partha pratim Dutta

Assam down town University · Faculty of Pharmaceutical Science

Background Cuts and wounds are unfortunate yet inevitable events. Traditional remedies have historically harnessed various plants for wound healing, undergoing clinical and pre-clinical scrutiny. Hence, this systematic review focuses on clinically researched herbal formulations for wound healing. Methodology Following Preferred Reporting Items for...

Type 2 Diabetes continues to be one of the major public health issues worldwide without any sustainable cure. The modulation of gut microbiota is believed to be caused by probiotic bacteria and several probiotic strains have previously shown antidiabetic activity. The present study aims to isolate potential probiotic bacteria from traditionally use...

Diabetes mellitus poses a significant health challenge globally, often leading to debilitating complications, such as neuropathy and retinopathy. Quercetin, a flavonoid prevalent in fruits and vegetables, has demonstrated potential therapeutic effects in these conditions due to its antioxidant, anti-inflammatory, and neuroprotective properties. Thi...

The Wnt/β-Catenin pathway (Wnt/β-CatP) is implicated in accelerating carcinogenesis and cancer progression, contributing to increased morbidity and treatment resistance. Even though it holds promise as a focus for cancer treatment, its intricate nature and diverse physiological effects pose significant challenges. Recent years have witnessed signif...

Euphorbia antiquorum L. is a small plant in the Euphorbiaceae family that is found primarily in tropical and subtropical Asia. It has a long tradition of being utilized in Chinese, Ayurvedic, and other traditional systems for a variety of ailments. To date, More than 116 bioactive constituents were isolated from Euphorbia antiquorum, with diterpeno...

Amomum dealbatum Roxb. parts have been traditionally used as remedies for joint pain, diabetes, muscular rheumatism, antiseptic, and abscesses in Arunachal Pradesh, Assam, and Tripura. Ethyl acetate sub-fraction E3 had significantly inhibited the α-glucosidase (IC50 5.385 μg/mL). The molecular docking revealed quercetin-3-O-galactoside to be the mo...

Chromene is a naturally abundant heterocyclic compound found in alkaloids, tocopherols, terpenes and other compounds. Its derivatives can be used as a scaffold that exhibits pharmacological activity in the human body. Chromene drugs and related bioactive molecules are the prime focus of this reference. It presents 13 thoroughly researched chapters...

The present study evaluated the therapeutic potential of the medicinal plant Lysimachia candida Lindl. against metabolic syndrome in male SD rats fed with a high-fat high-fructose (HFHF) diet. Methanolic extract of Lysimachia candida Lindl. (250 mg kg-1 body weight p.o.) was administrated to the HFHF-fed rats daily for 20 weeks. Blood samples were...

North East (NE) India is one of the 'biodiversity hotspots' of the world supporting about 50% of India's biodiversity. In the sparse to dense forests across alpine to tropical climatic conditions, the NE region has a vast distribution of medicinal plants. The present study has compiled and enlisted the wide range of medicinal plants used by differe...

Flavonoids are important bioactive phenolic compounds abundant in plants and exhibit different therapeutic potentials. A wound is a significant problem in diabetic individuals. A hyperglycaemic environment alters the normal wound-healing process and increases the risk of microbial infection, leading to hospitalization, morbidity, and amputation. Fl...

Novel antibiotic breakthroughs are urgently required to combat antimicrobial resistance. Actinomycetia are the principal producers of antibiotics.

Introduction Paederia foetida Linn. is a widespread plant of the Rubiaceae family distributed in temperate and tropical Asia. The plant has a distinct characteristic of emitting a strong and sulfurous odor on crushing and bruising of its leaves or stems. It has a long history of usage in Chinese, Ayurvedic, and other traditional systems of medicine...

Effective management of pain and inflammation associated with number of conditions like rheumatism, pneumonia, cancer, colitis, irritable bowel syndrome, neurodegenerative disease, heart problems etc is a major health concern. Currently, available medicines like non-steroidal anti-inflammatory drugs (NSAIDs), opioid analgesic, steroids may cause di...

Species of Clerodendrum are a well-known medicinal plant in the Indian traditional system of medicines for its multi-purpose use in the management of various diseases or disorders. For scientific validation of the traditional claims, this study aimed to delineate the antioxidant properties and phenolic contents of methanolic leaf extracts of five s...

Objectives: The Barak Valley is well known for its rich diversity of medicinal plants. Ethnomedicinal practices are prominent among Barak Valley’s major and minor ethnic groups. This systemic review focuses on traditionally used medicinal plants found in the Barak Valley as reported in different ethnobotanical surveys. Methods: We searched various...

Objectives: The Barak Valley is well known for its rich diversity of medicinal plants. Ethnomedicinal practices are prominent among Barak Valley's major and minor ethnic groups. This systemic review focuses on traditionally used medicinal plants found in the Barak Valley as reported in different ethnobotanical surveys. Methods: We searched vario...

Diabetes mellitus is a chronic metabolic disorder resulting in an increased blood glucose level and prolonged hyperglycemia, causes long term health conse-quences. Chronic wound is frequently occurring in diabetes patients due to compromised wound healing capability. Management of wounds in diabetic patients remains a clinical challenge despite man...

