Muditha Bandara Rathnayaka

University of Colombo · Department of Nuclear Science

Rationale and Objectives Interstitial fibrosis, common to most chronic kidney diseases, can potentially affect the speckle patterns of kidney ultrasound (US). Here we use Radiomics features derived from US images to identify kidneys with chronic kidney disease. Materials and Methods B-mode US without speckle reduction was performed on a cohort of...

Breast cancer (BC) can be identified as one of the extremely dominant cancers among women globally • Recently, the use of dynamic contrast-enhanced (DCE-MRI) breast magnetic resonance imaging provides an excellent opportunity to establish new approaches of noninvasive benign and malignant tumor diagnosis using radiomics. • Radiomics has the ability...

Prostate cancer is one of the most common cancers in males and one of the significant causes of cancer mortality. Most prostate malignancies are presently diagnosed based on an increased PSA level, despite this biomarker having only limited accuracy. Prostate cancer differs from most other cancers because it is frequently multifocal and does not ap...

PURPOSE : Degenerative disc disease (DDD) is one of the commonest causes of chronic back pain. Chronic back pain is defined as pain persis ting over three months and markedly influences occupation and quality of life. DDD refers to back pain due to intervertebral disc degeneratio n which consists of disc dehydration, fibrosis, and disc herniation....

Background - Breast cancer is one of the most common cancers among women globally and early identification is known to increase patient outcomes. Therefore, the main aim of this study is to identify the essential radiomic features as an image marker and compare the diagnostic feasibility of feature parameters derived from radiomics analysis and con...

Ultrasound (US) Elastography is a technique that uses low-frequency vibrations to measure the stiffness of the tissues. Liver elastography has shown the appropriability of detecting liver fibrosis which is considered to be the first stage of many liver diseases including cirrhosis. Chronic Kidney Disease (CKD) is known as one of the highly prevalen...

Radiomics is a technique used to extract a large number of texture features from medical images to support diagnostic decisions using mathematical algorithms. Chronic Kidney Disease (CKD) is one of the major global health challenges. Ultrasound B-mode imaging is considered a first-line diagnostic method in CKD, based on visual features. Renal biops...

Breast cancer is one of the most common cancers among women globally. Therefore, we investigated the diagnostic feasibility of feature parameters derived from Radiomics analysis and conventional Magnetic Resonance Imaging (MRI) to differentiate benign and malignant breast masses. T1W Dynamic Contrast-Enhanced (DCE) breast MR axial images of 151 (be...

The roughness characteristic of an organ surface is a key indicator for examining the finalities of that organ. There are traditional roughness calculation methods based on measurements using the stylus technique (contact system) which causes damages to the organ surface. However, compared to these traditional techniques, roughness calculations bas...

Objectives: The aim of this study was to use ultrasound-based kidney morphological features to classify chronic kidney disease (CKD) in an agricultural community in Sri Lanka where there is a high prevalence of CKD with unknown etiology. Materials and Methods: A cohort of CKD patients (n = 50) and healthy subjects (n = 26) underwent B-mode renal u...

Scientist have theoretically shown that there is a relationship between size and shape of the scatterers (s) and the bandwidth of the power spectrum (2σ) obtained from ultrasound echoes (RF echoes) . The purpose of this work is to conduct an experimental study to analyze as to how this s calculations can be utilized in tissue identification. A hete...

It has been found that the tissue structure changes due to different diseases, the level of disease, age etc. and these alterations cause observable changes in acoustic scattering properties. Also, frequency dependent back scatter information had been used to analyses tumors and organs. However, these studies were done by analyzing A mode or B mode...

Natural radionuclides are taken up by the herbs from the environment and are accumulated in varied concentrations in different parts of the plant. Therefore, it is considered as a type of contaminant in herbal medicines, which may harm consumers by long term usage. Centella asiatica (L) Urban is a weedy plant grown in Sri Lanka, which is widely use...

We show, for the first time, the feasibility of using MRI based renal resistivity index (RRI) to differentiate patients with chronic kidney disease from healthy subjects. RRI and the Pulse Wave Velocity (PWV) of the abdominal aorta were calculated using quantitative phase contrast imaging. The RRI was significantly higher in CKD patients (0.71 ± 0....

Frequency dependence of the tissue backscatters provides useful information about the tissue structure. Further, it has been found that structure of tissue changes due to different diseases and these alterations cause observable changes in acoustic scattering properties. Several parameters have been developed to identify these alterations and tissu...

Chronic kidney disease (CKD) of unknown etiology is recognized as a major public health challenge and a leading cause of morbidity and mortality in the dry zone in Sri Lanka. CKD is asymptomatic and are diagnosed only in late stages. Evidence points to strong correlation between progression of CKD and kidney fibrosis. Several biochemical markers of...

Classification of gray images based on their textural features is one of the main tools in medical image processing. Gray Level Co-occurrence Matrix (GLCM) is such a widely used technique which represents how frequently the different gray level combinations occur in an image, traditionally in Cartesian directions. Contrast, correlation, energy and...

Detection of early stage Chronic Kidney Disease (CKD) is essential to improve patient outcome but remains a challenge. In this study we generated T1 and T2 maps of renal cortex at 3.0 T in CKD patients and healthy volunteers (n=16). Modified Look-Locker sequence with simulated ECG and a multi-echo Gradient and Spin-Echo sequence were used to genera...

Chronic kidney disease (CKD) of unknown etiology is recognized as a major public health challenge and a leading cause of morbidity and mortality in the dry zone in Sri Lanka. CKD is asymptomatic and are diagnosed only in late stages. Evidence points to strong correlation between progression of CKD and kidney fibrosis. Several biochemical markers of...

The study was based on simulated magnetic resonance images (MRI) created by MATLAB software. The aim of the study was to estimate the effects of signal to noise ratio (SNR) and flip-angle variations, in the determination of longitudinal relaxation time T1. Simulated MRI experiments were used to determine optimal, image pixel sampling method to be u...

All living beings on earth are continuously exposed to radiation from primordial radio nuclides 232Th, 238U and 40K present in soils and sands. Due to their long half lives these radionuclide remain in soils and sands for long periods of time contributing to the natural background radiation. This study was carried out as a part of the island wide...