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cbic 201402202 sm miscellaneous information

Authors:
Hasan Y. Alniss at University of Sharjah
Hasan Y. Alniss
Marie-Virginie Salvia at Université de Perpignan
Marie-Virginie Salvia
Mykhailo Sadikov
Mykhailo Sadikov
Mykhailo Sadikov
  • This person is not on ResearchGate, or hasn't claimed this research yet.
Igor Golovchenko at University of Strathclyde
Igor Golovchenko
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Supporting Information
 Copyright Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, 2014
Recognition of the DNA Minor Groove by Thiazotropsin
Analogues
Hasan Y. Alniss ,[a, d] Marie-Virginie Salvia,[b] Mykhailo Sadikov,[b] Igor Golovchenko,[b]
Nahoum G. Anthony,[c] Abedawn I. Khalaf,[b] Simon P. MacKay,[c] Colin J. Suckling,[b] and
John A. Parkinson*[b]
cbic_201402202_sm_miscellaneous_information.pdf

                          
     !"     !"   "    !
" #$ % &      '()  # !*#+ "  
,'!-     !..$ !$+   /0#1#   
)   2*342+ "  3# )  &%5
*  .- %5%*
&   * %#     6  )
-      #       %*
 #
 
7     * *   0  !/8+
898:;;< +
%99******#

7     * *   0  !/8+
/ " !=   9  >
898:;;< +
%99******#
/ " !=   9  >
14- %9
? #+ %&9  
@
A**  + 2
/-
/3" ? $B" !=   C   9
0 !/8
%8:#=*  *  D%5
8&- )" ? $%  */#

A**  + 2
/-
/3" ? $B" != C   9
-0 !/8
   8:  *7 6+ "   7#=  *     
*  D%58&- )" ? $%  
*/#
0
  A* *     + 2
/-
/3 " ? $B "!=      6 % 
C   9
 >14 E  0  !/8  *7+" 6  7#  * 
 5%  %5/ /04/1
" ?$# (*+"  " ? $ *     %F * " ?$ *    
*F* " ? $*   *+ "  " ? $*  
%D#
 
  -
 +"  6 2∆δ G
δ
144C9
 6 C
+ *
,
  -
∆δ-/@C-!9 / C"- #9 
*
δ
%
δ

37 8 :4C9
 6 C
 6 C
!-#
9#     *  &  + "  E#
+ *
 *+"   #
*
%*
 6 C
-"9F >
9#     *  &  + "  E#
1
 $   *    - ∆δ- %  %   +"   >14
C%5%&9-8C%5%&9-8
: C %5 &9 /- "/- !/  # /@  #  + "  E  
  >14  8    %   %    +"  E   
8: %#
#

"
!
;
 % 9 + *   5* %* %  8 :   + "  6
C9
%9.&* *5*%C*9
  %  8 : CD 9      + "  6# /5* %  
*%5+&5* #

"
 
"
/" !=  *  + "  6 C9
Chemical Shift:
1
H (ppm)
H8
H6
H2
H5
CH
3
H1´
H2´
H2´´
H3´
H4´
H5´
H5´´
GH1/TH3
H41
H42
Base
C1 7.635 5.941 5.763 1.893 2.384 4.711 4.078 3.728 3.728
G2 7.980 5.456 2.742 2.811 5.015 4.322 3.983 3.983 13.01
A3 8.244 7.920 6.275 2.729 2.928 5.080 4.497 4.242 4.176
C4 7.203 5.237 5.603 1.939 2.339 5.081 4.281 4.162 4.162 8.196 6.509
G5 7.839 5.889 2.618 2.738 4.983 4.367 4.133 4.051 12.90
C6 7.297 5.318 5.691 2.075 2.415 4.856 4.194 4.145 4.145 8.324 6.509
G7 7.908 6.005 2.655 2.815 4.978 4.394 4.149 4.088 12.88
T8 7.286 1.458 6.058 2.093 2.475 4.880 4.222 4.141 4.141 13.80
C9 7.521 5.739 5.731 2.049 2.397 4.871 4.141 4.081 4.081 8.690 7.077
G10 7.980 6.199 2.441 2.766 4.708 4.085 4.085 4.085

"
/" !=  *  +"  C 9
E&#8:6
Chemical Shift:
1
H (ppm)
H8
H6
H2
H5
CH
3
H1´
H2´
H2´´
H3´
H4´
H5´
H5´´
GH1/TH3
H41
H42
H21
H22
Base
C1 7.660
5.951
5.795
1.926
2.424
4.745
4.103
3.755
3.755
G2 8.008
5.624
2.769
2.879
5.063
4.366
4.012
4.012
12.95
A3 8.312
7.937
6.093
2.684
2.794
5.094
4.465
4.231
4.231
C4 7.387
5.322
5.909
1.893
2.087
4.944
4.187
4.190
4.190
7.725
6.119
G5 7.920
5.390
2.458
2.604
4.677
2.247
3.847
3.501
13.20 8.022
8.497
C6 7.065
5.659
5.469
1.555
2.304
4.642
2.214
3.810
3.625
8.465
6.295
G7 7.847
5.304
2.180
2.745
4.688
3.845
3.502
3.502
13.36 8.031
8.499
T8 6.931
1.678
5.528
1.721
1.900
4.579
2.262
3.886
3.652
13.90
C9 7.459
5.726
5.676
2.165
2.393
4.899
4.174
4.021
3.591
8.808
6.962
G10 8.006
6.223
2.439
2.675
5.064
4.136
4.136
4.136

" 
/ " !=     C∆δ9  C∆δ9 GδC*%  +"  9δC*  +"  9  6 C9
    *    
8:#
4H  % %  + " #  *7A*   %  ∆δI # 7%F%*#
:5 ** ∆δI # #
Chemical shift differences:
1
H (ppm)
H8
H6
H2
H5
CH
3
H1´
H2´
H2´´
H3´
H4´
H5´
H5´´
GH1/TH3
H41
H42
H21
H22
Base
C1
0.025 0.010 0.032 0.033 0.040 0.034 0.025 0.027 0.027
G2
0.028 0.168 0.027 0.068 0.048 0.044 0.029 0.029 -0.060
A3
0.068 0.017
-0.182 -0.045 -0.134 0.014 -0.032 -0.011 0.055
C4
0.184 0.085 0.306 -0.046 -0.252 -0.137 -0.421 0.027 0.027 -0.471 -0.390
G5
0.081 -0.499 -0.160 -0.134 -0.306
-
2.120
-0.286
-
0.550
0.300 n/a n/a
C6
-0.232 0.341 -0.222 -0.520 -0.111 -0.214
-
1.980
-0.335
-
0.520
0.141 -0.214
G7
-0.061
-
0.701
-0.475 -0.070 -0.290
-
0.892
-0.304
-
0.586
0.480
T8
-0.355 0.220
-
0.530
-0.372
-
0.575
-0.301
-
1.960
-0.255 -0.489 0.110
C9
-0.062 -0.013 -0.055 0.116 -0.004 0.028 0.033 -0.060 -0.490 0.118 -0.115
G10
0.026 0.024 -0.002 -0.091 0.356 0.035 0.051 0.051

"
/" !=  *  +"  C 9
E&#>146
Chemical Shift:
1
H (ppm)
H8
H6
H2
H5
CH
3
H1´
H2´
H2´´
H3´
H4´
H5´
H5´´
GH1/TH3
H41
H42
H21
H22
Base
C1
7.630
5.927
5.772
1.887
2.386
4.724
4.075
3.275
3.250
G2
7.987
5.567
2.740
2.816
5.047
4.340
4.104
3.984
13.001
A3
8.395
8.005
5.983
2.617
2.927
5.111
4.505
4.260
4.178
C4
7.677
5.466
6.283
1.868
2.249
4.635
4.268
3.319
3.853
7.498
6.500
T5
7.268
1.725
4.535
1.902
2.198
4.721
2.771
3.711
3.558
13.12
A6
8.045
7.906
5.406
2.257
2.752
4.707
2.692
3.848
3.259
G7
7.686
5.260
2.105
2.612
4.678
2.580
3.882
3.552
12.79 8.515
6.172
T8
6.834
1.566
5.452
1.630
1.716
4.469
2.166
3.661
3.529
13.85
C9
7.394
5.638
5.553
2.120
2.308
n.a. 4.014
n.a. n.a. 8.712
6.883
G10
7.964
6.203
2.640
2.410
4.699
4.216
4.069
4.069
##H*
@
"
/ C∆δ9C∆δ9GδC*% +"  9δC*+ " 9 6 C 9
 *>14#
Chemical Shift:
1
H (ppm)
H8
H6
H2
H5
CH
3
H1´
H2´
H2´´
H3´
H4´
H5´
H5´´
GH1/TH3
H41
H42
H21
H22
Base
C1
0.011 0.011 0.027 0.016 0.014 0.026 0.008 n/a n/a
G2
0.021 0.081 0.001 -0.007 0.033 0.010 0.006 0.007 0.051
A3
0.155 -0.301 -0.148 -0.003 0.043 -0.006 0.023 -0.017
C4
0.409 0.260 -0.484 -0.072 -0.219 -0.058 0.055 -0.482
-
0.505
-0.150
T5
-0.065 0.132
-
1.149
-0.200 -0.277 -0.156
-
1.354
-0.440 n/a n/a
A6
-0.187
0.72
0
-
0.652
-
0.515
-0.152 -0.346
-
1.743
-0.242
-
0.916
G7
0.092
-
0.607
-0.367 -0.101 -0.189
-
1.800
-0.373
-
0.729
0.060
T8
-0.426 n/a 0.304
-
0.586
-0.436
-
0.727
-0.392
-
2.057
-
0.695
0.150
C9
-0.118 -0.285 -0.182 0.061 -0.082 -0.085 0.080 -0.140
G10
0.011 0.035 0.003 0.020 0.005 0.015
4H  % %  + " #  *7A*   %  ∆δI # 7%F%*#
:5 ** ∆δI # #

