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Phytochemical Analysis and Growth Inhibiting Effects of Salix viminalis L. Leaves Against Different Candida Isolates

Authors:
Mohd Sadiq S. Zarger
Mohd Sadiq S. Zarger
Mohd Sadiq S. Zarger
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Nida Akhtar at Indian Council of Medical Research
Nida Akhtar
Sheikh Shreaz at Kuwait University
Sheikh Shreaz
Rimple Bhatia at Federal University of Rio de Janeiro
Rimple Bhatia
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Abstract

Plants have been the inherent part of life since ancient times, there is a very close relationship between humans and plants. As a medicine plants have always been used since existence of life on this planet. Current study was designed to identify phytoconstituents composition and growth inhibiting effects of leaves extract of Salix viminalis L. against Candida glabrata, Candida guilliermondii and Candida parapsilosis. Phytochemical tests showed the presence of glycosides, phenols, steroids, alkaloids, terpenoids, flavanoids and tannins. By GC-MS analysis fifty two chemical constituents were analyzed in which 1-Heptacosanol (8.99%), Hexadecanoic acid (7.86%), Cholesterin (7.42%), Palmitic acid, methyl ester (5.49%), 1,2-Cyclohexanediol (4.96%), and Phytol (4.39%) were the major chemical constituents. The test extract has shown significant anticandidal activity against all Candida species. Scanning electron microscopy micrographs (SEM) showed ultrastructural changes in treated Candida cells. Antifungal results revealed that methanolic extract of S. viminalis leaves can be used as a raw material for future anti-candidal drugs.
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Advanced Science Letters, Volume 20, Numbers 7-9
Phytochemical Analysis and Growth Inhibiting
Effects of Salix viminalis L. Leaves Against
Different Candida Isolates
Authors: Zarger, Mohd Sadiq S.; Akhtar, Nida; Shreaz, Sheikh; Bhatia, R.; Khatoon, Fehmeeda
Source: Advanced Science Letters, Volume 20, Numbers 7-9, July 2014, pp. 1463-1467(5)
Publisher: American Scientific Publishers
Abstract:
Plants have been the inherent part of life since ancient times, there is a very close relationship between humans
and plants. As a medicine plants have always been used since existence of life on this planet. Current study was
designed to identify phytoconstituents composition and growth inhibiting effects of leaves extract of Salix
viminalis L. againstCandida glabrata, Candida guilliermondii and Candida parapsilosis. Phytochemical tests
showed the presence of glycosides, phenols, steroids, alkaloids, terpenoids, flavanoids and tannins. By GC-MS
analysis fifty two chemical constituents were analyzed in which 1-Heptacosanol (8.99%), Hexadecanoic acid
(7.86%), Cholesterin (7.42%), Palmitic acid, methyl ester (5.49%), 1,2-Cyclohexanediol (4.96%), and Phytol
(4.39%) were the major chemical constituents. The test extract has shown significant anticandidal activity
against all Candida species. Scanning electron microscopy micrographs (SEM) showed ultrastructural changes
in treated Candida cells. Antifungal results revealed that methanolic extract of S. viminalis leaves can be used
as a raw material for future anti-candidal drugs.
Document Type: Research Article
Publication date: July 1, 2014
... With respect to the flower extract, 1-heptacosanol has been reported to have antimicrobial and antioxidant activity [44], putative antibacterial activity [45], and significant antifungal activity against all Candida spp. [46]. Nonetheless, its efficacy against the phytopathogens referred herein was variable: moderate against E. amylovora, and high against E. vitivora and D. seriata. ...
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... Phytochemical compounds have been researched and shown to have inhibitory effects on all types of microorganisms and their activity mainly depends on the distribution of bioactive compounds in different parts of the plant. Solvents used for the extraction method plays a vital role for determination of active principal compounds isolated from plant material, therefore use of different solvent attempt is required for screening of plant material for extraction of phytochemicals [9,10]. ...
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