Yan Liu's research while affiliated with Fred Hutch Cancer Center and other places
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Publications (13)
The ability to predict adverse-event occurrences accurately in long-term survivors of childhood cancer is of high importance in late effects research, both clinically and methodologically.
This article considers a statistical prediction of future events in a cohort, taking second malignant neoplasm (SMN) incidence in a large cohort of long-term chi...
Despite interest in the well-being of adult survivors of childhood rhabdomyosarcoma (RMS), few studies have examined their health-related quality of life (HRQOL). This study evaluated physical and social aspects of HRQOL among long-term childhood RMS survivors relative to a sibling comparison group, and assessed whether physical impairment among RM...
Subsequent primary neoplasms of the central nervous system (CNS) have frequently been described as late events following childhood leukemia and brain tumors. However, the details of the dose-response relationships, the expression of excess risk over time, and the modifying effects of other host and treatment factors have not been well defined.
Subs...
This report examines the incidence of and risk factors for strokes that occur in > or = 5-year survivors of childhood leukemia and brain tumors.
The rate of first occurrence of self-reported late-occurring strokes was determined for leukemia survivors (n = 4,828), brain tumor survivors (n = 1,871), and a comparison group of a random sample of cance...
Radiation exposure at a young age is a strong risk factor for thyroid cancer. We conducted a nested case-control study of 69 thyroid cancer cases and 265 controls from a cohort of 14,054 childhood cancer survivors to evaluate the shape of the radiation dose-response relationship, in particular at high doses, and to assess modification of the radiat...
To examine the prevalence and predictors of health insurance coverage and the difficulties obtaining coverage in a large cohort of childhood cancer survivors.
This study included 12,358 5-year survivors of childhood cancer and 3,553 sibling controls participating in the Childhood Cancer Survivor Study. Data were collected by surveys distributed in...
We determined risk of cancer among first-degree relatives of 5-year survivors of childhood leukemia, lymphoma, central nervous system tumors, sarcomas, Wilms' tumor, and neuroblastoma. Subjects were 13,703 participants in the Childhood Cancer Survivor Study. Family history was collected on 56,759 first-degree relatives using a self-reported questio...
The objectives of this report are to examine the incidence of and risk factors for stroke among childhood Hodgkin's disease (HD) survivors.
The Childhood Cancer Survivor Study is a multi-institutional cohort study of more than 5-year cancer survivors diagnosed between 1970 and 1986 and a sibling comparison group. Incidence rates of stroke among HD...
Nonmelanoma skin cancer (NMSC) has become the most common type of cancer in many populations throughout the world. Ultraviolet and ionizing radiation are known risk factors. Because NMSCs are rarely lethal and most cancer registries do not routinely report data regarding these cancers, they have received little attention in studies evaluating long-...
We assessed late mortality in 854 individuals who had survived 2 or more years after autologous hematopoietic cell transplantation (HCT) for hematologic malignancies. Median age at HCT was 36.5 years, and median length of follow-up was 7.6 years. Overall survival was 68.8% +/- 1.8% at 10 years, and the cohort was at a 13-fold increased risk for lat...
Survivors of malignant disease in childhood who have had radiotherapy to the head, neck, or upper thorax have an increased risk of subsequent primary thyroid cancer, but the magnitude of risk over the therapeutic dose range has not been well established. We aimed to quantify the long-term risk of thyroid cancer after radiotherapy and chemotherapy....
Survival of childhood cancer patients has increased remarkably in the last several decades due to therapeutic improvements. Associated with this progress is the emerging need to accurately assess/minimize late effects of cancer therapy in long-term survivors. This paper considers a methodological issue in assessing the risk of second-primary malign...
The Childhood Cancer Survivor Study is a resource that was designed to investigate long-term effects among 5-year survivors of childhood and adolescent malignancies. Previous studies have shown that exposure to chemotherapy and/or radiation can compromise pulmonary function in these survivors of childhood cancer.
Using information obtained from que...
