Murat Canpolat

Murat Canpolat
Akdeniz University · Section for Biophysics

Doctor of Philosophy

About

76
Publications
8,241
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379
Citations
Citations since 2017
36 Research Items
225 Citations
20172018201920202021202220230102030405060
20172018201920202021202220230102030405060
20172018201920202021202220230102030405060
20172018201920202021202220230102030405060

Publications

Publications (76)
Preprint
The study aims to assess the thermal inactivation of airborne SARS-CoV-2 in a 30 m test room by an electric heater typically used to heat interior spaces during winter, particularly in resource-limited settings. Aerosolized SARS-CoV-2 was delivered to the test room at an ambient temperature of 20 C and 40% humidity. Two electric heaters with differ...
Article
Full-text available
PurposeThe present study aims to develop a new high-resolution imaging system for the early diagnosis of cervical neoplasia based on increased vessel density of the cervical tissue.Methods An optical device was developed to obtain high contrast and resolution images of vascular structures of the cervix in the present study. The device utilizes a te...
Article
Airborne transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the leading mechanisms of spread, especially in confined environments. The study aims to assess the thermal inactivation of SARS-CoV-2 at high temperatures in the time scale of seconds. An electric heater with a coiled resistance wire is located perpendi...
Article
Full-text available
The continuous-wave back reflection diffuse optical tomography (rCWDOT) system is one of the new medical imaging modalities. This study examines the success of reconstruction and three-dimensional (3D) image processing algorithms on data obtained from a heterogonous breast phantom by rCWDOT. Breast phantoms were prepared by putting a bit of spleen...
Article
Full-text available
In Diffuse Optical Tomography (DOT), data processing and reconstruction stages are crucial to obtain high-quality images. Thus, choosing suitable algorithms for the system is a critical choice. This study aims to determine an appropriate reconstruction algorithm for DOT imaging. There are several reconstruction algorithms used in DOT systems. Some...
Article
Full-text available
In breast cancer diagnosis, tumoral and non-tumoral breast lesions differentiation is a challenge. We investigate the feasibility of continuous-wave back reflection diffuse optical tomography (rDOT) in differentiation tumoral and non-tumoral breast lesions to solve this problem. Modified Beer-Lambert Law (MBLL) and Rytov solution of diffusion appro...
Article
Full-text available
Diffuse optical tomography (DOT) is a new emerging modality in the diagnosis of soft tissue abnormalities. DOT image quality substantially depends on the reconstruction stage. In the literature, there are many reconstruction algorithms used in DOT systems. However, some algorithms were improved for solving specific cases but still need to be improv...
Conference Paper
Full-text available
In the Diffuse Optical Tomography (DOT) after receiving data processing and reconstruction stages are crucial to obtain high-quality images. Thus, the selection of suitable algorithms for the system is a critical choice. In this study, the goal is to determine an appropriate reconstruction algorithm for medical imaging. There are many reconstructio...
Article
Background: Venous oxygen saturation reflects venous oxygenation status and can be used to assess treatment and prognosis in critically ill patients. A novel method that can measure central venous oxygen saturation (ScvO2) non-invasively may be beneficial and has the potential to change the management routine of critically ill patients. Objective...
Article
Full-text available
Background: Near-infrared spectroscopy (NIRS) is widely used to assess flap perfusions by measuring tissue oxygen saturation (StO2). However, the StO2 level for the onset of perfusion failure is still a controversial issue. Aim: This study proposes a new threshold of StO2 level for detecting the onset of perfusion failure as early as possible to...
Article
Full-text available
Difüz Optik Tomografi (DOT) sistemleri optik medikal görüntüleme yöntemlerindendir. DOT sistemlerinin görüntü oluşturma aşaması oldukça önemlidir. Bu çalışma da DOT sisteminde kullanılan iteratif geri çatım algoritmaları için ideal iterasyon sayının literatürdeki metotlara alternatif bir metot ile belirlenebilmesi amaçlanmaktadır. Bu metodun, kontr...
