Djordje Popovic

Djordje Popovic
Clinical Center of Vojvodina · Clinic for Endocrinology, Diabetes and Metabolic Disorders

Assistant Professor

About

70
Publications
4,974
Reads
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110
Citations
Additional affiliations
September 2011 - present
University of Novi Sad
Position
  • Research Assistant
November 2010 - present
Clinical Center of Vojvodina
Position
  • Internal medicine resident

Publications

Publications (70)
Article
Introduction: Atherosclerosis can be considered a chronic inflammatory process that stands out as a dominant cause of cardiovascular disease (CVD). Since blood lipids are the leading risk factor for atherosclerosis development, lowering low-density lipoprotein cholesterol (LDL-C) and other apolipoprotein B-containing lipoproteins reduces the risk...
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Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic plasma cell disorder characterised by a serum M protein level below 3 g/dL, percentage of bone marrow clonal plasma cells below 10%, absence of end-organ damage (hypercalcaemia, renal insufficiency, anaemia, bone lesions) and absence of any other disease known to produce M...
Article
The COVID-19 pandemic, as named by the World Health Organization, emerged in 2019 in Wuhan, China, secondary to the spread of the novel coronavirus, SARS-CoV-2, that has a human-to-human manner of transmission, with a high transmissibility rate and a lower fatality rate compared to other respiratory syndromes. Patients with diabetes are more suscep...
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There is increasing presence of fructose in food and drinks, and some evidence suggests that its higher consumption increases cardiovascular risk, although the mechanisms still remain not fully elucidated. Cardiovascular diseases (CVD) are still responsible for one-third of deaths worldwide, and therefore, their prevention should be assessed and ma...
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). The latter is a pandemic that has the potential of developing into a severe illness manifesting as systemic inflammatory response syndrome, acute respiratory distress syndrome, multi-organ involvement and shock. In addition, advanced age and mal...
Article
Tirzepatide is a dual gastric inhibitory peptide/glucagon-like peptide 1 (GIP/GLP-1) receptor agonist formulated as a synthetic linear peptide, based on the native GIP sequence. It has a prolonged half-life of 5 days, which enables once-weekly dosing. Studies have hitherto demonstrated its superiority in achieving optimal glycaemic control and body...
Article
Diabetic foot ulcers (DFUs) remain a common debilitating and costly complication of diabetes mellitus. Indeed, despite all efforts and emerging technologies, many DFUs are difficult to heal and frequently recur. Thus, novel therapeutic approaches are urgently needed. Specific targeting of different molecular and cellular pathways implicated in woun...
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Introduction: Insulin glargine 300 U/mL (Gla-300) is a novel glargine formulation which shows slower and more prolonged absorption following subcutaneous administration in comparison to insulin glargine 100 U/mL. In this prospective, observational, single-arm, multicenter, real-world study conducted in Serbia, we evaluated the effectiveness and sa...
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Prediabetes is defined as a condition of abnormal glucose metabolism, characterised by plasma glucose above normal range but not as high as required for the diagnosis of diabetes mellitus (DM). It represents a heterogeneous entity of intermediate glucose metabolism, including impaired fasting glucose, impaired glucose tolerance, and borderline glyc...
Article
The growing proportion of type 1 diabetes mellitus (T1DM) patients with clinical features of insulin resistance (IR) has led to the description of a distinctive T1DM subgroup, still unrecognised by current guidelines, called double diabetes, assumingly associated with poorer metabolic phenotype and increased risk of micro- and macrovascular complic...
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Interaction of microorganisms with the host innate immune system is a crucial factor that could modify diabetes and its associated complications. Recent reports have elucidated the role of NLRP3 inflammasome in diabetes, but to our knowledge there is no data regarding the role of other inflammasomes in diabetes-induced inflammation. To investigate...
Article
Introduction: Impaired fasting glucose (IFG) is an intermediate glucose metabolism abnormality indicating a high risk of diabetes development. Excessive accumulation of visceral adipose tissue is associated with the development of insulin resistance. Affected individuals with some degree of pancreatic β-cell dysfunction may develop glucose intolera...
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Sexuality is a significant part of female life and is under the impact of various life events, factors related to reproduction, relationships and socio-cultural specifics, but is also affected by different chronic medical conditions and related treatments. Physiologically, women`s sexual functioning consists of desire, arousal, plateau, orgasm and...
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Introduction/Objective. In different states of increased chronic inflammation, like obesity and diabetes, early changes in lipid metabolism could represent an adaptive response aimed at diminishing the elevated inflammatory reaction. The aim of study was to investigate the impact of glucose tolerance status on relationship between chronic inflammat...
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Introduction/Objective. The wider literature review of analysis in levels of catalase (CAT) or superoxide dismutase (SOD) enzymes in type 2 diabetes mellitus (T2DM) patients shows no pronounced consistency. We have assumed that the onset of diabetes does not significantly change individual quantities of these enzymes, but instead it changes the rel...
