Christopher Cutler's research while affiliated with Augusta University and other places
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Publications (20)
(1) Background: The aim of this study was to test whether matrix-bound zoledronate (zol) molecules enhanced the oral biofilm colonization of a mineralized matrix, rendering the alveolar bone more susceptible to medication-related osteonecrosis of the jaw (MRONJ) following invasive dental procedures. (2) Methods: We tested the effect of matrix-bound...
Dendritic cell (DC)-derived exosomes (DC EXO), natural nanoparticles of endosomal origin, are under intense scrutiny in clinical trials for various inflammatory diseases. DC EXO are well-tolerated by the host and can be custom-tailored for immunomodulatory functions. Previously we documented the efficacy of immunoregulatory DCs EXO (regDCs EXO) as...
Background:
Periodontitis is an infectious/inflammatory disease most often diagnosed by deepening of the gingival sulcus, which leads to periodontal pockets (PPs) conventional manual periodontal probing does not provide detailed information on the three-dimensional (3-D) nature of PPs.
Objectives:
To determine whether accurate 3-D analyses of th...
Objectives:
Approximately 109 bacteria can be harbored within periodontal pockets (PP) along with inflammatory byproducts implicated in the pathophysiology of systemic diseases linked to periodontitis (PD). Calculation of this inflammatory burden has involved estimation of total pocket surface area using analog data from conventional periodontal p...
Background:
Lip repositioning is a conservative surgical technique used to treat excess gingival display. An array of modifications has been introduced to the technique over time and as studies show the technique and its modifications to be successful, there is little standardized information for clinicians to make informed decisions when choosing...
This Point/Counterpoint discusses the long-argued debate over whether lecture attendance in dental school at the predoctoral level should be required. Current educational practice relies heavily on the delivery of content in a traditional lecture style. Viewpoint 1 asserts that attendance should be required for many reasons, including the positive...
The human microbiome consists of highly diverse microbial communities that colonize our skin and mucosal surfaces, aiding in maintenance of immune homeostasis. The keystone pathogen Porphyromonas gingivalis (P. gingivalis) induces a dysbiosis and disrupts immune homeostasis through as yet unclear mechanisms. The fimbrial adhesins of P. gingivalis f...
A critical need exists to better understand the physiological sequel of vitamin D supplementation in obese individuals and African Americans. The aim was to comprehensively evaluate dose- and time-responses of a panel of vitamin D biomarkers to vitamin D supplements in this population.
We conducted a 16-week randomized, double-blinded, and placebo-...
Objective: Autophagy, a physiologic process to eliminate cellular waste, has recently emerged as a major immune mechanism against pathogens. Dendritic cells (DCs), the “gatekeepers of the immune system” express pattern recognition receptors (PRRs) for pathogen discrimination, including TLRs, NOD and C-type lectins such as DC-SIGN. We presently unde...
Objective: Crosstalk between natural killer (NK) cells and dendritic cells (DC) is pivotal to regulation of immune defense against infection and tumors. Activated NK cells mature DCs, promoting effective adaptive immunity or can delete immature DCs. The purpose of the present study was to define the interaction of NK cells with DC and how it is inf...
Objective: The “stroke belt” runs through the southeastern U.S, with the “buckle” reportedly located around Augusta, Georgia. The aim of this collaborative study was to analyze the periodontal inflammatory burden in a group of young pre-diabetics (mean age ± SD = 21.8±7.6 years) with well-defined HbA1C levels, relative to non-diabetics of the same...
The human oral cavity harbors a wide array of different bacterial species (>100 bacterial genera and >700 species). Most of these bacterial species are thought to be of a commensal nature, engaging in complex biofilm formation and facilitating the colonization of more noxious and pathogenic bacteria. Oral bacteria are the main infectious cause of t...
Objectives: Dendritic cells (DCs) have a central role in priming the specific immune responses and in driving inflammation. A recent report (Carrion et al. 2012) showed that in chronic periodontitis, blood DCs carry a microbiome which includes Porphyromonas gingivalis (Pg) and other species. Pg in particular is able to influence DC differentiation...
Objective: A recent epidemiologic study estimated the prevalence of periodontitis (PD) at 47.1% of the U.S. adult population. This suggests a failure of the innate and/or adaptive immune system to prevent or resolve PD. Neutrophils (PMNs), the first line of defense in clearance of oral pathogens such as Porphyromonas gingivalis (Pg) are followed by...