" 
/" != * >14 6 C9
Chemical Shift:
1
H (ppm)
H1 H2 H3 H5 H7 H9 H11 H14 H16 H18 H21
8.455
7.532
7.436
8.764
9.738
6.045
7.637
10.930
6.426
7.882
10.65
0
Chemical Shift:
1
H (ppm)
H25 H29 H30 H31 H32 H33 HM1 HM2 HM3 HM4 HM
(6&7)
3.583
8.279
3.421
2.068
3.231
4.820
3.971
3.872 1.082
1.197
3.029
N
CH
3
O
N
S
N
O
N
CH
3
N
N
O
H
3
C
N
H
3
C
N
O
CH
3
H
3
C
N
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
1
2
3
7
9
5
11
HM1
14
16
18
HM2
21
HM4
HM3
29
HM6 HM7
33
30
30
31
31
32
32
25
0
" $   *   *    %  C9
7 6 >1#
Structure
free DNA Complex
NOE peak assignments
DNA intra-residue
265 336
DNA inter-residue
126 123
DNA inter-strand
- 21
DNA-ligand
- 173
Intra-ligand
- 62
Inter-ligand
- 41
Total NOE peak assignments 391 756
Amber input after conversion based on
duplex symmetry
a
603 968
Interproton distances 433 798
Interproton distances used after error
checking 418 766
Average atomic rmsd
b
(Å) 0.88 ± 0.12 2.20 ± 0.6
Distance restraint violations:
≥ 0.05 Å
c
7 5
≥ 0.10 Å
d
48 3
≥ 0.20 Å
e
36 0
> 0.50 Å
f
1 0
  *D-%D%  *-J D
 " ? $  #
%
&*     & &
%!+ #

+&& *
-∆  # K≤∆L # K#

# K≤∆L # K#

# K≤∆≤ # K#

∆I # K#
 
,
" %7    *    *    %  C9
7 6 8:#
Structure
Free DNA Complex
NOE Assignments
DNA intra-residue
137 318
DNA inter-residue
68 141
DNA inter-strand
2 16
DNA-ligand
- 176
Intra-ligand
- 63
Inter-ligand
- 26
Total NOE peak assignments 207 740
Amber input after conversion based on
duplex symmetry
a
425 958
Interproton distances 253 791
Interproton distances used after error
checking 239 749
Average atomic rmsd
b
(Å) 1.82 ± 0.52 1.72 ± 0.34
Distance restraint violations:
≥ 0.05 Å
c
17 12
≥ 0.10 Å
d
55 73
≥ 0.20 Å
e
77 48
> 0.50 Å
f
7 3
  *D-%D%  *-J D
 " ? $  #
%
&*     & &
%!+ #

+&& *
-∆  # KL∆L # K#

# K≤∆L # K#

# K≤∆≤ # K#

∆I # K#
 
1
& ' ( !(  
.!+ -  8E% * #
C9  &       8    +"    *      %5  
 D 

K
 C -+-C5G 9 %5 
  )**- 9- * %      K C9-   %5 C%G9F
   &5  C9#C9  +"  *  
 & 5     C -+-C5
G  9   %5     )**- 9- *  %     K C9- 
 %5 C%G9#C9$E%      " ? $
   #  5     *  " M  %  (*& 5    
E5

   >& #!+&&" M %
 C > -&59 * 
/>$
* 5*&5 %#!+   
  *         & #  " !=       * 
#  )     5 * )    &* %      !+ 
   *5  5 &*# !+    
N >"  & *0.N  # 
  " !=   8  :C 9
 >14C9
 6&% #
  
' !#) !#!

O#.#=5D-# /#:  *$$+ - ,H@#"  *  
$E!5  7!+5 D#
10
-
mer DNA
-
ligand complex: initial minimization prior to MD
&cntrl
imin = 1,
maxcyc = 500,
ncyc = 250,
ntb = 0,
igb = 0,
cut = 12
/
10
-
mer DNA
-
ligand
complex: MD in
-
vacuo, 12 angstrom cut off
&cntrl
imin = 0, nmropt=1, ntb = 0,
igb = 0, ntpr = 100, ntwx = 100,
ntt = 3, gamma_ln = 1.0,
tempi = 300.0, temp0 = 300.0
nstlim = 50000, dt = 0.001,
cut = 12.0
&end
&wt type='REST', istep1=0,istep2=1000,value1=1.0,
value2=1.0, &end
&wt type='END' &end
DISANG=filename.rest
LISTOUT=POUT
;
      " !=    8  : C9
 >14C9
 66&#
'  , #
'  -, -)
./"
Initial minimization fix solute minimized solvent+ions 12.0 cut
&cntrl
imin =1,
maxcyc =1000,
ncyc =500,
ntb = 1,
ntr = 1,
cut = 10
/
Hold The solute fixed
500.0
RES 1 20
END
END
initial minimization whole system
&cntrl
imin = 1,
maxcyc = 2500,
ncyc = 1000,
ntb = 1,
ntr = 0,
cut = 10.0
/
10
-
mer DNA
-
ligand complex: 20ps MD
with res on DNA
&cntrl
imin = 0,
irest = 0,
ntx = 1,
ntb = 1,
cut = 10,
ntr = 1,
ntc = 2,
ntf = 2,
tempi = 0.0,
temp0 = 300.0,
ntt = 3,
gamma_ln = 1.0,
nstlim = 10000, dt = 0.002
ntpr = 100, ntwx = 100, ntwr = 1000
/
Keep DNA fixed with weak restraints
10.0
RES 1 20
END
END
 
'  ! 0 ) !1 #! ( 
 
10
-
mer DNA
-
ligand complex: Production run
&cntrl
imin = 0, nmropt=1, irest = 1, ntx = 7,
ntb = 2, pres0 = 1.0, ntp = 1,
taup = 2.0,
cut = 10.0, ntr = 0,
ntc = 2, ntf = 2,
tempi = 300.0, temp0 = 300.0,
ntt = 3, gamma_ln = 1.0,
nstlim = 50000, dt = 0.002,
ntpr = 100, ntwx = 100, ntwr = 1000
&end
&wt type='REST', istep1=0,istep2=1000,value1=1.0,
value2=1.0, &end
&wt type='END' &end
DISANG=ACTAGT.rest
LISTOUT=POUT

"*" ? $  6%  >14+ " C 9
? !P ? !P)(? J P:" + N .P:" + M P+
/Q /@Q #1#1 #1
/0 RQ#0;@ #0;1 #0;0
/0 /@Q@#1 @#  @#;
/0 /Q# ; # # 
/0 /Q#@ #@@ #@
/0 /#@  #@  #@ 
/Q /Q# , # 1 # 1
/Q /Q#,1  #,1 #,1 
/Q /0#;00 #;0, #;00
/Q /@Q@#; @#0 @# 
/Q /Q#@0 #@1 #@,
/Q /#;1; #;; #;;
/Q /0#0 #0 #0
/Q /Q#@@ #@@ #@@
/Q /Q#,0 #1 #,1
/Q /Q#1,, #1,1 #1,,
/Q /@Q#;@ #;0 #;
/Q /@Q#; #;, #;
/Q /Q#0 #0, #0@
/1 /Q@# @#1 @#0,
/1 /Q#@01 #@,@ #@,
/1 /Q#0 #0; #00
/1 /Q@#1, @#1, @#1@@
/1 /Q#,1@ #,; #,; 
/1 /@Q#@ @ #@ 1 #@ 0
/1 /Q#1;1 #; #; @
/1 /Q#;  #;@ #;
/ /1# @ # 10 # 
/Q /@Q#;,, #;; #;1
/Q /Q#1  #1 #1
/Q /Q#0  #0  #0 
/Q /1#@ #@1 #@
/Q /@Q#00 #0, #000
/Q /Q#; #; #;
/Q /Q#  # @ # 
/Q /1#@1 #@1 #@1
/Q  /Q#0; #, #, 
/Q  /Q#; #; #;
/Q  /Q#1 #1@ #1
/Q  /@Q#11; #1; #1; 
/Q  /Q#@, #; #
/Q  /@Q#  #  # 
/Q  /Q# #@  #1
/1 /Q@# 0 @#1 @#
/1 /Q#,  #,1 #,@
/1 /1@#1 @#, @#@
/1 /Q# ; #  #  
/1 /Q#;1 #;;0 #;1;
/1 /Q@#  @#0  @#,
/1 /Q@#,1, @#1@0 @#1,
/1 /@Q#@, #@ #@10
/1 /Q@#  @# , @# 
/1 /Q# #0  #0
/ /Q@# 10 @# @# ;;
? !P ? !P)(? J P:" + N .P:" + M P+
/Q  /@Q #,1  #,1 #,1 
/Q  /Q #@ # #@
/Q  /Q #  #, #
/Q  /1#@@; #@  #@ 
/Q  /Q #;  #; #;
/Q  /Q #;1 #  # 
/Q  /1#;, #  # 
/Q@ /Q#  # @ # 
/Q@ /Q#  #0 #
/Q@ /@#10 @#  @# 
/Q@ /Q@#010 #0;0 #0;
/@@ /@@#, #,@ #,
/@ /Q#  # #
/@ /Q#,;, #,;1 #,;1
/@ /Q#1@@ #1@ #1@;
/@ /@@# #  #1
/@ /@@#11 #1 #10
/0@ /1@#;;0 # 0 #  
/0@ /Q#@ #@@ #;
/0@ /Q#@  #@0 #@
/0@ /@Q@#;,  #;, #;, 
/0@ /Q@#@ #@ #@
/0@ /Q@#, # #;
/0@ /@#1 #0  #;
/Q@ /@Q@#0, #0@ #0@
/Q@ /Q@#  #  # 
/Q@ /Q@#11 #;  #1;
/Q@ /0@#00; #01 #0,
/Q@ /@Q@#0 @ #0  #0 @
/Q@ /Q@#1@ #1 #1@
/Q@ /Q@#,; #1 #1
/Q@ /0@#,@ #, #,
/@Q /Q#0  #0  #0
/@Q /Q#00  #00 #00
/Q /@Q#1 #1 #1
/Q /Q#@@ #@0 #@
/Q /Q#; #; #;
/Q /@Q#; #;1 #;
/Q /Q#@;@ #@;@ #@;@
/Q /Q#11, #1; #1;
/Q /Q#1 # #
/Q /@Q#,, #,,0 #,,@
/Q /Q#@; #@@ #@@
/Q /Q#@01 #@,  #@0;
/ /@@#,  #@,1 #@@
/ /@@#0; #0@, #0@
! /Q@#; #;, #;
! /Q@#0;; #,  #0;;
! /Q@#0;  #0;@ #0;
! /0@#@@ #@0 #@
! /Q@#11 #;  #1;
/0 /Q@#00 #, #;
/0 /Q@#@ #@@ #@@
/0 /0@#@0 #@0 #@;

