Yang Zhang's research while affiliated with Third Military Medical University and other places
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Publication (1)
Previous studies have shown that iron redistribution and deposition in the brain occurs in some neurodegenerative diseases, and oxidative damage due to abnormal iron level is a primary cause of neuronal death. In the present study, we used the single prolonged stress (SPS) model to mimic post-traumatic stress disorder (PTSD), and examined whether i...
Citations
... In a clinical study, PTSD patients exhibited downregulation of certain genes related to the oxidative phosphorylation pathway in the dorsolateral prefrontal cortex, including Atp5e, Cox8a, NADH: ubiquinone oxidoreductase subunit B5 (Ndufb5), and NADH: ubiquinone oxidoreductase core subunit S2 (Ndufs2) [61]. Our results align with prior research that reported mitochondrial dysfunction in the prefrontal cortex of rats with PTSD through RNA sequencing [62,63]. More than 90% of the cellular energy generation takes place within the mitochondria through a process known as oxidative phosphorylation, and it has also been found that oxidative phosphorylation is a biochemical process that occurs in the inner mitochondrial membrane; it fuels neuronal physiological functions by producing ATP energy stores [64]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/639771781115904-1529544887512_Q64/Jiqiang-Zhang-3.jpg)
