Qing Cai

Jilin University | JUT

Statement of problem: Volumetric resorption of the alveolar ridge often occurs following tooth extraction in both horizontal and vertical directions. There is a specific lack of evidence for alveolar ridge reconstruction at molar and premolar sites with severe bone resorption. Purpose: This randomized and controlled trial aimed to use three dime...

Objectives Schneider membrane thickening is a common maxillary sinus disease. However, the effect of Schneider membrane thickness on the transcrestal sinus floor elevation still has not reached a consensus. This retrospective study evaluated the perforation and bone formation outcome of the transcrestal sinus floor elevation sites with different Sc...

Being the most common cause of implant failure, peri-implantitis is defined as a pathological condition associated with the occurrence of peri-implant plaque, characterized by peri-implant mucosal inflammation and progressive loss of the supporting bone tissue attributed to the persistence of pro-inflammatory cytokines. Docosahexaenoic acid (DHA),...

Fluorescence emission in the near-infrared-II (NIR-II) optical window affords reduced autofluorescence and light scattering, enabling deep-tissue visualization for both disease detection and surgical navigation. Small-molecule NIR-II dyes are preferable for clinical bioimaging applications, as the flexibility in their molecular synthesis allows for...

Objective This study investigated the main mechanism and role of caspase-11/4 as a pattern recognition receptor (PRR) in periodontitis through caspase-11 inhibition. Design Clinical tissue samples were collected from patients with periodontitis and healthy volunteers and evaluated through hematoxylin–eosin (HE) staining, immunohistochemical (IHC)...

Background Peri-implantitis is the main cause of dental implant failure, which is associated with pyroptosis. The roles of D-aspartic acid (D-Asp) on pyroptosis and the mechanism of the protective effect of D-Asp on human gingival fibroblasts (HGFs) remain unknown. This study investigated the effects of D-Asp on the pyroptosis of HGFs induced by hi...

Objectives: Ferroptosis is associated with multiple inflammatory diseases. Periodontitis is an inflammatory disease mainly caused by oral opportunistic pathogens. However, the ferroptosis-periodontitis relationship has not been thoroughly described. We here analyzed whether ferroptosis is involved in periodontitis. Materials and methods: Human g...

In recent years, dental implantation has become the preferred protocol for restoring dentition defects. Being the direct contact between implant and bone interface, osseointegration is the basis for implant exerting physiological functions. Nevertheless, biological complications such as insufficient bone volume, poor osseointegration, and postopera...

Objective: This randomized controlled trial was primarily aimed at evaluating the volumetric changes of the alveolar bone after alveolar ridge reconstruction (ARR)in molar sites with severe bone resorption as compared with unassisted socket healing by means of three dimensional and linear analyses. Material and methods: A total of 31 patients (15 m...

Peri-implantitis is the leading cause of dental implant failure, initially raised by biofilm accumulation on the implant surface. During the development of biofilm, Actinomyces viscosus (A. viscosus) plays a pivotal role in initial attachment as well as the bacterial coaggregation of multispecies pathogens. Hence, eliminating the A. viscosus-associ...

Bone is a preferred site for both primary and metastasis tumors. Current diagnosis of osteopathia typically relies on noninvasive skeleton radiography technology. However, due to the limited resolution of ionizing radiation, accurate diagnosis and effective identification impairment areas are still lacking. Near-infrared (NIR) bioimaging, especiall...

Periodontitis is a chronic inflammatory disease induced by Porphyromonas gingivalis (P. gingivalis) and other pathogens. P. gingivalis release various virulence factors including lipopolysaccharide (LPS). However, whether P. gingivalis–LPS inducing pyroptosis in human gingival fibroblasts (HGFs) remains unknown. In present study, P. gingivalis–LPS...

Porphyromonas gingivalis biofilms are implicated in the pathology of peri-implantitis and periodontitis. In this study, D-arginine (R), D-methionine (M), D-histidine (H), and a mixture of these D-amino acids (D-AAs) were investigated as an effective therapeutic strategy against P. gingivalis biofilms. The bacterial growth activity and minimum inhib...

Rationale: Traditional free gingival graft (FGG) technique is usually used for patients with insufficient peri-implant keratinized mucosa. However, this technique often requires a second surgical area which increases the pain as well as the risk of infection in patients. Xenogeneic collagen matrix (XCM) membrane technique can obtain good results f...

Porphyromonas gingivalis ( P. gingivalis ) biofilm is involved in peri-implantitis and periodontitis. Whether a mixture of D-AAs has synergistic effects on P. gingivalis biofilm remains unknown. The aim of this study was to investigate the effects of multiple D-AAs on P. gingivalis biofilm. D-arginine (R), D-methionine (M) and D-histidine (H) were...