? !P ? !P)(? J P:" + N .P:" + M P+
/0 /Q@#  #  # 
/0 /Q#01, #0;; #0;
/0 /Q#@ #0 #0 
/0 /@Q@#  @# @ @# 
/0 /Q@#@  @#0; @#
/0 /Q#0@@ #0@, #0@0
/0 /Q#@1 #@1 #@1
/0 /Q#,, #1; #1
/0 !# @  # @ # @
/@Q 0 /Q0#0,0 #0,, #0,0
/@Q 0 /Q0#0 #0@ #0
/Q 0 /Q0# #@ #
/Q 0 /@Q0#@@ #@@ #@@
/Q 0 /Q#;@ #;@, #;@0
/Q 0 /@Q0# #1 #0
/10 /Q#  # #
/10 /Q#0; #, #,
/10 /#,@ #,0 #,
/10 /0@#1  @#@ @#;0
/10 /Q0#, #1  #,0
/10 /Q0#  #, #
/10 /Q0@# 0 @# 1  @# ,
/0 /Q0@#@@ @#@,0 @#@0
/Q 0 /Q 0@# @ @# , @# 
/Q 0 /Q 0#,, #,1 #,,
/Q 0 /10#;0 #;01 #;00
/Q 0 /Q 0#1 1 #1  #1 ;
/Q 0 /Q 0#  # @ # 
/Q 0 /10#, #,@ #,
/Q 0 /Q 0# # #
/Q, /1 0@#@@ @#@, @#@
/Q, /Q0# 11 # ; # 1;
/@Q, /Q,#@  #@ #@
/@Q, /Q,#0 #0 #0
/Q, /Q,#;1 @#  #;;@
/Q, /@Q,# 0; # 0; # 0;
/Q, /0@#@; @#@0  @#@@@
/Q, /@Q,#  # , # 0
/Q, /Q,#@;; # @ # 
/1, /Q 0@#, @# @#@
/1, /10@#@ @#0@ @#
/1, /Q 0#1  #1 , #1 0
/1, /Q 0# # #
/1, /Q,#, #,@ #,;
/1, /Q,#,00 #,, #,, 
/1, /Q,#1, #110 #11
/, /0#, #,00 #,0 
/, /,#,,, #,1, #,1
/, /,#00 #0, #000
/, /,#0 #0 #0
/Q, /Q,#, #, #,
/Q, /Q,#0  #0 @ #0 
/Q, /1,#10; #1, #1, 
/Q, /Q,#00 #00 #00
/Q, /Q,#;0@ #;00 #;0
/Q, /1,#0@1 #0@; #0@;
? !P ? !P)(? J P:" + N .P:" + M P+
/Q1 /Q,#,1  #,1 #,1
/@Q1 /Q1#,1 #,; #,;
/@Q1 /Q1#0 #0 #0
/Q1 /Q1#, #, #,
/Q1 /Q1#,  #,  #,
/Q1 /@Q1# @0 # @; # @1
/Q1 /@Q1#, #@ #;
/Q1 /Q1#;01 #;0; #;0;
/Q1 /@Q1#0 #0@ #0,
/Q1 /Q1#0  #0 #0
/Q1 ! #  # @ # 
/Q1 /Q1#,1 #,1 #,1
/Q1 /@Q1#,0 #,00 #,0
/Q1 /Q1#@ #1 #0
/Q1 /Q1#@  #@ #@
/Q1 /Q1#1,, #1,; #1,1
!1 /Q,#;1  0# @, 0# @
!1 /1,#01 #0  #0;
!1 /Q,#01 #01, #010
!1 /Q,#00 #01 #0,
/01 /0#0  #0  #0 
/01 /Q,@#11 @#;  @#1, 
/01 /Q,#110 #1;; #1;
/01 /Q,#,1 #,; #,1
/01 /Q,#,, #,10 #,,;
/01 /@Q1# # #
/01 /Q1#, #,@ #,1
/01 /Q1#1, #; #; 
/01 /Q1#0  #0 #0 
/01 /Q1@# @# @#
/01 /1#@;  #@;0 #@;
/01 !1# , # 1 # 1
/Q; /@Q;# # #
/@; /@;#,, #,,0 #,,
/; /Q1#1  #1 #1
/; /Q1#0  #0 #0 ,
/; !1@# 0 @#  @# 1
/; /01#@,, #@1 #@,;
/; /@;#@ #@@ #@
/; /@;@# @ @# 0 @#  
/0; /Q1#,0 #,, #,,
/0; /Q1#;@ #;@ #;@
/0; /Q;#00 #0 #0;
/0; /;#,  #, 0 #, 
/Q; /@Q;@#0, @#; @#,;
/Q; /Q;#,  #, 0 #, 
/Q; /0;# 1 # 0 # 0
/Q; /Q;#@ #1 #0
/Q; /;#@, # #
/Q; /0;#@ #@ #@
/Q  /@Q #@ #@ #@
/Q  /@Q #@  #@ #@
/Q  /Q #@ #@0 #@@
/1  /Q;#;10 #;;; #;;
/1  /Q;#0  #0 #0 1
/1  /Q;#  #, #

