Yuan Hong's research while affiliated with The Third Xiangya Hospital of the Central South University and other places
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Publications (3)
The roles of androgens on cardiovascular physiology and pathophysiology are controversial as both beneficial and detrimental effects have been reported. Although the reasons for this discrepancy are unclear, multiple factors such as genetic and epigenetic variation, sex-specificity, hormone interactions, drug preparation and route of administration...
Background/aims:
This study aimed to investigate renalase gene polymorphism in patients with hypertension and concomitant coronary heart disease (CHD) and to evaluate the risk for CHD in hypertensive patients from the view of genetics.
Methods:
NCBI and HapMap genome database were employed to screen the Single nucleotide polymorphisms (SNP). The...
Growing evidences support that androgen displays beneficial effects on cardiovascular functions although the mechanism of androgen actions remains to be elucidated. Modulation of endothelial cell growth and function is a potential mechanism of androgen actions. We demonstrated in the present study that androgens [dihydrotestosterone (DHT) and testo...
Citations
... In cardiovascular diseases (CVD), sex differences are relevant to diagnosis, pathophysiology, and treatment efficiency [5,6] There are data showing the role of androgen hormones on the functionality of EPCs [7][8][9]. However, there are several conflicting reports that do not support this notion [10,11]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/281143602630668-1444041266338_Q64/Weihong-Jiang.jpg)
... In hypertensive patients, serum renalase concentrations were higher than in those with normal blood pressure values (27.2 ± 0.4 vs. 25.1 ± 0.2 µg/mL) [37]. Subsequent studies by other research groups have also focused on the polymorphism in this gene and its impact in different populations on cardiovascular disease incidence-not only hypertension, but also cardiac hypertrophy, ventricular dysfunction, poor exercise capacity, and inducible ischemia in individuals with stable coronary artery disease [48][49][50][51]. In addition, due to the frequent co-occurrence of hypertension with type 2 diabetes, studies were also conducted that show the association of the C allele of the rs2296545 SNP occurrence with hypertension in type 2 diabetes [51]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/278834248208386-1443490673045_Q64/Xiaogang-Li-5.jpg)
... It has been reported that androgens increase eNOS expression and NO production in HUVECs through AR-mediated genomic and non-genomic mechanisms [41]. They also promote angiogenesis, in part by activating the PI3-K/Akt-eNOS pathway in response to ischemic stress [42]. The results are in line with and extend our previous findings, namely that in MSCs, DHT promotes NO release and facilitates integration into cardiac tissue via ARs [26]. ...