Vertical bone insufficiency in the maxillary posterior teeth is a common clinical situation. At present, the bone insufficiency in the maxillary posterior teeth is mainly overcome by bone grafting through maxillary sinus floor elevation. Compared with traditional axial implantation, tilted implantation can better avoid bone grafting, reduce complic...

Porphyromonas gingivalis (P. gingivalis) is one of the major pathogenic bacteria of periodontitis or peri-implantitis. P. gingivalis tends to attach to the implant’s neck with the formation of biofilm, leading to peri-implantitis. d-arginine has been shown to have a potential antimicrobial role. In this study, P. gingivalis was cultured in Brain He...

A bone morphogenetic protein-2(BMP-2) derived synthetic oligopeptide, S[PO4]KIPKASSVPTELSAI-STLYLDDD(P24), has shown great potential for facilitating bone regeneration. However, P24 cannot be directly used onto bone defects, while a continuous sustained delivery of P24 may lead to a better formation of bone tissue. Based on this issue, we have deve...

Background: When presented with a surface or an interface, bacteria often grow as biofilms in which cells are held together by an extracellular matrix. Biofilm formation on implants is an initiating factor for their failure. Porphyromonas gingivalis is the primary etiologic bacteria of initiation and progression of periodontal disease. This microo...

The surface modification of titanium and its alloys with amino group plasma-enhanced chemical vapor deposition has been proven to enhance the performance of implants on initial osteoblast bioactivity in vitro. However, scarce information on the effect of this kind of surface modification on nerve regeneration exists. In this study, the surface chem...

Purpose: To study stability of soft and hard tissue with flapless immediate implant and immediate restoration of single tooth in the aesthetic region. Methods: 16 patients with unable retaining single tooth in the aesthetic region were randomly selected. After minimally invasive tooth extraction, implant was placed, resulting gap filled with platel...

The study aimed to evaluate the effects of different titanium surfaces on adhesion, proliferation, neurotrophin gene expressions of rat Schwann cell line (RSC96) and adhesion of dorsal root ganglion neurons (DRGns). Mechanical machining (M), sandblasted and acid-etched (S), and electrolytic etching (E) titanium surfaces were fabricated and observed...

In clinical applications, osseointegration is essential for the long-term stability of dental implants. Inspired by the hierarchical structure of natural bone, we applied the electrochemical etching (EC) technique to form a micro–nano structure on a titanium alloy (Ti6Al4V) substrate, called EC surface. Sand blasting and acid etching (SLA) and mach...

To evaluate the effect of parathyroid hormone (1-34) [PTH(1-34)] and coralline hydroxyapatite (CHA) on bone regeneration of peri- implant bone defects. Two implant sites were prepared on both sides of tibia in 8 mongrel dogs. The bone defect was created along one bone wall of each implant site. Implants were implanted into the implant sites, then C...

To investigate the influence of hierarchical hybrid micro/nano-textured titanium surface features on osteoblast differentiation. In this study, 3 different implant discs were produced: a hierarchical hybrid micro-/nanostructured titanium surface topography was modified using electrolytic etching (EE) technique, and a sandblasted, acid-etched (SLA)...

Resulting from their versatile functionality, nanomaterials with low systemic toxicity have offered high-performance diagnostic and therapeutic capabilities. Here, we designed and synthesized uniform magnesium silicate hollow spheres as high drug-loading nanocarriers for cancer therapy. Through a classical Stöber method and a hydrothermal process,...

A series of thermo-sensitive hydrogels were designed and synthesized via radical polymerization of AMsopropylacrylamide (NIPAAm) by using a biodegradable acryloyl-poly ( ε-caprolactone ) -2-hydroxylethyl methacrylate (AC-PCL-HEMA) as a cross-linker. The influence of temperature on the equilibrium swelling ratio and the optical transmittance of the...

To evaluate the application of image and information technology on the clinical study of delayed immediate implant, we chose clinical cases from May in 2008 to September in 2010, observed and followed up these cases and evaluated the treatment effects with digital images and X-ray examinations. We used the image and information technology before, d...

In the present work, osteoblast behavior on a hierarchical micro-/nano-structured titanium surface was investigated. A hierarchical hybrid micro-/nano-structured titanium surface topography was produced via Electrolytic Etching (EE). MG-63 cells were cultured on disks for 2 h to 7 days. The osteoblast response to the hierarchical hybrid micro-/nano...