? !P ? !P)(? J P:" + N .P:" + M P+
/1  RQ @#@ @#@ @#;
/1  /@Q @#@; @#@0 @#@
/1  /Q #1, #11 #1,,
/1  /Q #11 #101 #10
/Q  /@Q #;; @#  @# ,
/Q  /Q #; #;, #;0
/Q  /1 #0; #, #,
/Q  /@Q #,,  #,1 #,,
/Q  /Q #;; #0 0 #0 
/Q  /1 #1 #; #1
/Q /@Q#1  #1 #1
/0 RQ#,1 #, #,;
/0 /@Q@#11 @#  @#;,
/0 /Q# 1 #  # ;
/0 /Q#@  #@ #@
/0 /#@  #@ 0 #@ 
/Q /Q# 0 # 0 # 0
/Q /Q#,,1 #,,; #,,;
/Q /0#;0 #;0, #;00
/Q /@Q@#@1 @#, @#0
/Q /Q#@ #@, #@0
/Q /#;;  #;; #;;
/Q /0#0 #0 #0
/Q /Q#@@ #@@ #@@
/Q /Q#, #,1 #,
/Q /Q#1,0 #1,1 #1,,
/Q /@Q#; #; #;@
/Q /@Q#  # @ # 
/Q /Q#0; #0@, #0@
/1 /Q@#1 @#; @#,
/1 /Q#@01 #@, #@, 
/1 /Q#0 #0; #00
/1 /Q@#1 @#10, @#1;
/1 /Q#,1@ #,;@ #,1;
/1 /@Q#;; #@  #@ 
/1 /Q#1;0 #; 0 #; 
/1 /Q#;; #;  #;@
/ /@;@#,, @#;0 @#1,
/ /@;#; , #;1 #;
/ /1# @ # ,; # @0
/Q /@Q#;,; #;; #;1,
/Q /Q#10 #1, #10
/Q /Q#0 #0 #0
/Q /1#@ #@0 #@@
/Q /@Q#01 #000 #00
/Q /Q#;@ #; #;
/Q /Q#;;, #  #;;1
/Q /1#@1@ #@1 #@1@
/Q  /Q#1 #10 #1
/Q  /Q #;, #  #;;
/Q  /Q#,; #,;@ #,;@
/Q  /@Q#1 #1 #1
/Q  /Q#@@1 #@; #@
/Q  /@Q#;1 #;1, #;1
/Q  /Q# , # ,0 # ,
/1 /Q@#  @#; @#@
? !P ? !P)(? J P:" + N .P:" + M P+
/1 /Q#,@ #,@1 #,@@
/1 /1@#@ @#0, @#@
/1 /Q# ; #  #  
/1 /Q@# 0 @# 1; @# ,,
/1 /Q@#@0; @# 0 @#@11
/1 /Q@#,0 @#1 @#,;
/1 /@Q#@@ #,  # 
/1 /Q@#   @#  @# 0
/1 /Q#0; #,0 #,
/ /1 #10 #1, #10,
/ /Q@# , @#  @# 1,
/Q  /@Q #, #, #,
/Q  /Q# 1 # ; # ;
/Q  /Q #0 #0 #
/Q  /1#@@@ #@@@ #@@@
/Q  /Q#;  #;  #; @
/Q  /Q#0, #,  #0;
/Q  /1# @ # ; # ,
/Q@ /Q#11  #11@ #11
/Q@ /Q#1;, #;  #; 
/Q@ /@# 0 @#@@ @#
/Q@ /Q@#0 1 #01 #0
/@@ /,#;1, @# @ #;;
/@@ /,# ; #1 # 11
/@@ /,#,, #,1 #,,
/@@ /,#0; #,  #, 
/@@ /@@#,; #,@  #,;
/@ /Q#@, #@; #@1
/@ /Q#, #, #,
/@ /Q#@0 #@@, #@
/@ /@@#  # , # @
/@ /@@#0,0 #0; #01@
/0@ /01@# ,0 @# ;@ @# 1
/0@ /1@#1@ @#1; @#10,
/0@ /Q#, #,  #,,
/0@ /Q#  # # 1
/0@ /@Q@#@; #@@ #@@ 
/0@ /Q@#; # #
/0@ /Q@#; #0 #0
/0@ /@# # #
/Q@ /Q,#0@ #0@ #0@@
/Q@ /Q@#  #@ #
/Q@ /Q@#  # @ # @
/Q@/0@#,  #, #, 1
/Q@/@Q@#;; #;0 #;0 
/Q@/Q@# #0 #0
/Q@/Q@#1 #;1 #;
/Q@/0@#, ; #,  #, ;
/@Q /Q#,@ #, #,@
/@Q /Q#00 #000 #000
/Q /@Q#1  #1  #1 
/Q/Q#@ #@ #@
/Q /Q#;;, #;;; #;;1
/Q/@Q#;, #;@ #;
/Q/Q#@1  #@1 #@1 
/Q /Q#1@0 #1@; #1@,
@
? !P ? !P)(? J P:" + N .P:" + M P+
/Q /Q# # #
/Q /@Q#,, #,,, #,,0
/Q /Q#@@1 #@@1 #@@1
/Q /Q#@0 #@1 #@,
/ /@@# ;1 #; #1
/ /@@#,0 #,0 #,
!/,#; #;;; #;,
! /Q@#,@ #,@0 #,@@
!/Q@#@  #@  #@ @
!/Q@#@ #@0 #@@
!/0@#, #, #,@
! /Q@#; # #
/0 /Q@0#0 0#1;@ 0#,
/0 /Q@#  #  # 
/0 /0@#@0; #@,0 #@,
/0 /Q@# 0 # , # ,
/0 /Q#; #0  #;1
/0 /Q# #0 #1
/0 /@Q#;;@ @#  @# 
/0 /Q@# 0 @#@  @#
/0 /Q#0 #0@ #0
/0 /Q#@0, #@01 #@0,
/0 /Q#@ #@0 #@0
/0 !# 1 # 1@ # 1
/@Q 0 /Q0#0,  #0, #0, 
/@Q 0 /Q0#;0 #;, #;,
/Q 0 /Q0#  # @ # 
/Q 0 /@Q0#@0 #@0@ #@0@
/Q 0 /Q#; #;, #;0
/Q 0 /@Q0#@  #@ #@
/10 /Q#; #@  #;
/10 /Q#1 #@ #@ 
/10 /Q@#; # @@ @#;1 
/10 /#, ; #,  #, ;
/10 /0@#, @#1, @#,
/10 /Q0#0 #0 #01
/10 /@Q00#@; 0#1, 0#0
/10 /Q0#  #0 #
/10 /Q0@# 1@ @# ;1 @# ;
/0 /Q0@#@0 @#@0 @#@ 
/Q 0 /Q0@#  @#  @# 1
/Q 0 /Q0#, #,@ #,
/Q 0 /10#;00 #;01 #;0,
/Q 0 /Q0#1 #1@ #1@
/Q 0 /Q0#   #  # 
/Q 0 /10#,1 #,1@ #,1
/Q 0 /Q0# # #
/Q, /Q@#0,0 #0,1 #0,,
/Q, /10@#; @#@ @# 
/Q, /Q0# 0 # ; # 1
/@Q, /Q,#1 #; #;
/@Q, /Q,#; #0  #;
/Q, /Q,#,  #, #, 0
/Q, /@Q,# , # , # ,
/Q, /0@#@00 @#@; @#@1
/Q, /@Q,# 1 # 0  # ;
? !P ? !P)(? J P:" + N .P:" + M P+
/Q, /Q,# @ #  # ,
/1, /Q0@#0 @#,; @#, 
/1, /1 0@#  @#0, @#1
/1, /Q0#1  #1  #1 
/1, /Q0#@ #, #0
/1, /Q,#, 0 #, #,
/1, /Q,#,,  #,,1 #,,@
/1, /Q,#1,, #111 #11
/, !#;0, 0# @, 0# ,
/, / 0#,@0 #,0 #,
/, /@@#;@ #;01 #;0
/, /@@#,  #, #,
/, /,#,, #,0, #,0
/, /@@#  #; # 1
/, /@@#0  #0  #0
/, /,#0 1 #0, #0
/, /,#0  #0 #0 
/Q, /Q,#@ #@ #@
/Q, /Q,#0 ; #0 ; #0 ;
/Q, /1,#1,  #1, #1, 
/Q, /Q,#0, #01 #0,
/Q, /Q,#; #;0 #;
/Q, /1,#0@ #0@ #0@
/Q1 /Q,#,1 #,1 #,1@
/@Q1 /Q1#,@ #,0 #,
/@Q1 /Q1#00 #0, #0,
/Q1 /Q1#,0 #,0 #,0
/Q1 /Q1#, #, #,
/Q1 /@Q1# ; #   # ;
/Q1 /@Q1# #, #
/Q1 /Q1#;0, #;0; #;01
/Q1 /@Q1#0@, #0; #0
/Q1 /Q1#0; #0; #0;
/Q1 !#10 #1, #1,
/Q1 /Q1#,, #,,, #,,0
/Q1 /@Q1#,1 #,; #,1
/Q1 /Q1# # #
/Q1 /Q1#@; #@@  #@;
/Q1 /Q1#11  #11 #11
/1 /#1  #1; #1
!1 /Q,0#  0# 1  0# @0
!1 /1,#00 #001 #000
!1 /Q,#, #,, #,0
!1 /Q,#0@ #0, #0
/01 /0@@# ; @# @# 
/01 /0#,; #10 #1
/01 /Q,@#10@ @#; @#1;@
/01 /Q,#110 #;  #1;
/01 /Q,#,@ #,@ #,@
/01 /Q,#,, #,  #,@@
/01 /@Q1#@0 #@, #@0
/01 /Q1#,; #,0; #,0@
/01 /Q1#;  #;1 #;@
/01 /Q1#0@ #0@0 #0@0
/01 /Q1@#, @#@ @#0
/01 /1#@; #@;, #@;@

