William F. Richter's research while affiliated with University of Colorado Boulder and other places
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Publications (2)
The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits, controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining feature of Mediator is its intrinsic disorder and conformational flexibility, which contributes to its ability to undergo phase separation and to interact with a myriad of r...
Citations
... The Mediator complex is a general regulator of transcription. It serves as a bridge to facilitate functional interactions between the basal transcriptional machinery, general transcription factors and cofactors to orchestrate transcription through RNA Polymerase II (El Khattabi et al., 2019;Richter et al., 2022). In mammals, Mediator is a multiprotein complex comprised of 26-30 unique proteins that are ubiquitously expressed, and are organized into the Tail, Middle, Head, and Kinase submodules (Flanagan et al., 1991;Thompson et al., 1993;Kim et al., 1994;Fondell et al., 1996). ...
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