Article
Full-text available
Sürekli Dalga Difüz Optik Tomografi (Continuous Wave Diffuse Optical Tomography, CWDOT) sistemi tıp alanında kullanılan görüntüleme sistemlerinden biridir. Bu çalışmanın amacı, CWDOT sistemi ile oluşturulan üç boyutlu (3B) meme fantomu görüntülerine farklı görüntü işleme yöntemlerini 3B olarak uygulamak ve en uygun görüntü işleme yöntemini belirlem...
Preprint
Full-text available
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide with its different variants. The transmission efficiency of the new variants is much higher than the existing ones. Therefore, developing new preventive measures based on the transmission routes of the virus is needed to limit the spread. The possible transmission...
Article
Full-text available
In breast cancer diagnosis, tumoral and non-tumoral breast lesions differentiation is a challenge. We investigate the feasibility of continuous-wave back reflection diffuse optical tomography (rDOT) in differentiation tumoral and non-tumoral breast lesions to solve this problem. Modified Beer–Lambert Law and Rytov solution of diffusion approximatio...
Chapter
A key application for IoT based technologies in the field of healthcare is wireless medical sensors that can be used to monitor patients’ physiological information such as heartbeat, bowel activity and lung sounds. Real-time detection of bowel motility after major abdominal surgery has significant importance for the patients’ healing process. Due t...
Article
The aim of this study is to investigate the efficiency of elastic light single-scattering spectroscopy system, a noninvasive method, to acquire spectra during testicular biopsy from normal and damaged seminiferous tubules with various degrees of germ cell loss. Adult control rats and doxorubicin-injected rats to achieve seminiferous germ cell loss...
Article
Full-text available
Background: Photoplethysmography flow-mediated dilatation (PPG-FMD) is an endothelial function measurement tool, and its use is increasing as it is easy to apply and relatively inexpensive. The analysis protocol of PPG-FMD has not yet been standardized. This study aimed to define the continuous correction method in PPG-FMD analysis and interpret th...
Article
Full-text available
Cervical os Prediction, Cervix Uteri, Convolutional Neural Networks, Data Augmentation. In an automated cervical cancer test, the prediction of the location of the cervical os from 2D images is required. Cervical os is the reference point to determine the lesion's location by either using cervical four-quadrant location or by 12 o'clock locations....
Article
Full-text available
PurposeIn the present study, we investigated the potential application of elastic light single-scattering spectroscopy (ELSSS) as a noninvasive, adjunctive tool to differentiate between malignant and benign oral lesions in vivo.MethodsELSSS spectra were acquired from 52 oral lesions of 47 patients prior to surgical biopsy using a single optical fib...
Article
Full-text available
Diffüz optik tomografi (DOT), kanser tanısı veya kanser takibi için meme dokusunun doku kromoforlarının uzaysal dağılımını görüntülemek için 750-950 nm dalga boyu aralığını kullanır. DOT, doku optik özelliklerinin geri çatım teknikleri ile tomografik olarak gösterilmesini sağlar. Görüntülerdeki gürültüleri en aza indirmek ve daha gerçekçi tomografi...
Conference Paper
Cervical cancer is the second most common cancer in women􀇯s mortality and causes of death. Currently, the pap-smear test has been used for screening of cervical cancer. If the result of cytology (Pap test) is positive, the colposcopic examination is used to define the neoplastic region of the tissue for biopsy. Before the colposcopic examination, a...
Article
Full-text available
Ovarian torsion is agynecologic emergency that affects females of all ages. Early diagnosis is important to preserve ovarian function. The false positive rate for sonographic diagnosis of ovarian torsion is 50%; therefore, a new real-time approach is required to improve diagnostic accuracy. We investigated diffuse reflectance spectroscopy for diagn...
Article
A diffuse reflectance visible light spectroscopy method has been developed to estimate bovine cartilage thickness in real time. The system consists of a miniature UV-VIS spectrometer, a halogen tungsten light source, and an optical fiber probe including two 400-μm diameter fibers with a center-to-center separation of 1.2 mm used to acquire the spec...
Chapter
Günümüzde meme kanserlerinin erken teşhisi için birçok görüntüleme sistemleri kullanılmaktadır. Tomosentez, pozitron emisyon tomografi (PET) gibi sistemlerde iyonize radyasyon kullanılmaktadır. Manyetik Rezonans Görüntüleme (MRG) sisteminin maliyeti yüksek olup meme tümörlerinin teşhisi için kolayca ulaşılabilir değildir. Ultrasonun ise meme tümörl...
