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Introduction
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Publications
Publications (59)
Metabolomics is a powerful approach that allows for high throughput analysis and the acquisition of large biochemical data. Nonetheless, it still faces several challenging requirements, such as the development of optimal extraction and analytical methods able to respond to its high qualitative and quantitative requisites. Hence, the objective of th...
Supporting Information for the following article: Ghosson, H.; Raviglione, D.; Salvia, M.-V.; Bertrand, C. (2024). LC–HRMS-Driven Computational Toolbox to Assess Extraction Protocols Dedicated to Untargeted Analysis: How to Ease Analyzing Pesticide-Contaminated Soils? Analytical Chemistry, 96(7):2810-2821. doi:10.1021/acs.analchem.3c03242.
Supporting Information for the following article: Ghosson, H.; Raviglione, D.; Salvia, M.-V.; Bertrand, C. (2024). LC–HRMS-Driven Computational Toolbox to Assess Extraction Protocols Dedicated to Untargeted Analysis: How to Ease Analyzing Pesticide-Contaminated Soils? Analytical Chemistry, 96(7):2810-2821. doi:10.1021/acs.analchem.3c03242.
Commercial solutions of pesticides consist of two main components: The active substance and the formulation ingredients. These ingredients, mainly composed of polymeric surfactants, are considered inert vis-à-vis the targeted organisms and nature. Nonetheless, a relatively low attention is given to their analysis and fate tracking in the environmen...
Supporting Information for the following article: Ghosson, H.; Raviglione, D.; Salvia, M.-V.; Bertrand, C. Characteristic response of formulation ingredients revealed by ultra high performance liquid chromatography-electrospray ionization-high resolution mass spectrometry-based untargeted screening of pesticides in soil. Journal of Mass Spectrometr...
Supporting Information for the following article: Ghosson, H.; Raviglione, D.; Salvia, M.-V.; Bertrand, C. Characteristic response of formulation ingredients revealed by ultra high performance liquid chromatography-electrospray ionization-high resolution mass spectrometry-based untargeted screening of pesticides in soil. Journal of Mass Spectrometr...
Metabolomics, the science that describes a full range of small molecules in a sample at a time point, is a powerful tool to evaluate patterns in metabolite variations affected by environmental factors. We developed a multiblock metabolomics approach using LC-HRMS, HS-SPME-GC–MS and 1H NMR to study the interspecies and temporal metabolites variation...
Biocontrol agents (BCAs) and biopesticides are emerging as alternatives to replace synthetic pesticides. This chapter focuses on the recent omics‐based studies assessing BCAs and biopesticide risks. It introduces novel omics‐based proxies aiming to improve (bio)pesticides risk assessment protocols. The assessment of the environmental impact consist...
Evidence of chemical plant protection products' (PPPs) long-term impact has been found in all environmental compartments. Therefore, other types of PPPs are developed to complement chemical PPPs like PPPs from natural sources, namely biocontrol products (BPs). Little is known about those new BPs, and it is important to assess their potential long-t...
Supplementary Data for the following article: Ramos, M.; Ghosson, H.; Raviglion, D.; Bertrand, C.; Salvia, M.-V. (2022). Untargeted metabolomics as a tool to monitor biocontrol product residues' fate on field-treated Prunus persica. Science of The Total Environment, 807:150717. doi:10.1016/j.scitotenv.2021.150717
Supporting Information for the following article: Ghosson, H.; Guitton, Y.; Ben Jrad, A.; Patil, C.; Raviglione, D.; Salvia, M.-V.; Bertrand, C. (2021). Electrospray ionization and heterogeneous matrix effects in liquid chromatography/mass spectrometry based meta‐metabolomics: A biomarker or a suppressed ion? Rapid Communications in Mass Spectromet...
Supporting Information for the following article: Ghosson, H.; Guitton, Y.; Ben Jrad, A.; Patil, C.; Raviglione, D.; Salvia, M.-V.; Bertrand, C. (2021). Electrospray ionization and heterogeneous matrix effects in liquid chromatography/mass spectrometry based meta‐metabolomics: A biomarker or a suppressed ion? Rapid Communications in Mass Spectromet...
Rationale
Correct biomarker determination in metabolomics is crucial for unbiased conclusions and reliable applications. However, this determination is subject to several drifts, e.g. matrix effects and ion suppression in Liquid Chromatography/Mass Spectrometry (LC/MS)‐based approaches. This phenomenon provokes critical issues for biomarker determi...
