Zhe Li's scientific contributions
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Publications (2)
Purpose: To evaluate the effect of Coscinium fenestratum (CF) crude extract on hypertension in animal models. Methods: Dichloromethane (DCM), ethyl acetate (EA), and butanol (BuOH) extracts were obtained by fractionation from the crude methanol extract. The dried extracts were then administered to Sprague-Dawley (250 – 300 mg) rats (n = 20) and fro...
This study was done to evaluate the anti-hypertensive effects of stem extract of Coscinium fenestratum (CF). The stems were air dried for 2 days, grounded and then soaked in organic solvent for 2 days. Thereafter the filtered extract was concentrated using rotary evaporator at 450C to obtain the crude extract. Partial purification was done using si...
Citations
... In KCl-induced contraction, the highest concentration of the extract (160 g/mL) stimulated 33.1±2.3 and 26.6±3.4% relaxation in endothelium-intact and denuded-rings, respectively, while it produced 95.5±2.0 and 85.2±3.6% relaxation in the PE-contracted rings. Further, Zhang et al. (2018) evaluated the effect of crude methanol extract and its fractions on hypertension using animal models. The crude methanol extract and Fraction E significantly reduced mean arterial blood pressure (36.94 and 45.44%), heart rate (33.75 and 40.65 %), and force of contraction (54.69 and 59.22%), respectively. ...
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... The skeletal muscle is the largest (by mass) organ of the human body and is the primary site of glucose uptake, disposal, and storage, accounting for approximately 75% of the entire body's glucose uptake under insulin stimulation [25]. As a result, maintaining normal glucose levels requires proper skeletal tissue function [26,27]. The L6 skeletal muscle cell line and skeletal muscle tissue from STZ-induced diabetic rats were used in this investigation because they express a high level of GLUT4, which is required for glucose absorption from the plasma. ...
