Yoshiko Hirano's research while affiliated with Asahikawa Medical University and other places
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Publications (7)
To examine the effects of thrombin on RANTES mRNA expression through protease activated receptor in synovial fibroblasts in patients with rheumatoid arthritis (RA).
A semiquantitative reverse transcriptase-polymerase chain reaction and reporter gene assay were performed using cultured human synovial fibroblasts from patients with RA. The up regulat...
Fibrates, hypolipidemic agents, are reported to be effective in treatment of primary biliary cirrhosis. However, the mechanism involved in therapeutic benefits of fibrates in primary biliary cirrhosis remains unknown. In contrast, hepatic regulated upon activation, normal T-cell expressed and secreted (RANTES) is increased in patients with primary...
Abstract We investigated the role of nuclear factor (NF)-κB on tumor necrosis factor (TNF)-α-induced regulated upon activation, normal T-cell expressed and secreted (RANTES) expression in fibroblast-like synoviocytes from patients with rheumatoid arthritis (RA). Using cultured human fibroblast-like synoviocytes from patients with RA, semiquantitati...
Regulated upon activation, normal T-cells expressed and secreted (RANTES) mainly migrates memory type CD4+ T-lymphocytes to inflamed tissues. In this study, we examined effects of bile acids on RANTES gene expression in human hepatoma cells. Upon stimulation with hydrophobic bile acids, RANTES proteins were clearly increased. Semiquantitative RT-PC...
We investigated the effect of EPC-K1, which is a phosphodiester compound of vitamin E and vitamin C, on NF-kappaB activity in human cultured astrocytoma cells T98G. In TNFalpha-stimulated T98G cells, treatment with EPC-K1 inhibited both DNA binding activity and transactivation of NF-kappaB in a dose-dependent manner, and the suppressive effect of E...
Gene activation by NF-κB/Rel transcription factors is modulated by synergistic or antagonistic interactions with other promoter-bound
transcription factors. For example, Sp1 sites are often found in NF-κB-regulated genes, and Sp1 can activate certain promoters
in synergism with NF-κB through nonoverlapping binding sites. Here we report that Sp1 act...
Citations
... Because the RANTES promoter contains two NF-kB regulatory sites (21), it is suggested that RANTES expression is regulated by NF-kB. In our study, RANTES accumulation evoked by LPS stimulation was markedly inhibited in the presence of PDTC and DPN, respectively. ...
... NF-κB regulates BACE1 expression differently under different conditions, such as lowering BACE1 expression in physiological conditions but promoting Aβ generation in pathology [128]. SP1 is one of the first identified regulators for BACE1, working as an activator for β-secretase expression and also interacting with NF-κB [129,130]. The transcription of APOE can be upregulated by cyclic AMP (cAMP), retinoic acid (RA), PPARγ, and Aβ itself. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/808726118277122-1569826740642_Q64/Masaki-Hiramoto-2.jpg)
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... Vitamin C is water-soluble and is one of the most important antioxidants in the aqueous environment. The administration of ascorbic acid inhibits the expression of Nuclear-kappa B factor NF-κB in the kidney, which increases the synthesis of reactive oxygen species [7][8][9]. In addition, it plays an important role in the regeneration of αtocopherol [10]. ...
... Furthermore, bile acids increase the expression of regulated on activation normal T-cell expressed and secreted (RANTES), which migrates memory type CD4+ Tlymphocytes to inflamed tissues, in the hepatocytes of patients with PBC [29]. Bezafibrate and fenofibrate decrease the chenodeoxycholic acid-and tumor necrosis factor-induced mRNA expression and production of RANTES protein in human hepatoma cells [30,31]. ...
... Fibrate treatment has also been found to reduce CD4 + T cell migration to the liver. Bezafibrate and fenofibrate have been shown to decrease elevated normal T-cell expressed and secreted (RANTES) levels induced by chenodeoxycholic acid (75). RANTES, a member of the CC chemokine family, mediates the migration of CD4 + T cells to inflamed tissues, and in PBC RANTES expression has been observed to be elevated (75,76). ...
... In RA, synovial fibroblasts proliferate and form a hyperplastic and invasive tissue called pannus. Through PAR-1 cleavage, thrombin upregulates the expression of RANTES which then induces NF-kB and IL-6 expression, leading ultimately to synovial fibroblast differentiation and pannus formation [25,37,57,58]. In contrast, a protective role for PAR-1 in the joint has also been described. ...
Reference: Protease Activated Receptors and Arthritis