? !P ? !P)(? J P:" + N .P:" + M P+
/01 !1# ,, # ,1 # ,1
/Q; /@Q;# ,0 # ,; # ,,
/@; /@#  @#  @#
/@; /#; @ #;@ #; ;
/@; /@;#,0 #,0@ #,0
/; /Q1#1@ #1@ #1@
/; /Q1#00 #00 #0
/; !1@# @0 @# @; @# @1
/; /01#@, #@1 #@,1
/; /@;#@  #@  #@ 
/; /@;#;;0 @# ; @# 
/0; /Q1#01 #,  #0;
/0; /Q1#1, #1, #1,
/0; /Q;#;; #0 0 #0 
/0; /;#,  #,  #, 
/Q; /@Q;@#  @#@ @#
/Q; /Q;#0; #0; #0;
/Q; /0;# @@ # @0 # @
/Q; /Q;#;; # @ # 
/Q; /;#@ #; #0
/Q; /0;#@ #@@ #@@
/Q  /@Q #@1 #@10 #@1
/Q  /@Q #@ #@0  #@,
/Q  /Q #@  #@@ #@
/1  /Q;#;0 #;,@ #;01
/1  /Q;#0 , #0@ #0
/1  /Q;# 1 # #
/1  RQ @#1 @#, @#
/1  /@Q @#@ @#@, @#@0
/1  /Q #1 #10@ #1;
/1  /Q #1 #10 #10
/Q /@Q @# @#0 @#@
/Q /Q #@  #@ #@ 
/Q /1 #1, #; #1;
/Q /@Q #1 0 #1, #1
/Q /Q # #, #@
/Q /1 #00 #00 #00
/0( /Q0#11, #;  #1;
/0( /0#,@@ #,@ #,@@
/0( /Q,@#1 @#; @#1
/0( /@Q,#1 #11 #1
/0( /Q,#1@ #1@ #1@
/0( /,#, #, #
/0( /@Q,#@, #@ #@ 
/0( /Q,#,1 #,1 #,1
/( /00#,1 ,# , 0#1
/( /# ; #, #
/( /@Q,#11 #  #@@
/( /Q,#10 #;@ #; 
/( /Q,@#0 @#, ; @#01
/( /Q1@#, @# ; @#;
/( /@Q1@# @#,1 @#00
/( /Q1@#, 1 @#,0 @#,@
/( /0(#0 #  #1
!@( /@Q;@#01 @#0; @#01,
!@( /Q@#0@ #0@0 #0@@
? !P ? !P)(? J P:" + N .P:" + M P+
!@( /@Q1@#,  @#,@ @#, 
!@( /(#;00 #;0, #;0,
!( /(#1, #11 #11
/;( /Q1#  #@ #
R ( /Q;#;;0 #;;, #;;,
R ( /#,  #,  #, 
R ( /Q@#,,@ #,1, #,1 
R ( /;(#;@ #;@  #;,
R( /01@#0,0 @#, 1 @#0;
R( /@Q;#;, #;1 #;,,
R( /#;0 #;00 #;0
R( /Q@#0, #, #0;
R( /Q #@ #@ #@
R( /;(@#@ @#0 @#;
R( R (# # #@
R( /Q;#@@ #@, #@
R( /#, #, #,@
R( /Q@@#@@  @#@,; @#@;
R( /;(#0 #0 #0
R( R(#10 #1, #10
/( /1#1 #11 #1
/( /@# @#1 @#@
!0( /@Q;@#0 @#01 @#0
!0( /Q;#; 0 #; #; ;
!0( /@Q#@1 #@1, #@10
!0( /Q # 1 #  # 
!0( /#,, #, #,;
!0( /Q@#,, #1  #,;
!0( R(# 0 # 0, # 00
!( /0(@#;@ @#;, @#;0
!( !@(@# @# @#@
/1( /Q,#,  #, #, 0
/1( /@Q,#@ #; #,
/1( /@Q,#1 # #;
/1( /0(#1@  #1 #1@0
/1( !(#100 #100 #100
/@( /0#0; #,  #0;;
/@( /Q@#  @#  @#1
/@( /@Q0#  #@ #,
/@( /Q0#@; #@@ #@@
/@( /Q0#0 1 #,, #0;
/@( /@Q,#0 #  #@
/@( /0(#0;; #, 0 #, 
/@( !(,#1 ,#00 ,#;
!( /@Q 0#;, #;,, #;,
!( /@(0#  0# ,  0# 0
/( /@Q0#;; #  #
/( /Q0#;; #; #;@0
/(!(# , # , # ,
/,( /Q# #0 #@
/,( /Q @#  @# ; @# 
/,( /Q 0 @#@ @#0 @ @#,
/,( /@Q0#;  0#, 0# 
/,( /0 @#@, @# @#@;
/,( /@(@#@  @#@1; @#@0;
/,( /(0# 0#1, 0#0;0
0
? !P ? !P)(? J P:" + N .P:" + M P+
/( /Q@#,, #,, #,00
/( /@Q# #0  #1
/( /Q# # #
/( /Q 0# ; # #
/( /(@#@;, @#  @#
/( /Q@#  # @ # 
/( /Q@#0 #0 #0,
/( /Q #;@, #;0  #;@
/( /Q@#; #0@ #0
/( /Q#; #0 #0
/( /Q#; #; #;;
/( /@Q#1,1 #11 #11
/( /(#,, #,1@ #,,1
/( /Q@#0 #0@ #0
/( /# 1 #@ #0
/( /Q@#00 #01 #0,
/( /Q@#,0, #,, #,0;
/( /Q@#,0 #,0, #,0
/( /,(# , # ,@ # ,
/( /(#0,0 #0,, #0,0
/( /Q@#;  #; #;
/( /@#00@ @#,1 @#, 
/( /Q#1  #1 #1
/( /0#,@@ #,0 #,@
/( /,#,@ #,; #,,
/( /,(#0 #, #,
/( /(#0 #, #
/( /(#, #1 #,1
/;( /@Q0#   #  # 
/;( /Q0#;11 #;;  #;1;
/;( /0#,; #,; #,;
/;( /@(# #@ #
/;( /(#@@ #01@ #0@
/;( /,(#@ # #,
/;( /(#, # #
/0(/@Q,#@; #@@ #@
/0(/Q,#,0 #,1 #,,
/0(/Q0#111 #;  #1;@
/0(/0#,  #, #,
/0( /Q,@#@ @#0 @#@1
/0(/@Q,#1 #1; #1
/0(/Q,#1@@ #1@0 #1@
/0(/,#1 #0 #
/0(/;(#, #1 #,;
/(/# @ # 1, # 
/(/@Q,#; # #@0@
/(/Q,#1  #11 #1@
/( /Q,@#0@ @#0;1 @#0, 
/(/Q1@#1  @#0 @#;1
/(/@Q1@#0  @#1 @#,
/(/Q1@#,; @#,01 @#,@
/(/00#1 0#; 0#1,
/(/(@#;  @#; @#
/(/(@#@; @#1 @#0,
/( /0(#  # #
/(/(#, #, #,
? !P ? !P)(? J P:" + N .P:" + M P+
/(/(# , # # 
!@( /Q@#,@  #,@ #,@
!@(/@Q1@#,10 @#1 1 @#,;,
!@(/@Q;@# ,, @# 11 @# 1
!@(/(0# ; 0# 0#@,
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R( /Q # 1 # 10 # 10
R(/01@#1; @#1 @# @
R(/@Q;#0 #0@ #00
R(/(#111 #1; #11;
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R( /;(@#, @#;@ @#,0
R( R (#00 #01 #0,
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R(/Q;#0; #0;1 #0;0
R(/(@# @#, @#0@
R(/(# , # #
R(/(@#1 @#,  @#0
R( /;(# #; #,
R( R(#  #  # 
/(/#;; #;@ #;@,
/(/1#1@ #11 #1
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!0( /Q #@ #@0 #@@
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!0(/Q@#1 # # 
!0( /@Q;#;1, #;;@ #;; 
!0(/Q;#;,  #;, #;,
!0(/(0#@; ,#@  0#;,
!0( R(#01 #,  #0;
!( /(#,, #,,@ #,,
!(/;(#,  #,@ #,
!( /0(@#;, @#;00 @#;
!( !@(@#@ @#@@ @#@
/1(/@Q,#; # #
/1( /Q,#, #,00 #,0 
/1( /@Q,#@ #; #0
/1( !(@#  @# 1 @# 
/1( /(@#,@0 @#,10 @#,00
/1(/;(@# @#1 @#0,
/1( /0(#1@ #1@ #1@1
/1( !(#; #; #;
/@( /Q@#0 @#;; @#,1
,
? !P ? !P)(? J P:" + N .P:" + M P+
/@(/@Q0#; #@0 #@ 
/@(/Q0#@ #@0 #@@
/@( /Q0#0, #1, #,,
/@(/@Q,#, #@11 #@ 
/@(/0#, @ #, #, ,
/@( /0(#,  #,; #,
/@( !(,#; ,#0, ,#@1
!( /@Q 0#;; #;;, #;;
!( /1(@# , @# 0 @# ;
!( /@(#;  #;1; #;@,
/( /Q0#;0, #;1@ #;,
/(/@Q0#, #  #;
/( !(#0@  #0@ #0@
/( /1(@#,  @#1  @#,,1
/( !(# @ #  # @
/,( /Q 0@#  @#0, @#1@
/,( /@Q0#1 0#  0# 
/,( /0@#,@ @#0@ @#;;
/,( /Q#10 #;  #11
/,( /Q#1; #1,, #101
/,( /Q0#  0#, 0#@
/,( /@(@#@; @#@@ @#@,
/,( /(0#0  0#1  0#0
/( /@Q#1 #@@ #@
/( /Q#  # # 
/( /Q 0#@ #; #0
/( /@#, #,@; #,@
/( /(# #, #
/( !@(@#,,  @#,11 @#,,;
/( !(#;10 #;1; #;1,
/( R(#1 # #,
/( /(@# @ @#@; @#,
/( /Q # #0 #1
/( /Q@#0 #0, #0
/( /Q#,0 #, #,;
/( /Q#  # 0@ # 1
/( /@Q# ; # , # 
? !P ? !P)(? J P:" + N .P:" + M P+
/( /Q@# ,  # , # ,
/( /#0;; #, #,
/( !(#0@ #, #0;
/( R (#  #0 #
/( R(#00 #00 #00
/( !0(#10 0#1  0#
/( /(#;0 #;0 #;
/( /Q@#11 #11@ #11
/( /Q@#;01 #;, #;, 
/( /Q@# ; # @ # 
/( /Q@#  # , # 
/( /0#, 0#; 0#,
/( /(@#1 @#0; @#0
/( /;( #;1 @#  #;;
/( R(#, #  #1
/( R(#0 #,@ #0;
/( /,(# @ #  # @
/( /(#;,  #;,  #;,
/( /Q# , #  # ;
/( /0 @# 1; @# @# 
/( /, #@0 #@0 #@;
/( /Q@ # #; #0
/( / #0  #1  # 
/( /( @# @#0 @#@
/( R( 0#, @ 0#; 0#1 1
/( /,( #1  #1 @ #1 
/( /( #, #1 #,;
/( /( # ,1 # 11 # 1
/;( /@Q0 # @ # 0 # 
/;( /Q0 #;11 #;1; #;11
/;( /0 #1  #1  #1 
/;( /0( #;0 #0  #;;
/;( !( #00 #00 #00
/;( /1( @#@ @#1 @#0
/;( /@( #1 # #;
/;( /( #1 #, #0
/;( /,( #@,0 #@1@ #@1 
/;(/( #0;  #0, #0
  