Polyphenols are the class of natural compounds present in all vascular plants possessing scavenging properties towards radical oxygen species. Phenolic compounds can be divided into two main groups are flavonoids and non-flavonoids. The beneficial health effects of polyphenols are related to several remarkable biological properties, such as antio...

Toxic plants and their effects on Humans and Animals

Background : Premna herbacea Roxb., a perennial herb is well documented for its therapeutic uses among the traditional health care-givers of Assam, India. Scientific validation on the traditional use of the medicinal plant using modern technology may promote further research in health care. Purpose : This study evaluates the therapeutic potential...

Fatty liver is one of the most common metabolic syndrome affecting the global population. Presently, limited treatment modalities with symptomatic approach are available for alleviating fatty liver. Traditional and herbal treatment modalities have shown evidence to improve the disease pathology. In the present research work, evaluation of a selecte...

A series of transition metal (II) complexes with general formula [M(L¹⁻⁴)2(H2O)2] (where M = Co(II), Ni(II), Cu(II) and Zn(II)) was synthesized by the reaction of metal(II) acetates with hydrazones [HL¹–HL⁴] obtained from condensation of tetralone with hydrazide derivatives. The characterization of synthesized compounds (1–20) was done by using ele...

Inspired by the role of organotin(IV) complexes in inhibition of cancer cell growth and interaction with different target proteins, we have synthesized a series of new organotin(IV) complexes of Schiff base ligands of benzylidene benzohydrazide analogues. The structural elucidation of compounds was done by spectroscopic studies showing tridentate n...

Eco-friendly synthesis of metal nanoparticles has accrued utmost interest by researchers in the last decade for their distinct properties making them applicable in different fields of science and technology. With regard to its low cost, low environmental effect, zero contamination and higher reducing potential, their synthesis by green chemistry pr...

Mahanine (MH), a carbazole alkaloid isolated from an edible plant (Murraya koenigii), potentially inhibits thegrowth of altered subtypes of breast cancer cellsin vitroand significantly reduced the mammary tumor burden inN-Methyl-N-nitrosourea (MNU) induced rat. The experimental results showed that 20–25μM of MH for 24 h oftreatment was very potent...

Gnetum gnemon L. (Gnetaceae) is used traditionally for treating malaria related fever by indigenous people of North East India. In our preliminary study, the ethanol extract of G. gnemon leaves showed promising antiplamodial activity against Plasmodium falciparum chloroquine sensitive (3D7) strain in vitro with an IC50 value of 29.4 μg/mL. Therefor...

The essential oil extracted from fruit of Micromelum integrrimum were evaluated through gas chromatography and gas chromatography-mass spectroscopy. 52 compounds were identified from the fruit oil representing 99.98% of the oil. The major components of the total fruit oil are monoterpene hydrocarbons (72.23%), oxygenated monoterpenes (14.78%) and s...

In the present study, we are reporting antimalarial potential of silver (AgNPs) and gold (AuNPs) nanoparticles synthesized by leaf and bark extract of Syzygium jambos (L.) Alston (Myrtaceae). AuNPs and AgNPs obtained by both the extracts were characterized using UV–vis spectroscopy, zeta potential, transmission electron microscopy (TEM), X-ray diff...

The aim of this study was to isolate and characterize bioactive secondary metabolites from the flora of the Indo-Burma biodiversity belt for controlling leaf blight disease of Solanum khasianum Clarke (Solanaceae) caused by Alternaria tenuissima and Alternaria alternata during commercial cultivation, the berries of which contains 1.80–3.45% solasod...

Aims: The aim of this study was to isolate and characterize the bioactive compound of Micromonospora auratinigra, HK-10 and its antibacterial inhibitory mechanism. Methods and results: An oily bioactive compound was extracted from HK-10 (GenBank accession no. JN381554) and found to have promising antibacterial activity. The compound was characte...

The study was conducted to evaluate the adaptogenic activity of hydroethanolic extract of Elsholtzia communis (Collett & Hemsl.) Diels. by estimation of neurobiological and biochemical changes associated with acute and chronic stress. Adult male Wistar rats were given forced swimming induced acute and chronic stress for 3 and 7 days, respectively....

Beneficial effects of Gnetum gnemon L. on acute and chronic stress induced neurobehavioural and biochemical perturbations in rats

Star fishes (Asteroidea) are rich in polar steroids with diverse structural characteristics. The structural modifications of star fish steroids occur at 3β, 4β, 5α, 6α (or β), 7α (or β), 8, 15α (or β) and 16β positions of the steroidal nucleus and in the side chain. Widely found polar steroids in starfishes include polyhydroxysteroids, steroidal su...

Antibiotic resistance is a major challenge to combat tuberculosis. Several reports of antibiotic resistance strains of Mycobacterium tuberculosis is strongly demanding the need of new and alternative antibiotics for its inhibition. Therefore, current investigation is an attempt to screen few lead molecules for the inhibition of arbinosyl transferas...

In continuation of our search for efficient pest control natural products from the flora of the South Eastern Sub-Himalayan biodiversity region, we have investigated wild edible Piper pedicellatum C. DC (Piperaceae) from Arunachal Pradesh, India against five important plant pathogenic fungi through an activity guided method, and a new compound, ped...