Darjana Jovanović

Oncology Institute of Vojvodina · oncohematology

Background: Systemic adjuvant treatment might mitigate the high risk of disease recurrence in patients with resected stage IIC-III melanoma. The BRIM8 study evaluated adjuvant vemurafenib monotherapy in patients with resected, BRAFV600mutation-positive melanoma. Methods: BRIM8 was a phase 3, international, double-blind, randomised, placebo-contr...

Multiple cytokines released in tumor microenvironment can promote anticancer effects, or carcinogenesis and tumor growth. Although cytokines mainly act locally, the changes in their circulating levels may reflect the interactions between tumor and inflammatory cells during the disease course. The aim of this study was to analyze the serum cytokine...

Myeloma multiplex is a malignant disease of bone marrow plasma cells. It is usually confined to the bone marrow, but in rare cases, patients can develop extramedullary disease. The involvement of lymph nodes is rare and can be a diagnostic challenge. Here, we describe a 36-year-old male patient who presented with abdominal pain and discomfort initi...

Breast metastases from an extra-mammary malignancy are rare. Among the lung malignancies that metastasise in the breasts, previous literature has described approximately 30 cases of NSCLC and only a few cases of SCLC. Here, we present a 54-year-old woman with metachronous breast metastasis from pulmonary small cell carcinoma. She presented with a s...

Purpose: Follicular lymphoma (FL) is an indolent lymphoma that responds well to rituximab+chemotherapy. We evaluated the prognosis and efficacy of immunochemotherapy in patients with previously untreated, advanced FL. Methods: REFLECT 1 is a multicentre, prospective study of 99 patients with previously untreated FL stage III-IV. All patients wer...

Testicular germ cell cancer (TGCC) is rare form of malignant disease that occurs mostly in young man between age 15 and 40. The worldwide incidence of TGCC is 1.5 per 100000 man with the highest rates in North Europe. After discovery of cisplatin cure rates of TGCC are very favorable between 90%-95% and unlike most solid tumors, cure rate for metas...

Sarcomas represent large and diverse group of malignant tumours, originating from mesenchymal cells. Nearly 15% of all childhood tumours and about 1% of all tumours in adults are sarcomas [1]. The incidence of adult soft tissue sarcomas in Europe is 5/100,000 [2]. Rhabdomyosarcoma accounts for 4.6% of all soft tissue sarcomas and it is the most com...

Association between chronic lymphocytic leukemia and other malignancies has been known for a long time. This epidemiological phenomenon is explained by immunosuppression caused by disease itself or by the applied therapy. Merkel cell carcinoma is a rare malignant tumor of the skin of neuroendocrine origin diagnosed almost exclusively in immunocompr...

Background The combination of absolute lymphocyte count (ALC) and absolute monocyte count (AMC) at diagnosis has prognostic relevance in patients with diffuse large B cell lymphoma (DLBCL). Aims The present study was designed to investigate the prognostic significance of ALC and AMC and to determine whether ALC/AMC ratio or ALC/AMC prognostic scor...

Hodgkin lymphoma and anaplastic large cell lymphoma are malignancies that highly express CD30 antigen on the cell surface. Both are generally curable by standard chemotherapy but refractory diseases and relapses are treatment problems. Brentuximab-vedotin is a labeled monoclonal antibody against CD30 and it is approved for the treatment of Hodgkin...

Background: In the second half of the twentieth century, cancer treatment options evolved with more sophisticated selection of targets for cancer therapy, which led to the development of more intelligent drugs directed against these specific targets. One group of pharmaceutical molecules with specific and unique properties against (or for) a well d...

Primary breast lymphoma is rare location of this disease. Diffuse large B-cell lymphoma is the most common histological subtype. We presented two cases of primary diffuse large B-cell lymphoma of the breast and reviewed a literature about this topic.

One of the very rare types of the ovarian tumor is lymphoma. The origin of ovarian lymphoma is primary only if it arises from ovarian tissue. The paper describes a case of ovarian lymphoma in a 42-years old patient. The patient was operated; histopthological finding confirmed lymphoma of the ovaries.

Definition: Cancer of unknown primary (CUP) origin refers to patients who present with histologicaly confirmed metastatic cancer in whom a detailed medical history, complete physical examination, including pelvic and rectal examination, full blood count and biochemistry, urinalysis and stool occult blood testing, hisinpathological review oJ biopsy...

Background: Breast carcinoma recurrence appears in 5%-30% of cases, after the completion of breast cancer treatment. Recurrence appears on thoracic wall (chest wall), on the skin, on the breast tissue remaining after the surgery, equal sided axillary lymph nodes, supraclavicular lymph nodes or on the internal mammary lymph nodes. Recurrence often s...

Primary uterine cervical non-Hodgkin's lymphomas (NHL) are rare. Limited experience dictates careful pretherapy evaluation and multidisciplinary approach in treatment planning. A 53-year-old woman presented with postmenopausal bleeding and PAP smear IIIb. Cervical biopsy and endocervical curettage biopsy revealed NHL of the uterine cervix. Abd...

Mesenteric lipodystrophy is a rare condition characterized by a nonspecific inflammatory process that involves the root of the mesentery in a lipoma-like lesion. We reported a case of sclerosing mesenteritis presenting as recurrent abdominal pain, profound weight loss, dilated cardiomyopathy, malabsorption and a mass on computed tomography scan of...

Paraneoplastic limbic encephalitis is uncommon neurological side effect of cancer in the absence of direct effect of primary tumor or metastasis, side effects of treatment or metabolic dysfunctions (6). Non-Hodgkin's lymphoma triggers such side effect very rarely. We present a case of a young adult with complete clinical course of non- Hodgkin...

Background: It has been acknowledged that morphometry can contribute to distinction and classification of different histological forms of hepatocellular carcinoma (HCC) based on new criteria, and hence to the prognosis of HCC. However, overlapping of the results among different forms makes the capacity of these measurements somewhat restricted. In...

There is an increasing interest for using probiotics to suppress harmful bacteria. Three freeze-dried probiotic products were studies for their antimicrobial effect against Helicobacter pylori (ATCC 43504) in vitro. The product A, contained viable Lactobacillus delbrueckii subsp. bulgaricus strain Lb-51, the second product B, contained viable Lacto...

Primary gastric lymphoma is the most common site of extranodal lymphoma. The best management of the disease is inconclusive. From January 1983 to January 1993 we observed and treated 36 patients with primary lymphomas of the stomach; 16 were males and 20 females. Median age was 55.5 years (range 28-78 years). Epigastric pain (100%), weight loss (91...

Numerous living trichomonads were seen in a parapneumonic pleural effusion, in a patient who was at risk of aspiration pneumonia because of acute alcoholism. Of all the drugs administered, metronidazole had the most favourable therapeutic effect. However, decortication was necessary for the successful outcome.