 
1
"2" ? $   6% 8: +"  C 9

? !P ? !P)(? J P:" + N .P:" + M P+
/Q /@Q #;,  #;, #;,
/Q RQ @#; @#@, @#@
/Q /@Q #@@ #@ #@@
/Q /Q # 0 # 0 # 0
/Q RQ #,  #, #,
/Q /@Q # ;  # ; # ; 
/Q /Q #;,1 #;,; #;,;
/Q RQ #@  #@  #@ 
/Q /Q @#@, @# @#
/Q /Q #  #  # 
/Q /Q #0 ; #0  #0 ;
/0 RQ #;  #; #;
/0 /@Q #;0 #; #;;
/0 /Q #@ #@, #@0
/0 /Q # #, #0
/0 /Q #0 #00 #00
/0 /Q #00 #0; #01
/ /Q #,;@ #,; #,;@
/ /0 #0@ #0@ #0@
RQ /Q @#  @# @#
/Q /@Q # # #
/Q /@Q #0  #0  #0 
/Q /Q #,, #,,@ #,,
/Q /@Q #;@ #;, #;
/Q /Q #1 ; #1  #1 ;
/Q RQ @#, @#, @#,
/Q /@Q #  #  # 
/Q /Q #0 #0; #0,
/Q /Q #10 #10 #10
/1 /Q @#1@ @#; @#1;
/1 /Q #0; #0; #0;
/1 /Q #; #0 #0 
/1 /Q #,@ #, #,
/1 /0 @#1;, @#;  @#; 1
/1 RQ @#0 @#@ @# 
/1 /@Q @#0;1 @#,@ @#, 0
/1 /Q #1@, #1 #1 
/1 /Q #;0 #;0 #;0
/1 /Q #@@  #@@  #@@ 
/1 /Q @#  @# @ @# ,
RQ /Q #0, #01 #0,
/Q RQ #   #  #  
/Q /@Q #0 #, #,
/Q  /@Q  #01 #,  #0;
/Q  /Q  #00; #00; #00;
/Q  /@Q  #0@ #0@ #0@
/Q  /Q  #, #, #,
/Q RQ #@ #@ #@
/Q /@Q #, #, #,
/Q /Q #;1 #@  #;;
/Q /Q #  # #
/Q /Q #@1 #  #@;
/1 /Q #0, #0@ #0;
? !P ? !P)(? J P:" + N .P:" + M P+
/1 /Q #@ #0 #
/1 /1 @#;@ @#;0; @#;
/1 RQ @# @#0 @#@
/1 /@Q @#0 @#00; @#00 
/1 /Q #, #, #,
/1 /Q #@0 #@0@ #@0
/1 /Q #  #  # 
/1 /Q #@ #@0 #@@
/ /Q @#0@ @#0@ @#0
/Q@ / @#010 @#, 0 @#0;0
/Q@ RQ@ #  # 0 # 0
/Q@ RQ@ #  #  # 
/Q@ /Q@ #,0 #,, #,0
/Q@ RQ@ #@ 1 #@  #@ ;
/Q@ RQ@ # @ #  # @
/Q@ /Q@ #1 #1, #1
/Q@ /Q@ #00 #00 #00
/Q@ /Q@ #1 #1 #1
/0@ /Q #@, #  #@;
/0@ /Q #0 #; #1
/0@ /Q #, #; #1
/0@ /Q @# 0 @# ,  @# 00
/0@ /1 @# , @# @#
/0@ RQ@ #; #; #;@
/0@ /Q@ #0 #01 #00
/0@ /Q@ #01 #0; #0;
/0@ /Q@ #11 #11 #11
/0@ /Q@ #00 #00  #01
/@ /Q #@1 #@1@ #@1
/@ /Q #;1 #;; #;1
/@ /Q # #, #0
/@ /Q @#,1 @#1, @#1
/@ /1 @#1 @#0 @#
/@ /Q@ #  # #
/@ /0@ #,1 #,1 #,1
/@Q /Q # , # , # ,
/@Q /Q # # #
/Q /Q #0  #0  #0 
/Q /Q #1@1 #1@; #1@;
/1 RQ@ #1 #1, #1
/1 /Q@ @# ; @# ;; @# ;
/1 /Q@ #0 #; #1
/1 /Q@ # ,1 # ,; # ,1
/1 /Q@ #1@0 #1 #1@1
/1 /0@ @#0 @#0 @#0@
/1 /Q #1 #11 #1@
/1 /Q #, #0  #;
/1 /@Q #00 #000 #00
/1 /Q #,0  #,0 #,0
/1 /Q #1@ #1@0 #1@0
/ / #0 #0  #0,
/ / @#1 , @#11 @#1
/Q0 /Q #@ #@@ #@
;
? !P ? !P)(? J P:" + N .P:" + M P+
/@Q0 /Q0 # #0 #
/@Q0 /Q0 #@ #@ #@
/Q0 / 0#,  0# 0#
/Q0 /Q0 #1 , #1 #1
/Q0 /Q0 #;; #  # 
/Q0 /@Q0 #,  #,  #, 
/Q0 /Q0 #,11 #,1; #,11
/Q0 /@Q0 #01@ #01 #01
/Q0 /Q0 #;1 #;; #;;
/Q0 /Q0 #0 #0 #0
/Q0 /Q0 #10; #1,  #10;
/Q0 /Q0 #; #0 #0 
/Q0 /@Q0 #,, #,,, #,,0
/Q0 /Q0 #@; #@;, #@;0
/Q0 /Q0 #00; #00; #00;
/Q0 /Q0 #,;  #,;  #,; 
/00 /Q #@1  #@1 #@1
/00 /Q #@0  #@0@ #@0
/00 /Q #@0 #@1 #@,
/00 /Q0 #, #; #1
/00 /Q0 #; #; #;1
/00 /@Q0 # 01 # ,  # 0;
/00 /Q0 #@ #@ #@
/00 /Q0 # 1 # 1 # 1
/00 /Q0 #,@ #,@ #,@
/00 /Q0 #@ #@ #@
/0 /Q #;  #; #;
/0 /Q #1@ #1 #1
/0 /Q0 #0, #,  #0;
/0 /00 #,, #,, #,,
/@0 /@0 # 0 # ; # ,
/Q, RQ, #;  #;, #;@
/Q, /Q, #;; #  # 
/Q, /Q, #@@ #@@ #@@
/Q, /@Q, #  #  # 
/Q, /Q, #0  #0 0 #0 
/Q, /Q, #;11 #;1; #;11
/Q, /Q, #@@ #@@ #@@
/1, /Q0 #,; #,@ #,@
/1, /Q0 #;@; #;@; #;@;
/1, /Q0 #@  #@ #@
/1, /Q0 #0@; #0 #0 
/1, /00 #,@, #, #,@;
/1, RQ, @# @# @# 
/1, /@Q, @# 0 @# @ @# @
/1, /Q, #1 1 #1 #1 ;
/1, /Q, #1 #; #1
/1, /Q, #00 #00 #00
/1, /Q, #;; #0  #0 
/, /@0 #; #;, #;@
RQ1 /Q, #,,, #,,; #,,1
/Q1 RQ1 @# @#; @#0
/Q1 /@Q1 #; #; #;
/Q1 /Q1 #1 #1 #1
/Q1 /@Q1 #  #  # 
/Q1 /Q1 #1,, #1,1 #1,1
? !P ? !P)(? J P:" + N .P:" + M P+
/Q1 RQ1 #@ ; #@  #@ ;
/Q1 /@Q1 #; #; #;
/Q1 /Q1 #0@ #0@@ #0@
/Q1 /Q1 #;;0 #;;, #;;0
/Q1 /Q1 #@; #  # 
/01 /Q, #,; #,;1 #,;0
/01 /Q, #;; #;; #;;
/01 /Q, #1; #; #; 
/01 /Q, #1, #11 #1,1
/01 /1, #1 #1, #1
/01 /Q1 #,; #,@ #,
/01 /Q1 #,  #,@ #,
/01 /Q1 #@, #@, #@,
/01 /Q1 #@ ; #@ #@ 
!1 /Q, @#  @# 0 @# @
!1 /Q, #,,0 #,,, #,,0
!1 /Q, #, #1 #1
!1 /Q, @#; @#0 @#0
!1 /1, #@1; #@;  #@1;
!1 /01 # , # 1 # 1
/Q; /Q1 #11, #1;@ #1; 
/Q; /Q1 #@@ #@@0 #@@@
/Q; /Q1 #,; #,0@ #,0
/Q; /Q1 # ;  # ; # ;
/@Q; /Q1 @#@ @#@ @#@1
/Q; /@Q; #;1, #;11 #;11
/Q; /Q; # # #
/Q; /Q; #; ; #;  #; ;
/Q; /Q; #0 ; #0 #0
/Q; /Q; #1 0 #1 0 #1 0
/Q; /@Q; #@@0 #@@, #@@0
/Q; /Q; #,,1 #,1 #,1 
/Q; /Q; #1  #1  #1 
/Q; /Q; #1, #1,@ #1,@
/0; /Q1 #10 #1 #1;
/0; /Q1 #0,; #01  #01 
/0; /Q1 #@@ #@0 #@
/0; /Q1 @# @; @# , @# 
/0; /Q; #; #0 #0 
/0; /Q; #;, #;0 #;0
/0; /@Q; # , # ,0 # ,
/0; /Q; #; #; #;
/0; /Q; #;  #; #; 
/0; /Q; #;, #;1 #;,
/0; /Q; #,1 #1  #,;
/; /Q1 #0@ #0, #00
/; /Q1 #@10 #@1; #@1,
/; /Q1 #@0 #@1 #@,
/; /Q1 #;1@ #;;  #;1,
/; /01 @# @#0  @#0
/; !1 @#0 @#0; @#0
/; /Q; # @; #  #  
/; /0; #; #; #;
/@;  /1 @#; @#;, @#;
/Q  RQ  #1@1 #1 #1@;
/Q  /@Q  #0 #01 #0
 
