Efficient energy harvesting for ultra-low frequency vibrations remains a large challenge. An ultra-low frequency ball-impacted potential-variable nonlinear energy harvester (abbreviated as BPNEH) is proposed in this work to provide a new solution for the challenge. Upon excitation, a horizontal beam, which is magnetically coupled to a vertical one, vibrates back and forth with large amplitudes through ball-impacts, along with a variable potential energy due to the vibration of the coupled vertical one. A prototype of the proposed BPNEH is fabricated to demonstrate the effective contribution of both the ball-impact and the variable potential energy under an ultra-low frequency excitation. Compared to a conventional potential-variable nonlinear energy harvester (abbreviated as PNEH), the RMS voltage of the proposed BPNEH is increased by 78.4 % in 1–8 Hz, along with a sub-peak that appears to the left side of the main peak. This new finding of a double peak phenomenon is further observed and clarified by a theoretical model, where the output voltage of the proposed BPNEH is increased by 209.6 % in 1–10 Hz. In addition, the main factors affecting the sub-peak in the observed double peak phenomenon are also considered and discussed with respect to harvesting more energy. The proposed BPNEH along with the double peak phenomenon is believed to be applicable to ultra-low frequency scenes, especially with large amplitudes, of engineering fields such as wearable devices, structural health monitoring systems, etc.
Oncorhynchus mykiss is delicious and contains abundant flavor substances. However, few studies focused on umami peptides of O. mykiss. In the current work, umami peptides derived from O. mykiss were identified using virtual screening, molecular docking, and electronic tongue analysis. First, the O. mykiss protein was hydrolyzed using the PeptideCutter online enzymolysis program. Subsequently, water-soluble and toxicity screening were performed by Innovagen and ToxinPred software, respectively. The potential peptides were docked with umami receptor T1R1/T1R3. Furthermore, taste properties of potential peptides were validated by electronic tongue. Docking results suggested that the three tetrapeptide EANK, EEAK, and EMQK could enter the binding pocket in the T1R1 cavity, wherein Arg151, Asp147, Gln52, and Arg277 may play key roles in the production of umami taste. Electronic tongue results showed that the umami value of EANK, EEAK, and EMQK were stronger than monosodium glutamate. This work provides a new insight for the screening of umami peptides in O. mykiss.
Extracellular trap (ET) appears as a double-edged sword for the host since it participates in host immune defense by entrapping pathogens, while excessive ET release also contributes to various diseases progression including atherosclerosis, cancer, and autoimmune disorders. A better understanding of ET formation and regulation will be beneficial for developing strategies for infection control and ET-associated disease treatment. There is some evidence indicating that prior infection can enhance extracellular killing. Neutrophils from cancer or sepsis are predisposed to generate ET. It is reasonable to suspect that ET may be trained to form as a memory response, just like cytokine memory response termed “trained immunity.” The mice were intraperitoneally injected with heat-killed Candida albicans (HK-C. albicans), 3 days later bone marrow-derived macrophages (BMDM) were isolated and challenged with Clostridium perfringens as a second stimulation. We found that HK-C. albicans priming enhanced ET formation upon Clostridium perfringens infection, accompanied by increased extracellular killing capacity. Mannan priming also enhanced ET formation. Since ETs memory was induced in chicken PBMC, ETs memory may be evolutionarily conserved. Moreover, mTOR was required for ETs memory response. Collectively, this study showed that ETs can be trained as a memory response and indicated that memory property of ETs should be considered during the understanding of recurrent infection and ET-associated disorders. © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
The Qianjiadian deposit is a typical sandstone-hosted uranium deposit that is hosted mainly in sandstone and siltstone of the Lower Cretaceous Yaojia Formation, located within the transition between the Kailu Depression and Jiamatu Uplift in the Songliao Basin, northeastern China. We studied the geological characteristics of this deposit, and analysed the mineralized sandstone by scanning electron microscopy (SEM) and electron probe microanalysis (EPMA) to identify the host minerals of fluid inclusions associated with uranium mineralization and describe their petrographic characteristics. In addition, this research investigated the origin of ore-forming fluids and the relationship between petroleum fluids and uranium mineralization, based on the following findings. (1) EPMA and SEM data show that uranium minerals are hosted mainly in hydrothermal quartz (HQ) within sandstone cement, which indicates that uranium minerals co-precipitated with HQ. (2) The fluid inclusions in the HQ show low homogenization temperatures (102.5–169.5°C) and low salinities (1.7–6.1 wt%). In contrast, aqueous inclusions in quartz overgrowths show lower temperatures (60.5–117°C) and higher salinities (4.2–8.7 wt%). (3) Petroleum fluids trapped in HQ homogenize fluid and those along healed microfractures in quartz overgrowth or plagioclase overgrowths at ~70–80°C, those trapped in present-day organic inclusions at ~85–95°C, and at the boundary of detrital mineral grains show higher homogenization temperatures (~135–145°C). These results indicate that the hydrothermal quartz cement is associated with uranium mineralization, and the ore-forming fluid of Qianjiadian sandstone-hosted uranium deposit are characterized by low-temperature, low-salinity hydrothermal fluids, and the changes of temperature and salinity of hydrothermal fluids may not be intimately associated with uranium mineralization.
