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Publications (37)
This cross-sectional study investigates changes in the number of chronic obstructive pulmonary disease (COPD)–related admissions before, during, and after the COVID-19 pandemic in France.
Airway-liquid interface cultures of primary epithelial cells and of induced pluripotent stem-cell-derived airway epithelial cells (ALI and iALI, respectively) are physiologically relevant models for respiratory virus infection studies because they can mimic the in vivo human bronchial epithelium. Here, we investigated gene expression profiles in hu...
Asthma is defined as severe when it is uncontrolled despite the high intensity of treatment, or that loses control when a therapeutic step down is tried.
These patients, for years, have been “uniformly” treated with massive doses of inhaled and oral corticosteroids regardless of their inflammatory state.
Initially, asthma was considered of genesis...
Airway-liquid interface cultures of primary epithelial cells and of induced pluripotent stem cell-derived airway epithelial cells (ALI and iALI, respectively) are physiologically relevant models for respiratory virus infection studies because they can mimic the in vivo human bronchial epithelium. Here, we investigated gene expression profiles in hu...
COPD affects millions of people and is now ranked as the third leading cause of death worldwide. This largely untreatable chronic airway disease results in irreversible destruction of lung architecture. The small lung hypothesis is now supported by epidemiological, physiological and clinical studies. Accordingly, the early and severe COPD phenotype...
Background
Obesity is known to diminish lung volumes and worsen asthma. However, mechanistic understanding is lacking, especially as concerns small‐airway responsiveness. The objective of this study was therefore to compare small‐airway responsiveness, as represented by the change in expiratory:inspiratory mean lung density ratios (MLDe/i, as deter...
Le projet vise à obtenir un modèle d’épithélium bronchique innervé permettant l’étude de différentes maladies respiratoires comme la BPCO ou encore l’asthme sévère en utilisant des cellules souches pluripotentes induites (iPSC). Les iPSC sont obtenues par reprogrammation de cellules sanguines de patients puis sont différenciées dans certains types...
Background:
Chronic Obstructive Pulmonary Disease (COPD), a major cause of mortality and disability, is a complex disease with heterogeneous and ill-understood biological mechanisms. Human induced pluripotent stem cells (hiPSCs) are a promising tool to model human disease, including the impact of genetic susceptibility.
Methods:
We developed a s...
Introduction
Chronic airway diseases are a common medical condition worldwide and include diseases such as cystic fibrosis, asthma or chronic obstructive pulmonary disease (COPD). COPD is the third leading cause of death in the world, and there is still no curative treatment. Air liquid interface cultures (ALI) mimic the lung development and diseas...
Introduction
COPD, the third leading cause of death worldwide, is an under-diagnosed major public health issue without any curative treatment available. Early onset of the disease — under 50 years old in individuals with clinical criteria and 10 or more pack-years smoking history — is inevitably associated with an increased risk of acute respirator...
Mesenchymal cells are an essential cell type because of their role in tissue support, their multilineage differentiation capacities and their potential clinical applications. They play a crucial role during lung development by interacting with airway epithelium, and also during lung regeneration and remodeling after injury. However, much less is kn...
Background
The course of chronic obstructive pulmonary disease (COPD) is punctuated by exacerbations, most often of infectious origin, responsible for many intensive care unit (ICU) and intermediate care unit (IMCU) admissions. Our objective was to study in-hospital mortality during severe COPD exacerbations in ICU and IMCU based on the performance...
Introduction
La production in vitro, de manière reproductible et en larges quantité, d’un épithélium bronchique à partir de cellules souches pluripotentes est un objectif clé pour le criblage de médicaments à haut débit pour identifier de nouvelles molécules et la production de cellules pour une thérapie cellulaire en pneumologie (Pharmacol Ther 20...
Résumé
L’asthme “difficile à prendre en charge” est facilement identifiable par une prise excessive de corticoïdes oraux, au-delà de 500 mg à 1g par an. Cela correspond un statut temporaire justifiant d’un parcours clinique rigoureux comprenant la remise en cause du diagnostic, l’évaluation de l’adhésion à la prise en charge proposée et la prise en...
Background: Distal airway metaplasia may precede honeycombing in progressive fibrosing interstitial lung disease (ILD). The SCGB1A1 ⁺ bronchiolar-specific club cell may play a role in this aberrant regenerative process.
Objective: To assess the presence of club cells in the small airways of patients suffering from ILD.
Methods: Small airways (inter...
The natural history of COPD is complex, and the disease is best understood as a syndrome resulting from numerous interacting factors throughout the life cycle with smoking being the strongest inciting feature. Unfortunately, diagnosis is often delayed with several longitudinal cohort studies shedding light on the long ‘preclinical’ period of COPD....
Chronic obstructive pulmonary disease (COPD) is a common and preventable airway disease causing significant worldwide mortality and morbidity. Lifetime exposure to tobacco smoking and environmental particles are the two major risk factors. Over the last decades, COPD has become a growing public health problem with an increase in incidence. COPD is...
Asthma exacerbations are inflammatory events that rarely result in full hospitalization following an ER visit. Unfortunately, certain patients require prolonged support, including occasional external lung support through ECMO or ECCOR (with subsequent further exposure to other life‐threatening issues), and some die. In parallel, biologics are revol...
