Cagri Akin Sekerci

Marmara University · Department of Urology

Objective: The aim of this study was to investigate whether urinary glycosaminoglycans (GAG) levels reflect clinical status in men with lower urinary tract symptoms and if they could be used as a marker in management of overactive bladder (OAB). Methods: A total of 34 patients were recruited who were admitted with LUTS and diagnosed as having clini...

Aim We aimed to study the presence of lower urinary tract dysfunction (LUTD) and those objective parameters obtained from voiding diary (VD), uroflowmetric (UF) and postvoiding residual urine (PVR) and voiding dysfunction symptom score (VDSS) as possible factors effecting the success rate on STING to correct VUR. Materials and methods Children who...

Purpose The aim of this study is to evaluate the outcomes of retrograde intra renal surgery (RIRS) in the setting of large or multiple stones in children (<18 years). Materials and Methods Retrospective analysis was performed of paediatric RIRS cases at nine centres worldwide over a 6‐year period. Patients were divided into two groups: Group 1 had...

Aim The aim of this systematic review is to assess urinary biomarkers studied in children with neurogenic and non‐neurogenic lower urinary tract dysfunction (LUTD). Materials and Methods The systematic review was conducted in accordance with the PRISMA guidelines. The screening was performed on PUBMED without any publication date limitation. Only...

Studies on the effects of various urinary biomarkers in children with neurogenic or non-neurogenic lower urinary tract dysfunction (LUTD) have been published in recent years. Three of them are Brain Derived Neurotrophic Factor (BDNF), Adenosine Triphosphate (ATP), Matrix Metallopreteinase-2 (MMP-2), and various positive effects in diagnosis and fol...

Aim: The voiding diary (VD) yields crucial insights into voiding volumes (VV), voiding frequency (VF), and management habits in children with lower urinary tract (LUT) dysfunction. It is recommended to be conducted for a minimum of 2 days. Nevertheless, certain studies have indicated similarities in voided volumes between days in a three-day VD. T...

Aim: The purpose of our study was to evaluate the relationship of urinary brain-derived neurotrophic factor (BDNF), adenosine triphosphate (ATP), matrix metallopreteinase-2 (MMP-2) with urodynamic findings and upper urinary tract deterioration (UUTD) in children with myelodysplasia. Materials and methods: Children with myelodysplasia evaluated i...

Objective:This study aimed to investigate the protective effects of ellagic acid on testicular ischemia/reperfusion injury in rats.Materials and Methods:Twenty-one Sprague-Dawley rats were randomly divided into three groups: sham, ischemia/reperfusion (I/R), I/R + ellagic acid (EA). All animals underwent left scrotal exploration. In all groups exce...

BACKGROUND In the modern era of healthcare, advancements in artificial intelligence and natural language processing have allowed for the development of chatbots that can assist in answering patient questions and providing healthcare information [1]. One such chatbot is ChatGPT, a large language model trained by Open AI. ChatGPT can provide accurate...

Aim: The aim of the study is to compare the intra- and inter-observer interpretations of the same uroflowmetry study at two different times. Materials and methods: Two-hundred children with a voided volume of 50% above the expected bladder capacity were included. All traces were asked to be evaluated by 11 observers two times in a time span of 1...

Objective: To determine the normal vertical urethral meatus length (ML), maximum glanular width (MGW), the glanular seam length (between the lowest edge of urethral meatus and the glans closure line corona) (GSL) and GSL/ML ratio in all age groups. Materials and methods: Consecutive patients presented to urology and pediatric urology outpatient...

Objective: To develop near-infrared spectroscopy (NIR spectroscopy) device to diagnose testicular torsion with high sensitivity and specificity. Specifically, we aim to investigate the differentiation between testicular torsion from other pathologies such as orchidoepididymitis, varicocele, and hydrocele. Methods: Two LEDs with wavelengths of 66...

Objective: Biofeedback is an effective treatment in children with standard urotherapy-resistant dysfunctional voiding (DV). However, the duration of the session intervals is not standardized. We aimed to compare the effectiveness of daily and weekly sessions of biofeedback treatments. Methods: The data of children who received biofeedback due to...

Purpose To analyse and report the practice, outcomes and lessons learnt from a global series of retrograde intrarenal surgery (RIRS) in a paediatric multicentre series. Methods A retrospective review of anonymized pooled data gathered globally from 8 centres in paediatric patients (≤ 18 years of age) who had renal stones and underwent RIRS from 20...