Chapter
One of the applications of big data research is to utilize inexpensive and unobtrusive Internet of Things- (IoT) driven devices for monitoring hospitalized patients whose physiological status requires close attention. This type of solution employs sensors to collect physiological information and uses gateways to send the data or warnings to caregiv...
Conference Paper
Full-text available
In recent years, breast cancers have been diagnosed by various imaging modalities. One of those imaging methods is Diffuse Optical Tomography (DOT). Currently, in imaging systems, image processing methods which is the next stage when digital images are obtained, are important task for the images to be well formed. This study was applied interpolati...
Conference Paper
Full-text available
Cartilage damage is a major problem with orthopedist and affects millions of people. The development of diagnostic methods is a fact that will enhance the quality of treatment decisions. The gold standard for the diagnosis of articular cartilage damage is visual assessment, which is based on subjective criteria's. In this study, a spectroscopic met...
Conference Paper
Full-text available
Several methods are used in the early diagnosis of breast cancer. Due to the disadvantages of these methods, the diffuse optical tomography (DOT) system is one of new methods have been developed to support these methods. In the DOT, the reconstruction technique used to create image is very important. Each reconstruction technique has some disadvant...
Conference Paper
Full-text available
Currently, there are several devices have been used for diagnosis of breast cancer such as X-ray tomography ultrasound and MRI. These devices sending harmful photons to the body, costly, lack of resolution and portability. Therefore searching new methods to diagnose breast cancer are necessity. One of these methods is Diffuse Optical Tomography (DO...
Conference Paper
Full-text available
Abstract: In recent years, breast cancers have been diagnosed by several imaging modalities. One of these imaging methods is the diffuse optical tomography (DOT) system. In the presented study, in-vitro data were acquired from a breast phantom using the our designed DOT system. Breast phantoms were reconstructed in three dimensions (3D) using Trunc...
Article
Objectives/hypothesis: The elastic light single-scattering spectroscopy (ELSSS) system is a new tool for the real-time diagnosis of cancerous lesions. In the current study, we have employed ELSSS to investigate its ability in differentiation between normal and cancerous larynx tissues ex vivo. Study design: Basic science study in assessment of l...
Article
Elastic light-scattering spectra acquired with single-fiber optical probes with diameters of 100, 200, 400, 600, 800, 1000, 1200, and 1500 μm were used to differentiate cancerous from noncancerous prostate tissues. The spectra were acquired ex vivo on 24 excised prostate tissue samples collected from four patients. For each probe, the spectra and h...
Article
Tissue oxygen saturation (StO2) is a useful parameter for medical applications. A spectroscopic method has been developed to detect pathologic tissues, due to a lack of normal blood circulation, by measuring StO2. In this study, human blood samples with different levels of oxygen saturation have been prepared and spectra were acquired using an opti...
Article
Elastic Light Single-Scattering Spectroscopy System (ELSSS) is a biomedical tool which is used for detection of cancerous tissues ex-vivo. ELSSS spectra depend primarily on the size of scatterers in the tissue and are not directly related to changes in the absorption which are caused by variations of the biological macromolecules. In the present st...
Conference Paper
Full-text available
This study presents a bioacoustic sensor system developed for early detection of the recovery of bowel activity after abdominal surgery and to perform analysis on bowel sounds. Different than other studies, in order to be able to attenuate noise, two capacitive microphones oriented in opposite directions are used. Bowel sounds are typically observe...
Article
Full-text available
We have designed a continuous wave, back-reflection diffuse optical tomography system; and developed a new practical calibration method including both optode efficiency and positional error corrections. System design, data acquisition and calibration protocols are described in detail. Monte Carlo (MC) simulations of photon distribution for tissue p...
Article
We have designed a continuous wave, back-reflection diffuse optical tomography system; and developed a new practical calibration method including both optode efficiency and positional error corrections. System design, data acquisition and calibration protocols are described in detail. Monte Carlo (MC) simulations of photon distribution for tissue p...
