Adriana Ladeira de Araújo's research while affiliated with Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo and other places
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Publications (10)
Introduction: Post-COVID-19 condition (PCC) is characterised by a plethora of
symptoms, with fatigue appearing as the most frequently reported. The alterations
that drive both the persistent and post-acute disease newly acquired symptoms
are not yet fully described. Given the lack of robust knowledge regarding the
mechanisms of PCC we have examined...
Introduction
The COVID-19 pandemic has prompted global research efforts to reduce infection impact, highlighting the potential of cross-disciplinary collaboration to enhance research quality and efficiency.
Methods
At the FMUSP-HC academic health system, we implemented innovative flow management routines for collecting, organizing and analyzing de...
The aim of this study was to determine whether Post-acute Sequelae of SARS-CoV-2 Infection (PASC) are associated with physical inactivity in COVID-19 survivors. This is a cohort study of COVID-19 survivors discharged from a tertiary hospital in Sao Paulo, Brazil. Patients admitted as inpatients due to laboratory-confirmed COVID-19 between March and...
Background:
Sociodemographic and environmental factors are associated with incidence, severity, and mortality of COVID-19. However, little is known about the role of such factors in persisting symptoms among recovering patients. We designed a cohort study of hospitalized COVID-19 survivors to describe persistent symptoms and identify factors assoc...
Preliminary methodologically limited studies suggested that taste and smell known as chemosensory impairments and neuropsychiatric symptoms are associated in post-COVID-19. The objective of this study is to evaluate whether chemosensory dysfunction and neuropsychiatric impairments in a well-characterized post-COVID-19 sample. This is a cohort study...
The aim of this study was to determine whether Post-acute Sequelae of SARS-CoV-2 Infection (PASC) are associated with physical inactivity in COVID-19 survivors. This is a cohort study of COVID-19 survivors discharged from a tertiary hospital in Sao Paulo, Brazil. Patients admitted as inpatients due to laboratory-confirmed COVID-19 between March and...
Background
Despite the multitude of clinical manifestations of post-acute sequelae of SARS-CoV-2 infection (PASC), studies applying statistical methods to directly investigate patterns of symptom co-occurrence and their biological correlates are scarce.
Methods
We assessed 30 symptoms pertaining to different organ systems in 749 adults (age = 55 ±...
Introduction COVID-19 may lead to persistent and potentially incapacitating clinical manifestations (post-acute sequelae of SARS-CoV-2 infection (PASC)). Using easy-to-apply questionnaires and scales (often by telephone interviewing), several studies evaluated samples of COVID-19 inpatients from 4 weeks to several months after discharge. However, s...
Citations
... COVID-19 survivors classified as having prolonged sedentary behavior (i.e., ≥10 h/d) had a 25% higher risk (odds ratio [OR], 1.25; 95% confidence interval [CI], 1.01-1.55) of developing at least one long-COVID symptom. Gil et al. 8 prospectively followed 614 patients (mean age: 56 [13] y; 53% males) hospitalized with a laboratoryconfirmed diagnosis of SARS-CoV-2 infection for 6 to 11 months. In the multivariable analysis, physically inactive patients (i.e., <150 min/ wk of moderate to vigorous activity) had an over 50% (OR, 1.57; 95% CI, 1.04-2.39) ...
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... Un estudio de cohorte realizado en el Hospital das Clínicas de la Facultad de Medicina de la Universidad de São Paulo, Brasil (Ferreira et al. 2022), investigó a pacientes positivos para COVID-19 de la primera oleada. Los criterios de selección fueron la supervivencia posterior a la hospitalización por más de seis meses, hospitalización de por lo menos 24 horas, mayores de 18 años y diagnóstico confirmado por PCR. ...
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... Systemic inflammation and the accompanying elevated production of cytokines and reactive oxygen species are major stressors that, while indirect, can cause pathological effects on the brain (Figure 1) [13][14][15][16]. Cytokines can cross even the intact BBB and the barrier becomes more porous under inflammatory conditions; therefore, the brain receives exposure to the elevated cytokine levels that result from COVID-19 infection [17][18][19][20]. ...
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... Regarding the multidisciplinary follow-up initiative, the COVID-19 Steering Committee encouraged participating groups to publish interim findings [e.g., (58)]. However, most teams opted to wait until data collection was completed in April 2021. ...
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... It was found that fatigue, as well as psychiatric and cognitive manifestations were the most discriminative symptoms, indicating that these alterations tend to occur together in a cohort of 749 patients who were hospitalised due to . This latent traitco-occurrence of fatigue, psychiatric and cognitive manifestations-as identified through factor analysis, was also associated with body weight loss, poor physical performance, and persistent inflammation, with high C-reactive protein (CRP) and D-dimer (16) content in the circulation. However, no association was found between these inflammatory markers and any individual symptoms of PCC (16). ...
... The hospital became a reference in the management of severe COVID-19. 19 In this context, our team designed in 2020 a prospective follow-up study, 6-12 months after hospital discharge, to monitor COVID-19 survivors. 11,14 This study found that 82% of the patients presented lung sequelae in the CT imaging, which impacted the pulmonary function tests. ...
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