Citations
... Frequently assessed endocrine outcomes have included obesity, metabolic syndrome, and growth hormone deficiency [52]. Though less studied, late effects involving other organ systems have been identified, including pulmonary abnormalities (e.g., pulmonary fibrosis, pleurisy, and recurrent pneumonia) [53], ocular impacts (e.g., cataracts, glaucoma, legal blindness, dry eyes) [54], musculoskeletal late effects [55], and reproductive consequences (altered pubertal timing and sexual dysfunction for both sexes, ovarian failure for females, oligo/azoospermia for males) [56]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272804029399051-1442052957540_Q64/Marilyn-Stovall.jpg)
... To investigate the effect of each factor after having adjusted for potential confounders, multivariable Poisson regression models that included a random intercept for each country were used [20]. Directed acyclic graphs [21] and evidence from current literature [22] were used to guide the choice of potential set of confounders to include in each Poisson regression model. RRs derived from these Poisson regression models can be interpreted as a ratio of SIRs, having adjusted for potential confounders [23]. ...
... Conditioning regimens have evolved from chemotherapy with total body irradiation and high-dose chemotherapy to new drug combinations of chemotherapy. Although BEAM remains the classic high-dose chemotherapy regimen, many clinical studies of alternative regimens have been performed in recent years due to the pulmonary toxicity and shortage of carmustine, and the BeEAM regimen containing bendamustine is one alternative regimen [9][10][11][12]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/279972175466512-1443761976499_Q64/Smita-Bhatia-2.jpg)
... NMSC is known as the most common type of cancer in the general population, but usually does not occur until later in life. For individuals of European ancestry, incidence of NMSC peaks at around 70 years of age and is highly unusual in the teenage years, but were observed at these ages in patients with FA (11). In a recent study that analyzed statistical associations between clinical parameters in NMSC occurrences, researchers found that the mean diagnostic age was 70.1 years for BCC and 74.2 years for SCC (12). ...
... The eye lens dose was used to estimate the stochastic effect such as cataracts, were reported with a tolerance dose at 150 mSv/year (Stewart et al., 2012). We also estimated the parotid dose, according to the benefit of IMRT technique for reducing the parotid dose, and estimated the dose to thyroid gland as a radiosensitive organ, because of high risk of radiation-induced secondary cancers (Ronckers et al., 2006;Sigurdson et al., 2005). The depth correction factor (C Depth ) was used to estimate absorbed dose. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281191026872-1695586520715_Q64/Cecile-Ronckers.jpg)
... Seventy, although we hypothesized that the type of cancer influences fear about offspring and health and parenting behavior, this research question could not be answered due to a lack of statistical preconditions. Lastly, given the increased risk of cancer in siblings of CCS (Friedman et al., 2005), who also grow up with highly distressed parents (Ljungman et al., 2014), and for whom the issue of childhood cancer is very real, it might be reasonable to survey people who are unaffected by this topic as an additional control group in future studies. To offer adequate patient counseling and address concerns, further assessment of offspring health is crucial. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/959028981137408-1605661735075_Q64/Nina-Kadan-Lottick.jpg)
... Furthermore, the same meta-analysis showed consistent differences in carotid AS and IMT between irradiated and unirradiated carotid arteries. The main issue was that the majority of studies utilized sub-optimally matched controls for each endpoint [7,[37][38][39][40]. We also found a significant positive correlation between neck RT dose and AS which has not been described so far. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/997423694499840-1614815748861_Q64/Daniel-Bowers-2.jpg)
... 122 Additionally, inequities within the financial service landscape for cancer survivors have been highlighted such as job discrimination or reduced access to travel or life insurance, bank loans and adoption services which can further exacerbate financial toxicity. 109,123,124 ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272379289010199-1441951691459_Q64/Elyse-Park.jpg)
... [4][5][6][7][8] For instance, 25% of RMS survivors who participated in the Childhood Cancer Survivor Study (CCSS) reported endocrine morbidity and nearly 40% reported neurosensory sequelae. 8 Subsequent work on HRQOL in the same cohort showed that RMS survivors experience limitations in routine activities at work and in school, 9 which is in line with other studies. 10,11 Research in survivors of RMS remains limited, and existing studies typically include small samples from single sites. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/278419733532672-1443391845105_Q64/James-Gurney-3.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/281220836544521-1444059680253_Q64/K-Scott-Baker.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/711471487000579-1546639429951_Q64/Robert-Hayashi-2.jpg)
... The eye lens dose was used to estimate the stochastic effect such as cataracts, were reported with a tolerance dose at 150 mSv/year (Stewart et al., 2012). We also estimated the parotid dose, according to the benefit of IMRT technique for reducing the parotid dose, and estimated the dose to thyroid gland as a radiosensitive organ, because of high risk of radiation-induced secondary cancers (Ronckers et al., 2006;Sigurdson et al., 2005). The depth correction factor (C Depth ) was used to estimate absorbed dose. ...
