant failures have been reported. However, bladder perforation remains a rare complication after orthopedic surgery. Although a few reports have described bladder perforation after total hip arthroplasty, no previous studies have reporte...
Verbal or physical abuse from coaches has negative effects on young athletes, and the parents of athletes also have an influence on the sports environment. It is therefore important to understand parents' attitudes towards abuse against their children from the coaches. This study aimed to elucidate the characteristics of parents who accept the infl...
Key-points:
•Fractalkine receptor antagonist inhibited neutrophil recruitment to masseter muscles and exacerbated fatigability during masticatory activity. •Fractalkine-mediated neutrophil recruitment is required for both upregulation of myokines (CXCL1, IL-6) and enhanced GLUT4 translocation in response to masticatory activity. •Fractalkine and I...
Background:
Functional disability is a significant problem after natural disasters. Musculoskeletal pain is reported to increase after disasters, which can cause functional disability among survivors. However, the effects of musculoskeletal pain on functional decline after natural disasters are unclear. The present study aimed to examine the assoc...
Objective
Prolonged periods of living in prefabricated houses (PHs) may increase the risk of musculoskeletal (MSK) symptoms; however, the association is not clear. This study aimed to investigate the association between continued residence in PHs and MSK pain in a population affected by a natural disaster, the Great East Japan Earthquake (GEJE) sur...
Background:
Evidence is scarce concerning the relationship of physical dysfunction of the trunk and lower extremities with elbow and shoulder pain in young baseball players. This study aimed to examine the association of joint flexibility of the trunk and lower extremities and dynamic postural control with elbow and shoulder pain among elite young...
Contraction of cultured myotubes with application of electric pulse stimulation (EPS) has been utilized for investigating cellular responses associated with actual contractile activity. However, cultured myotubes derived from human subjects often exhibit relatively poor EPS-evoked contractile activity, resulting in minimal contraction-inducible res...
Muscle pain is a common condition in many diseases and is induced by muscle overuse. Muscle overuse induces an increase in uric acid, which stimulates the nucleotide-binding oligomerization domain-like receptor (NLR). This receptor contains the pyrin domain NLRP-3 inflammasome which when activated, results in the secretion of potent pro-inflammator...
Verbal and physical abuse from coaches has negative effects on young athletes. Although the abuse can lead to the athletes’ dropping out, no studies have reported on this topic. The purpose of this study was to elucidate the association between experience of verbal or physical abuse from coaches and loss of motivation for the present sport in young...
Rotator cuff disease is one of the most prevalent shoulder disabilities especially in the elderly population. Tear progression is significantly greater in the symptomatic patients than in the asymptomatic ones. From these aspects, shoulder surgeons interpret surgical indications and counsel patients regarding the risk of non-operative treatments. H...
Objectives
After the Great East Japan Earthquake (GEJE) of 2011, many survivors have been forced to live in prefabricated temporary housing, which is uncomfortable and insufficiently durable for permanent living. Public reconstruction housing has been built to improve their living conditions; however, those moving have to rebuild personal relations...
Background
Little consensus has been achieved on conservative treatments in patients with Rotator Cuff Tears (RCTs).
Objective
To determine whether anatomical severities of RCTs were poor prognostic factors in conservative treatments.
Method
This study included 102 shoulders with atraumatic RCTs diagnosed by magnetic resonance imaging. Partial-th...
Context:
Range of motion (ROM) in the glenohumeral joint decreases with age in healthy subjects; however, the underlying mechanism remains unclear. The process of aging of the joint capsule, including the coracohumeral ligament (CHL), could affect ROM limitation.
Objective:
This study investigated correlations between elasticity of the CHL, eval...
Objectives
The Great East Japan Earthquake and subsequent tsunami cause large‐scale destruction in the north‐eastern coastal areas in Japan, and forced many survivors to relocate to prefabricated temporary housing, a typical emergency accommodation. Based on the hypothesis that higher toothache prevalence among the disaster survivors is associated...
