Ting Qi

UCSF University of California, San Francisco | UCSF · Department of Neurology

Language skills increase as the brain matures. Language processing, especially the comprehension of syntactically complex sentences, is supported by a brain network involving functional interactions between left inferior frontal and left temporal regions in the adult brain, with reduced functional interactions in children. Here, we examined the gra...

The humans' brain asymmetry is observed in the early stages of life and known to change further with age. The developmental trajectory of such an asymmetry has been observed for language, as one of the most lateralized cognitive functions. However, it remains unclear how these age-related changes in structural asymmetry are related to changes in la...

During childhood, the brain is gradually converging to the efficient functional architecture observed in adults. How the brain's functional architecture evolves with age, particularly in young children, is however, not well understood. We examined the functional connectivity of the core language regions, in association with cortical growth and lang...

Background Schizophrenia is a polygenetic disorder associated with changes in brain structure and function. Integrating macroscale brain features and microscale genetic data may provide a more complete overview of the disease etiology and may serve as potential diagnostic markers for schizophrenia. Objective We aim to systematically evaluate the i...

Reading comprehension is a vital cognitive skill that individuals use throughout their lives. The neurodevelopment of reading comprehension across the life span, however, remains underresearched. Furthermore, factors such as maturation and experience significantly influence functional brain development. Given the complexity of reading comprehension...

Developmental dyslexia (DD) is characterized by difficulties in reading due to a core impairment in phonological awareness. The clinical manifestation also includes a more general auditory verbal short-term memory (vSTM) dysfunction. However, little is known about the behavioral and brain basis of vSTM deficits in children with dyslexia, failing to...

Most studies of dyslexia focus on domains of impairment: reading and phonology among others. Few studies on dyslexia examine possible strengths. In the present study, we investigated a cognitive strength in English-speaking children with dyslexia aged 8-13, namely semantic fluency. We adjusted performance for letter fluency and tested the specifici...

How genetic risk variants may relate to brain abnormalities is crucial for understanding cross-scale pathophysiological mechanisms underlying schizophrenia. The present study identifies brain structural correlates of variation in gene expression in schizophrenia and its clinical significance. Of 43 patients with schizophrenia, RNA-seq data from blo...

Developmental dyslexia (DD) is typically associated with difficulties in manipulating speech sounds and, sometimes, in basic auditory processing. However, the neuroanatomical correlates of auditory difficulties in DD and their contribution to individual clinical phenotypes are still unknown. Recent intracranial electrocorticography (ECoG) findings...

BACKGROUND Schizophrenia (SCZ) and bipolar disorder (BD) are severe psychiatric conditions that can involve symptoms of psychosis and cognitive dysfunction. The two conditions share symptomatology and genetic etiology and are regularly hypothesized to share underlying neuropathology. Here we examined how genetic liability to SCZ and BD shapes norma...

Schizophrenia (SCZ) and bipolar disorder (BD) are severe psychiatric conditions that can involve symptoms of psychosis and cognitive dysfunction. The two conditions share symptomatology, neuropathology, and genetic etiology and are thus regularly hypothesized to share underlying biology. Here we examined the effect of their combined genetic liabili...

The framework of assimilation and accommodation has been proposed to explain the brain mechanisms supporting second language reading acquisition (Perfetti et al. [2007]: Bilingual Lang Cogn 10:131). Assimilation refers to using the procedures of the native language network in the acquisition of a new writing system, whereas accommodation refers to...