Aim: We previously reported that some urodynamic parameters change with repetitive filling in children with neurogenic lower urinary tract dysfunction (LUTD). In this study, we aimed to search if three-times repeated filling cystometries (FC) and pressure-flow studies (PFS) would change the urodynamics parameters in children with non-neurogenic LU...

Objective: To evaluate the outcomes of flouroscopy-free retrograde intrarenal surgery (ffRIRS) and to investigate the factors that may affect stone-free rate. Materials and methods: The charts of patients who underwent ffRIRS between January 2017 and August 2019 were reviewed retrospectively. Patients with missing preoperative imaging and patien...

Aim There are scanty data on the rate of abnormal Tc-99 m dimercaptosuccinic acid (DMSA) renal scintigraphy and associated factors in children older than 5 years with diagnosis of VUR. We do not have knowledge about which older children should undergo DMSA after VUR diagnosis. This study aims to assess the rate of abnormal DMSA findings and associa...

Purpose We designed a multicenter, retrospective study to investigate the current trends in initial management of reflux with respect to European Association of Urology (EAU) Guidelines in Urology clinics of our country. Materials and Methods The study group consisted of 1988 renal units (RU) of 1345 patients treated surgically due to vesicoureter...

Introduction Following the Covid‐19 pandemic, the face‐to‐face meetings are delayed to a future date , which is still not clear. However, seminars, meetings, and conferences are necessary for updating our knowledge and skills. The web‐based seminars (webinars) are the solutions to this issue. This study aimed to show the participant behavior when w...

Objective: The objective of this study was to investigate the impact of kidney stones (KSs) on critically ill older adults (CIOA) staying longer than 24 hours in the ICU. Sepsis is one of the leading causes of mortality for ICU patients. KS disease is a well-known risk factor for bacteriuria and urinary tract infection. Methods: A total of 256 C...

Introduction: Following the Covid-19 pandemic, the face-to-face meetings are delayed to a future date , which is still not clear. However, seminars, meetings, and conferences are necessary for updating our knowledge and skills. The web-based seminars (webinars) are the solutions to this issue. This study aimed to show the participant behavior when...

Aim: To date, various molecules have been investigated to reduce the effect of renal ischemia/reperfusion (I/R) injury. However, none have yet led to clinical use. The present study aimed to investigate the protective effect of cordycepin (C) on renal I/R injury in an experimental rat model. Materials and methods: Twenty-four mature Sprague Dawl...

Purpose: We designed a multicenter, retrospective study to investigate the current trends in initial management of reflux with respect to EAU guidelines in Urology clinics of our country. Materials and Methods: The study group consisted of 1988 renal units (RU) of 1345 patients treated surgically due to VUR between years 2003-2017 in 9 different in...

Aim: International Children's Continence Society (ICCS) recommends urodynamics repeated at least twice for the optimal result. We aimed to search if three times repeating filling urodynamics in the same session would change the urodynamics parameters in children with neurogenic lower urinary tract dysfunction (NLUTD) due to myelodysplasia. Materi...

Objective: Since microscopic hematuria and pyuria can be observed in patients with a ureteral double-J (DJ) stent in place, urinalysis findings are not considered significant in terms of predicting stent-related infections. This study evaluates the presence of bacterial colonization and the value/ effectiveness of urine tests in predicting the resu...

Objective:To evaluate the clinical risk factors contributing to the development of extended spectrum beta-lactamase (ESBL)- producing asymptomatic bacteriuria in myelodysplastic children performing clean intermittent catheterization (CIC).Materials and Methods:The clinical risk factors for ESBL-producing bacteriuria were retrospectively investigate...

Paraurethral cysts are rare and occur with obstruction of the Skene duct. In this case, we aimed to present a paraurethral cyst in a baby girl. A 4-day-old newborn was consulted for pediatric urology because of an interlabial mass. In genital examination, a noninvasive mass measuring 2 × 1.5 cm was observed in the interlabial region, and the introi...

Objectives: Ischemia/reperfusion (I/R) injury is a common cause of renal injury and to date, many pharmacological agents have been identified to decrease I/R injury. One of the potential compound that can target I/R injury is chlorogenic acid (CGA). It has potent antiinflammatory, antibacterial, anti-oxidant, analgesic and antipyretic activities in...

