Federal University of Rio de Janeiro

Resumo O objetivo do artigo é analisar a estratificação horizontal do ensino superior no Brasil com enfoque nos cursos de engenharia, medicina e direito. Pretende-se investigar se essas áreas se diferenciam de acordo com o perfil socioeconômico de seus concluintes e se houve transformações nesse perfil em um período de rápida expansão do sistema de ensino. Resultados obtidos através de modelos multinomiais e de regressão logística indicam que esses cursos apresentam diferentes padrões de desigualdade de acordo com raça, sexo e escolaridade dos pais. O trabalho identificou uma diminuição nas desigualdades para o período analisado, mas com particularidades importantes entre as áreas e entre os tipos institucionais. As análises reforçam as hipóteses de que a estratificação horizontal pode ser um mecanismo de manutenção das desigualdades em períodos de expansão dos sistemas de ensino e que deve variar de acordo com o grupo profissional.

The cheese after processing, generates whey, which is a residue that has potential benefit to human health. However, there are still few studies that seek to evaluate the composition and potential benefits of goat milk whey, even though it is a promising dairy source. Despite this, the large-scale generation of this waste can favor the environmental impact when improperly disposed of. Given this, the use of all content of dairy production can reverse this impact and increase the income of the dairy industry. Thus, this research prepared a powdered product based on goat’s milk whey from the spray drying technique and evaluate its physicochemical composition by chemical analytical methods and protein profile through polyacrylamide gel electrophoresis. The elaborated product had a higher carbohydrate content than protein, and the identification of protein fractions showed that the most expressive bands represented beta-lactoglobulin and alpha-lactoalbumin. Therefore, the elaborated product has the potential to generate novel products for human consumption and with potential health benefits.

Objective: to analyze the prevalence of tuberculosis, coronavirus, chronic conditions and vulnerabilities among migrants and refugees in Brazil. Method: this is a cross-sectional study of the electronic survey type conducted with international migrants during the COVID-19 pandemic. Descriptive statistics was applied for the analysis, with calculation of position and dispersion measures. Regarding the categorical variables, relative and absolute frequencies were estimated. Results: the study participants were 553 migrants and refugees, verifying 3.07%, 7.2% and 27.3% prevalence of tuberculosis, COVID-19 and chronic conditions, respectively. Among the vulnerabilities, 32% reported unemployment, 37.6% moved to Brazil as a result of the social situation in their countries and 33.6% were living as refugees or sheltered people. Conclusion: tuberculosis, chronic diseases and COVID-19 presented higher prevalence values in migrants and refugees than in the general population. As this is a population group that still has significant difficulty accessing health services and social protection systems, based on diverse evidence, the study will subsidize public policies, Nursing care and the incorporation of new routines in the service.

The purpose of this article is to present a theoretical discussion about the institutional dimension of the concept of adaptive governance. We discuss examples of this institutional dimension based on an analysis of the limits to the implementation of adaptive governance in Brazilian metropolises, based on: 1) the financial resources available to the environmental management of municipalities belonging to metropolitan regions; 2) the creation of an institutional arrangement for climate governance in the municipality of Rio de Janeiro. Despite the incremental aspect, the analyzed data indicate the low fiscal relevance of the environmental issue, as well as difficulties in implementing governance arrangements that succeed in providing transversal planning capacity, mechanisms for the integrated action of different agents, and incentives to an enhanced participatory dynamics in the formulation and implementation of climate policies.

Resumo A capacidade institucional e o aparato normativo do Estado são importantes campos de disputas pela produção do espaço e pelo reconhecimento de direitos sociais. Tais disputas ganham especial relevância na cidade do Rio de Janeiro, marcada por intensas desigualdades sociais. Nesse quadro, as políticas de urbanização de favelas consolidadas entre as décadas 1990 e 2010 representam importante reconhecimento das favelas enquanto espaços de moradia popular. Este artigo analisa as políticas de urbanização de favelas realizadas no Rio de Janeiro nesse período, focando nos modelos institucionais e conteúdos normativos, situando-as nas conjunturas políticas locais e tendo o direito à moradia como norteador. Observam-se a continuidade e centralidade relativa dessas políticas no período analisado, contudo, são ressaltadas importantes contradições e limitações.

Resumo O objetivo deste artigo é discutir teoricamente a dimensão institucional do conceito de governança adaptativa. Portanto, buscamos explorar essa dimensão a partir da análise dos limites para a implementação de uma governança adaptativa nas metrópoles brasileiras, considerando: 1) os recursos financeiros disponíveis para a gestão ambiental dos municípios pertencentes às Regiões Metropolitanas; e 2) a criação de um arranjo institucional de governança climática no município do Rio de Janeiro. Apesar do aspecto incremental, os dados analisados indicam a baixa relevância fiscal da questão ambiental e as dificuldades de implementação de arranjos de governança que forneçam: capacidade de planejamento transversal, mecanismos para a ação integrada entre diferentes agentes e incentivos para uma profunda dinâmica participativa na formulação e na implementação de políticas climáticas.