Article
Elastic Light Scattering Spectroscopy (ELSS) system with a single optical fiber probe was employed to detect positive surgical margins of prostate cancer in combination with principal components and linear discriminant analysis. ELSSS spectra in the 450-750 nm wavelength regions were obtained from the total of 299 tissue samples from 27 patients. T...
Article
Full-text available
Background: The aim of our study was to evaluate whether a portable, light-weight, light-emitting-diode phototherapy unit designed for home use is as effective as conventional blue-light fluorescent phototherapy (CFP) for treating hyperbilirubinemia in neonates. Methods: A total of 50 patients were recruited sequentially for treatment using CFP (n...
Article
Full-text available
Diffuse Optical Tomography (DOT) systems are becoming popular for research purposes. In DOT systems there are some obstacles that have to be solved such as, low noise to signal ratio, short acqusition time and the system calibration. We have developed a DOT system with less enery consumption and less component. In this work, DDC232 integrated curci...
Article
Full-text available
Continuous wave reflectance diffuse optical tomography (CWRDOT) systems incapable for accurate depth localization, since physical nature of light. We have used a new approach to calculate the unknown optical properties of breast like tissue by getting weight data from Monte Carlo (MC) simulation codes. In this work, we have developed a depth normal...
Conference Paper
Full-text available
Abstract The free flap is a unit of tissue and is transferred from one site to another with the aim of improving form and function while maintaining its own blood supply. A perfusion with sufficient tissue oxygenation is important for the survival of free flaps. The gold standard method for monitoring free flap has yet to be established. Many faili...
Article
This study describes a method for analysis of back reflectance spectroscopic data to estimate the concentration of endogenous or exogenous chromophores of tissue, noninvasively and in real time. In the study, tissue phantoms were prepared using intralipid and two chromophores, indocyanine green and meth� ylene blue. Reduced scattering and absorptio...
Conference Paper
A single optical fiber probe with a core diameter of 100 μm was used to deliver visible light to tissue and from tissue to a spectrometer to diagnose cancerous tissues of different organs. Measurements were performed on brain, skin, cervix and prostate tumor specimens and surrounding normal tissues exvivo. The spectral slopes were positive for norm...
Conference Paper
Full-text available
Loss of gastrointestinal motility occurs for patients who experience abdominal surgery and in order to avoid postoperative nausea and vomiting a period of fasting is commonly practiced. This study presents a system which acquires bowel sound signals by means of a devised stethoscope, performs real-time signal processing and notifies clinicians if b...
Article
Elastic light single-scattering spectroscopy (ELSSS) system has been developed and tested in diagnosis of cancerous tissues of different organs. ELSSS system consists of a miniature visible light spectrometer, a single fiber optical probe, a halogen tungsten light source and a laptop. Measurements were performed on excised brain, skin, cervix and p...
Article
Potential application of elastic light single-scattering spectroscopy (ELSSS) for differentiating high-grade squamous intraepithelial lesions (HSIL) from non-HSIL tissues was investigated. An elastic light single-scattering spectroscopy system was used to acquire spectra from cervix tissues. A single-fiber optical probe with a diameter of 100 Ým wa...
Article
Scattering and absorption coefficients were estimated within an error of 4.8% and 13.3% respectively using the back reflection spectral measurements and Monte Carlo simulations results from tissue phantoms consist of Intralipid and methylene blue.
Article
Scattering and absorption coefficients were estimated within an error of 4.8% and 13.3% respectively using the back reflection spectral measurements and Monte Carlo simulations results from tissue phantoms consist of Intralipid and methylene blue.
Article
Elastic light single-scattering spectroscopy (ELSSS) is a noninvasive and real-time technique that has been used to differentiate tumors from surrounding nontumor tissue in animal models and humans. To investigate potential application of ELSSS as an adjunctive tool for noninvasive, in vivo, real-time differentiation of malignant and benign skin le...
Article
Full-text available
Elastic light single-scattering spectroscopy (ELSSS) system with a single optical fiber probe was employed to differentiate cancerous prostate tissue from non-cancerous prostate tissue ex-vivo just after radical prostatectomy. First, ELSSS spectra were acquired from cancerous prostate tissue to define its spectral features. Then, spectra were acqui...