A review of the literature indicated that sirtuin‐1 expression, a regulator of nitric oxide bioavailability in erectile dysfunction (ED) after melatonin therapy, has not yet been investigated. The objective of this study was to evaluate the protective effects of melatonin for erectile function with sirtuin‐1 protein expression in type 1 diabetic ra...

Aim: To explore the effects of experimental subarachnoid hemorrhage (SAH) on rabbit urinary bladder and to assess the potential protective effects of hyperbaric oxygen therapy (HBOT). Methods: A total of 15 male New Zealand white rabbits were divided randomly to one of three groups: group I was spared as the control group (n = 5), group II was e...

Background: The aim this study was to explain the underlying etiology of unknown scrotal masses. Case presentation: This study included 3 patients with a intrascrotal mass. One patient was over 50 years. The remaining patients were between the ages of 30-50. Patients had no serious complaints (two complained about having 3 testicles and one compla...

Objective:The aim of this study was to evaluate the efficacy and safety of extracorporeal shock wave lithotripsy (SWL) in a large patient group treated with SWL due to kidney stone.Materials and Methods:Data of 1997 patients, who underwent SWL due to renal stone in the at Atatürk University Medical Faculty Clinic of Urology between 2008 and 2013, w...

Although the standard treatment for testicular tumors is radical orchiectomy in children, testis-sparing surgery (TSS) is an alternative method in selected cases according to tumor size, tumor markers and histopathological findings. In this paper, we present two patients aged 11 and 12 years who underwent TSS in our clinic. Frozen section examinati...

Clitoromegaly due to non-hormonal causes is rare. In this case, we aimed to present an epidermal cyst that caused clitoromegaly after traditional female circumcision. A 22-year-old African female was referred to our clinic with enlarged clitoris. There is a mobile, soft, nonfluctuant mass with a size of 6 cm originating from the clitoral region at...

Purpose of Review Tethered cord syndrome (TCS) due to adhesion defect of the spinal cord is one of the major causes of lower urinary tract dysfunction (LUTD) in children. The aim of this article is to evaluate the association, diagnosis, and treatment of TCS with LUT disorders in children. Recent Findings TCS is divided into two groups as primary...

Abstract Purpose Urinary cytokines are proposed to predict the urodynamic findings and outcome of intradetrusor botulinum neurotoxin type A injection (iBoNT-Ai) in children with myelodysplasia. The relationship between urinary brain-derived neurotrophic factor (BDNF) and neurogenic and non-neurogenic detrusor overactivity (NDOA) has been shown, as...

Objective: To compare changes in connective, neural and muscle tissues, and extracellular matrix in child and adult patients so that we can create a more objective view on the timing of surgery. Materials and Methods: Twenty-six patients, who were operated for ureteropelvic junction (UPJ) obstruction in our clinic between September 2014 and May 201...

Objective: To determine the efficacy and safety of repeated intradetrusor onabotulinum toxin A (onaBoNT-A) injections in children with neurogenic detrusor overactivity due to myelodysplasia. Methods: The study group consisted of 19 children (4 boys, 15 girls), with a mean age of 10.3±3.1 years old, who had received at least two injections of 10...

Objective: The aim of this study was to determine the significance of contralateral testis size in predicting monorchism in pediatric patients with unilateral undescended testis. Materials and Methods: The data of patients who underwent surgical operation by a single pediatric urologist for undescended testis between 2013 and 2016 was evaluated ret...

To differentiate ureteral stones and phleboliths by measuring density [as Hounsfield unit (HU)] and volume (as mm(3)) of the opacities in the bony pelvis on unenhanced computerized tomography (U-CT). A total of 52 patients, who underwent semirigid ureteroscopy and laser lithotripsy for distal ureteral stone and had isochoronous phleboliths in U-CT,...

Objective: The aim of this study was to determine the effectiveness of the voiding dysfunction symptom score (VDSS) in evaluation of children with nocturnal enuresis. Materials and Methods: Four hundred children with nocturnal enuresis were included in the study. They were evaluated with VDSS, physical examination, urinalysis and 2-day voiding diar...

NTRODUCTION & OBJECTIVES:Urodynamic studies are the gold standard method for assessment oftreatment success following intradetrusor Botulinum Neurotoxin Type A (BoNTA) injections in childrenwith myelodysplasia. In this study we aimed to address the influence of BoNTA treatment on urine brainderived neurotrophic factor (BDNF) levels in patients who...