? !P ? !P)(? J P:" + N .P:" + M P+
/Q  /@Q  #  #  # 
/Q  /Q  #010 #01, #010
/Q  /@Q  #@ #@@ #@
/Q  /Q  #; #; #;
/1  RQ  #@ #@ #@
/1  /Q; @#@;, @#; @# 1
/1  /Q; #, #, #,
/1  RQ  #0 #0@ #0
/1  /Q  @#  @#  @# ,
/1  /Q  #0 #0@ #0
/Q /@Q #;, #;, #;,
/Q RQ @#; @#0 @#
/Q /@Q #@, #@, #@,
/Q /Q # 1 # 1 # 1
/Q RQ #,@; #, #,
/Q /@Q # ; # ;, # ;0
/Q /Q #;1 #;1@ #;1@
/Q /Q  #  #  # 
/Q RQ #@ #@@ #@
/Q /Q @# @#0 @#;
/Q /Q #0  #0 #0 
/Q /Q #0 #0@ #0
/0 RQ #;@ #;, #;
/0 /@Q #; #; #;1
/0 /Q #@0 #@1 #@,
/0 /Q #1 #  #;
/0 /Q #0; #0@  #0@ 
/0 /Q #00 #0  #01
/ /Q #,;; #,;; #,;;
/ /0 #0@0 #0@0 #0@0
RQ /Q @#1 @# @#;
/Q /@Q #@ # #@
/Q /@Q #1 #1 #1
/Q /Q #, #,@ #,
/Q /@Q #1 #11 #10
/Q /Q #,1  #,1 #,1
/Q RQ @#;; @# @ @# 
/Q /@Q #;;0 #;;, #;;,
/Q /Q #0 #0@ #0
/Q /Q #10 #10 #10
/1 /Q @#1 @#;0 @#; 
/1 /Q #0;@ #0;@ #0;@
/1 /Q #0 #0 #0@
/1 /Q #1 #1, #10
/1 /0 @#; @ @#; @#;1
/1 RQ @#0 @#0@ @#0 
/1 /@Q @#0;, @#,; @#, 1
/1 /Q #10 #1@  #11
/1 /Q #;0 #;0 #;0
/1 /Q #@1 #@; #@1
/1 /Q @#; @#1 @#
/ /; #11 #;, #11,
/ /@; @#; @#;@1 @#;
/ /@; @# @#@ @#@
RQ  /Q #0;  #0; #0; 
/Q  RQ # @ # @ # @
? !P ? !P)(? J P:" + N .P:" + M P+
/Q  /@Q #0; #, #, 
/Q  /@Q #1 #1 #1
/Q  /Q #010 #010 #010
/Q  /@Q #0 #00  #01
/Q  /Q #; #; #;
/Q  RQ #@  #@  #@ 
/Q  /@Q #,1 #,1 #,1
/Q  /Q #@ #@ #@
/Q  /Q # ; # # 
/Q  /Q #@; #  #@;
/1 /Q #00 #0; #0,
/1 /Q # ; # # 
/1 /1 @#; @#;0 @#; 
/1 RQ @#, @#,, @#,@
/1 /@Q @#01; @#, ; @#0;;
/1 /Q #, #,; #,,
/1 /Q #@0 #@0 #@0
/1 /Q #  # @ # @
/1 /Q #@0 #@1 #@,
/ /, #1; #1;1 #1;
/ /Q @#  @#1 @# 
/Q@ / @#,1 @#,1 @#,@1
/Q@ RQ@ #@ # #@
/Q@ RQ@ #0 #0 #0
/Q@ /Q@ #,; #,; #,;
/Q@ RQ@ #@1 #@; #@;
/Q@ RQ@ #  #  # 
/Q@ /Q@ #1 #1  #11
/Q@ /Q@ #01 #01 #01
/Q@ /Q@ #1; #1; #1;
/0@ /Q #, #,0 #,
/0@ /Q #, #  #;
/0@ /Q #0 #0@ #0
/0@ /Q @# 00 @# , @# 0;
/0@ /1 @#@ @# @#
/0@ RQ@ #;@@ #;@, #;@0
/0@ /Q@ #0; #0 #0 
/0@ /Q@ #, #, #,
/0@ /Q@ #1; #1; #1;
/0@ /Q@ #0; #00 #00
/@ /Q # @ # , # 
/@ /Q #;, #;1 #;,
/@ /Q #, #1 #,
/@ /Q @#,; @#;  @#1@
/@ /1 @# @#@  @#
/@ /Q@ #@ #1 #0
/@ /0@ #,1@ #,1 #,1@
/@@ /, @# @#; @#
/@Q/Q#,, #,1 #,,
/@Q/Q#@ # #
/Q /Q#, #,@ #,@
/Q /Q#,;  #,; #,; 
/1RQ@ #,; #,;0 #,;@
/1/Q@ @# @ @#  @# @,
/1/Q@ #  # #
/1/Q@ # ; # @ # @ 

? !P ? !P)(? J P:" + N .P:" + M P+
/1/Q@ #1 #11 #1
/1/0@ @#0  @#0; @#0 
/1/Q#1@ #1  #1@,
/1/Q#1  #1 #1
/1/@Q# # #
/1/Q#, #,; #,0
/1/Q #1, #1, #1,
//#0 #00 #0@
//@#,;; @#11 @#1
/Q0/Q#1; #; #; 
/@Q0/Q0#@;; #@;; #@;;
/@Q0/Q0#00 #0, #0,
/Q0/0# 0#  0#,
/Q0/Q0#10 #10; #100
/Q0/Q0#1 #  #;
/Q0/@Q0#;1; #;;  #;1;
/Q0 /Q0#,,@ #,, #,,
/Q0 /@Q0#;; #;; #;;
/Q0 /Q0#;@ #;@0 #;@
/Q0 /Q0 #01 #01 #01
/Q0/Q0#;1 #;10 #;1
/Q0/Q0#  #  # 
/Q0/@Q0# 0 # , # 0
/Q0/Q0#@,0 #@,1 #@,,
/Q0/Q0 #01  #01 #01 
/Q0/Q0 #1 @ #1  #1 @
/00 /Q#@@ #@0 #@
/00/Q #@0, #@,  #@01
/00/Q #@ #@ #@
/00/Q0#@1 #@0  #@;
/00/Q0#;1 #;;  #;10
/00/@Q0#@  #@  #@ 
/00/Q0#@  #@ @ #@ 
/00/Q0 # 1, # 11 # 11
/00/Q0 #, #, #,
/00/Q0# #@ #@
/0/Q #;  #; #;
/0/Q #1@  #1@ #1@
/0/Q0 #,; #1 #1
/0/00#,,1 #,,; #,,1
/@0/@0# #1 #0
/Q,RQ,@#1 @#1, @#1@
/Q, /Q,#,@ #,0 #,
/Q, /Q,#10 #10 #10
/Q,/@Q,#01; #0;  #0; 
/Q,/Q,#11 #; #; 
/Q,/Q, #;; #;; #;;
/Q,/Q, #@ ; #@ ; #@ ;
/1,/Q0#,; #, #,
/1,/Q0 #;@; #;  #;@;
/1,/Q0 #@, #@1 #@,
/1,/Q0#00 #00@ #00
/1,/00#, #, #,
/1,RQ,@#0@1 @#0; @#0
/1,/@Q,#0  #0 ; #0 
/1,/Q,#,, #,,; #,,,
? !P ? !P)(? J P:" + N .P:" + M P+
/1,/Q, #; #  # 
/1,/Q, #0 #0 #0
/1,/Q,#0 , #0 #0 ;
/,/ @#  @#  @# 1
/,/@@ 0#  0#@0 0# ,;
/,/@@ @#; @#@ 1 @#@ 
/,/@0#;,0 #;1 #;,;
RQ1/Q,@#1; @#; @#; 
/Q1RQ1@#; @#0@ @#0
/Q1/@Q1#;, #;1 #;1
/Q1 /Q1#1; #10  #1;
/Q1 /@Q1# , # , # ,
/Q1 /Q1#1,1 #1,; #1,;
/Q1RQ1#@ # #
/Q1/@Q1#;0 #;1 #;,
/Q1/Q1#0 #01 #0,
/Q1/Q1 #;; #;; #;;
/Q1/Q1 #1 #1 #1
/01/Q,#,0; #,, #,,
/01/Q, #  #  # 
/01/Q, #,  #, #,
/01/Q,#; ; #; #;
/01/1,#1@@ #1@1 #1@0
/01/Q1#,@, #, #,@;
/01/Q1 #@0; #@, #@,
/01/Q1 #1 #1 #1
/01/Q1#@@ #@0 #@
!1/Q,@#@00 @#@, @#@01
!1/Q, #1  #1  #1 
!1/Q, #@;@ #@; #@;@
!1/Q,@#, @#0 @#;
!1/1,# 0 # , # ,
!1/01#@ # #
/1/ # #0@ #@
/Q;/Q1#11 #111 #11
/Q;/Q1 #@; #@ #@
/Q;/Q1#,, #,@ #,@ 
/Q;/Q1 #;@ #;@ #;@
/@Q;/Q1@#@1 @#@ @#@0
/Q;/@Q;#;; #;;@ #;;
/Q; /Q;# # #
/Q; /Q;#; #; #;
/Q;/Q;#0; #, #,
/Q;/Q;#,0; #,0; #,0;
/Q;/@Q;#@@ #@@ #@@
/Q;/Q;#,,1 #,1 #,1
/Q;/Q; #;@ #;@ #;@
/Q;/Q; #1,0 #1,, #1,,
/0;/Q1#1 #1, #1@
/0;/Q1 #0;0 #0;0 #0;0
/0;/Q1 #0  #0 #0
/0;/Q1@#  @# 1 @# @
/0;/Q;#0, #0; #01
/0;/Q;#,; #, #,
/0;/@Q;# ,  # , # ,
/0;/Q;#, #, #,