Article
In order to recover distributions of optical parameters of underlining tissues utilizing backreflection optic tomography or diffuse reflectance spectroscopy for diagnostic proposes, trajectories of photons should be correctly estimated within tissue. Therefore, we have simulated the soft tissues with 1% Intralipid emulsion and have determined photo...
Article
Joint cartilage thickness has been estimated using spatially resolved steady-state reflectance spectroscopy noninvasively and in-real time. The system consists of a miniature UV-VIS spectrometer, a halogen tungsten light source, and an optical fiber probe with six 400 um diameter fibers. The first fiber was used to deliver the light to the cartilag...
Article
Joint cartilage thickness has been estimated using spatially resolved steady-state reflectance spectroscopy noninvasively and in-real time. The system consists of a miniature UV-VIS spectrometer, a halogen tungsten light source, and an optical fiber probe with six 400 um diameter fibers. The first fiber was used to deliver the light to the cartilag...
Article
The aim of this study was to develop an optical system to measure damaged cartilage thickness in-vivo and real time using an optical fiber probe and conducting ex-vivo elastic light-scattering spectroscopy experiments on different thicknesses of damaged calf's patella cartilage. An elastic light-scattering spectroscopy system was assembled with a m...
Article
We have investigated the potential application of elastic light single-scattering spectroscopy in detection of cervical precancerous lesions non-invasively and in real time. Ex-vivo spectroscopic measurements were performed on 95 cervix biopsy tissue of 60 patients. Normal cervix tissue from 10 patients after hysterectomy was used as a control grou...
Article
We have investigated the potential application of elastic light single-scattering spectroscopy (ELSSS) as an adjunctive tool for screening of cervical precancerous lesions non-invasively and in real time. Ex-vivo measurements were performed on 95 cervix biopsy tissue of 60 patients. Normal cervix tissue from 10 patients after hysterectomy was used...
Article
We have investigated the potential application of elastic light single-scattering spectroscopy (ELSSS) as an adjunctive tool for intraoperative rapid detection of brain tumors and demarcation of the tumor from the surrounding normal tissue. Measurements were performed on 29 excised tumor specimens from 29 patients. There were 21 instances of low-gr...
Article
Cutaneous melanoma is the most serious form of skin cancer and is curable only if it is detected early. The most effective treatment for the melanoma is surgical excision of the lesion. Traditionally, wide margins of excision have been used for effective treatment, but are not always desirable due to increased risk of infection and esthetic reasons...
Article
We have used elastic light scattering spectroscopy to differentiate between malign and benign skin lesions. The system consists of a UV spectrometer, a single optical fiber probe and a laptop. The single optical fiber probe was used for both delivery and detection of white light to tissue and from the tissue. The single optical fiber probe received...
Article
The goal of this study was to differentiate the parts of lamb brain according to elastic scattering spectroscopy and detect the optical alterations due to coagulation. Cells and tissues are not uniform and have complex structures and shapes. They can be referred to as scattering particles. The process of scattering depends on the light wavelength a...

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Projects (5)
Project
Hastalar ve diş hekimleri için en sık uygulanan tedavilerden birisi dolgudur. Dolgu işleminin gerçekleştirilebilmesi için piyasadaki kompozitlere uygun dalga boyunda bir polimerizasyon cihazına ihtiyaç vardır. Bu tip ürünlerde yurt dışı menşeili üretimlere rastlanmakla beraber, yerli bir ürün bulunmamaktadır. Bu ürünler sadece kısa süreli kullanım için uygundurlar. Ayrıca bu cihazlarda, çoğunlukla dalga boyu çok dardır. (örn:420nm-480nm) Bunların yanında bu ürünlerin yurt dışı menşeili cihazlar olmasından dolayı, yüksek fiyatın yanında, cihazların sıklıkla arızalanması gibi sorunları da bulunmaktadır. Projemiz, hasta ve diş hekimi için konforlu, kullanılan teknoloji sayesinde ısınmayan, geniş dalga boyunda (385nm-515nm) daha kapsamlı bir kullanım sağlarken, tıbbi cihazların yerlileştirmesinde önemli bir adım olacağı düşünülmektedir.
Project
Karaciğer nakillerinde hayvan modeli ve postoperatif klinik takibinde kullanılması planlanan cihazların başarılı bir şekilde geliştirilmesi ve uygulaması