Osteofibrous dysplasia is a benign fibro-osseous lesion of bone which is most commonly occurred in cortical bone of anterior mid-shaft of the tibia of infancy and childhood. This study reported a case of osteofibrous dysplasia arising in the humerus of adult, resulting in good prognosis after a surgical treatment. A 34-year-old male had felt left u...
Background:
Because the relationship between coaches and athletes is unequal, verbal and physical abuse remains a common problem among sports coaches. We aimed to elucidate the characteristics of baseball coaches who verbally/physically abuse young baseball players.
Methods:
A cross-sectional study was conducted on youth sports team coaches in M...
Background
Although the shoulder range of motion significantly decreases with advancing age, how the natural aging process affects the joint capsule, including the Coracohumeral Ligament (CHL), in healthy subjects is still unknown.
Objective
To use shear wave elastography to investigate the correlations between age, sex, and shoulder dominance, an...
Background
Evaluation of the Range Of Motion (ROM) is one of the important procedures for shoulder disorders. The purpose of this study was to investigate correlations between capsular changes and ROM restrictions evaluated by both plain magnetic resonance imaging (MRI) and Magnetic Resonance Arthrography (MRA) in the same patients with frozen shou...
Ultrasonic irradiation induces alternating electromagnetic polarization through electro- or magneto-mechanical coupling. It follows that electromagnetic fields are generated from a variety of materials when they are acoustically stimulated. In this paper, the acoustically stimulated electromagnetic response is investigated in biomedical tissues tha...
Background
A thickened coracohumeral ligament is a highly specific manifestation of, and primary restraint against external rotation in frozen shoulders.
Objective
The purpose of this study was to evaluate the effects of complete arthroscopic coracohumeral ligament release on range of motion in frozen shoulder.
Methods
Fifty-two consecutive shoul...
Purpose
Considerable research has focused on shoulder and elbow injuries among baseball players; however, although lumbar spine and knee injuries are commonly experienced, they are less frequently studied. During common motions in baseball, such as throwing, hitting, and running, energy is transferred from the lower extremities through the lower ba...
Lower back pain (LBP) is a common health problem after natural disasters. Although some related factors have been reported, the effect of sleep disturbances on LBP is not clear. The purpose of this study was to elucidate the influence of sleep disturbances on LBP after the Great East Japan earthquake (GEJE). A panel study was conducted with the sur...
Background
Soccer is a high-intensity sport with a high injury rate. Among youth soccer players, lower extremity pain is a major problem that could be associated with trunk function. This study investigated the association between lower extremity pain and trunk pain among youth soccer players.
Methods
A cross-sectional study involving youth soccer...
Background:
The effect of lifestyle factors on elbow or shoulder pain in young baseball players remains unclear. This study examined the association of game playing and television viewing with elbow or shoulder pain among elite young baseball players.
Methods:
Study participants were young baseball players (age, 9-12 years) who participated in t...
Objective
Psychological distress is a common symptom after natural disasters. Although musculoskeletal pain also increases after natural disasters, its relation to psychological distress is not known. This study aimed to examine the association of musculoskeletal pain with new-onset psychological distress among survivors of the Great East Japan Ear...
Citations
... Athletes were not exempted from the self-restraint imposed during the lockdown, which has led to a renewed awareness of the importance of caring for and maintaining mental health in sport [1]. Mental health problems during the pandemic were observed in the general population, as well as in athletes, underlining the importance of psychiatrists [2,3,4]. In particular, sports psychiatrists are more familiar than general psychiatrists with the mental health problems of athletes, albeit from different countries and cultures, and with the prevention and treatment of psychiatric symptoms and disorders through sports and exercise therapy [5]. ...
... Как продемонстрировали результаты ряда масштабных эпидемиологических исследований, проведенных в разных странах, именно ПБ представляет собой одну из наиболее распространенных причин роста суммарных показателей временной утраты трудоспособности, а также количества лет, прожитых с заболеванием (бремя болезни) [3,4]. Также следует отметить, что исключительно высокая социально-экономическая значимость проблемы ПБ связана с высокими материальными расходами на лекарственную и немедикаментозную терапию, реабилитационные мероприятия и непрямыми затратами, обусловленными снижением производительности труда, необходимостью выполнять менее квалифицированную трудовую деятельность, сокращением рабочего времени в связи с состоянием здоровья, преждевременным прекращением трудовой деятель-ности с последующим выходом на пенсию или установлением (у ряда пациентов) инвалидности [5,6]. Прямые и непрямые материальные потери, обусловленные ПБ, в значительной степени возрастают в случае, если болевой синдром приобретает хронический характер, становясь по сути самостоятельным заболеванием [7,8]. ...
