Jassem G Mahdi

• BSc, MSc, PhD
• Fellow at Cardiff University

Stereoselective photobromination of 1,6-anhydro-β-D-glucopyranose derivatives occurs at exo-H6. However, photobromination of 4-benzoyl-2,3-isopropylidene-1,6-anhydro-β-D-mannopyranose 6 produced unstable 4-benzoyl-1,6-anhydro-3-keto-β-D-mannopyranose 7. The mechanism of stereoselective oxidation at C-3 could be attributed to the facile radical prot...

Acetylsalicylic acid, or aspirin, is one of the most common non-steroidal anti-inflammatory drugs, which has been shown to have anti-cancer effects. However, high doses are needed making it unsuitable as an oncology agent. We have previously reported increased potency in a series of hydroxybenzoate zinc (HBZn) aspirin analogues. Here we show that 3...

The association of medicinal plants and their therapeutic action is an interested subject which reflects the close relation of genomics and proteomics and DNA sequences among different biological systems. Since the early ancient era, human health and therapy has been supported by plants through the action of certain phyto chemical molecules. Some o...

Hydroxybenzoate (HB) compounds have shown their significance in inducing apoptosis in primary chronic lymphocytic leukemia (CLL) and cancer cell lines, including HT-1080. The current study focuses on assessing the effects of 2-, 3- and 4-hydroxybenzoate calcium (HBCa) compounds on MCF-10A, MDA-MB231 and MCF-7 epithelial breast cell lines. The HBCa-...

Hydroxybenzoate (HB) compounds have shown to modulate the morphology in human fibrosarcoma HT-1080 cells. The changes in HT-1080 cells showed marker signs of apoptosis, which included the condensation of nucleus, cell round, blebbing and the formation of apoptotic bodies. The different stages of apoptosis were assessed microscopically using differe...

Beta-D-Salicin 1 (Mahdi et al. [8]) is an interesting medicinal phytochemical that exhibits cross functions in plants and humans immunologically. This molecule 1 (Mahdi et al. [8]) has attracted the attention of scientists in various interdisciplinary fields, including chemistry, pharmacology and medicine. The biological cross functions of b-D-sali...

Aim: Hydroxybenzoic acids are one of the major classes of phenolic compounds and are widely distributed in the phytochemicals of various plants. The aim of this study is to assess the efficacy of 2-, 3- and 4-hydroxybenzoate calcium (HBCa) complexes on HT-1080 cells and examine their anti-proliferative and pro-apoptotic effects in relation to 2-ace...

Chemistry is one of the foundations of science, technology and industry. It forms the fundamentals of the life sciences. This study, aims to investigate what make students choose or not to choose Chemistry and what are the main factors that contribute to the understanding of Chemistry as a subject? Four aspects were used to appraise students' attit...

Salicylates are a group of phenolic compounds that are found naturally in plants. They exert anti-inflammatory and pro-apoptosis activities. Three salicylates (acetyl salicylic acid, ASA; acetyl salicylate calcium, ASCa and salicylate calcium, SACa) were tested in human fibrosarcoma cells for their apoptotic activities in HT-1080 cells using both b...

Simple phenolic (SP) compounds are natural products that exhibit multiple pharmacological functions. The best known of these compounds is -D-salicin, the first discovered phenolic glycoside and salicylic acid, or 2-hydroxybenzoic acid (2-HBA). Both of these compounds have attracted the interest of scientists in various interdisciplinary fields, in...

There has been a growing interest in the beneficial effects of simple phenolic acids and their ability to exhibit various biological activities. The aim of this study was to assess in vitro biological activities of 2-, 3-, and 4-hydroxybenzoate lithium (HBLi) complexes on HT-1080 human fibrosarcoma cells by methods of using a metabolic activity ass...

Non-steroidal anti-inflammatory drugs have been shown to induce apoptosis in primary B-cell chronic lymphocytic leukaemia (CLL) cells, but the molecular mechanisms that underpin this observation have not been fully elucidated. Here, we have analysed the effect two novel aspirin analogues, 2-hydroxy benzoate zinc (2HBZ) and 4-hydroxy benzoate zinc (...