Objectives: Immature dendritic cells (DCs) are elevated in peripheral blood of chronic periodontitis (CP) patients compared to healthy counterparts. Increases occur rapidly after scaling and root planning (SRP) and are maintained after treatment. As pathogen-laden DCs can provide an efficient vehicle for pathogen dissemination and have adverse risk...
Objectives: PMNs are early responders to infection, for which they possess potent bacterial killing mechanisms. The PMN response is followed by influx of macrophages/dendritic cells (DCs) which presumably clean up effete PMNs and cross-present antigens to T cells in the secondary lymphoid organs. However, very little is understood about the ability...
Colocalization of Dendritic Cells with P.gingivalis and Endothelium in Gingiva/Atherosclerotic plaques. L. JAIN1, H.G. AN1, J.A. CARRION1, E. KOZAROV2, and C.W. CUTLER1, Stony Brook University School of Dental Medicine, Stony Brook, NY1 and Columbia University, College of Dental Medicine, NY, NY2 Objectives: Recent studies have shown DC-SIGN+ myelo...
Citations
... The link between periodontal disease and the development of MRONJ has been extensively demonstrated, with the spread of bacteria through periodontal pockets identified as a primary mechanism for infection propagation through the alveolar bone. Notably, the promotion of MRONJ development is likely influenced not only by the presence of Porphyromonas gingivalis and other periodontogenic bacteria in the periodontal pockets but also by IgG products [3,18,[23][24][25][26] . ...
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... These bacteria are grouped in plaques that interfere in the periodontal homeostasis and promote the occurrence and recurrence of periodontal diseases (Asikainen & Chen, 1999). For this reason, the great volume and complexity of bacterial plaques figure as main etiological factor behind the periodontal disease (Arjunan et al., 2017). Additionally, there are risk factors that also may aggravate patients' conditions, and these factors rely on systemic, behavioral, social, economic and demographic aspects inherent to each patient. ...
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... (g) The depth and volumetric measurement of the periodontal pockets using CBCT. Reprinted with permission from [89]. (h) 3D volumetric reconstructive CBCT image obtained from a patient with aggressive periodontitis. ...
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... Different periodontal pocket imaging technologies currently in use.(Table modifiedfromElashiry et al. 2018) 13 ...
Reference: Digitization in Periodontics
... A recent surge in research focused on the treatment of EGD reflects the increasing interest among clinicians and the growing demand from patients to address EGD [19]. There have been systematic reviews conducted on the more common techniques for the reduction of EGD, such as BTX injection [20][21][22][23][24][25][26], LRS [27][28][29][30][31], and the use of skeletal anchorage devices [32]. The majority of studies included in these systematic reviews were case reports and case series with a small patient pool. ...
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... However, students' attendance in classrooms had declined significantly in the recent years on a local and national levels [4]. This maybe attributed in part to change in attitude, their ability to learn the material on their own and today's era of evolving online education rendering class attendance unneeded [5]. Other factors linked to students' interest in attending classroom lectures include class subject (the scope and difficulty of the subject), faculty member lecturing style and transportation to school, stress, time management and poor health were also reported as secondary factors contributing to classroom attendance [4,6,7]. ...
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... The primary function of the fimbrial systems is to adhere to host epithelial cells and colonize subgingival tissue. However, Mfa1 is also involved in microorganism auto-aggregation, microbe-microbe interactions, and suppression of the host immune response (Arjunan et al., 2016), via the evasion of autophagy-lysosome function of myeloid dendritic cell (DC) when it internalizes P. gingivalis (El-Awady et al., 2015). Mfa1 is also able to induce osteoclastogenesis by interacting with the Toll-like receptor of murine macrophage (RAW264 cells) in vitro (Suzuki et al., 2022). ...
... Trummer report that vitamin D supplementation has no significant effect on FGF23 in a ran controlled trial conducted in subjects with arterial hypertension, however, the serve an increase of FGF23 concentrations in individuals with serum 25OHD ng/mL. In contrast, Bhagatwala et al. [77] fail to demonstrate this effect in a simi A systematic review and meta-analysis published in 2019 by Charoenngam Inflammation is a common feature of chronic diseases and has a major i morbidity and mortality. Vitamin D and FGF23/Klotho interact reciprocally and significant effects on immunity. ...