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Introduction. Fine needle aspiration biopsy is a non-surgical invasive diagnostic method for the cytological evaluation of the thyroid gland. Complications of fine needle aspiration biopsy are rare. Case Report. A female patient, 64 years of age, underwent left-sided nodulectomy in 2006, due to a follicular adenoma of the thyroid gland. In Septembe...
Article
Pregnancy in women with pre-existing diabetes is associated with a doubled, or even up to four-fold increased risk of preeclampsia, preterm delivery, and perinatal mortality compared to the risk observed in a background population. Diabetic nephropathy (DN) is a progressive disease that affects about one third of diabetic patients and is among the...
Article
In both types of diabetes mellitus (DM), type 1 and type 2 (T1DM and T2DM), there are both endocrine and exocrine dysfunctions of the pancreas (PED), as well as disturbances in serum magnesium levels. The aim of this study was to examine the frequency of PED according to the level of fecal elastase-1 (FE-1) in patients with T1DM and T2DM, determini...
Article
Background: Apolipoproteins A-I and B (apoA-I and apoB) may be better indicators of the risk of cardiovascular and cerebrovascular diseases than conventional risk factors (RFs). The onset of ischemic stroke (IS) may be preceded by the development of atherosclerotic changes in carotid arteries, which can be detected by ultrasound. Only a certain %...
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Obesity is the result of excessive accumulation of adipose tissue, and positive energy balance is the dominant cause of obesity. Obesity has reached pandemic proportions and represents a major global health issue. It contributes to the development of several major illnesses, including Type 2 diabetes, cardiovascular diseases, and various types of c...
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Background: Sclerostin is an inhibitor of the wingless-type mouse mammary tumor virus integration site family/β-catenin signalling pathway (WβcSP), which plays an important role in bone metabolism and in vascular biology. It could act protective regarding atherosclerosis development through its effect on WβcSP in vascular cells. Nevertheless, resu...
Article
Background and aim: Current data show that 1h oral glucose tolerance test (OGTT) blood glucose (1h-BG) might identify persons at increased risk of developing type 2 diabetes and cardiovascular diseases more precisely than fasting blood glucose (FBG) and 2h OGTT blood glucose (2h-BG). The aim of study was to determine whether is justified to use 1h...
Article
Background and objectives: Obesity is often associated with insulin resistance (IR). We considered different IR indexes: the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) index, the two specimen (0 and 120 min) oral glucose tolerance test Matsuda Index (MI) and the Homeostasis Model Assessment-Adiponectin (HOMA-AD) index. These IR inde...
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Obesity is a disease with pandemic frequency, often accompanied by chronic metabolic and organic complications. Type 2 diabetes mellitus (T2DM) is among the most common metabolic complications of obesity. The first step in the treatment of T2DM is medical nutrition therapy combined with moderate physical activity and with advice to patients to redu...
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Background/Aims: Prolonged corrected QT interval (QTc) is related to ventricular malignant arrhythmia and increases the risk of sudden cardiac death. This study assesses the association between cardio metabolic abnormalities and length of the QTc interval in the Province of Vojvodina, a region with the highest prevalence of obesity in Serbia. Cardi...
Article
Introduction: It is indisputable importance of vitamin D for the preserved integrity of the skeleton and bone metabolism. The aim of the study was to analyse bone turnover parameters in relation to the vitamin D status in women with postmenopausal osteoporosis. Materials and methods: This study included a total of 195 postmenopausal women with oste...
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Introduction: Obesity is associated with wide variety of electrocardiographic (ECG) abnormalities. Prolonged QTc interval is common in obesity and it represents a delayed ventricular repolarisation which is associated with ventricular arrhythmias, syncope and sudden cardiac death. The aim of our study is to evaluate the effects of weight reduction...
Article
Type 1 diabetes (T1DM) is a disease characterized by autoimmune mediated destruction of the insulin producing beta cells of endocrine pancreas. Beside insulin deficiency, T1DM is also characterized by abnormal suppression of glucagon secretion in response to hyperglycemia. All these abnormalities are likely to leave patients dependent upon exogenou...
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Introduction: Uric acid level (UAL) might represent an indirect marker of metabolic syndrome (MS). Study investigates differences in UAL in the overall study group and in separate groups of normal weight, overweight and obese subjects, regarding the presence of MS. Materials and Methods: Cross sectional study included 1333 participants. Anthropomet...
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Diabetic retinopathy is a common micro vascular complication of diabetes. The risk of diabetic retinopathy is closely associated with the type and duration of diabetes, blood glucose, blood pressure and lipid disorders. This study aims to compare features of type 2 diabetes patients with and without diagnosed diabetic retinopathy. The cross-section...
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Introduction: Bisphosphonates are commonly used in the treatment of osteoporosis. The aim was to determine the effect of bisphosphonate therapy for osteoporosis on bone mineral density (BMD) depending on the Dolga index. Materials and methods: The study included 36 postmenopausal women with osteoporosis. BMD was measured by DXA of the spine and hip...