Background: Testicular torsion is a common problem and, to date, there is no agent to preserve testicular function following detorsion. Platelet-rich plasma (PRP), with its rich growth factor composition, has proven beneficial in regenerative therapy. It is believed that PRP has not been studied in testis for ischemia/reperfusion (I/R) injury. Ob...

Aims: The aim of this study was to determine the value of urine nerve growth factor (NGF), transforming growth factor beta 1 (TGF-Beta-1), tissue inhibitor of matrix metalloproteinase 2 (TIMP-2) levels to predict the urodynamic profile before and after botulinum neurotoxin type A (BoNT-A) treatment in children with myelodysplasia. Methods: This...

Bruselloz, ulkemizin bircok bolgesinde endemik olarak gorulen, insan ve hayvanlarda hastalik yapabilen, brusella bakterilerinin yol actigi onemli bir hastaliktir. Hastalik tum organ ve sistemleri etkileyebilir. Genitouriner sistem tutulumu %2-10 arasinda degismektedir. Bu makalede, epididimoorsit bulgulari ile basvurup, spesifik olmayan antibiyotik...

Purpose: The purpose of this study, is to find out the most accurate cut-off level for the detrusor leak point pressure (DLPP) in terms of upper urinary tract (UUT) protection in a cohort of children with myelodysplasia. Materials and methods: One hundred and ninety-three children with myelodysplasia were included in the study based on the avail...

Priapism in a newborn is a rare entity with only 15 cases reported in the literature since 1879. The most commonly detected etiologic factor is polycythemia, but most of the cases are idiopathic. Conservative treatment seems to be sufficient and surgical approach is usually unnecessary. Here, we present a prolonged erection in two newborns which oc...

Objectives: To evaluate the presence of upper urinary tract deterioration (UUTD) and accompanying pathologies in children treated with the diagnosis of non-neurogenic bladder-sphincter dysfunction (NNBSD). Patients and Methods: We retrospectively reviewed the medical records of 316 consecutive patients with NNBSD who were treated. All cohort were g...

Objective Nuclear imaging techniques such as 99mTc-dimercaptosuccinic acid (DMSA) and 99mTc-mercaptoacetyltriglycine (MAG-3) are widely used for the diagnosis and follow-up of urinary tract obstructions. Both imaging techniques provide the differential renal function (DRF) in slightly different ways. The aim of this study was to assess the MAG-3 sc...

Objective “Traditional subureteral transurethral injection” (STING) and “Double hydrodistention-implantation” (Double-HIT) injection techniques for vesicoureteral reflux (VUR) treatment are a less invasive, yet very effective options. The influence of injection techniques in treatment success is not adequately searched in children with overactive b...

Priapism in pediatric patients is a rare entity. We present an 8-yearold boy with known cerebral palsy. He came to the emergency department with sustained painful erection for 12 hours. Physical examination showed rigid penis. Blood count and biochemical analysis were normal. Although penile Doppler ultrasound revealed normal arterial and venous fl...

Objective To analyze the parameters that predict the surgical margin positivity after radical prostatectomy for localized prostate cancer. Materials and Methods In this multicenter study, the data of 1607 consecutive patients undergoing radical prostatectomy for localized prostate cancer in 12 different clinics in Turkey between 1993-2011 were asse...

To evaluate the role of the patient’s mood as a possible cause of erectile dysfunction (ED) following transrectal ultrasound-guided saturation biopsy.

This was a prospective single-arm study to assess the efficacy and safety of intradetrusor injections of onabotulinum toxin-A in children with urinary incontinence associated with neurogenic detrusor overactivity due to myelomeningocele. All patients had failed the first-line treatment of a combination of oral antimuscarinics and intermittent cathe...

Dimercaprosuccinic acid (DMSA) scintigraphy and urodynamic studies are gold standards to evaluate renal scarring and neurogenic bladder dysfunction (NBD), respectively. The aim of this study is to establish the value of bladder wall thickness (BWT) together with urine nerve growth factor (NGF), transforming growth factor β1 (TGF-β1) and tissue inhi...

Objective: To review the current literature of open radical retropubic prostatectomy and report the results of the last 250 open radical retropubic prostatectomies performed in our University clinic. Patients and Methods: A literature review was performed using the PubMed database with combinations of the following keywords radical prostatectomy, o...