Koudai Inata's research while affiliated with Tottori University and other places
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Publications (4)
Purpose
To evaluate the efficacy of real-time PCR for 16S ribosomal DNA (16S r-DNA) and sequencing for diagnosing microbial keratitis.
Methods
We studied 272 eyes of 272 patients with keratitis. Eyes with keratitis were classified as “definite” (N = 118), “likely” (N = 71), or “non-bacterial” (N = 83) to have bacterial keratitis. The diagnostic ef...
Corneal endothelial cells are known to be targets of herpes simplex virus type 1 (HSV-1) infection; however, the pathogenesis of HSV infections of the endothelial cells has not been definitively determined. The purpose of this study was to examine an unrecognised strategy of corneal endothelial cells to protect themselves from HSV-1 infection.
Immo...
Pharmacologic inhibitors of IκB kinase (IKK), especially IKK-β, have been developed to treat inflammatory diseases. However, their interactions with components of the NF-κB pathways are not fully known in allergic diseases. To examine whether IKK is involved in immediate hypersensitivity reactions and to determine whether counterregulatory mechanis...
To evaluate the efficacy of Gram-Fungiflora Y double staining for corneal scraping samples collected by impression in diagnosing infectious keratitis.
Two hundred and thirteen eyes of 192 patients suspected of having infectious keratitis were retrospectively studied for the sensitivity and specificity of Gram-Fungiflora Y based on final diagnosis....
Citations
... Another ancillary test-PCR (polymerase chain reaction)-targets selected microorganisms (mainly bacteria, viruses, Acanthamoeba and fungi) and represents similar sensitivity and specificity to corneal scraping. However, it requires targeted primers for each suspected etiology leading to high costs [96]. Finally, next generation sequencing (NGS) may play complementary role, especially in treatment-resistant infiltrates [97]. ...
... Recently, KP has also been reported to play a critical role in modulating immune homeostasis [15], and the KP metabolites might be associated with immune disorders [50][51][52]. For example, IDO1 could inhibit the replication of human cytomegalovirus, HSV-1, and retroviruses through the increased consumption of L-Try [53][54][55]. However, the role of KMO in modulating innate immunity against viral infections has not been investigated. ...
... A diagnose of fungal keratitis was made by the detection of hypha in the smear by fluorescent staining with Fungiflora Y or a positive fungal culture 15,16 . The clinical characteristics included dry-appearing infiltrates with feathered margins and multifocal infiltrates as satellite lesions. ...
... Studies have shown that IL-1/IL-1R is important for mast cell activation and mast cell-mediated AC [82,83]. Fukuda reported that IL-1 released from necrotic corneal epithelial cells cooperates with Th2 cytokines to induce chemokine (C-C motif) ligand 11 production and vascular cell adhesion molecule 1 expression in corneal fibroblasts and may, therefore, play an important role in ocular allergic diseases [116]. ...