This work introduces a novel online Headspace-Solid Phase Microextraction-Gas Chromatography-Mass Spectrometry-based untargeted metabolomics approach, suggested as an alternative tool to study the environmental fate of volatile xenometabolites in emerging complex biopesticides, e.g. the Myrica gale methanolic extract herbicide containing several un...
Supplementary Data for the following article: Ghosson, H.; Raviglione, D.; Salvia, M.-V.; Bertrand, C. (2020). Online Headspace-Solid Phase Microextraction-Gas Chromatography-Mass Spectrometry-based untargeted volatile metabolomics for studying emerging complex biopesticides: A proof of concept. Analytica Chimica Acta, 1134:58-74. doi:10.1016/j.aca...
Supplementary Data for the following article: Ghosson, H.; Raviglione, D.; Salvia, M.-V.; Bertrand, C. (2020). Online Headspace-Solid Phase Microextraction-Gas Chromatography-Mass Spectrometry-based untargeted volatile metabolomics for studying emerging complex biopesticides: A proof of concept. Analytica Chimica Acta, 1134:58-74. doi:10.1016/j.aca...
Supplementary Data for the following article: Ghosson, H.; Raviglione, D.; Salvia, M.-V.; Bertrand, C. (2020). Online Headspace-Solid Phase Microextraction-Gas Chromatography-Mass Spectrometry-based untargeted volatile metabolomics for studying emerging complex biopesticides: A proof of concept. Analytica Chimica Acta, 1134:58-74. doi:10.1016/j.aca...
Untargeted metabolomics is an analytical chemistry approach dedicated for the analysis of small biomolecules called “metabolites”. One of its strengths is the ability of covering wide ranges of metabolic information in biological systems. However, exhaustive coverage of information is challenging from a chemical-analytical point of view. In fact, t...
Introduction Electrospray Ionization is one of the most utilized ionization techniques for LC-MS-based metabolomics [1]. However, it presents several drawbacks, e.g. the ion suppression phenomenon, causing ion intensity decrease [2]. The occurrence of the phenomenon is higher if the sample is more complex. Thus, studying samples with different comp...
Despite their known risks, herbicides are still essential for agriculture. Thus, natural herbicides are increasingly recommended to replace synthetic ones. However, there are still limitations in studying the environmental fate of several of them. The main reason is the lack of methods dedicated for this type of complex bio-herbicides. Hence, in th...
Despite their known risks, herbicides are still essential for agriculture. Thus, natural herbicides are increasingly recommended to replace synthetic ones. They are supposed less harmful on human health and ecosystem. However, there are still limitations in studying the environmental fate of several of them. The main reason is the lack of methods d...
Environmental meta-metabolomics consider studying mixtures containing endogenous and xenobiotic metabolites, issued from the application of anthropogenic compounds to an environmental matrix.
Our main research aim is to develop a Chromatography-Mass Spectrometry-based meta-metabolomics approach as an alternative tool for the evaluation of pesticide...
L’utilisation généralisée des Produits PhytoPharmaceutiques (PPP) issus de la synthèse chimique a causé certains problèmes environnementaux et de santé aujourd’hui de plus en plus Documentés. Parmi les PPP, il existe une classe de produits issus de la nature, les PPP de biocontrôle, qui sont plébiscités pour leur réputation moins impactante pour la...
Pesticides are regularly used for a variety of applications and are disseminated throughout the environment. These substances may have significant negative impacts. To date, the half-life, t1/2, was often used to study the fate of pesticides in environmental matrices (water, soil, sediment). However, this value gives limited information. First, it...
Bioherbicides appear as an ecofriendly alternative to synthetic herbicides, generally used for weed management, because they are supposed to have low side on human health and ecosystems. In this context, our work aims to study abiotic (i.e., photolysis) and biotic (i.e,. biodegradation) processes involved in the fate of leptospermone, a natural β-t...
Herbicide consumption is yearly increasing in order to enhance crop yield and its quality. However, these chemical compounds are threatening environment, and for instance, soil. Thus, tendency for natural bioherbicide use is increasing. In fact, these “bio-compounds” are supposed less harmful for the environment and its biodiversity. However, the e...
The emergence of pesticides of natural origin appears as an environmental-friendly alternative to synthetic pesticides for managing weeds. To verify this assumption, leptospermone, a natural β-triketone herbicide, and sulcotrione, a synthetic one, were applied to soil microcosms at 0× (control), 1× or 10× recommended field dose. The fate of these t...
