Nuzli Fahdia Mazfufah's research while affiliated with Stem Cell And Cancer Institute and other places
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Publications (8)
Background: Reprogrammed cell therapy has not been applied for clinical purposes due to the malignancy issue. The aim of this study was to design the recombinant vector of the transcription factors and analyze the effectiveness of cell-penetrating peptide delivering system for human primary fibroblast transfection to avoid the malignancy issue.Mate...
Mesenchymal stem cells (MSC) and induced pluripotent stem cells (iPSC) have been reported to be able to differentiate to hepatocyte in vitro with varying degree of hepatocyte maturation. A simple method to decellularize liver scaffold has been established by the Department of Histology, Faculty of Medicine, Universitas Indonesia, in SCTE IMERI lab....
Various implant treatments, including total disc replacements, have been tried to treat lumbar intervertebral disc (IVD) degeneration, which is claimed to be the main contributor of lower back pain. The treatments, however, come with peripheral issues. This study proposes a novel approach that complies with the anatomical features of IVD, the so-ca...
Pulsed electromagnetic fields (PEMFs) have an important role in cell differentiation. Previous study reported that PEMFs had positive and negative effect towards cell differentiation that depends on their frequencies applied to the cells. Human adipose-derived stem cells (ASCs) are mesenchymal stem cells that have an ability to differentiate into s...
Ovarian cancer is one of the gynecologic cancers with a high mortality rate and increased incidence. Surgery and therapies are used to treat ovarian cancer patients. Therapies such as chemotherapy and radiotherapy can cause resistance therefore immunotherapy using natural killer (NK) cells can be an alternative therapy. NK cells have shown an impor...
The pathway for the introduction of NK cell into abnormal cells is mediated by the receptor-ligand interaction on the cell surface. Among all the activation receptors, NKP44 has become a unique activation receptor because it has an ITIMs signaling pathway and actively plays an important role in several functions of stimulated NK cells. A potential...
A
liver organoid is an in vitro reconstruction of the liver that mimics the in
vivo liver microstructure and performs liver functions. Liver organoids can be
used for drug testing, as a model of liver disease pathogenesis, and as a
bioartificial liver prototype material to develop promising alternative therapies
for liver failure. In this study, we...
Citations
... The results of geometric assessment present tolerable production results, and the two materials show slight degradation rates and well wettability. Mechanical investigation exhibits that ABC-MTDR has more similar mechanical characteristics to an IVD than FLC-MTDR [10]. Wang et al. ...
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... Acellular liver scaffolds have been produced from various species, including rats [6][7][8], pigs [9][10][11], sheep [12] and humans [13][14][15]. These scaffolds have been used to culture various hepatic cell lines, primary hepatocytes, and stem cell-derived hepatocyte-like cells [16,17]. Researchers have investigated the efficacy of different reagents, such as sodium dodecyl sulphate (SDS), Triton X-100, peracetic acid, and sodium deoxycholate, in liver decellularization [18,19]. ...
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... Several therapies have been practiced for several years to treat cancer, such as chemotherapy and radiotherapy which seemed to cause resistance in the tumor cells or treatment of it within 3 years, that is why a proficient alternate source to cure cancer with promising results is being employed in which the NK cells perform specific anticancer activity-called immunotherapy. 20,41,42 ...
... NID1 ligand expression is increased in ovarian cancerous tissue and is recognized by the NKp44 receptor expressed on NK cells within the TME. This receptor-ligand interaction is thought to increase NK cell recognition of malignant cells (72) and has been shown to promote the migration, invasion and resistance of ovarian cancer cells and metastasis (73). ...
... An Indonesian case report also showed that stem cell administration improved the outcome of chronic spinal cord injury patients (Phedy et al., 2019). Another study in vitro showed that combining human stem cells and hepatocyte-reconstructed liver organoid is important for developing tissue engineering (Sibuea et al., 2020). Several sources of stem cells can be used for research and therapy. ...
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