? !P ? !P)(? J P:" + N .P:" + M P+
/0;/Q; #;@ #; #;
/0;/Q; #@ #@@ #@
/0;/Q;#,1 #1  #,;
/;/ #; 0#  #;,
/;/Q1#0@, #0  #0@1
/;/Q1 #@;1 #  # 
/;/Q1 #; #0 #0 
/;/Q1#;1 #;; #;11
/;/01@#, @#1 @#,,
/;!1@#01 @#0;  @#011
/;/Q; # 0@ # 00 # 0
/;/0;#;@ #; #;
/@; /1@#;, #  @#;;@
/@; / @#, @#,1 @#,01
/Q  /Q #0@ #0@@ #0@
/Q  RQ  #1@  #1@ #1@
/Q  /@Q  #@ #, #0
/Q  /Q #0 #0 #0
/Q  /@Q  #00 #0, #00
/Q  /Q  #,1 #,; #,1
/Q  /@Q  # ; #  # 
/Q  /Q  #0 #, #0
/Q  RQ  #; #; #;
/1  /Q;@#@, @#@; @#@1
/1  /Q; #,, #,, #,,
/1  RQ  #00@ #00, #00
/1  /@Q  #1, #; ; #1;
/1  /Q  #;0  #;01 #;0@
/1  /Q  #; #;@ #;
!( / #;@; #; #;
!( /Q@ #0 #1 #,
!( /Q@ #0; #0; #0;
!( /Q #@1 #@1, #@10
!( RQ, # 00 # 00 # 00
!( /@Q,#0 #0 #0
!( /,,# @  ,# ,#0
/( /Q @#;@ @#;0; @#;0
/( / 0#@1@ 0#01 0#1
/( / #0@ #, #010
/( / @#,;0 @#11 @#1
/( !( @#@1@ @#@; @#@11
/@( /Q0@#00 @#1 @#,@
/@( /Q0#0, #0, #0,
/@( /@Q0#, #,, #,0
/@( /Q0@#,; @#; @#1,
!( /@Q #;1@ #;1@ #;1@
!( /Q,#1 #1 #1
!( /@( #,; #,;0 #,;
/1( /@ 0#@1 0#00 0#,@
/1( /Q #; 0# ; 0# 
/1( /Q 0#1@ 0#1@ 0#, ;
/1( /1 # #1 #@,
/1( / 0#;1 ,#; 0#;@
/1( / @#,@ @#,, @#,1
/1( / @#0  @#1 @#,
/1( /Q0 #00 #00  #01
? !P ? !P)(? J P:" + N .P:" + M P+
/1( /Q0 0# 0#@;  0#@ 0
/1( /Q0 0#1,; 0#;, 0#; 
/ ( /0 #@; # # 
/ ( !( #; #@  #@ 
!0( /@Q0 #;1 #  #;;
!0( /Q0 @#, @#,  @#,0
!0( /Q#@0 #@0@ #@0
!0( /Q #1 #1 #1;
!0( /Q #, 0 #,  #, 1
!;( /@Q #;; #@  #;;
!;( /@Q # #0 #;
!;( /Q; #  # , # 0
!;( /@Q; # #@ #
!;( /Q; #;1 #;0  #;;
!;( /Q  @#, @#,1 @#,
!;( RQ #01 #0; #01
!;( /Q @#1 @#1, @#1
!;( /  @#0,1 @#010 @#01
!;( /Q@ @#@1 @#@0 @#@0 
R( /@Q; #  #  # 
R( /Q; #1@; #1 #1
R( / #0, #00  #0;
R( /Q@ #1@; #1 #1 
/@( /  #1, #1,@ #1,@
/@( !;( #; #  # 
/@( R( #0  #0 #0
/@( /  #0; #,  #, 
/@( !;( #,, #,0  #,;
/@( R( #; #;@ #;
/( /  #  #  # 
/( /Q;# #, #@
/( /@( #,, #,1 #,1
/( /@( #,00 #,0, #,0,
/( /Q, #1; #1@ #1@ 
/( /@Q; #,, #1  #,;
/( /  #10 #10 #10
/( /Q@ #1@1 #10 #1
/( /Q0#, #@  #;
/( /Q;#@ #, #0
/( !;( #, #,@ #,
/( /@( #;, #;, #;,
/( /Q1 0#0 0#10 0#,
/( /Q1@#; @#, @#
/( /@( 0#@1 0#,  0#00
/( /@( 0#, 0#;0 0#1 
/( /( @#  @# @# 
/( /( @#;0 @#@ @# 
!,( RQ, #@  #@ #@
!,( RQ1 #, #,1 #,
!,( /Q1 @# @#, @#
!,( /Q; #0  #0 #0
!,( RQ@ #1, #11 #11
!,( RQ1@#10  @#10 @#10
!,( /@Q1#;0 #;0 #;0
!,( !;( #  #  # 0
!1( !0( @#@ @#@@ @#@

? !P ? !P)(? J P:" + N .P:" + M P+
!1( !;( #00 #, #, 
/ ( !,( #1  #1 #1 
/ ( !1( #,,, #,,, #,,,
/@( /Q0 #0 #@  #1
/@( /Q, @#, @#@0 @#@
/@( /Q, 0#1@ 0#;1; 0#11
/@( /Q, #;1 0# 10 0# ,
/@( /, 0#; ; ,#  0#;@
/@( /, @#,;, @#1  @#1
/@( RQ1 0#;@ 0#011 0#0@
/@( /Q1 #111 #;1@ #;0
/@( /01 0#;1  ,# 0#;1,
/@( /@Q#; #0 #,,
/@( /, @#@0 @#@@ @#@@
/@( /1( 0#,, 0#; 0#1
/( /Q0 @# @#@0 @#@ 
/( /Q, # # #
/( /@#@0 @#0, @#,
/( /, #, #,0 #,
/( /1( @#, @#,@, @#,0
/( / ( #, 0 #,  #, 1
/( /@( #;0 #;,  #;01
!( /@Q, #01  #01  #01 
!( /, ,#0 ,#1@@ ,#,;
!( /  @#  @# @#
!( /Q@ #@1 #@1, #@10
!( /Q@ #0  #0 0 #0 0
!( /Q# #@ #
!( RQ,#0  #0  #0 
!( !0( #0,, #0;1 #011
!( !;( @#, @#, @#,
!( R( #0;1 #0;; #0;1
!( /( #10 #10; #10,
!( /( #,; #,0@ #,0
!( /( 0#@, 0#@, 0# ;
/( /Q@#1 @#10  @#1@,
/( /0#0 0#,; 0#0,1
/( /# ; #1 #0
/( /@#1 @#11 @#10,
/( /1( 0#; 0#, 0#@1
/( !( @#1 @#1 @#11
/@( /Q0 @# @ @#  @# ;
/@( /Q0 #, #,0 #,0
/@( /@Q0 #; #;0 #;@
/@( /Q0 @#,;@ @#1, @#1 
/@( !0( #1@ #1@0 #1@
/@( !,( @#,  @#, @#,
!( /Q, #,@  #,@ #,@
!( /@Q#0@ #0@ #0@
!( / ( #0@ #0@ #0@
!( /( # @ # 0 # 
!( /@( #1;1 #;  #1;;
/1( /@ 0#@ 0#0 1 0#
/1( /Q#1@  #;0  #; 
/1( /Q0#0 0#0 0# ;
/1( /1#@  # @ #@0,
? !P ? !P)(? J P:" + N .P:" + M P+
/1( /@#@ @#00 @#@
/1( /@#0 @#, @#0
/1( /Q0#1@ #1, #10
/1( /Q0 0#@ 0#;1 0#0
/1( /Q0 #; 0# @ #;11
/1( /000#;  ,#0 0#;0
/1( /1( #1  #1  #1 
/1( !0( ,#,1@ 1#  ,#1,
/ ( /0#@ #@, #@0
/ ( !( # # #
/ ( !( #@;; #  #@;;
!0( /Q #1; #; #; 
!0( /Q @# 1 @# @@ @# @
!0( /Q #1@ #1@0 #1@@
!0( /@Q0#,0, #,0; #,01
!0( /Q0@#1; @#; @#;
!0( !( @#0, @#0@  @#0;
!0( /@( #;, #;, #;,
!;( RQ #0,, #0,1 #0,,
!;( /Q @#  @#0 @#
!;( /  @#@; @#0 @#
!;( /Q@ @#;  @#;@ @#;
!;( /@Q # # #
!;( /@Q # 0 # @1 # @
!;( /Q;#,@  #,@ #,@
!;( /@Q;#@11 #@1; #@11
!;( /Q;#1, #1; #11
!;( /Q  @#  @# @#
!;( !( #  #  # 
R( / #,; #, #, 
R( /Q@ #0; #, #, 
R( /@Q;#1, #11 #1,
R( /Q;@#, @# @#;
R( !( @#; @#;0 @#;
/@( / #;,@ #;, #;,@
/@( !;( #  # , # 0
/@( R( #0, #0,0 #0,
/@( !;( #00 #0; #0,
/@( R( # #, #0
/( /  # #@ #
/( /Q; #@ #1 #0
/( !( #,1  #,1 #,1
/( /@( #1 @ #1 @ #1 @
/( /@( #,; #,; #,;
/( /  #1  #1 @ #1 
/( /Q@ #01 #0@ #0
/( /Q0 #;; #  # 
/( /Q; #@ #, #0
/( /Q,#,;; #1  #1 
/( /@Q;#;, #  #;;
/( !( #011 #0; #01;
/( !;( #  # #
/( /@( #;, #;, #;,
/( /Q1 @# @#0  @#
/( /Q1 #1; 0#  #;;
/( /Q1 0#; ,#@;1 0#;;
@
? !P ? !P)(? J P:" + N .P:" + M P+
/( !( 0#  0# ,@ 0# @,
/( /@( 0#00@ 0#11  0#,,
/( /@( #0 #,1 #01
/( /( @#@ @#@@; @#@@
/( /( @#, @#; @#1
!,( RQ@ #;  #;  #; 
!,( RQ1 @#@  @#@@ @#@
!,( /@Q1 #, #,1 #,0
!,( RQ,#; #; #;
!,( RQ1@#@  @#@ 1 @#@ 0
!,( /Q1 @# 0 @# ; @# 1
!,( /Q;#,; #1  #1 
!,( /@( #01 #010 #01@
!,( !;( #;1 #;; #;1,
!1( !;( #,1 #1 #1
/ ( !,( #1 #1 #1
/ ( !1( #,0  #,0 #,0
/@( /@Q #;@ #@; #@@@
? !P ? !P)(? J P:" + N .P:" + M P+
/@( /, @#@@ @#@ @#@@
/@( /Q0 #@ #0 #1
/@( /Q,@#1 @#1; @#1
/@( /Q, 0#, 0#,  0#@0@
/@( /Q, #,1 #1,1 #1 
/@( /, #0 # #11
/@( RQ10#@1 0#,  0#1
/@( /Q10# 0#01 0#;0
/@( !( ,#@0  ,#0,; ,#, 
/@( /1( 0# 0#01 0#;0
/( / # 1 #@ # 
/( /, #,@ #,  #,,
/( /Q0@#, @#@0 @#@
/( /Q,#00 #00 #00
/( !( # 1 # 10 # 1
/( /1( 0# 0#@ 0#
/( / ( #01  #01@ #01
/( /@( #; #;, #;@
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