Pesticide use is permanently increasing for several reasons. However, these chemical compounds are threatening human health and environment. Thus, natural pesticides are recently emerging as an alternative solution. In fact, as these biopesticides are issued from nature, they are supposed less harmful versus the environment. However, the evaluation...
Properly designed monolayer-protected nanoparticles (2 nm core diameter) can be used as nanoreceptors for selective detection and identification of phenethylamine derivatives (designer druges) in water. The molecular recognition mechanism is driven by the combination of electrostatic and hydrophobic interactions within the coating monolayer. Each n...
A simple and effective method for high-sensitivity NMR detection of selected compounds is reported. The method combines 1D NMR diffusion filter experiments and small monolayer-protected nanoparticles as high-affinity receptors. Once bound to the nanoparticles, the diffusion coefficient of the analyte decreases in such way that spectral editing base...
By exploiting a magnetization transfer between monolayer-protected nanoparticles and interacting analytes, the NMR chemosensing protocol provides a general approach to convert supramolecular receptors into chemosensors via their conjugation with nanoparticles. In this context, the nanoparticles provide the supramolecular receptor not only with the...
In this work, we develop a self-consistent route to inspect the conformational mobility of single chains in gold nanoparticles passivated with a monolayer of decanethiols. The approach is based on the match between a theoretical modeling under a coarse-grained level (i.e., system definition, buildup of the free energy profiles along relevant coordi...
This work describes the development of a sensitive analytical method to determine simultaneously traces of tetracycline and fluoroquinolone antibiotics in sludge and soil, based on PLE extraction, followed by SPE purification and finally an analysis by LC-MS/MS. Recoveries were greater than 87% in the case of fluoroquinolones and between 25.4 and 4...
Monolayer-protected nanoparticles provide a straightforward access to self-organized receptors that selectively bind different substrates in water. Molecules featuring different kinds of non-covalent interactions (namely, hydrophobic, ion pairing, and metal-ligand coordination) can be grafted on the nanoparticle surface to provide tailored binding...
Veterinary antibiotics and steroid hormones can be present at low levels in soil. Analytical methodologies are therefore necessary to analyse these compounds at the trace level in such a complex matrix. The goal of this work was to compare Pressurised Liquid Extraction (PLE), which is usually used to extract drugs from soil, and a modified-QuEChERS...
Solution-phase self-association characteristics and DNA molecular-recognition properties are reported for three close analogues of minor-groove-binding ligands from the thiazotropsin class of lexitropsin molecules; they incorporate isopropyl thiazole as a lipophilic building block. Thiazotropsin B (AcImPyiPrThDp) shows similar self-assembly charact...
Numerous chemical products are dispersed into the environment, and the consequences can be sometimes harmful to humans and ecosystems. Pharmaceutical compounds and hormone steroids are among these substances that concern the scientific community. Currently, little data are available on the presence and fate of these compounds in the environment and...
Several chemical products are dispersed in the environment and the consequences can be sometimes harmful for humans and the ecosystems. Among these substances appear the antibiotics and the hormonal steroids. Nowadays, only few data are available on the presence and the fate of these substances in the environment in particular for solid matrices, m...
Nanoparticles composed of a silver core coated with a silica shell (Ag@SiO2) were prepared. A dye, fluorescein isothiocyanate (FITC), was further encapsulated during the growth of a second silica shell onto Ag@SiO2 nanoparticles. The proximity of silver nanoparticles led to a 4-fold maximal enhancement in the fluorescence of FITC when the first sil...
The aim of this study was to develop an analytical method for the analysis of traces of hormonal steroids and veterinary and human drugs in soil. Thus, 31 substances were selected, including 14 veterinary products, 11 hormonal steroids and 6 other well-known human contaminant compounds. The procedure inspired by the quick, easy, cheap, effective, r...
communication par affiche
L'utilisation croissante de produits chimiques pour l'agriculture et l'activité domestique est responsable de la dissémination de nombreuses substances nuisibles à l'homme dans l'environnement. Parmi ces dernières, les stéroïdes hormonaux et les composés pharmaceutiques ont suscité une vive attention ces dernières années. Si plusieurs méthodes d'an...
The dyes Nile Blue (C. I. Basic Blue 12) and Thionine (C. I. 52000) were examined in both ionic and neutral forms in different solvents using NMR and UV–visible spectroscopy to firmly establish the structures of the molecules and to assess the nature and extent of their aggregation. 1H and 13C NMR assignments and chemical shift data were used, toge...
