Surovi Saikia

Bharathiar University · Department of Biotechnology

Esophageal cancer is a complex disease influenced by genetic and environmental factors. Single nucleotide polymorphisms [SNPs] in non-coding regions of the genome have emerged as crucial contributors to esophageal cancer susceptibility. This review provides a comprehensive overview of the role of SNPs in non-coding regions and their association wit...

With the objective to identify novel anticancer leads, herein ruthenium-catalyzed electrochemical homo- and heterocoupling reactions of terminal alkynes have been developed for the synthesis of the desired products. Among the synthesized 1,3-diynes, some of them were rigorously examined for possible in vitro anticancer activity against HeLa (human...

The authors aim to shed light on the practicality of using machine learning in finding complex chemoinformatics and bioinformatics applications as well as identifiying AI in biological and chemical data points. The chapters are designed in such a way that they highlight the important role of AI in chemistry and bioinformatics particularly for the c...

Lipids have received less attention than nucleic acids and proteins, which play a major role in building up the cell. They are a complex group of biomolecules varying in structure and function whose complexity can only be revealed by refining the present analytical tools. Lipogenesis is critical for tumor growth as it has been observed that FA (Fat...

The use of computers in cancer diagnosis is increasing continually powered by new modalities of imaging and advanced image processing methods. The use of bioinformatics, chemoinformatics, mathematical models and artificial intelligence is some of the critical fields but not limited to employing computers for drug design. Medical imagining remains t...

The study involves cold extraction of the powdered dried leaves of Camellia assamica, which helps in ensuring that all the plant components are extracted to the maximum for better outcome. Phytochemical analysis was carried out using standard procedure. Total phenolic content was determined using standard Folin-Ciocalteau's (FC) method. In vitro an...

Machine learning (ML) is the most promising subset of artificial intelligence. Quantum computing is prevalent for fast problem-solving approaches. The complex problems are classified and solved using huge multi-dimensional space. The various algorithms can interfere in multi-dimensional space and resolve the problems. Quantum Machine Learning provi...

Background The North East (NE) India region has a quite distinct gene pool with over 160 scheduled tribes and 400 other sub-tribal populations. This region is the fourth contributor to the gene pool of the Indian sub-continent, which has associations with Tibeto-Burman speakers and Austro-Asiatic speakers settled in East and NE-India with Asian tie...

The core concept of drug design is data analysis and the methods used in such analysis. The angle of artificial intelligence (AI) in drug discovery is mainly concentrated towards the methodological aspect of computation such as deep learning. With the growth in computing power and advancement in AI methods, this field including machine learning/dee...

Nanomaterials have undergone rapid development in the last few decades, galvanized by the versatility of their functional attributes and many inherent advantages over bulk materials. The state of art experimental techniques to synthesize nanoparticles (NPs) from varied sources, offers unprecedented opportunities for utilization and exploration of m...

Glioblastoma is the malignant tumor affecting the central nervous system. Despite the advancement in treatment modalities, presence of blood-brain barrier, recurrence after surgical removal, resistance to radiotherapy and chemotherapy remain the major obstacles for long term survival of the patients. In this context, finding suitable therapeutics w...

Illicium griffithii Hook. f. & Thoms is an endemic medicinal plant of North East India found in the Eastern Himalayan region of biodiversity mega centre. Herein, chemical investigation of I. griffithii, afforded five compounds and their structures were determined through extensive use of NMR, HRMS, and FT-IR spectroscopy. The complete proton-proton...

Removal of cancer tissues does not always lead to disease cure due to lack of early detection, poor prognosis, and limited therapeutic options. The use of nanoparticles (NPs) as detectors has been widespread in recent years for cancer cell detection. Cancer diagnosis and therapy is expected to leap forward in the future with the development of NPs....

Polyoxyethylene tallow amine (POEA) is a nonionic surfactant added to insecticide and herbicide formulations. Experimental data have been shown the toxic effects of POEA on aquatic organisms and remain to be a serious concern. In this study, total of thirty-two potential bacteria that were isolated from herbicide-contaminated soil samples showed th...

Eurya acuminata DC and Croton caudatus Gieseler are two ethno-medicinal plants used by Kuki community of North East India. From these plants, we have characterized fifteen phytochemicals (1–15) by extensive use of chromatographic and spectroscopic methods. They were also tested for in vitro cytotoxic effects against A549 and MIAPACA2 cell lines and...

Eco-friendly synthesis of metal nanoparticles has accrued utmost interest by researchers in the last decade for their distinct properties making them applicable in different fields of science and technology. With regard to its low cost, low environmental effect, zero contamination and higher reducing potential, their synthesis by green chemistry pr...

The key down player remains for drug industries is the selection of biological target currently attracting huge investments to validate them in patient subsets in order to study potential drugs. GPCRs are one such druggable target wherein non-olfactory GPCRs are encoded by 50% of the human genome-encoded which are therapeutically unexploited. The c...

Molecular docking is a process through which small molecules are docked into the macromolecular structures for scoring its complementary values at the binding sites. It is a vibrant research area with dynamic utility in structure based drug-designing, lead optimization, biochemical pathway and for drug designing being the most attractive tools. Two...

Hit, Lead & Candidate Discovery Plant‐based antiviral therapy is the current need for holistic health care management, which can be achieved through screening of phytochemicals and designing of antiviral peptides. There exist certain host's factors which are directly involved for rapid viral replication causing worldwide pandemic. A total of 177 p...

The essential oil extracted from fruit of Micromelum integrrimum were evaluated through gas chromatography and gas chromatography-mass spectroscopy. 52 compounds were identified from the fruit oil representing 99.98% of the oil. The major components of the total fruit oil are monoterpene hydrocarbons (72.23%), oxygenated monoterpenes (14.78%) and s...

Background: Cancer is a grave health problem for the world as global cancer burden rises to 14 million new cases with 8.2 million deaths every year which is expected to rise by 70% in next 2 decades as reported by WHO. These steady rises in death demand for rapid developments in anti-cancer agents. Essential oils, being natural and multi-component...

The aim of this study was to isolate and characterize bioactive secondary metabolites from the flora of the Indo-Burma biodiversity belt for controlling leaf blight disease of Solanum khasianum Clarke (Solanaceae) caused by Alternaria tenuissima and Alternaria alternata during commercial cultivation, the berries of which contains 1.80–3.45% solasod...

Aims: The aim of this study was to isolate and characterize the bioactive compound of Micromonospora auratinigra, HK-10 and its antibacterial inhibitory mechanism. Methods and results: An oily bioactive compound was extracted from HK-10 (GenBank accession no. JN381554) and found to have promising antibacterial activity. The compound was characte...

Star fishes (Asteroidea) are rich in polar steroids with diverse structural characteristics. The structural modifications of star fish steroids occur at 3β, 4β, 5α, 6α (or β), 7α (or β), 8, 15α (or β) and 16β positions of the steroidal nucleus and in the side chain. Widely found polar steroids in starfishes include polyhydroxysteroids, steroidal su...

Malaria parasite Plasmodium falciarum are becoming drug resistant and the present drugs are becoming ineffective towards the disease. The Plasmodium falciparum causes the most malignant form of malaria highly prevalent to North–East India. In this investigation, a study was conducted to search and predict potent anti-malarial lead compounds from tw...

Herbal application of different plant parts has long been used as anti-diabetic agent by rural people since time immemorial in North East India. This unexplored paradise of India is geographically rich in medicinal plants diversity, where more than two hundred plant species are documented for their potential use in diabetic treatment by various eth...