Blunted: The Effects of Cannabis on Cognition and Motivation
The effects of cannabis on cognition and motivation are key considerations both for clinicians and policy makers alike. The medical research on this topic shows some inconsistency in their conclusions but overall suggests that cannabis can indeed lead to reduced cognitive and motivational abilities, particularly in the areas of verbal memory and attention. Despite suggestions to the contrary, the strength of this evidence goes well beyond simple correlational studies. Fortunately, evidence suggests that at least most of the deficits can be reversed with sustained abstinence, although more research in this area needs to be done. One reason for some of the inconsistent findings in this area may be related to important variables such as amount of use, age, and perhaps THC content that can moderate the amount of risk involved in cannabis use. Research is now going beyond the question of if cannabis is related to cognitive problems and toward a greater understanding of mechanisms that may underlie this process.
Cannabis and Psychiatric Conditions
Cannabis has been legalized in several states for both medical and recreational purposes despite the paucity of scientific evidence regarding its safety and efficacy. Since 2009, a variety of public health and safety trends and statistics have been published, raising questions about the long-term impact of cannabis use on mental health. Research on the use of cannabis for psychiatric conditions is lacking, partly because cannabis is classified as a Schedule I drug, making it all but impossible to conduct the randomized, double-blind, placebo-controlled studies necessary to assess efficacy and safety. For the most part, past studies have been retrospective, with small numbers of subjects. Differing cannabinoid concentrations, differing exclusion criteria, and confounding variables limit the reliability of early study outcomes. Unlike medications approved by the FDA, no post-marketing surveillance is conducted to track unforeseen adverse effects. Despite being a Schedule I drug, cannabis has bypassed the prescription drug monitoring program in many states. Psychosis, depression, anxiety, addiction, violence, and suicidality have all been associated with cannabis use in recent years. In this chapter, I will summarize information about the use of cannabis and how it relates to mental illnesses and behavior, using the strongest publications identified in the literature.
Cannabis Use and Psychosis, Mood, and Anxiety Disorders
Over the past 25 years, results of numerous studies have shown an association between cannabis use and psychosis, mood, and anxiety disorders. However, methodological limitations of individual studies have prevented determination of whether the association is causal or not. Moreover, most previous studies were conducted prior to the increasingly widespread access to high potency cannabis products available in a post-legalization environment. This chapter reviews current research examining the relationship between cannabis use and psychiatric disorders, including findings from a recent meta-analysis (Murrie et al. Schizophr Bull. 16:sbz102, 2019) and a growing body of research addressing the effects of high potency cannabis on this relationship.
Marijuana and Suicide: Case-Control Studies, Population Data, and Potential Neurochemical Mechanisms
A substantial body of epidemiological case-control literature now supports a relationship between chronic marijuana use and an increased risk for suicide, while an emerging clinical literature suggests acute use can lead to the sudden development of suicidal urges in an important minority of subjects. This chapter will review those studies, as well as covering regression analyses conducted on population data for the United States vis-á-vis the correspondence between suicide rates and marijuana use rates, in conjunction with potentially confounding covariates. The data show cause for alarm and highlight the need for public health agencies to forecast potential impacts for the United States as marijuana use rates continue to climb. Mechanisms for an effect of marijuana on suicide are explored, from indirect effects through mental disorders promoted by chronic use to more direct effects relating to underlying neurochemical changes elicited by marijuana both in humans and in animal models.
Cannabis Use Disorder, Treatment, and Recovery
Recovery from a cannabis use disorder is the same as recovery from any substance use disorder from a clinical perspective; from a practical or “real-world” application, it can have many unique qualities.
In this chapter we will refer often to the treatment of SUD, the diagnostic criteria, and treatment recommendations set forth in the latest version of the Diagnostic Statistical Manual (American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th edn. 2013.). Recommending cannabis-/THC-specific treatment strategies should be considered adjunctive and complementary to all we know and currently practice when treating SUD. While the cannabis-dependent patient is in many ways unique, they are still a patient being treated/evaluated for SUD.