The chemokine stromal cell-derived-factor 1 (SDF)-1/CXCL12 acts by binding to its receptors, the CXC-4 che-mokine receptor (CXCR4) and the CXC-7 chemokine receptor (CXCR7). The binding of CXCL12 to its receptors results in downstream signaling that leads to cell survival, proliferation and migration of tumor cells. CXCL12 and CXCR4 are highly expressed in breast cancer (BC) and glioblastoma (GBM) compared to normal cells. High expression of this chemokine axis correlates with increased therapy resistance and grade, tumor spread and poorer prognosis in these tumors. Tamoxifen (TMX) is a selective estrogen receptor modulator (SERM) that inhibits the expression of estrogen-regulated genes, including growth and angiogenic factors secreted by tumor cells. Additionally, TMX targets several proteins, such as protein kinase C (PKC), phospholipase C (PLC), P-glycoprotein (PgP), phosphatidylinositol-3-kinase (PI3K) and ion channels. This drug showed promising anti-tumor activity against both BC and GBM cells. In this review, we discuss the role of the CXCL12-CXCR4-CXCR7 chemokine axis in BC and GBM tumor biology and propose TMX as a potential modulator of this axis in these tumors. TMX modulates the CXCL12-CXCR4-CXCR7 axis in BC, however, there are no studies on this in GBM. We propose that studying this axis in GBM cells/patients treated with TMX might be beneficial for these patients. TMX inhibits important signaling pathways in these tumors and the activation of this chemokine axis is associated with increased therapy resistance.

A major drawback in deploying central bank digital currencies (CBDC) is the offline puzzle, which requires that a CBDC must keep the liquidity provision given by cash, and, simultaneously, avoid double‐spending, cloning, and other issues. The puzzle is solved by minting the coins in serial numbers, which are stored on a local blockchain inside a smartphone or EMV card. The local blockchain is strengthened by a two‐stage approval architecture that mitigates attacks and enables non‐repudiation handling. The coins are protected by hardware keys embedded in the microchip and can be continuously mined by the wallet to enhance security. The coins can be either minted as hot coins, which can be retrieved in case of loss, or minted as cold coins, like physical cash.

Objective of the study: This paper gathers, and reviews published empirical or theoretical articles in which the entrepreneurial logics of causation and effectuation, coined by Sarasvathy in 2001, are discussed to answer the research question of “Under what circumstances do firms combine effectuation with causation?”. Methodology/approach: The research is based on a systematic literature review of top-tier journals over a 20-year period. Main results: Findings suggest causation and effectuation logics can be applied simultaneously or in sequence, depending on factors at the micro (the entrepreneur), meso (the firm), and macro levels (business context—institutional and situational). Theoretical/methodological contributions: It delivers a compiled, synthesized, and contrasted set of past work for future researchers to build upon and a preliminary conceptual matrix for further testing and refinement, not to mention an in-depth discussion at the micro, meso and macro level. Relevance/originality: Over 20 years after Sarasvathy’s seminal work, most literature investigating decision-making still focuses on contrasting the logics of causation or effectuation, not fully understanding the conditions under which each prevails or when they are combined. Social/management contributions: At the micro level, this research can help entrepreneurs better understand their profile and the benefits of considering both logics throughout their decision-making process. At the meso level, companies can benefit from understanding how logics relate at each life stage. Finally, at the macro level, policymakers and educators can help entrepreneurs navigate uncertain and turbulent environments if different logics and circumstances are more broadly acknowledged.

This chapter provides a conversation in the form of an opinion piece about strategies commonly utilized in games that can be “transferred” to Serious Games (SGs) and games for serious contexts. The aim of this chapter is to provide different perspectives and examples that are currently utilized by entertainment games that could be utilized in SG development. SGs are often developed for particular situations, and with that, the development process might be attached to specific stakeholders, becoming, most of the time, a “one-off” product, which may limit the SG life cycle and game repurposing. This chapter brings with three complementary perspectives to address future challenges and opportunities regarding emerging aspects of player agency and SG modification and transferability across different contexts. First, we discuss emergent possibilities, bringing examples from digital entertainment transferability. Second, we take into consideration “modding” strategies to provide insights for SG modification and transferability, discussing the role of the “context” in games development. Third, we demonstrate the importance of AI emotion modelling to inform better game design. To conclude, we respond to these ideas and provide suggestions for SG research and practice.