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Leptin is a hormone secreted by adipose tissue in direct proportion to amount of body fat and it regulates energy homeo-stasis. Leptin resistance is often associated with insulin resistance and lipid metabolism disorders in obese persons. Study investigates correlation of leptinemia with insulin resistance, and lipid and lipoprotein metabolism para...
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A key step for developing atherosclerosis and cardiovascular ischemic diseases is lipid peroxidation. Metabolism of iron is closely associated with oxidative stress and could be contributing cardiometabolic risk factor. Redox-active iron is effectively controlled by ferritin induced sequestration and ferroxidase activity. One source of redox-active...
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Given its possible protective effect on vascular endothelial function, we hypothesized that the circulating level of insulin-like growth factor 1 (IGF-1) could be associated with biomarkers of endothelial dysfunction and vascular inflammation, i.e., soluble intercellular adhesion molecule 1 (sICAM-1), soluble E-selectin (sE-selectin) and high-sensi...
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Aims Long-term hyperglycemia, characteristic for type 1 diabetes, causes enhanced oxidative stress, chronic inflammation and endothelial dysfunction which are the key events in the development of vascular complications. On the other hand, some data shows that existence of chronic degenerative complications may cause increased inflammatory marker le...
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Lingual thyroid gland is a rare anomaly of thyroid gland development, occurring more frequently in females. If it causes local symptomatology such as dysphagia, dysphonia or dyspnea it is diagnosed in childhood, however, if it is asymptomatic it is usually diagnosed in adulthood. We present a 23-year-old female patient in whom we diagnosed lingual...
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Background/Aim. Women with diabetes, especially diabetes type 1, have worse pregnancy outcomes, as well as increased incidence of spontaneous abortions, pre-eclampsia, fetal macrosomia, preterm delivery, congenital anomalies and perinatal mortality. The aim of this study was to analyze the course and outcome of pregnancy in the patients with diabet...
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Introduction: Although diagnostics and therapy are much improved over the years, women with gestational diabetes still have more adverse course and outcome of pregnancy than healthy women. Their pregnancies are more often complicated with the different forms of maternal and fetal morbidity. Our study investigates all cause early neonatal morbidity...
Article
Introduction: MTC originates from the parafollicular calcitonin secreting cells. One quarter of MTC patients have familial form of the disease with RET mutation. Case reports: First female patient underwent total thyroidectomy for MTC at the age 40. Further investigation showed elevated urinary catecholamine levels and MIBG scintiscan verified bila...
Article
Introduction: Diabetic retinopathy screening is the most accessible method of visualization of the affected small blood vessels in diabetic patients. Diabetic retinopathy is associated with age of patients, duration of diabetes, male sex, poor blood glucose control, central obesity, arterial hypertension, increased proteinuria, chronic inflammation...
Article
Introduction: Literature data suggests increased fracture risk in women with diabetes mellitus type 2 but the underlying mechanism is not fully understood. Aim of the study was to analyse bone turnover parameters in women with DM2 and in healthy women with osteoporosis in menopause. Materials and methods: There were 76 participants out of wich 36 w...
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Introduction and objectives: The aim of our study was to determine which characteristics of the uncontrolled diabetes are among randomly selected patients with type 1 (T1DM) and type 2 (T2DM) diabetes. Material and methods: A total of 194 diabetic patients were observed, 142 with T2DM and 52 with T1DM, recruted in outpatient clinic. Patients were d...
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Background: Phthalates presents widespread endocrine disrupting chemicals in many personal-care and consumer products. A limited number of experimental and human studies suggest that exposure to phthalate may be associated with altered thyroid function, but a problem is not elucidated enough. This study focused to examination of the association bet...
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Introduction: Epidemiological studies show that one half of vertebral fractures, which play an important role in estimation of future fracture risk, remain unrecognized. Aim: To establish vertebral fracture frequency in relation to bone mineral density in postmenopausal women. Methods: Study comprised 146 postmenopausal women. On the grounds of spi...
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Hodgkin lymphoma and anaplastic large cell lymphoma are malignancies that highly express CD30 antigen on the cell surface. Both are generally curable by standard chemotherapy but refractory diseases and relapses are treatment problems. Brentuximab-vedotin is a labeled monoclonal antibody against CD30 and it is approved for the treatment of Hodgkin...
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Diabetes mellitus type 2 and malignant diseases are among the most frequent causes of morbidity and mortality worldwide. Number of studies showed that breast carcinoma and other cancers are more frequent and have worse prognosis in patients with diabetes. The mechanisms of effect of type 2 diabetes to frequency and prognosis of breast carcinoma are...

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