Xinshuo Huang

Sun Yat-Sen University | SYSU · Department of Microelectronics

Effective intracellular DNA transfection is imperative for cell-based therapy and gene therapy. Conventional gene transfection methods, including biochemical carriers, physical electroporation and microinjection, face challenges such as cell type dependency, low efficiency, safety concerns, and technical complexity. Nanoneedle arrays have emerged a...

The limited lifespan of batteries is a challenge in the application of implantable electronic devices. Existing wireless power technologies such as ultrasound, near-infrared light and magnetic fields cannot charge devices implanted in deep tissues, resulting in energy attenuation through tissues and thermal generation. Herein, an ultra-low frequenc...

Background: Precise and dynamic blood glucose regulation is paramount for both diagnosing and managing diabetes. Continuous glucose monitoring (CGM) coupled with insulin pumps forms an artificial pancreas, enabling closed-loop control of blood glucose levels. Indeed, this integration necessitates advanced micro-nano fabrication techniques to miniat...

Metabolic substances play a pivotal role in maintaining the body's regular physiological functions. When these processes are disrupted, it can lead to metabolic disorders which may cause severe damage to various organs. Diabetes mellitus, a prevalent metabolic disorder, arises from disturbances in sugar metabolism among other substances. Consequent...

Modern medicine is increasingly interested in advanced sensors to detect and analyze biochemical indicators. Ion sensors based on potentiometric methods are a promising platform for monitoring physiological ions in biological subjects. Current semi-implantable devices are mainly based on single-parameter detection. Miniaturized semi-implantable ele...

Conventional blood sampling for glucose detection is prone to cause pain and fails to continuously record glucose fluctuations in vivo. Continuous glucose monitoring based on implantable electrodes could induce pain and potential tissue inflammation, and the presence of reactive oxygen species (ROS) due to inflammation may affect glucose detection....

Semi‐implantable devices have shown potential for real‐time sensing of physiological information in vivo. For glucose detection in diabetes, semi‐implantable electrodes have the ability to measure glucose concentration directly from interstitial fluid (ISF) with high accuracy and continuous monitoring performance. However, electrochemical detection...

The utilization of dendritic cell (DC) vaccines is a promising approach in cancer immunotherapy, and the modification of DCs for the expression of tumor-associated antigens is critical for successful cancer immunotherapy. A safe and efficient method for delivering DNA/RNA into DCs without inducing maturation is beneficial to achieve successful DC t...

Point-of-Care-Testing (POCT) is a convenient and timely clinical analysis method, leading the development trend of advanced biosensors. The development of POCT equipment that can achieve minimally invasive percutaneous monitoring can avoid the pain felt by the subjects and achieve in vivo and efficient measurement. Here, we reported the development...

Monitoring human health is of considerable significance in biomedicine. In particular, the ion concentrations in blood are important reference indicators related to many diseases. Microneedle array-based sensors have enabled promising breakthroughs in continuous health monitoring due to their minimally invasive nature. In this study, we developed a...

Current catheter devices in minimally invasive surgery still possess limited functional options, lacking multimodal integration of both sensing and therapy. Catheter devices usually operate outside the tissue, incapable to detect intra‐tissue biochemical information for accurate localization and assessment of lesions during surgery. Inspired by the...

Integrated systems for diabetic theranostics present advanced technology to regulate diabetes yet still have critical challenges in terms of accuracy, long-term monitoring, and minimal invasiveness. Inspired by the feature and functions of animal masticatory system, we presented a biomimetic microneedle theranostic platform (MNTP) for intelligent a...

Developing techniques to effectively and real-time monitor and regulate the interior environment of biological objects is significantly important for many biomedical engineering and scientific applications, including drug delivery, electrophysiological recording and regulation of intracellular activities. Semi-implantable bioelectronics is currentl...

The flexible pressure sensor is the foundation of wearable / implantable biosensing and human-machine interface, which mainly consists of the piezoresistive, capacitive, piezoelectric, and triboelectric types. As each type of...

Microneedle systems have been widely used in health monitoring, painless drug delivery, and medical cosmetology. Although many studies on microneedle materials, structures, and applications have been conducted, the applications of microneedles often suffered from issues of inconsistent penetration rates due to the complication of skin-microneedle i...

A closed‐loop system that can mini‐invasively track blood glucose and intelligently treat diabetes is in great demand for modern medicine, yet it remains challenging to realize. Microneedles technologies have recently emerged as powerful tools for transdermal applications with inherent painlessness and biosafety. In this work, for the first time to...

Biosensors worn on or implanted in eyes have been garnering substantial attention since being proven to be an effective means to acquire critical biomarkers for monitoring the states of ophthalmic disease, diabetes. Among these disorders, glaucoma, the second leading cause of blindness globally, usually results in irreversible blindness. Continuous...

Biosensors that can automatically and continuously track fluctuations in biomarker levels over time are essential for real-time sensing in biomedical and environmental applications. Although many electrochemical sensors have been developed to quickly and sensitively monitor biomarkers, their sensing stability in complex biofluids is disturbed by un...

Liquid food containers commonly suffer from inevitable contamination and even biofilm formation due to the adhesion of food residuals or saliva, which requires detergents to clean. Although previously reported superhydrophobic and omniphobic coatings can resist the adhesion of liquids, the requirements of specific nanostructures or infused lubrican...

Programmed cell death protein-1 (PD-1) on T-cells combined with programmed cell death ligand-1 (PD-L1) critically accounts for tumor immune evasion. Anti-PD-1 (aPD-1) blocks the binding of PD-1 to PD-L1, thus allowing T-cell activation for tumor cell eradication. Currently, the major challenges for cancer immunotherapy are how to improve the respon...

Hydrophobic particles have been suffering from aggregation in aqueous-media, which limits their applications in oil/water separation. Surfactants have been used to increase the dispersity of the hydrophobic particles in water, but this approach compromises particles' hydrophobicity and oil absorption capabilities. Recently, hierarchical micropartic...

A variety of nanomaterial‐based biosensors have been developed to sensitively detect biomolecules in vitro, yet limited success has been achieved in real‐time sensing in vivo. The application of microneedles (MN) may offer a solution for painless and minimally‐invasive transdermal biosensing. However, integration of nanostructural materials on micr...

Slow relaxation of magnetization is observed in a neodymium(III) single-ion magnet based on phosphine oxide, which successfully extends our pentagonal bipyramidal family to light lanthanides. Comprehensive magnetic characterizations reveal that the magnetic dynamics follow the power law that corresponds to a Raman process, despite an energy splitti...