Here, this work presents an air-stable ultrabright inverted organic light-emitting device (OLED) by using zinc ion-chelated polyethylenimine (PEI) as electron injection layer. The zinc chelation is demonstrated to increase the conductivity of the PEI by three orders of magnitude and passivate the polar amine groups. With these physicochemical properties, the inverted OLED shows a record-high external quantum efficiency of 10.0% at a high brightness of 45,610 cd m ⁻² and can deliver a maximum brightness of 121,865 cd m ⁻² . Besides, the inverted OLED is also demonstrated to possess an excellent air stability (humidity, 35%) with a half-brightness operating time of 541 h @ 1000 cd m ⁻² without any protection nor encapsulation.
Higher intake of β-carotene and β-cryptoxanthin were associated with lower risk of osteoporosis. A very high intake of lutein + zeaxanthin was also associated with lower risk of osteoporosis. These results support the beneficial role of carotenoids on bone health.PurposeTo examine the associations of α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein + zeaxanthin intake with the risk of osteoporosis based on the cross-sectional data from the National Health and Nutrition Examination Survey (NHANES), 2005–2018.Methods This study identified individuals ≥ 50 years old with valid and complete data on carotenoid intake and bone mineral density (BMD). Intake of α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein + zeaxanthin was averaged from two 24-h recall interviews. BMD was measured by dual-energy X-ray absorptiometry (DXA) and converted to T-scores; osteoporosis was defined as a T-score ≤ − 2.5. We used logistic regression models to test the associations between carotenoids and osteoporosis, adjusting for factors such as age, sex, race, and education.ResultsParticipants were on average 61.9 years of age, with 57.5% identifying as females. Higher quintiles of β-carotene (odds ratio [OR] for quintile 5 vs. 1:0.33; 95% CI: 0.19–0.59; P for trend = 0.010) and β-cryptoxanthin intake (OR for quintile 5 vs. 1:0.61; 95% CI: 0.39–0.97; P for trend = 0.037) were associated with reduced risk of osteoporosis. Similar and marginally significant results for lutein + zeaxanthin intake was found (OR for quintile 5 vs. 1:0.53; 95% CI: 0.30–0.94; P for trend = 0.076). There was no association of α-carotene and lycopene intake with osteoporosis. These associations did not differ by sex (all P_interaction > 0.05).Conclusions Higher β-carotene and β-cryptoxanthin intake was associated with decreased osteoporosis risk. A very high intake of lutein + zeaxanthin was also associated with lower risk of osteoporosis.
Vertical infiltration of water plays an important role in the recharged of contaminated water and enhanced moisture content in the unsaturated porous media. The mathematical model used for such type of phenomenon is Burger's equation. Unsaturated porous media are analyzed by solving Burger's equation using the variational iterative modeling and homotopy perturbation method. When considering all moisture contents, it appears that the cumulative coefficient is unchanged. It is also shown that the soil's moisture content decreases with depth (y) and time (t). The results indicate that this method is very efficient and can be useful to solve large-scale problems that arise in civil engineering, geology, material science, and fossil fuel problems.
The Hox transcript antisense intergenic RNA (HOTAIR) has been identified as a tumor gene, and its expression in HCC is significantly increased. HOTAIR is associated with the proliferation, invasion, metastasis and poor prognosis of HCC. In addition, HOTAIR can also regulate the expression and function of microRNA by recruiting the polycomb repressive complex 2 (PRC2) and competitive adsorption, thus promoting the occurrence and development of HCC. In this review, we discussed the two mechanisms of HOTAIR regulating miRNA through direct binding miRNA and indirect regulation, and emphasized the role of HOTAIR in HCC through miRNA, explained the regulatory pathway of HOTAIR-miRNA-mRNA and introduced the role of this pathway in HCC proliferation, drug resistance, invasion and metastasis.
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