Fertile soil known as Amazonian dark earth is central to the debate over the size and ecological impact of ancient human populations in the Amazon. Dark earth is typically associated with human occupation, but it is uncertain whether it was created intentionally. Dark earth may also be a substantial carbon sink, but its spatial extent and carbon inventory are unknown. We demonstrate spatial and compositional similarities between ancient and modern dark earth and document modern Indigenous practices that enrich soil, which we use to propose a model for the formation of ancient dark earth. This comparison suggests that ancient Amazonians managed soil to improve fertility and increase crop productivity. These practices also sequestered and stored carbon in the soil for centuries, and we show that some ancient sites contain as much carbon as the above-ground rainforest biomass. Our results demonstrate the intentional creation of dark earth and highlight the value of Indigenous knowledge for sustainable rainforest management.

Leaf-galling Eriophyidae (Acarina) may promote simple or complex alterations in the organs of their host plants, such as an increase in indumentum density or the reorganization of epidermis and ground system tissue patterns. To test if hairy galls of Eriophyidae on Avicennia schaueriana (Acanthaceae) are related to complex changes, leaf galls in distinct developmental phases were compared to non-galled leaves using anatomical, histochemical, and histometric analyses. Quantitative comparisons of preferential gall induction sites and gall area according to distinct leaf portions were made to evaluate if the impacts of gall formation can be related to the distinct potentialities of leaf microsites. The apical portion of the leaves and leaf margins were the sites with the highest occurrence of galls, but no relationship was detected between gall area and induction site. The gall anatomy revealed that epidermal features are influenced the most with the development of abnormal stomata and projected or sunken salt glands. The most striking change is the neoformation of elongated filiform trichomes on the abaxial surface (where the mites occur) that accumulate reducing sugars and proteins. The filiform trichomes may protect the inducers against abiotic stressors and enemies, and the primary metabolites that accumulate are important foods for mites. The mesophyll has simple alterations, only in the spongy parenchyma. Complex alterations occur only in abaxial epidermal cells close to feeding sites of the inducer. The number of inducers per gall seems to be the most important influence on gall size, since gall area is not related to the position in the leaves.

Despite being extensively studied because of the current coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interactions with mammalian cells are still poorly understood. Furthermore, little is known about this coronavirus cycle within the host cells, particularly the steps that lead to viral egress. This study aimed to shed light on the morphological features of SARS-CoV-2 egress by utilizing transmission and high-resolution scanning electron microscopy, along with serial electron tomography, to describe the route of nascent virions towards the extracellular medium. Electron microscopy revealed that the clusters of viruses in the paracellular space did not seem to result from collective virus release. Instead, virus accumulation was observed on incurved areas of the cell surface, with egress primarily occurring through individual vesicles. Additionally, our findings showed that the emission of long membrane projections, which could facilitate virus surfing in Vero cells infected with SARS-CoV-2, was also observed in non-infected cultures, suggesting that these are constitutive events in this cell lineage.

Objective To map the inclusion of affirmative policies in Postgraduate Nursing courses in Brazil. Method This is a descriptive, document-based study, carried out with information collected on the Sucupira Platform, via the Coordination for the Improvement of Higher Education Personnel, linked to the Ministry of Education. After data collection, carried out between October 2021 and March 2022, each public notice was read in full, in order to extract the following elements: name of the program; program code; name of the Higher Education Institution; acronym; Federative unit; and number of vacancies for master’s courses. Results 79 institutions in the country were identified, with a final sample of 67 evaluated programs, which were classified into nine types, based on the use of affirmative policy principles in academic and professional master’s degrees. Conclusion Postgraduate Nursing courses present an imbalance regarding the implementation of affirmative policies in their offers of regular vacancies, as well as in issues of equity in regional access and diversity in the social groups contemplated. DESCRIPTORS Public Policy; Social Vulnerability; Education, Nursing, Graduate; Teaching; Social Inclusion

Objective To map the inclusion of affirmative policies in Postgraduate Nursing courses in Brazil. Method This is a descriptive, document-based study, carried out with information collected on the Sucupira Platform, via the Coordination for the Improvement of Higher Education Personnel, linked to the Ministry of Education. After data collection, carried out between October 2021 and March 2022, each public notice was read in full, in order to extract the following elements: name of the program; program code; name of the Higher Education Institution; acronym; Federative unit; and number of vacancies for master’s courses. Results 79 institutions in the country were identified, with a final sample of 67 evaluated programs, which were classified into nine types, based on the use of affirmative policy principles in academic and professional master’s degrees. Conclusion Postgraduate Nursing courses present an imbalance regarding the implementation of affirmative policies in their offers of regular vacancies, as well as in issues of equity in regional access and diversity in the social groups contemplated. DESCRIPTORS Public Policy; Social Vulnerability; Education, Nursing, Graduate; Teaching; Social Inclusion