... Despite their physical benefits, knee injuries are common, particularly in contact and pivoting sports, such as touch football, netball, soccer, rugby union, rugby league, and Australian football. Australia has one of the highest numbers of ACL reconstruction surgeries [9,10]. Most young athletes with knee injuries can resume, to some extent, a level of sports activity through non-pharmacological treatment, such as rest from aggravating activities, icing, and medications if required [11]. ...
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... Consistent with this finding, there was a prospective and bi-directional association between poor sleep quality and chronic low back pain in school teachers [46]. Conversely, a previous study showed that previous lower back pain was a factor in causing sleep disruption [47]. Our developed conceptual model demonstrated that insomnia, sleep quality, and job stress were all predictive factors for MSDs. ...
... Another explanation is that disability attributed to BP varies substantially across countries and it is influenced by social norms, local health approaches, and legislation [3]. A Japanese study demonstrated that BP is associated with functional disability, and such association is observed to be stronger in a dose-dependent manner, which includes the intensity, frequency, and duration of BP [47]. In the present study the sample was considered as a whole, which may have masked possible effects in subgroups. ...
... ESWT has shown promising results in reducing fibrous tissue adhesion and fibrous cell density, restoring joint mobility, and preventing abnormal fibrous tissue formation [52]. Additionally, ESWT also downregulates type I collagen and connective tissue growth factor expression [53]. Low-energy ESWT has been found to reduce inflammation to inhibit fibroblast density via macrophage transfer [54]. ...
... As RSPO3 regulates vascular network remodeling and activates inflammatory gene expression that can exert synergistic effects on BBB permeability, 36-38 the adverse neuroimaging and clinical outcomes associated with RSPO3 may reflect secondary consequences of aberrant inflammatory signaling (a postulation supported by its positive relationship with plasma GFAP), compromised BBB integrity or systemic drivers of angiogenesis, such as differential metabolic demands. 39 With the exception of RSPO3, our candidate BEC proteins displayed unexpected associations with ADRD biomarkers, including Aβ 42/40 and pTau-181. Given that BBB integrity likely influences the extent to which biomarkers originating from the central nervous system can migrate into the periphery, the observed relationships may be attributed to neurobiological mechanisms that are distinct from coevolving neurodegenerative processes. ...
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![[object Object]](https://i1.rgstatic.net/ii/profile.image/272378290765824-1441951453052_Q64/Makoto-Kanzaki.jpg)
... However, most clinical symptoms arise due to compression of the spinal cord, nerve roots, or cauda equina. A spinal ligament called the ligamentum flavum (LF) covers the posterior and lateral parts of the dural sac, and its abnormal hypertrophy is a key factor leading to nerve compression and one of the primary causes of symptoms in patients with LSCS [2,3]. Despite numerous studies exploring the mechanism of LF hypertrophy, the exact molecular regulation remains unclear. ...
... Studies have shown that infiltrating neutrophils formed NETs after spinal cord injury [61]. Due to the web-like structure of NETs, uric acid could be captured leading to local uric acid accumulation and promoting hyperalgesia during muscle trauma [62]. Besides, intraarticular injection NETs reduced the mechanical threshold in mice and joint hyperalgesia induced by NETs was prevented in mice deficient for Tlr4 and Tlr9 [63]. ...
... Fibrotic ligaments were defined as those thicker than 4 mm based on T2-weighted magnetic resonance imaging of the lumbar spine. 36 The collection and analysis of human samples in this study was approved by the Ethics Committee of Wangjing Hospital of the China Academy of Chinese Medical Sciences (WJEC-YJS-2020-009-P002). ...