The willow tree is a symbolic medicinal plant that has been associated with the discovery of aspirin, chemically known as acetylsalicylic acid, or salicylate, which still offers surprises as a revival drug. The philosophical perspective of the significance of the willow tree has been elaborated since the Assyrians (4000 BC) and Sumerians (3500 BC),...

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To examine the effect of a novel phenolic-based compound, 2-hydroxy benzoate zinc (2HBZ), and acetylsalicylic acid (ASA) on human HT-1080 fibrosarcoma cells. MTT assay was used to assess cell proliferation while different methods were used to detect apoptosis morphologically and immunohistochemically in Human HT-1080 fibrosarcoma cells. Apoptosis w...

The preparation of allyl chlorostannan 5 was achieved into two steps via free radical displacement of the sulphone group by tributyltin radical. The chemical structure of compound 5 was confirmed by normal spectroscopic methods, including NMR, IR and MS. The mechanism for the free radical reaction of chlorosulphone 6 with tributyltinhydride is like...

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Salicylates are novel biologically active compounds that exhibit multiple therapeutic activities. The anti-cancer effectiveness of calcium salicylate has been investigated on human HT-1080 fibrosarcoma cell lines at relatively low concentrations (predominantly 0.4 mM) compared to those previously reported. Although low calcium salicylate concentrat...

For several millennia, the willow tree and salicin have been associated with salicylic acid, the key precursor molecule that has contributed to the discovery of acetylsalicylic acid, traded as aspirin. These molecules have been shown to possess phyto- and chemotherapeutic activities as analgesic drugs. In recent decades, aspirin has become the focu...

Tri-O-benzoyl-6-exo-bromo-levoglucosan undergoes stereoselective free radical alkylation to give 6-exo-substituted-1,6-anhydrosugars with six contiguous chiral centres.

To avoid adverse effects and optimise the therapeutic value of enantiomeric drugs, it is necessary that methods for the resolution of racemates be evolved and devolved to determine isomeric purity, establish the effectiveness of isomers of the drug, and detect the presence of an enantiomer with lower therapeutic activity and undesirable adverse eff...

The enantiomeric bicyclic ketones 1, 3 and the tricyclic ketone 5 undergo stereochemically congruent Baeyer-Villiger oxidations with CHMO from Acinetobacter sp., CPMO from Pseudomonas sp. as well as 2,5-DKCMO, 3,6-DKCMO and MO2 from P. putida; in every case the tricyclic ketone 5 is transformed with > 96% ee. N-terminal sequences for the FAD/NADPH...

Whole cell oxidation of aryl alkyl sulfides to sulfoxides with Acinetobacter sp. NCIMB 9871 is only slightly less enantioselective than isolated enzyme transformation with the cyclohexanone monooxygenase (CHMO) from the same species. Pseudomonas sp. NCIMB 9872 oxidises the same substrates with high and mostly opposite enantioselectivity (73–100%ee)...

An active site model for enzyme catalysed Baeyer–Villiger reactions is proposed and validated by transformation of the tricyclic ketone 6; Baeyer–Villiger reactions (and Baeyer–Villigerases) are classified by the stereochemistry of the hydroxyperoxide intermediate.

An active-site model for enzyme-catalysed Baeyer–Villiger reactions is proposed and tested by transformation of the tricyclic ketone 6 to the lactone 7( > 98% ee) using purified enzymes from Acinetobacter sp. NCIMB 9871 and Pseudomonas putida NCIMB 10 007 (MO1). The absolute stereochemistry of the lactone 7 was determined by a single-crystal X-ray...

The oxidation of bicyclo[3.2.0]hept-2-en-6-one and 7-endo propylbicyclo[3.2.0]hept-2-en-one was investigated using whole cells of Pseudomonas putida NCIMB 10007 and Xanthobacter autotrophicus NCIMB 10811. The bacteria demonstrated both regio- and enantioselective oxidation of the substrates. P. putida gave ‘mirror image’ with both substrates when t...