Sailee Shroff

University of Jyväskylä | JYU · Nanoscience Center

Viruses may persist on solid surfaces for long periods, which may contribute to indirect transmission. Thus, it is imperative to develop functionalized surfaces that will lower the infectious viral load in everyday life. Here, we have tested a plastic surface functionalized with tall oil rosin against the seasonal human coronavirus OC43 as well as...

Three novel monomethine cyanine dyes were synthesized carrying electron donating groups to obtain even brighter nucleic acids probes. Photophysical properties of these dyes were evaluated with DNA and selected dyes...

In recent years, the studies of RNA and its use for the development of RNA based vaccines have increased drastically. Although cyanine dyes are commonly used probes for studying nucleic acids, in a wide range of applications, there is still a growing need for better and brighter dyes. To meet this demand, we have systematically studied the structur...

To efficiently lower virus infectivity and combat virus epidemics or pandemics, it is important to discover broadly acting antivirals. Here, we investigated two naturally occurring polyphenols, Epigallocatechin gallate (EGCG) and Resveratrol (RES), and polyphenol-functionalized nanoparticles for their antiviral efficacy. Concentrations in the low m...

Enteroviruses cause several severe diseases, with lytic infections that lead to rapid cell death but also persistent infections that are more silent and lead to chronic states of infection. Our study compared a cytolytic echovirus 1 infection to persistent coxsackievirus B5 infection by making a chimera with the structural proteins of echovirus 1 a...

Gold nanoparticles (GNPs) stabilized with amino acid L-Cysteine were studied for their cytotoxicity, cell internalization and their ability as drug delivery cargos for increasing the efficacy of Azidothymidine (AZT) against HIV-1Ba-L virus in vitro. GNPs exhibited low toxicity and increased cell internalization in peripheral blood mononuclear cells...

Gold nanoparticles (GNP), in recent years have gained special impetus in different fields of biomedical sciences such as targeted drug delivery, DNA labelling, sensors etc. As the morphologies and size of nanoparticles determine their properties and application; developing an easy, reproducible and eco-friendly synthesis method which can yield nano...